1M7W
HNF4a ligand binding domain with bound fatty acid
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003323 | biological_process | type B pancreatic cell development |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0050796 | biological_process | regulation of insulin secretion |
| A | 0055088 | biological_process | lipid homeostasis |
| A | 0070365 | biological_process | hepatocyte differentiation |
| B | 0003323 | biological_process | type B pancreatic cell development |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0050796 | biological_process | regulation of insulin secretion |
| B | 0055088 | biological_process | lipid homeostasis |
| B | 0070365 | biological_process | hepatocyte differentiation |
| C | 0003323 | biological_process | type B pancreatic cell development |
| C | 0003700 | molecular_function | DNA-binding transcription factor activity |
| C | 0050796 | biological_process | regulation of insulin secretion |
| C | 0055088 | biological_process | lipid homeostasis |
| C | 0070365 | biological_process | hepatocyte differentiation |
| D | 0003323 | biological_process | type B pancreatic cell development |
| D | 0003700 | molecular_function | DNA-binding transcription factor activity |
| D | 0050796 | biological_process | regulation of insulin secretion |
| D | 0055088 | biological_process | lipid homeostasis |
| D | 0070365 | biological_process | hepatocyte differentiation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DAO A 700 |
| Chain | Residue |
| A | SER181 |
| A | GLN185 |
| A | ARG226 |
| A | LEU236 |
| A | GLY237 |
| A | MET252 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE DAO B 701 |
| Chain | Residue |
| B | GLN185 |
| B | ARG226 |
| B | LEU236 |
| B | GLY237 |
| B | LEU249 |
| B | MET252 |
| B | HOH30 |
| B | SER181 |
| B | MET182 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE DAO C 702 |
| Chain | Residue |
| C | HOH31 |
| C | VAL178 |
| C | SER181 |
| C | GLN185 |
| C | ALA223 |
| C | ARG226 |
| C | LEU236 |
| C | GLY237 |
| C | MET252 |
| C | ILE259 |
| C | ILE346 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DAO D 703 |
| Chain | Residue |
| D | SER181 |
| D | GLN185 |
| D | ARG226 |
| D | LEU236 |
| D | GLY237 |
| D | MET252 |
| D | SER256 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine; by PKA => ECO:0000305|PubMed:9234678 |
| Chain | Residue | Details |
| A | SER142 | |
| A | ILE143 | |
| B | SER142 | |
| B | ILE143 | |
| C | SER142 | |
| C | ILE143 | |
| D | SER142 | |
| D | ILE143 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P41235 |
| Chain | Residue | Details |
| A | ASN144 | |
| B | ASN144 | |
| C | ASN144 | |
| D | ASN144 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P41235 |
| Chain | Residue | Details |
| A | ASP166 | |
| B | ASP166 | |
| C | ASP166 | |
| D | ASP166 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P41235 |
| Chain | Residue | Details |
| A | ILE167 | |
| B | ILE167 | |
| C | ILE167 | |
| D | ILE167 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by AMPK => ECO:0000250|UniProtKB:P41235 |
| Chain | Residue | Details |
| A | TYR313 | |
| B | TYR313 | |
| C | TYR313 | |
| D | TYR313 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 12 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P41235 |
| Chain | Residue | Details |
| A | LEU234 | |
| C | GLN307 | |
| D | LEU234 | |
| D | GLN307 | |
| A | GLN307 | |
| B | LEU234 | |
| B | GLN307 | |
| C | LEU234 |
