PDB keyword search results

2B7A
THE STRUCTURAL BASIS OF JANUS KINASE 2 INHIBITION BY A POTENT AND SPECIFIC PAN-JANUS KINASE INHIBITOR
Descriptor:Tyrosine-protein kinase JAK2 (E.C.2.7.1.112)
Authors:Lucet, I.S., Fantino, E., Styles, M., Bamert, R., Patel, O., Broughton, S.E., Walter, M., Burns, C.J., Treutlein, H., Wilks, A.F., Rossjohn, J.
Deposit date:2005-10-04
Release date:2006-01-10
Modification date:2009-02-24
Cite:The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor.
Blood, 107, 2006
2E2B
CRYSTAL STRUCTURE OF THE C-ABL KINASE DOMAIN IN COMPLEX WITH INNO-406
Descriptor:Proto-oncogene tyrosine-protein kinase ABL1 (E.C.2.7.10.2)
Authors:Horio, T., Hamasaki, T., Wakayama, T., Takagaki, K., Ohgi, T.
Deposit date:2006-11-10
Release date:2007-05-22
Modification date:2009-02-24
Cite:Structural factors contributing to the Abl/Lyn dual inhibitory activity of 3-substituted benzamide derivatives
Bioorg.Med.Chem.Lett., 17, 2007
2W1I
STRUCTURE DETERMINATION OF AURORA KINASE IN COMPLEX WITH INHIBITOR
Descriptor:JAK2 (E.C.2.7.10.2)
Authors:Howard, S., Berdini, V., Boulstridge, J.A., Carr, M.G., Cross, D.M., Curry, J., Devine, L.A., Early, T.R., Fazal, L., Gill, A.L., Heathcote, M., Maman, S., Matthews, J.E., Mcmenamin, R.L., Navarro, E.F., O'Brien, M.A., O'Reilly, M., Rees, D.C., Reule, M., Tisi, D., Williams, G., Vinkovic, M., Wyatt, P.G.
Deposit date:2008-10-17
Release date:2009-01-27
Cite:Fragment-Based Discovery of the Pyrazol-4-Yl Urea (at9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity.
J.Med.Chem., 52, 2009
2XA4
INHIBITORS OF JAK2 KINASE DOMAIN
Descriptor:TYROSINE-PROTEIN KINASE JAK2 (E.C.2.7.1.112, 2.7.10.2)
Authors:Read, J., Green, I., Pollard, H., Howard, T., Mott, R.
Deposit date:2010-03-26
Release date:2010-12-15
Modification date:2011-10-12
Cite:Discovery of 5-Chloro-N2-[(1S)-1-(5-Fluoropyrimidin-2-Yl) Ethyl]-N4-(5-Methyl-1H-Pyrazol-3-Yl)Pyrimidine-2,4-Diamine (Azd1480) as a Novel Inhibitor of the Jak/Stat Pathway
J.Med.Chem., 54, 2011
2YIY
CRYSTAL STRUCTURE OF COMPOUND 8 BOUND TO TAK1-TAB
Descriptor:MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7, TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1 (E.C.2.7.11.25)
Authors:Brown, D.G., Phillips, C.
Deposit date:2011-05-17
Release date:2012-05-23
Cite:The Discovery and Synthesis of Selective Dfg-Out Tak-1 Inhibitors
To be Published
2ZV7
LYN TYROSINE KINASE DOMAIN, APO FORM
Descriptor:Tyrosine-protein kinase Lyn (E.C.2.7.10.2)
Authors:Williams, N.K., Rossjohn, J.
Deposit date:2008-11-04
Release date:2008-11-11
Modification date:2009-01-13
Cite:Crystal Structures of the Lyn Protein Tyrosine Kinase Domain in Its Apo- and Inhibitor-bound State
J.Biol.Chem., 284, 2009
2ZV8
LYN TYROSINE KINASE DOMAIN-AMP-PNP COMPLEX
Descriptor:Tyrosine-protein kinase Lyn (E.C.2.7.10.2)
Authors:Williams, N.K., Rossjohn, J.
Deposit date:2008-11-04
Release date:2008-11-11
Modification date:2009-01-13
Cite:Crystal Structures of the Lyn Protein Tyrosine Kinase Domain in Its Apo- and Inhibitor-bound State
J.Biol.Chem., 284, 2009
2ZV9
LYN TYROSINE KINASE DOMAIN-PP2 COMPLEX
Descriptor:Tyrosine-protein kinase Lyn (E.C.2.7.10.2)
Authors:Williams, N.K., Rossjohn, J.
Deposit date:2008-11-04
Release date:2008-11-11
Modification date:2009-01-13
Cite:Crystal Structures of the Lyn Protein Tyrosine Kinase Domain in Its Apo- and Inhibitor-bound State
J.Biol.Chem., 284, 2009
2ZVA
LYN TYROSINE KINASE DOMAIN-DASATINIB COMPLEX
Descriptor:Tyrosine-protein kinase Lyn (E.C.2.7.10.2)
Authors:Williams, N.K., Rossjohn, J.
Deposit date:2008-11-04
Release date:2008-11-11
Modification date:2011-07-13
Cite:Crystal Structures of the Lyn Protein Tyrosine Kinase Domain in Its Apo- and Inhibitor-bound State
J.Biol.Chem., 284, 2009
3CC6
CRYSTAL STRUCTURE OF KINASE DOMAIN OF PROTEIN TYROSINE KINASE 2 BETA (PTK2B)
Descriptor:Protein tyrosine kinase 2 beta (E.C.2.7.10.2)
Authors:Busam, R.D., Lehtio, L., Karlberg, T., Arrowsmith, C.H., Bountra, C., Collins, R., Dahlgren, L.G., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Helleday, T., Herman, M.D., Johansson, A., Johansson, I., Kallas, A., Kotenyova, T., Moche, M., Nilsson, M.E., Nordlund, P., Nyman, T., Persson, C., Sagemark, J., Svensson, L., Thorsell, A.G., Tresaugues, L., Van den Berg, S., Weigelt, J., Welin, M., Berglund, H., Structural Genomics Consortium (SGC)
Deposit date:2008-02-25
Release date:2008-03-11
Modification date:2011-07-13
Cite:Structure of Protein Tyrosine Kinase 2 Beta (PTK2B) Kinase domain.
To be Published
3E62
FRAGMENT BASED DISCOVERY OF JAK-2 INHIBITORS
Descriptor:Tyrosine-protein kinase JAK2 (E.C.2.7.10.2)
Authors:Antonysamy, S., Fang, W., Hirst, G., Park, F., Russell, M., Smyth, L., Sprengeler, P., Stappenbeck, F., Steensma, R., Thompson, D.A., Wilson, M., Wong, M., Zhang, A., Zhang, F.
Deposit date:2008-08-14
Release date:2008-10-14
Modification date:2012-02-08
Cite:Fragment-based discovery of JAK-2 inhibitors.
Bioorg.Med.Chem.Lett., 19, 2009
3E63
FRAGMENT BASED DISCOVERY OF JAK-2 INHIBITORS
Descriptor:Tyrosine-protein kinase JAK2 (E.C.2.7.10.2)
Authors:Antonysamy, S., Fang, W., Hirst, G., Park, F., Russell, M., Smyth, L., Sprengeler, P., Stappenbeck, F., Steensma, R., Thompson, D.A., Wilson, M., Wong, M., Zhang, A., Zhang, F.
Deposit date:2008-08-14
Release date:2008-10-14
Modification date:2012-02-08
Cite:Fragment-based discovery of JAK-2 inhibitors.
Bioorg.Med.Chem.Lett., 19, 2009
3E64
FRAGMENT BASED DISCOVERY OF JAK-2 INHIBITORS
Descriptor:Tyrosine-protein kinase JAK2 (E.C.2.7.10.2)
Authors:Antonysamy, S., Fang, W., Hirst, G., Park, F., Russell, M., Smyth, L., Sprengeler, P., Stappenbeck, F., Steensma, R., Thompson, D.A., Wilson, M., Wong, M., Zhang, A., Zhang, F.
Deposit date:2008-08-14
Release date:2008-10-14
Modification date:2012-02-08
Cite:Fragment-based discovery of JAK-2 inhibitors.
Bioorg.Med.Chem.Lett., 19, 2009
3ET7
CRYSTAL STRUCTURE OF PYK2 COMPLEXED WITH PF-2318841
Descriptor:Protein tyrosine kinase 2 beta (E.C.2.7.10.2)
Authors:Han, S.
Deposit date:2008-10-07
Release date:2009-06-23
Cite:Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2): structure-activity relationships and strategies for the elimination of reactive metabolite formation.
Bioorg.Med.Chem.Lett., 18, 2008
3FUP
CRYSTAL STRUCTURES OF JAK1 AND JAK2 INHIBITOR COMPLEXES
Descriptor:Tyrosine-protein kinase JAK2 (E.C.2.7.10.2)
Authors:Williams, N.K., Bamert, R.S., Patel, O., Fantino, E., Rossjohn, J., Lucet, I.S.
Deposit date:2009-01-14
Release date:2009-02-10
Modification date:2009-05-05
Cite:Dissecting specificity in the Janus kinases: the structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase domains.
J.Mol.Biol., 387, 2009
3FZO
CRYSTAL STRUCTURE OF PYK2-APO, PROLINE-RICH TYROSINE KINASE
Descriptor:Protein tyrosine kinase 2 beta (E.C.2.7.10.2)
Authors:Han,S.
Deposit date:2009-01-26
Release date:2009-03-31
Modification date:2010-01-19
Cite:Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design.
J.Biol.Chem., 284, 2009
3FZP
CRYSTAL STRUCTURE OF PYK2 COMPLEXED WITH ATPGS
Descriptor:Protein tyrosine kinase 2 beta (E.C.2.7.10.2)
Authors:Han,S.
Deposit date:2009-01-26
Release date:2009-03-31
Modification date:2010-01-19
Cite:Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design.
J.Biol.Chem., 284, 2009
3FZR
CRYSTAL STRUCTURE OF PYK2 COMPLEXED WITH PF-431396
Descriptor:Protein tyrosine kinase 2 beta (E.C.2.7.10.2)
Authors:Han,S.
Deposit date:2009-01-26
Release date:2009-03-31
Modification date:2010-01-19
Cite:Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design.
J.Biol.Chem., 284, 2009
3FZS
CRYSTAL STRUCTURE OF PYK2 COMPLEXED WITH BIRB796
Descriptor:Protein tyrosine kinase 2 beta (E.C.2.7.10.2)
Authors:Han,S.
Deposit date:2009-01-26
Release date:2009-03-31
Modification date:2010-01-19
Cite:Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design.
J.Biol.Chem., 284, 2009
3FZT
CRYSTAL STRUCTURE OF PYK2 COMPLEXED WITH PF-4618433
Descriptor:Protein tyrosine kinase 2 beta (E.C.2.7.10.2)
Authors:Han,S.
Deposit date:2009-01-26
Release date:2009-03-31
Modification date:2010-01-19
Cite:Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design.
J.Biol.Chem., 284, 2009
3H3C
CRYSTAL STRUCTURE OF PYK2 IN COMPLEX WITH SULFOXIMINE-SUBSTITUTED TRIFLUOROMETHYLPYRIMIDINE ANALOG
Descriptor:Protein tyrosine kinase 2 beta (E.C.2.7.10.2)
Authors:Han, S., Mistry, A.
Deposit date:2009-04-16
Release date:2009-05-26
Modification date:2009-07-07
Cite:Sulfoximine-substituted trifluoromethylpyrimidine analogs as inhibitors of proline-rich tyrosine kinase 2 (PYK2) show reduced hERG activity.
Bioorg.Med.Chem.Lett., 19, 2009
3IO7
2-AMINOPYRAZOLO[1,5-A]PYRIMIDINES AS POTENT AND SELECTIVE INHIBITORS OF JAK2
Descriptor:Tyrosine-protein kinase JAK2 (E.C.2.7.10.2)
Authors:Zuccola, H.J., Ledeboer, M.W., Pierce, A.C.
Deposit date:2009-08-13
Release date:2009-11-10
Modification date:2009-11-17
Cite:2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2.
Bioorg.Med.Chem.Lett., 19, 2009
3IOK
2-AMINOPYRAZOLO[1,5-A]PYRIMIDINES AS POTENT AND SELECTIVE INHIBITORS OF JAK2
Descriptor:Tyrosine-protein kinase JAK2 (E.C.2.7.10.2)
Authors:Zuccola, H.J., Ledeboer, M.W., Pierce, A.C.
Deposit date:2009-08-14
Release date:2009-11-10
Modification date:2013-04-03
Cite:2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2.
Bioorg.Med.Chem.Lett., 19, 2009
3JY9
JANUS KINASE 2 INHIBITORS
Descriptor:Tyrosine-protein kinase JAK2 (E.C.2.7.10.2)
Authors:Zuccola, H.J., Ledeboer, M.W., Pierce, A.C.
Deposit date:2009-09-21
Release date:2009-12-01
Modification date:2013-04-03
Cite:Janus kinase 2 inhibitors. Synthesis and characterization of a novel polycyclic azaindole.
J.Med.Chem., 52, 2009
3KCK
A NOVEL CHEMOTYPE OF KINASE INHIBITORS
Descriptor:Tyrosine-protein kinase JAK2 (E.C.2.7.10.2)
Authors:Zuccola, H.J., Wang, T., Ledeboer, M.W.
Deposit date:2009-10-21
Release date:2009-11-24
Modification date:2010-02-16
Cite:A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010
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