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1NHX
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BU of 1nhx by Molmil
PEPCK COMPLEX WITH A GTP-COMPETITIVE INHIBITOR
Descriptor: 1,2-ETHANEDIOL, MANGANESE (II) ION, N-{4-[1-(2-FLUOROBENZYL)-3-BUTYL-2,6-DIOXO-2,3,6,7-TETRAHYDRO-1H-PURIN-8-YLMETHYL]-PHENYL}-ACETAMIDE, ...
Authors:Foley, L.H, Wang, P, Dunten, P, Ramsey, G, Gubler, M.-L, Wertheimer, S.J.
Deposit date:2002-12-19
Release date:2003-09-30
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:X-RAY STRUCTURES OF TWO XANTHINE INHIBITORS BOUND TO PEPCK and N-3 modifications of substituted 1,8-Dibenzylxanthines
Bioorg.Med.Chem.Lett., 13, 2003
6P5O
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BU of 6p5o by Molmil
The structure of rat cytosolic PEPCK in complex with 3-(carboxymethylthiol)-picolinic acid
Descriptor: 3-[(carboxymethyl)sulfanyl]pyridine-2-carboxylic acid, MANGANESE (II) ION, Phosphoenolpyruvate carboxykinase, ...
Authors:Mcleod, M.J, Holyoak, T.
Deposit date:2019-05-30
Release date:2019-09-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Characterization of 3-[(Carboxymethyl)thio]picolinic Acid: A Novel Inhibitor of Phosphoenolpyruvate Carboxykinase.
Biochemistry, 58, 2019
5I67
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BU of 5i67 by Molmil
Crystal Structure Analysis of MTB PEPCK mutant C273S
Descriptor: DI(HYDROXYETHYL)ETHER, GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Dostal, J, Pachl, P, Machova, I, Pichova, I, Snasel, J.
Deposit date:2016-02-16
Release date:2016-04-06
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.602 Å)
Cite:Crystal Structure Analysis of MTB PEPCK mutant C273S
To Be Published
6YI9
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BU of 6yi9 by Molmil
Crystal structure of the rat cytosolic PCK1, acetylated on Lys244
Descriptor: 1,2-ETHANEDIOL, Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
Authors:Latorre-Muro, P, Baeza, J, Hurtado-Guerrero, R, Hicks, T, Delso, I, Hernandez-Ruiz, C, Velazquez-Campoy, A, Lawton, A.J, Angulo, J, Denu, J.M, Carrodeguas, J.A.
Deposit date:2020-04-01
Release date:2020-12-23
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Self-acetylation at the active site of phosphoenolpyruvate carboxykinase (PCK1) controls enzyme activity.
J.Biol.Chem., 296, 2021
4OX2
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BU of 4ox2 by Molmil
I45T cytosolic phosphoenolpyruvate carboxykinase in complex with beta-sulfopyruvate and GTP
Descriptor: 2-ETHOXYETHANOL, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Holyoak, T.
Deposit date:2014-02-04
Release date:2014-06-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Three rare diseases in one Sib pair: RAI1, PCK1, GRIN2B mutations associated with Smith-Magenis Syndrome, cytosolic PEPCK deficiency and NMDA receptor glutamate insensitivity.
Mol.Genet.Metab., 113, 2014
2ZCI
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BU of 2zci by Molmil
Structure of a GTP-dependent bacterial PEP-carboxykinase from Corynebacterium glutamicum
Descriptor: Phosphoenolpyruvate carboxykinase [GTP]
Authors:Aich, S, Prasad, L, Delbaere, L.T.J.
Deposit date:2007-11-09
Release date:2008-04-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of a GTP-dependent bacterial PEP-carboxykinase from Corynebacterium glutamicum.
Int.J.Biochem.Cell Biol., 40, 2008
4RCG
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BU of 4rcg by Molmil
Crystal Structure Analysis of MTB PEPCK without Mn+2
Descriptor: DI(HYDROXYETHYL)ETHER, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Brynda, J, Dostal, J, Snasel, J, Fanfrlik, J, Pichova, I, Machova, I.
Deposit date:2014-09-16
Release date:2015-04-08
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural and Functional Studies of Phosphoenolpyruvate Carboxykinase from Mycobacterium tuberculosis.
Plos One, 10, 2015
4R43
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BU of 4r43 by Molmil
Crystal Structure Analysis of MTB PEPCK
Descriptor: DI(HYDROXYETHYL)ETHER, GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Brynda, J, Dostal, J, Pichova, I, Snasel, J, Fanfrlik, J, Machova, I.
Deposit date:2014-08-19
Release date:2015-04-08
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and Functional Studies of Phosphoenolpyruvate Carboxykinase from Mycobacterium tuberculosis.
Plos One, 10, 2015
2FAH
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BU of 2fah by Molmil
The structure of mitochondrial PEPCK, Complex with Mn and GDP
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MALONIC ACID, MANGANESE (II) ION, ...
Authors:Holyoak, T, Sullivan, S.M, Nowak, T.
Deposit date:2005-12-07
Release date:2006-06-27
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structural Insights into the Mechanism of PEPCK Catalysis
Biochemistry, 45, 2006
2FAF
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BU of 2faf by Molmil
The structure of chicken mitochondrial PEPCK.
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, MANGANESE (II) ION, PENTAETHYLENE GLYCOL, ...
Authors:Holyoak, T, Sullivan, S.M, Nowak, T.
Deposit date:2005-12-07
Release date:2006-06-27
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Insights into the Mechanism of PEPCK Catalysis
Biochemistry, 45, 2006
3MOE
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BU of 3moe by Molmil
The structure of rat cytosolic PEPCK mutant A467G in complex with Beta-Sulfopyruvate and GTP
Descriptor: 1,2-ETHANEDIOL, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Johnson, T.A, Holyoak, T.
Deposit date:2010-04-22
Release date:2010-06-02
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Increasing the conformational entropy of the Omega-loop lid domain in phosphoenolpyruvate carboxykinase impairs catalysis and decreases catalytic fidelity .
Biochemistry, 49, 2010
3MOF
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BU of 3mof by Molmil
The structure of rat cytosolic PEPCK mutant A467G in complex with oxalate and GTP
Descriptor: 1,2-ETHANEDIOL, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Johnson, T.A, Holyoak, T.
Deposit date:2010-04-22
Release date:2010-06-02
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Increasing the conformational entropy of the Omega-loop lid domain in phosphoenolpyruvate carboxykinase impairs catalysis and decreases catalytic fidelity .
Biochemistry, 49, 2010
3MOH
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BU of 3moh by Molmil
The structure of rat cytosolic PEPCK mutant A467G in complex with phosphoglycolate and GDP
Descriptor: 1,2-ETHANEDIOL, 2-PHOSPHOGLYCOLIC ACID, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Johnson, T.A, Holyoak, T.
Deposit date:2010-04-22
Release date:2010-06-02
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Increasing the conformational entropy of the Omega-loop lid domain in phosphoenolpyruvate carboxykinase impairs catalysis and decreases catalytic fidelity .
Biochemistry, 49, 2010
7L3M
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BU of 7l3m by Molmil
PEPCK MMQX structure 40ms post-mixing with oxaloacetic acid
Descriptor: CARBON DIOXIDE, GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Clinger, J.A, Moreau, D.W, McLeod, M.J, Holyoak, T, Thorne, R.E.
Deposit date:2020-12-18
Release date:2021-10-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Millisecond mix-and-quench crystallography (MMQX) enables time-resolved studies of PEPCK with remote data collection.
Iucrj, 8, 2021
7L3V
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BU of 7l3v by Molmil
PEPCK MMQX structure 120ms post-mixing with oxaloacetic acid
Descriptor: CARBON DIOXIDE, GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Clinger, J.A, Moreau, D.W, McLeod, M.J, Holyoak, T, Thorne, R.E.
Deposit date:2020-12-18
Release date:2021-10-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Millisecond mix-and-quench crystallography (MMQX) enables time-resolved studies of PEPCK with remote data collection.
Iucrj, 8, 2021
7L36
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BU of 7l36 by Molmil
PEPCK steady-state structure with Mn and GTP
Descriptor: CHLORIDE ION, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Clinger, J.A, Moreau, D.W, McLeod, M.J, Holyoak, T, Thorne, R.E.
Deposit date:2020-12-17
Release date:2021-10-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Millisecond mix-and-quench crystallography (MMQX) enables time-resolved studies of PEPCK with remote data collection.
Iucrj, 8, 2021
2GMV
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BU of 2gmv by Molmil
PEPCK complex with a GTP-competitive inhibitor
Descriptor: MANGANESE (II) ION, N-(4-{[3-BUTYL-1-(2-FLUOROBENZYL)-2,6-DIOXO-2,3,6,7-TETRAHYDRO-1H-PURIN-8-YL]METHYL}PHENYL)-1-METHYL-1H-IMIDAZOLE-4-SULFONAMIDE, PHOSPHOENOLPYRUVATE, ...
Authors:Dunten, P.
Deposit date:2006-04-07
Release date:2007-05-29
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:C-8 Modifications of 3-alkyl-1,8-dibenzylxanthines as inhibitors of human cytosolic phosphoenolpyruvate carboxykinase.
Bioorg.Med.Chem.Lett., 17, 2007
4WIE
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BU of 4wie by Molmil
Crystal structure of apo-PEPCK from Mycobacterium tuberculosis with glycerol
Descriptor: GLYCEROL, MANGANESE (II) ION, Phosphoenolpyruvate carboxykinase [GTP]
Authors:Kim, H.L, Sacchettini, J.C.
Deposit date:2014-09-25
Release date:2014-10-22
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Crystal structure of apo-PEPCK from Mycobacterium tuberculosis with glycerol
To Be Published
4WIU
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BU of 4wiu by Molmil
Crystal Structure of PEPCK (Rv0211) from Mycobacterium tuberculosis in complex with oxalate and Mn2+
Descriptor: GLYCEROL, MANGANESE (II) ION, OXALATE ION, ...
Authors:Kim, H.L, Sacchettini, J.C.
Deposit date:2014-09-26
Release date:2014-10-22
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Crystal Structure of PEPCK (Rv0211) from Mycobacterium tuberculosis in complex with oxalate and Mn2+
to be published
4WPV
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BU of 4wpv by Molmil
Crystal Structure of E83A mutant of Mtb PEPCK in complex with Zn2+ and phosphate ion
Descriptor: GLYCEROL, PHOSPHATE ION, Phosphoenolpyruvate carboxykinase [GTP], ...
Authors:Kim, H.L, Sacchettini, J.C.
Deposit date:2014-10-21
Release date:2015-11-04
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.672 Å)
Cite:Crystal Structure of E83A from Mtb PEPCK in complex with Zn2+ and phosphate ion
To Be Published
4WPT
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BU of 4wpt by Molmil
Crystal Structure of Mtb PEPCK in complex with PEP
Descriptor: GLYCEROL, PHOSPHATE ION, PHOSPHOENOLPYRUVATE, ...
Authors:Kim, H.L, Krieger, I.V, Sacchettini, J.C.
Deposit date:2014-10-21
Release date:2015-11-04
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structure of Mtb PEPCK in complex with PEP
To Be Published
3DT4
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BU of 3dt4 by Molmil
The structure of rat cytosolic PEPCK in complex with oxalate and GTP
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, OXALATE ION, ...
Authors:Sullivan, S.M, Holyoak, T.
Deposit date:2008-07-14
Release date:2008-08-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Enzymes with lid-gated active sites must operate by an induced fit mechanism instead of conformational selection.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3DTB
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BU of 3dtb by Molmil
The structure of rat cytosolic PEPCK in complex with phosphoglycolate and GDP
Descriptor: 2-PHOSPHOGLYCOLIC ACID, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, BICARBONATE ION, ...
Authors:Sullivan, S.M, Holyoak, T.
Deposit date:2008-07-14
Release date:2008-08-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Enzymes with lid-gated active sites must operate by an induced fit mechanism instead of conformational selection.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3DT2
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BU of 3dt2 by Molmil
The structure of rat cytosolic PEPCK in complex with oxalate and GTP
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, OXALATE ION, ...
Authors:Sullivan, S.M, Holyoak, T.
Deposit date:2008-07-14
Release date:2008-08-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Enzymes with lid-gated active sites must operate by an induced fit mechanism instead of conformational selection.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3DT7
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BU of 3dt7 by Molmil
The structure of rat cytosolic PEPCK in complex with beta-sulfopyruvate and GTP
Descriptor: 2-ETHOXYETHANOL, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Sullivan, S.M, Holyoak, T.
Deposit date:2008-07-14
Release date:2008-08-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Enzymes with lid-gated active sites must operate by an induced fit mechanism instead of conformational selection.
Proc.Natl.Acad.Sci.Usa, 105, 2008

 

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