PDB keyword search results

1U54
CRYSTAL STRUCTURES OF THE PHOSPHORYLATED AND UNPHOSPHORYLATED KINASE DOMAINS OF THE CDC42-ASSOCIATED TYROSINE KINASE ACK1 BOUND TO AMP-PCP
Descriptor:Activated CDC42 kinase 1 (E.C.2.7.1.112)
Authors:Lougheed, J.C., Chen, R.H., Mak, P., Stout, T.J.
Deposit date:2004-07-26
Release date:2004-08-31
Modification date:2011-07-13
Cite:Crystal Structures of the Phosphorylated and Unphosphorylated Kinase Domains of the Cdc42-associated Tyrosine Kinase ACK1.
J.Biol.Chem., 279, 2004
2Y4I
KSR2-MEK1 HETERODIMER
Descriptor:KINASE SUPPRESSOR OF RAS 2, DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 (E.C.2.7.12.2)
Authors:Brennan, D.F., Barford, D.
Deposit date:2011-01-06
Release date:2011-01-19
Modification date:2011-04-27
Cite:A Raf-Induced Allosteric Transition of Ksr Stimulates Ksr and Raf Phosphorylation of Mek
Nature, 472, 2011
3D7T
STRUCTURAL BASIS FOR THE RECOGNITION OF C-SRC BY ITS INACTIVATOR CSK
Descriptor:Tyrosine-protein kinase CSK (E.C.2.7.10.2), Proto-oncogene tyrosine-protein kinase Src (E.C.2.7.10.2)
Authors:Levinson, N.M., Seeliger, M.A., Cole, P.A., Kuriyan, J.
Deposit date:2008-05-21
Release date:2008-08-05
Modification date:2009-02-24
Cite:Structural basis for the recognition of c-Src by its inactivator Csk.
Cell(Cambridge,Mass.), 134, 2008
3D7U
STRUCTURAL BASIS FOR THE RECOGNITION OF C-SRC BY ITS INACTIVATOR CSK
Descriptor:Tyrosine-protein kinase CSK (E.C.2.7.10.2), Proto-oncogene tyrosine-protein kinase Src (E.C.2.7.10.2)
Authors:Levinson, N.M., Seeliger, M.A., Cole, P.A., Kuriyan, J.
Deposit date:2008-05-21
Release date:2008-08-05
Modification date:2013-09-18
Cite:Structural basis for the recognition of c-Src by its inactivator Csk.
Cell(Cambridge,Mass.), 134, 2008
3SRV
CRYSTAL STRUCTURE OF SPLEEN TYROSINE KINASE (SYK) IN COMPLEX WITH A DIAMINOPYRIMIDINE CARBOXAMIDE INHIBITOR
Descriptor:Tyrosine-protein kinase SYK (E.C.2.7.10.2)
Authors:Somers, D.O., Neu, M.
Deposit date:2011-07-07
Release date:2011-09-21
Modification date:2011-10-12
Cite:Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor.
Bioorg.Med.Chem.Lett., 21, 2011
1AGW
CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH SU4984 INHIBITOR
Descriptor:FGF RECEPTOR 1, 3-[4-(1-FORMYLPIPERAZIN-4-YL)-BENZYLIDENYL]-2-INDOLINONE
Authors:Mohammadi, M., Schlessinger, J., Hubbard, S.R.
Deposit date:1997-03-25
Release date:1998-03-25
Modification date:2009-02-24
Cite:Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors.
Science, 276, 1997
1BYG
KINASE DOMAIN OF HUMAN C-TERMINAL SRC KINASE (CSK) IN COMPLEX WITH INHIBITOR STAUROSPORINE
Descriptor:PROTEIN (C-TERMINAL SRC KINASE) (2.7.1.112)
Authors:Antson, A.A., Lamers, M.B.A.C., Scott, R.K., Williams, D.H., Hubbard, R.E.
Deposit date:1998-10-14
Release date:1999-10-14
Modification date:2009-02-24
Cite:Structure of the protein tyrosine kinase domain of C-terminal Src kinase (CSK) in complex with staurosporine.
J.Mol.Biol., 285, 1999
1FGI
CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH SU5402 INHIBITOR
Descriptor:FGF RECEPTOR 1, 3-[(3-(2-CARBOXETHYL)-4-METHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE
Authors:Mohammadi, M., Schlessinger, J., Hubbard, S.R.
Deposit date:1997-03-22
Release date:1998-04-08
Modification date:2009-02-24
Cite:Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors.
Science, 276, 1997
1FGK
CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1
Descriptor:FGF RECEPTOR 1
Authors:Mohammadi, M., Schlessinger, J., Hubbard, S.R.
Deposit date:1997-02-08
Release date:1997-07-23
Modification date:2009-02-24
Cite:Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism.
Cell(Cambridge,Mass.), 86, 1996
1FPU
CRYSTAL STRUCTURE OF ABL KINASE DOMAIN IN COMPLEX WITH A SMALL MOLECULE INHIBITOR
Descriptor:ABL KINASE
Authors:Schindler, T., Bornmann, W., Pellicena, P., Miller, W.T., Clarkson, B., Kuriyan, J.
Deposit date:2000-08-31
Release date:2000-09-20
Modification date:2009-02-24
Cite:Structural mechanism for STI-571 inhibition of abelson tyrosine kinase.
Science, 289, 2000
1FVR
TIE2 KINASE DOMAIN
Descriptor:TYROSINE-PROTEIN KINASE TIE-2 (E.C.2.7.1.112)
Authors:Shewchuk, L.M., Hassell, A.M., Ellis, B., Holmes, W.D., Davis, R., Horne, E.L., Kadwell, S.H., McKee, D.D., Moore, J.T.
Deposit date:2000-09-20
Release date:2001-09-20
Modification date:2009-02-24
Cite:Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail.
Structure Fold.Des., 8, 2000
1GAG
CRYSTAL STRUCTURE OF THE INSULIN RECEPTOR KINASE IN COMPLEX WITH A BISUBSTRATE INHIBITOR
Descriptor:INSULIN RECEPTOR (E.C.2.7.1.112), TYROSINE KINASE DOMAIN, PEPTIDE INHIBITOR
Authors:Parang, K., Till, J.H., Ablooglu, A.J., Kohanski, R.A., Hubbard, S.R., Cole, P.A.
Deposit date:2000-11-29
Release date:2001-01-17
Modification date:2011-07-13
Cite:Mechanism-based design of a protein kinase inhibitor.
Nat.Struct.Biol., 8, 2001
1GJO
THE FGFR2 TYROSINE KINASE DOMAIN
Descriptor:FIBROBLAST GROWTH FACTOR RECEPTOR 2 (E.C.2.7.1.112)
Authors:Ceska, T.A., Owens, R., Doyle, C., Hamlyn, P., Crabbe, T., Moffat, D., Davis, J., Martin, R., Perry, M.J.
Deposit date:2001-07-31
Release date:2003-08-15
Modification date:2009-02-24
Cite:The Fgfr2 Tyrosine Kinase Domain
To be Published
1I44
CRYSTALLOGRAPHIC STUDIES OF AN ACTIVATION LOOP MUTANT OF THE INSULIN RECEPTOR TYROSINE KINASE
Descriptor:INSULIN RECEPTOR (E.C.2.7.1.112)
Authors:Till, J.H., Ablooglu, A.J., Frankel, M., Kohanski, R.A., Hubbard, S.R.
Deposit date:2001-02-19
Release date:2001-03-07
Modification date:2009-02-24
Cite:Crystallographic and solution studies of an activation loop mutant of the insulin receptor tyrosine kinase: insights into kinase mechanism.
J.Biol.Chem., 276, 2001
1IEP
CRYSTAL STRUCTURE OF THE C-ABL KINASE DOMAIN IN COMPLEX WITH STI-571.
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL (E.C.2.7.1.112)
Authors:Nagar, B., Bornmann, W., Schindler, T., Clarkson, B., Kuriyan, J.
Deposit date:2001-04-10
Release date:2001-04-18
Modification date:2009-02-24
Cite:Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571)
Cancer Res., 62, 2002
1IR3
PHOSPHORYLATED INSULIN RECEPTOR TYROSINE KINASE IN COMPLEX WITH PEPTIDE SUBSTRATE AND ATP ANALOG
Descriptor:INSULIN RECEPTOR, PEPTIDE SUBSTRATE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Hubbard, S.R.
Deposit date:1997-09-22
Release date:1998-01-07
Modification date:2009-02-24
Cite:Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog.
EMBO J., 16, 1997
1IRK
CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HUMAN INSULIN RECEPTOR
Descriptor:INSULIN RECEPTOR (TYROSINE KINASE DOMAIN) MUTANT WITH CYS 981 REPLACED BY SER AND TYR 984 REPLACED BY PHE (C981S, Y984F)
Authors:Hubbard, S.R., Wei, L., Ellis, L., Hendrickson, W.A.
Deposit date:1995-01-02
Release date:1995-02-27
Modification date:2009-02-24
Cite:Crystal structure of the tyrosine kinase domain of the human insulin receptor.
Nature, 372, 1994
1JQH
IGF-1 RECEPTOR KINASE DOMAIN
Descriptor:IGF-1 receptor kinase(E.C.2.7.1.112)/ PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Pautsch, A., Zoephel, A., Ahorn, H., Spevak, W., Hauptmann, R., Nar, H.
Deposit date:2001-08-07
Release date:2002-04-19
Modification date:2009-02-24
Cite:Crystal structure of bisphosphorylated IGF-1 receptor kinase: insight into domain movements upon kinase activation.
Structure, 9, 2001
1K2P
CRYSTAL STRUCTURE OF BRUTON'S TYROSINE KINASE DOMAIN
Descriptor:Tyrosine-protein kinase BTK (E.C.2.7.1.112)
Authors:Mao, C., Zhou, M., Uckun, F.M.
Deposit date:2001-09-28
Release date:2002-06-26
Modification date:2009-02-24
Cite:Crystal structure of Bruton's tyrosine kinase domain suggests a novel pathway for activation and provides insights into the molecular basis of X-linked agammaglobulinemia.
J.Biol.Chem., 276, 2001
1K3A
STRUCTURE OF THE INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR KINASE
Descriptor:INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (E.C.2.7.1.112)/INSULIN RECEPTOR SUBSTRATE-1
Authors:Favelyukis, S., Till, J.H., Hubbard, S.R., Miller, W.T.
Deposit date:2001-10-02
Release date:2001-11-28
Modification date:2009-02-24
Cite:Structure and autoregulation of the insulin-like growth factor 1 receptor kinase.
Nat.Struct.Biol., 8, 2001
1LUF
CRYSTAL STRUCTURE OF THE MUSK TYROSINE KINASE: INSIGHTS INTO RECEPTOR AUTOREGULATION
Descriptor:Muscle-specific Tyrosine Kinase receptor musk (E.C.2.7.1.112)
Authors:Till, J.H., Becerra, M., Watty, A., Lu, Y., Ma, Y., Neubert, T.A., Burden, S.J., Hubbard, S.R.
Deposit date:2002-05-22
Release date:2002-09-11
Modification date:2009-02-24
Cite:Crystal structure of the MuSK tyrosine kinase: insights into receptor autoregulation.
Structure, 10, 2002
1M52
CRYSTAL STRUCTURE OF THE C-ABL KINASE DOMAIN IN COMPLEX WITH PD173955
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1 (E.C.2.7.1.112)
Authors:Nagar, B., Bornmann, W., Pellicena, P., Schindler, T., Veach, D., Miller, W.T., Clarkson, B., Kuriyan, J.
Deposit date:2002-07-08
Release date:2002-09-18
Modification date:2009-02-24
Cite:Crystal Structures of the Kinase Domain of c-Abl in Complex with the Small Molecule Inhibitors PD173955 and Imatinib (STI-571)
Cancer Res., 62, 2002
1M7N
CRYSTAL STRUCTURE OF UNACTIVATED APO INSULIN-LIKE GROWTH FACTOR-1 RECEPTOR KINASE DOMAIN
Descriptor:Insulin-like growth factor I receptor (E.C.2.7.1.112)
Authors:Munshi, S., Kuo, L.
Deposit date:2002-07-22
Release date:2003-01-07
Modification date:2009-02-24
Cite:Crystal structure of the Apo, unactivated insulin-like growth factor-1 receptor kinase. Implication for inhibitor specificity.
J.Biol.Chem., 277, 2002
1MP8
CRYSTAL STRUCTURE OF FOCAL ADHESION KINASE (FAK)
Descriptor:focal adhesion kinase 1 (E.C.2.7.1.112)
Authors:Nowakowski, J., Cronin, C.N., McRee, D.E., Knuth, M.W., Nelson, C.G., Pavletich, N.P., Rodgers, J., Sang, B.-C., Scheibe, D.N., Swanson, R.V., Thompson, D.A.
Deposit date:2002-09-11
Release date:2003-09-16
Modification date:2009-02-24
Cite:Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography
Structure, 10, 2002
1MQB
CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE
Descriptor:Ephrin type-A receptor 2 (E.C.2.7.1.112)
Authors:Nowakowski, J., Cronin, C.N., McRee, D.E., Knuth, M.W., Nelson, C., Pavletich, N., Rogers, J., Sang, B.C., Scheibe, D.N., Swanson, R.V., Thompson, D.A.
Deposit date:2002-09-16
Release date:2003-09-16
Modification date:2009-02-24
Cite:Structures of the Cancer Related Aurora-A, FAK and EphA2 Protein Kinases from Nanovolume Crystallography
Structure, 10, 2003
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