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1ALU
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HUMAN INTERLEUKIN-6
Descriptor: INTERLEUKIN-6, L(+)-TARTARIC ACID, SULFATE ION
Authors:Somers, W.S, Stahl, M, Seehra, J.S.
Deposit date:1997-06-03
Release date:1998-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:1.9 A crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling.
EMBO J., 16, 1997
7NXZ
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Synthetic glycoform of Human Interleukin 6
Descriptor: Interleukin-6
Authors:Weyand, M, Unverzagt, C.
Deposit date:2021-03-19
Release date:2021-04-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.998 Å)
Cite:Natural Glycoforms of Human Interleukin 6 Show Atypical Plasma Clearance.
Angew.Chem.Int.Ed.Engl., 60, 2021
4CNI
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Crystal structure of the Fab portion of Olokizumab in complex with IL- 6
Descriptor: INTERLEUKIN-6, OLOKIZUMAB HEAVY CHAIN, FAB PORTION, ...
Authors:Shaw, S, Bourne, T, Meier, C, Carrington, B, Gelinas, R, Henry, A, Popplewell, A, Adams, R, Baker, T, Rapecki, S, Marshall, D, Neale, H, Lawson, A.
Deposit date:2014-01-22
Release date:2014-04-30
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery and Characterization of Olokizumab: A Humanized Antibody Targeting Interleukin-6 and Neutralizing Gp130-Signaling.
Mabs, 6, 2014
4ZS7
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Structural mimicry of receptor interaction by antagonistic IL-6 antibodies
Descriptor: Interleukin-6, Llama Fab fragment 68F2 heavy chain, Llama Fab fragment 68F2 light chain
Authors:Blanchetot, C, De Jonge, N, Desmyter, A, Ongenae, N, Hofman, E, Klarenbeek, A, Sadi, A, Hultberg, A, Kretz-Rommel, A, Spinelli, S, Loris, R, Cambillau, C, de Haard, H.
Deposit date:2015-05-13
Release date:2016-05-04
Last modified:2016-07-06
Method:X-RAY DIFFRACTION (2.93 Å)
Cite:Structural Mimicry of Receptor Interaction by Antagonistic Interleukin-6 (IL-6) Antibodies.
J.Biol.Chem., 291, 2016
1IL6
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HUMAN INTERLEUKIN-6, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor: INTERLEUKIN-6
Authors:Xu, G.Y, Yu, H.A, Hong, J, Stahl, M, Mcdonagh, T, Kay, L.E, Cumming, D.A.
Deposit date:1997-01-31
Release date:1998-02-04
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Solution structure of recombinant human interleukin-6.
J.Mol.Biol., 268, 1997
2IL6
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HUMAN INTERLEUKIN-6, NMR, 32 STRUCTURES
Descriptor: INTERLEUKIN-6
Authors:Xu, G.Y, Yu, H.A, Hong, J, Stahl, M, Mcdonagh, T, Kay, L.E, Cumming, D.A.
Deposit date:1997-01-31
Release date:1998-02-04
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Solution structure of recombinant human interleukin-6.
J.Mol.Biol., 268, 1997
2L3Y
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BU of 2l3y by Molmil
Solution structure of mouse IL-6
Descriptor: Interleukin-6
Authors:Veverka, V, Redpath, N.T, Carrington, B, Muskett, F.W, Taylor, R.J, Henry, A.J, Carr, M.D.
Deposit date:2010-09-25
Release date:2011-09-28
Last modified:2013-01-02
Method:SOLUTION NMR
Cite:Conservation of functional sites on interleukin-6 and implications for evolution of signaling complex assembly and therapeutic intervention.
J.Biol.Chem., 287, 2012
4NI7
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BU of 4ni7 by Molmil
Crystal structure of human interleukin 6 in complex with a modified nucleotide aptamer (SOMAMER SL1025)
Descriptor: Interleukin-6, SODIUM ION, SOMAmer SL1025
Authors:Davies, D, Edwards, T, Gelinas, A, Jarvis, T, Clifton, M.C.
Deposit date:2013-11-05
Release date:2014-01-22
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of interleukin-6 in complex with a modified nucleic Acid ligand.
J.Biol.Chem., 289, 2014
4NI9
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Crystal structure of human interleukin 6 in complex with a modified nucleotide aptamer (SOMAMER SL1025), FORM 2
Descriptor: Interleukin-6, SODIUM ION, SOMAmer SL1025
Authors:Davies, D, Edwards, T, Gelinas, A, Jarvis, T, Clifton, M.C.
Deposit date:2013-11-05
Release date:2014-01-22
Last modified:2016-06-01
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal structure of interleukin-6 in complex with a modified nucleic Acid ligand.
J.Biol.Chem., 289, 2014
4O9H
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BU of 4o9h by Molmil
Structure of Interleukin-6 in complex with a Camelid Fab fragment
Descriptor: Heavy Chain of the Camelid Fab fragment 61H7, Interleukin-6, Light Chain of the Camelid Fab fragment 61H7
Authors:Klarenbeek, A, Blanchetot, C, Schragel, G, Sadi, A.S, Ongenae, N, Hemrika, W, Wijdenes, J, Spinelli, S, Desmyter, A, Cambillau, C, Hultberg, A, Kretz-rommel, A, Dreier, T, De haard, H.J.W, Roovers, R.C.
Deposit date:2014-01-02
Release date:2015-04-15
Last modified:2015-04-29
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Combining residues of naturally-occurring Camelid somatic affinity variants yields ultra-potent human therapeutic IL-6 antibodies
To be Published
4J4L
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BU of 4j4l by Molmil
Modular evolution and design of the protein binding interface
Descriptor: Interleukin-6, Internalin B,REPEAT MODULES,Variable lymphocyte receptor B
Authors:Cheong, H.K, Kim, H.J.
Deposit date:2013-02-07
Release date:2014-02-12
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Modular evolution and design of the protein binding interface
To be Published
5FUC
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BU of 5fuc by Molmil
Biophysical and cellular characterisation of a junctional epitope antibody that locks IL-6 and gp80 together in a stable complex: implications for new therapeutic strategies
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, INTERLEUKIN-6, INTERLEUKIN-6 RECEPTOR SUBUNIT ALPHA, ...
Authors:Adams, R, Griffin, R, Doyle, C, Ettorre, A.
Deposit date:2016-01-25
Release date:2017-01-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Discovery of a junctional epitope antibody that stabilizes IL-6 and gp80 protein:protein interaction and modulates its downstream signaling.
Sci Rep, 7, 2017
8D82
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BU of 8d82 by Molmil
Cryo-EM structure of human IL-6 signaling complex in detergent: model containing full extracellular domains
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-6, ...
Authors:Zhou, Y, Franklin, M.C.
Deposit date:2022-06-07
Release date:2023-03-29
Method:ELECTRON MICROSCOPY (3.22 Å)
Cite:Structural insights into the assembly of gp130 family cytokine signaling complexes.
Sci Adv, 9, 2023
1P9M
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BU of 1p9m by Molmil
Crystal structure of the hexameric human IL-6/IL-6 alpha receptor/gp130 complex
Descriptor: Interleukin-6, Interleukin-6 receptor alpha chain, Interleukin-6 receptor beta chain
Authors:Boulanger, M.J, Chow, D.C, Brevnova, E.E, Garcia, K.C.
Deposit date:2003-05-12
Release date:2003-07-01
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (3.65 Å)
Cite:Hexameric Structure and Assembly of the Interleukin-6/IL-6 alpha-Receptor/gp130 Complex
Science, 300, 2003
8QY5
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BU of 8qy5 by Molmil
Structure of interleukin 6.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-6, ...
Authors:Gardner, S, Bubeck, D, Jin, Y.
Deposit date:2023-10-25
Release date:2024-02-21
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structure of interleukin 6.
To Be Published
8QY6
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BU of 8qy6 by Molmil
Structure of interleukin 6 (gp130 P496L mutant).
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-6, ...
Authors:Gardner, S, Bubeck, D, Jin, Y.
Deposit date:2023-10-25
Release date:2024-02-21
Method:ELECTRON MICROSCOPY (3.16 Å)
Cite:Structure of interleukin 6 (gp130 P496L mutant).
To Be Published
1I1R
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CRYSTAL STRUCTURE OF A CYTOKINE/RECEPTOR COMPLEX
Descriptor: INTERLEUKIN-6 RECEPTOR BETA CHAIN, VIRAL IL-6
Authors:Chow, D, He, X, Snow, A.L, Rose-John, S, Garcia, K.C.
Deposit date:2001-02-02
Release date:2001-03-28
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of an extracellular gp130 cytokine receptor signaling complex.
Science, 291, 2001

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