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1BJC
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SOLUTION NMR STRUCTURE OF AMYLOID BETA[F16], RESIDUES 1-28, 15 STRUCTURES
Descriptor: AMYLOID BETA-PEPTIDE
Authors:Poulsen, S.-A, Watson, A.A, Craik, D.J.
Deposit date:1998-06-23
Release date:1998-11-18
Last modified:2021-11-03
Method:SOLUTION NMR
Cite:Solution structures in aqueous SDS micelles of two amyloid beta peptides of A beta(1-28) mutated at the alpha-secretase cleavage site (K16E, K16F)
J.Struct.Biol., 130, 2000
1NMJ
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BU of 1nmj by Molmil
The Solution Structure of Rat Ab-(1-28) and its Interaction with Zinc: Insights into the Scarity of Amyloid Deposition in Aged Rat Brain
Descriptor: amyloid beta-peptide from Alzheimer's disease amyloid A4 protein homolog
Authors:Huang, J, Yao, Y, Tang, W.X.
Deposit date:2003-01-10
Release date:2003-01-28
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:The solution structure of rat Abeta-(1-28) and its interaction with zinc ion: insights into the scarcity of amyloid deposition in aged rat brain
J.Biol.Inorg.Chem., 9, 2004
5OQV
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BU of 5oqv by Molmil
Near-atomic resolution fibril structure of complete amyloid-beta(1-42) by cryo-EM
Descriptor: Amyloid beta A4 protein
Authors:Gremer, L, Schoelzel, D, Schenk, C, Reinartz, E, Labahn, J, Ravelli, R, Tusche, M, Lopez-Iglesias, C, Hoyer, W, Heise, H, Willbold, D, Schroeder, G.F.
Deposit date:2017-08-14
Release date:2017-09-13
Last modified:2017-10-18
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Fibril structure of amyloid-beta (1-42) by cryo-electron microscopy.
Science, 358, 2017
7RTZ
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BU of 7rtz by Molmil
X-ray crystallographic structure of a beta-hairpin peptide derived from amyloid beta 14-40
Descriptor: Amyloid-beta protein 40, CHLORIDE ION
Authors:Samdin, T.D, Kreutzer, A.G, Nowick, J.S.
Deposit date:2021-08-16
Release date:2022-08-31
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A beta-Barrel-Like Tetramer Formed by a beta-Hairpin Derived From A beta
Chem Sci, 2023
3IFN
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BU of 3ifn by Molmil
X-ray structure of amyloid beta peptide:antibody (Abeta1-40:12A11) complex
Descriptor: 12A11 FAB antibody heavy chain, 12A11 FAB antibody light chain, Amyloid beta A4 protein
Authors:Weis, W.I, Feinberg, H, Basi, G.S, Schenk, D.
Deposit date:2009-07-24
Release date:2009-11-17
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural correlates of antibodies associated with acute reversal of amyloid beta-related behavioral deficits in a mouse model of Alzheimer disease.
J.Biol.Chem., 285, 2010
1Z0Q
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BU of 1z0q by Molmil
Aqueous Solution Structure of the Alzheimer's Disease Abeta Peptide (1-42)
Descriptor: Alzheimer's disease amyloid
Authors:Tomaselli, S, Esposito, V, Vangone, P, van Nuland, N.A, Bonvin, A.M, Guerrini, R, Tancredi, T, Temussi, P.A, Picone, D.
Deposit date:2005-03-02
Release date:2006-05-23
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:The alpha-to-beta Conformational Transition of Alzheimer's Abeta-(1-42) Peptide in Aqueous Media is Reversible: A Step by Step Conformational Analysis Suggests the Location of beta Conformation Seeding
Chembiochem, 7, 2006
1BA6
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BU of 1ba6 by Molmil
SOLUTION STRUCTURE OF THE METHIONINE-OXIDIZED AMYLOID BETA-PEPTIDE (1-40). DOES OXIDATION AFFECT CONFORMATIONAL SWITCHING? NMR, 10 STRUCTURES
Descriptor: AMYLOID BETA-PEPTIDE
Authors:Watson, A.A, Fairlie, D.P, Craik, D.J.
Deposit date:1998-04-22
Release date:1998-06-17
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:Solution structure of methionine-oxidized amyloid beta-peptide (1-40). Does oxidation affect conformational switching?
Biochemistry, 37, 1998
1BJB
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SOLUTION NMR STRUCTURE OF AMYLOID BETA[E16], RESIDUES 1-28, 14 STRUCTURES
Descriptor: AMYLOID BETA-PEPTIDE
Authors:Poulsen, S.-A, Watson, A.A, Craik, D.J.
Deposit date:1998-06-23
Release date:1998-11-04
Last modified:2021-11-03
Method:SOLUTION NMR
Cite:Solution structures in aqueous SDS micelles of two amyloid beta peptides of A beta(1-28) mutated at the alpha-secretase cleavage site (K16E, K16F)
J.Struct.Biol., 130, 2000
1HZ3
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BU of 1hz3 by Molmil
ALZHEIMER'S DISEASE AMYLOID-BETA PEPTIDE (RESIDUES 10-35)
Descriptor: A-BETA AMYLOID
Authors:Zhang, S, Iwata, K, Lachenmann, M.J, Peng, J.W, Li, S, Stimson, E.R, Lu, Y, Felix, A.M, Maggio, J.E, Lee, J.P.
Deposit date:2001-01-23
Release date:2001-01-31
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:The Alzheimer's peptide a beta adopts a collapsed coil structure in water.
J.Struct.Biol., 130, 2000
7B3J
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Dynamic complex between all-D-enantiomeric peptide D3 with wild-type amyloid precursor protein 672-726 fragment (amyloid beta 1-55)
Descriptor: D3 all D-enantimeric peptide, Isoform L-APP677 of Amyloid-beta precursor protein
Authors:Bocharov, E.V, Volynsky, P.E, Okhrimenko, I.S, Urban, A.S.
Deposit date:2020-12-01
Release date:2021-01-13
Last modified:2021-12-08
Method:SOLUTION NMR
Cite:All - d - Enantiomeric Peptide D3 Designed for Alzheimer's Disease Treatment Dynamically Interacts with Membrane-Bound Amyloid-beta Precursors.
J.Med.Chem., 64, 2021
1IYT
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BU of 1iyt by Molmil
Solution structure of the Alzheimer's disease amyloid beta-peptide (1-42)
Descriptor: Alzheimer's disease amyloid
Authors:Crescenzi, O, Tomaselli, S, Guerrini, R, Salvadori, S, D'Ursi, A.M, Temussi, P.A, Picone, D.
Deposit date:2002-09-06
Release date:2003-02-11
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Solution structure of the Alzheimer amyloid beta-peptide (1-42) in an apolar microenvironment. Similarity with a virus fusion domain.
EUR.J.BIOCHEM., 269, 2002
7B3K
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Dynamic complex between all-D-enantiomeric peptide D3 with L723P mutant of amyloid precursor protein (APP) 672-726 fragment (amyloid beta 1-55)
Descriptor: D3 all D-enantimeric peptide, Isoform L-APP677 of Amyloid-beta precursor protein
Authors:Bocharov, E.V, Volynsky, P.E, Okhrimenko, I.S, Urban, A.S.
Deposit date:2020-12-01
Release date:2021-01-13
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:All - d - Enantiomeric Peptide D3 Designed for Alzheimer's Disease Treatment Dynamically Interacts with Membrane-Bound Amyloid-beta Precursors.
J.Med.Chem., 64, 2021
2BEG
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BU of 2beg by Molmil
3D Structure of Alzheimer's Abeta(1-42) fibrils
Descriptor: Amyloid beta A4 protein
Authors:Luhrs, T, Ritter, C, Adrian, M, Riek-Loher, D, Bohrmann, B, Dobeli, H, Schubert, D, Riek, R.
Deposit date:2005-10-24
Release date:2005-11-22
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:3D structure of Alzheimer's amyloid-{beta}(1-42) fibrils.
Proc.Natl.Acad.Sci.Usa, 102, 2005
5AEF
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BU of 5aef by Molmil
Electron cryo-microscopy of an Abeta(1-42)amyloid fibril
Descriptor: AMYLOID BETA A4 PROTEIN
Authors:Schmidt, M, Rohou, A, Lasker, K, Yadav, J.K, Schiene-Fischer, C, Fandrich, M, Grigorieff, N.
Deposit date:2015-08-29
Release date:2015-10-14
Last modified:2019-10-23
Method:ELECTRON MICROSCOPY (5 Å)
Cite:Peptide Dimer Structure in an Abeta(1-42) Fibril Visualized with Cryo-Em
Proc.Natl.Acad.Sci.USA, 112, 2015
7U4P
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Covalently stabilized triangular trimer composed of Abeta17-36 beta-hairpins
Descriptor: Amyloid-beta 17-36 peptide
Authors:Kreutzer, A.G, Haerianardakani, S, Nowick, J.S.
Deposit date:2022-02-28
Release date:2023-03-15
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.803 Å)
Cite:Antibodies Raised Against an A beta Oligomer Mimic Recognize Pathological Features in Alzheimer's Disease and Associated Amyloid-Disease Brain Tissue.
Acs Cent.Sci., 10, 2024
5KK3
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BU of 5kk3 by Molmil
Atomic Resolution Structure of Monomorphic AB42 Amyloid Fibrils
Descriptor: Beta-amyloid protein 42
Authors:Colvin, M.T, Silvers, R, Zhe Ni, Q, Can, T.V, Sergeyev, I, Rosay, M, Donovan, K.J, Michael, B, Wall, J, Linse, S, Griffin, R.G.
Deposit date:2016-06-20
Release date:2016-07-13
Last modified:2019-12-11
Method:SOLID-STATE NMR
Cite:Atomic Resolution Structure of Monomorphic A beta 42 Amyloid Fibrils.
J.Am.Chem.Soc., 138, 2016
5HOX
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BU of 5hox by Molmil
X-ray crystallographic structure of an A-beta 17_36 beta-hairpin. Synchrotron data set. (LVFFAEDCGSNKCAII(SAR)LMV).
Descriptor: Amyloid beta A4 protein, O-(O-(2-AMINOPROPYL)-O'-(2-METHOXYETHYL)POLYPROPYLENE GLYCOL 500)
Authors:Kreutzer, A.G, Nowick, J.S, Spencer, R.K.
Deposit date:2016-01-19
Release date:2016-03-23
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:X-ray Crystallographic Structures of a Trimer, Dodecamer, and Annular Pore Formed by an A beta 17-36 beta-Hairpin.
J.Am.Chem.Soc., 138, 2016
5HOW
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BU of 5how by Molmil
X-ray crystallographic structure of an Abeta 17-36 beta-hairpin. LV(PHI)FAEDCGSNKCAII(SAR)L(ORN)V
Descriptor: Amyloid beta A4 protein
Authors:Kreutzer, A.G, Nowick, J.S, Spencer, R.K.
Deposit date:2016-01-19
Release date:2016-03-23
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.295 Å)
Cite:X-ray Crystallographic Structures of a Trimer, Dodecamer, and Annular Pore Formed by an A beta 17-36 beta-Hairpin.
J.Am.Chem.Soc., 138, 2016
5HOY
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BU of 5hoy by Molmil
X-ray crystallographic structure of an A-beta 17_36 beta-hairpin. X-ray diffractometer data set. (LVFFAEDCGSNKCAII(SAR)LMV).
Descriptor: Amyloid beta A4 protein, O-(O-(2-AMINOPROPYL)-O'-(2-METHOXYETHYL)POLYPROPYLENE GLYCOL 500)
Authors:Kreutzer, A.G, Spencer, R.K, Nowick, J.S.
Deposit date:2016-01-19
Release date:2016-03-23
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.295 Å)
Cite:X-ray Crystallographic Structures of a Trimer, Dodecamer, and Annular Pore Formed by an A beta 17-36 beta-Hairpin.
J.Am.Chem.Soc., 138, 2016
7Q4B
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BU of 7q4b by Molmil
Type I beta-amyloid 42 Filaments from Human Brain
Descriptor: Amyloid-beta precursor protein, UNKNOWN ATOM OR ION
Authors:Yang, Y, Arseni, D, Zhang, W, Huang, M, Lovestam, S.K.A, Schweighauser, M, Kotecha, A, Murzin, A.G, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Garringer, H.J, Gelpi, E, Newell, K.L, Kovacs, G.G, Vidal, R, Ghetti, B, Falcon, B, Scheres, S.H.W, Goedert, M.
Deposit date:2021-10-30
Release date:2021-11-24
Last modified:2023-03-08
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Cryo-EM structures of amyloid-beta 42 filaments from human brains.
Science, 375, 2022
7Q4M
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Type II beta-amyloid 42 Filaments from Human Brain
Descriptor: Amyloid-beta precursor protein, UNKNOWN ATOM OR ION
Authors:Yang, Y, Arseni, D, Zhang, W, Huang, M, Lovestam, S.K.A, Schweighauser, M, Kotecha, A, Murzin, A.G, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Garringer, H.J, Gelpi, E, Newell, K.L, Kovacs, G.G, Vidal, R, Ghetti, B, Falcon, B, Scheres, S.H.W, Goedert, M.
Deposit date:2021-11-01
Release date:2021-11-24
Last modified:2023-03-08
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Cryo-EM structures of amyloid-beta 42 filaments from human brains.
Science, 375, 2022
5MYK
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Structure of Pyroglutamate-Abeta-specific Fab c#17 in complex with murine Abeta-pE3-18PEGb
Descriptor: Amyloid beta A4 protein, Fab c#17 heavy chain, Fab c#17 light chain
Authors:Parthier, C, Piechotta, A, Stubbs, M.T.
Deposit date:2017-01-26
Release date:2017-06-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural and functional analyses of pyroglutamate-amyloid-beta-specific antibodies as a basis for Alzheimer immunotherapy.
J. Biol. Chem., 292, 2017
5MYX
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Structure of Pyroglutamate-Abeta-specific Fab c#24 in complex with human Abeta-pE3-18
Descriptor: Fab c#24 heavy chain, Fab c#24 light chain, Pyroglutamate-Abeta pE3-18
Authors:Parthier, C, Piechotta, A, Stubbs, M.T.
Deposit date:2017-01-30
Release date:2017-06-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.492 Å)
Cite:Structural and functional analyses of pyroglutamate-amyloid-beta-specific antibodies as a basis for Alzheimer immunotherapy.
J. Biol. Chem., 292, 2017
6NB9
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Amyloid-Beta (20-34) with L-isoaspartate 23
Descriptor: Amyloid-beta A4 protein
Authors:Sawaya, M.R, Warmack, R.A, Boyer, D.R, Zee, C.T, Richards, L.S, Cascio, D, Gonen, T, Clarke, S.G, Eisenberg, D.S.
Deposit date:2018-12-06
Release date:2019-08-07
Last modified:2022-09-07
Method:ELECTRON CRYSTALLOGRAPHY (1.05 Å)
Cite:Structure of amyloid-beta (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface.
Nat Commun, 10, 2019
7Y8Q
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Amyloid-beta assemblage on GM1-containing membranes
Descriptor: Amyloid-beta protein 40
Authors:Yagi-Utsumi, M, Itoh, S.G, Okumura, H, Yanagisawa, K, Kato, K, Nishimura, K.
Deposit date:2022-06-24
Release date:2023-07-05
Last modified:2023-09-20
Method:SOLID-STATE NMR
Cite:The Double-Layered Structure of Amyloid-beta Assemblage on GM1-Containing Membranes Catalytically Promotes Fibrillization.
Acs Chem Neurosci, 14, 2023

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