PDB keyword search results

1RV1
CRYSTAL STRUCTURE OF HUMAN MDM2 WITH AN IMIDAZOLINE INHIBITOR
Descriptor:Ubiquitin-protein ligase E3 Mdm2 (E.C.6.3.2.-)
Authors:Lukacs, C., Kammlott, U., Graves, B.
Deposit date:2003-12-12
Release date:2004-01-20
Modification date:2009-02-24
Cite:In vivo activation of the p53 pathway by small-molecule antagonists of MDM2.
Science, 303, 2004
1T4E
STRUCTURE OF HUMAN MDM2 IN COMPLEX WITH A BENZODIAZEPINE INHIBITOR
Descriptor:Ubiquitin-protein ligase E3 Mdm2 (E.C.6.3.2.-)
Authors:Grasberger, B.L., Schubert, C., Koblish, H.K., Carver, T.E., Franks, C.F., Zhao, S.Y., Lu, T., LaFrance, L.V., Parks, D.J.
Deposit date:2004-04-29
Release date:2005-02-08
Modification date:2011-11-16
Cite:Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells
J.Med.Chem., 48, 2005
1T4F
STRUCTURE OF HUMAN MDM2 IN COMPLEX WITH AN OPTIMIZED P53 PEPTIDE
Descriptor:Ubiquitin-protein ligase E3 Mdm2 (E.C.6.3.2.-), optimized p53 peptide
Authors:Grasberger, B.L., Schubert, C., Koblish, H.K., Carver, T.E., Franks, C.F., Zhao, S.Y., Lu, T., LaFrance, L.V., Parks, D.J.
Deposit date:2004-04-29
Release date:2005-02-08
Modification date:2009-02-24
Cite:Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells
J.Med.Chem., 48, 2005
1TTV
NMR STRUCTURE OF A COMPLEX BETWEEN MDM2 AND A SMALL MOLECULE INHIBITOR
Descriptor:Ubiquitin-protein ligase E3 Mdm2 (E.C.6.3.2.-)
Authors:Fry, D.C., Emerson, S.D., Palme, S., Vu, B.T., Liu, C.M., Podlaski, F.
Deposit date:2004-06-23
Release date:2005-01-04
Modification date:2009-02-24
Cite:NMR structure of a complex between MDM2 and a small molecule inhibitor.
J.Biomol.Nmr, 30, 2004
1UHR
SOLUTION STRUCTURE OF THE SWIB DOMAIN OF MOUSE BRG1-ASSOCIATED FACTOR 60A
Descriptor:SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily D member 1
Authors:Yamada, K., Saito, K., Nameki, N., Inoue, M., Koshiba, S., Shirouzu, M., Terada, T., Yabuki, T., Aoki, M., Matsuda, T., Seki, E., Hirota, H., Yoshida, M., Tanaka, A., Osanai, T., Arakawa, T., Carninci, P., Kawai, J., Hayashizaki, Y., Kigawa, T., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2003-07-09
Release date:2004-08-24
Modification date:2009-02-24
Cite:Solution structure of the SWIB domain of mouse BRG1-associated factor 60a
To be Published
1V31
SOLUTION STRUCTURE OF THE SWIB/MDM2 DOMAIN OF THE HYPOTHETICAL PROTEIN AT5G14170 FROM ARABIDOPSIS THALIANA
Descriptor:hypothetical protein RAFL11-05-P19
Authors:Yoneyama, M., Tochio, N., Koshiba, S., Inoue, M., Kigawa, T., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2003-10-21
Release date:2004-04-21
Modification date:2009-02-24
Cite:Solution structure of the SWIB/MDM2 domain of the hypothetical protein At5g14170 from Arabidopsis thaliana
To be Published
1V32
SOLUTION STRUCTURE OF THE SWIB/MDM2 DOMAIN OF THE HYPOTHETICAL PROTEIN AT5G08430 FROM ARABIDOPSIS THALIANA
Descriptor:hypothetical protein RAFL09-47-K03
Authors:Yoneyama, M., Tochio, N., Koshiba, S., Inoue, M., Kigawa, T., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2003-10-24
Release date:2004-04-24
Modification date:2009-02-24
Cite:Solution structure of the SWIB/MDM2 domain of the hypothetical protein At5g08430 from Arabidopsis thaliana
To be Published
1YCQ
XENOPUS LAEVIS MDM2 BOUND TO THE TRANSACTIVATION DOMAIN OF HUMAN P53
Descriptor:MDM2, P53
Authors:Kussie, P.H., Pavletich, N.P.
Deposit date:1996-09-30
Release date:1997-11-19
Modification date:2009-02-24
Cite:Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain.
Science, 274, 1996
1YCR
MDM2 BOUND TO THE TRANSACTIVATION DOMAIN OF P53
Descriptor:MDM2, P53
Authors:Kussie, P.H., Pavletich, N.P.
Deposit date:1996-09-30
Release date:1997-11-19
Modification date:2009-02-24
Cite:Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain.
Science, 274, 1996
1Z1M
NMR STRUCTURE OF UNLIGANDED MDM2
Descriptor:Ubiquitin-protein ligase E3 Mdm2 (E.C.6.3.2.-)
Authors:Uhrinova, S., Uhrin, D., Powers, H., Watt, K., Zheleva, D., Fischer, P., McInnes, C., Barlow, P.N.
Deposit date:2005-03-04
Release date:2005-06-28
Modification date:2009-02-24
Cite:Structure of Free MDM2 N-terminal Domain Reveals Conformational Adjustments that Accompany p53-binding
J.Mol.Biol., 350, 2005
2AXI
HDM2 IN COMPLEX WITH A BETA-HAIRPIN
Descriptor:Ubiquitin-protein ligase E3 Mdm2 (E.C.6.3.2.-), cyclic 8-mer peptide
Authors:Mittl, P.R.E., Fasan, R., Robinson, J., Gruetter, M.G.
Deposit date:2005-09-05
Release date:2006-03-21
Modification date:2011-07-13
Cite:Structure-Activity Studies in a Family of beta-Hairpin Protein Epitope Mimetic Inhibitors of the p53-HDM2 Protein-Protein Interaction.
Chembiochem, 7, 2006
2GV2
MDM2 IN COMPLEX WITH AN 8-MER P53 PEPTIDE ANALOGUE
Descriptor:Ubiquitin-protein ligase E3 Mdm2 (E.C.6.3.2.-)
Authors:Schubert, C., Sakurai, K.
Deposit date:2006-05-02
Release date:2006-09-05
Modification date:2009-02-24
Cite:Crystallographic Analysis of an 8-mer p53 Peptide Analogue Complexed with MDM2.
J.Am.Chem.Soc., 128, 2006
2LZG
NMR STRUCTURE OF MDM2 (6-125) WITH PIP-1
Descriptor:E3 ubiquitin-protein ligase Mdm2
Authors:Michelsen, K.B., Jordan, J.B., Lewis, J., Long, A.M., Yang, E., Rew, Y., Zhou, J., Yakowec, P., Schnier, P.D., Huang, X., Poppe, L.
Deposit date:2012-10-02
Release date:2012-11-07
Cite:Ordering of the N-Terminus of Human MDM2 by Small Molecule Inhibitors.
J.Am.Chem.Soc., 134, 2012
2VYR
STRUCTURE OF HUMAN MDM4 N-TERMINAL DOMAIN BOUND TO A SINGLE DOMAIN ANTIBODY
Descriptor:MDM4 PROTEIN, HUMAN SINGLE DOMAIN ANTIBODY
Authors:Yu, G.W., Vaysburd, M., Allen, M.D., Settanni, G., Fersht, A.R.
Deposit date:2008-07-28
Release date:2008-11-25
Modification date:2013-03-06
Cite:Structure of Human Mdm4 N-Terminal Domain Bound to a Single-Domain Antibody.
J.Mol.Biol., 385, 2009
2Z5S
MOLECULAR BASIS FOR THE INHIBITION OF P53 BY MDMX
Descriptor:Mdm4 protein, Cellular tumor antigen p53
Authors:Popowicz, G.M., Czarna, A., Rothweiler, U., Szwagierczak, A., Holak, T.A.
Deposit date:2007-07-17
Release date:2007-11-06
Modification date:2009-02-24
Cite:Molecular basis for the inhibition of p53 by Mdmx.
Cell Cycle, 6, 2007
2Z5T
MOLECULAR BASIS FOR THE INHIBITION OF P53 BY MDMX
Descriptor:Mdm4 protein, Cellular tumor antigen p53
Authors:Popowicz, G.M., Czarna, A., Rothweiler, U., Szwagierczak, A., Holak, T.A.
Deposit date:2007-07-17
Release date:2007-11-06
Modification date:2009-02-24
Cite:Molecular basis for the inhibition of p53 by Mdmx.
Cell Cycle, 6, 2007
3DAB
STRUCTURE OF THE HUMAN MDMX PROTEIN BOUND TO THE P53 TUMOR SUPPRESSOR TRANSACTIVATION DOMAIN
Descriptor:Mdm4 protein, Cellular tumor antigen p53
Authors:Popowicz, G.M., Czarna, A., Holak, T.A.
Deposit date:2008-05-29
Release date:2008-09-02
Modification date:2009-02-24
Cite:Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain
Cell Cycle, 7, 2008
3DAC
STRUCTURE OF THE HUMAN MDMX PROTEIN BOUND TO THE P53 TUMOR SUPPRESSOR TRANSACTIVATION DOMAIN
Descriptor:Mdm4 protein, Cellular tumor antigen p53
Authors:Popowicz, G.M., Czarna, A., Holak, T.A.
Deposit date:2008-05-29
Release date:2008-09-02
Modification date:2009-02-24
Cite:Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain
Cell Cycle, 7, 2008
3EQS
CRYSTAL STRUCTURE OF HUMAN MDM2 IN COMPLEX WITH A 12-MER PEPTIDE INHIBITOR
Descriptor:E3 ubiquitin-protein ligase Mdm2 (E.C.6.3.2.-)
Authors:Pazgier, M., Lu, W.
Deposit date:2008-10-01
Release date:2009-03-17
Modification date:2011-07-13
Cite:Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX.
Proc.Natl.Acad.Sci.USA, 106, 2009
3EQY
CRYSTAL STRUCTURE OF HUMAN MDMX IN COMPLEX WITH A 12-MER PEPTIDE INHIBITOR
Descriptor:Mdm4 protein
Authors:Pazgier, M., Lu, W.
Deposit date:2008-10-01
Release date:2009-03-17
Modification date:2011-07-13
Cite:Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX.
Proc.Natl.Acad.Sci.USA, 106, 2009
3FDO
STRUCTURE OF HUMAN MDMX IN COMPLEX WITH HIGH AFFINITY PEPTIDE
Descriptor:Protein Mdm4, Synthetic high affinity peptide
Authors:Czarna, A.L., Popowicz, G.M., Holak, T.A.
Deposit date:2008-11-26
Release date:2008-12-16
Modification date:2011-07-13
Cite:High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx
Cell Cycle, 8, 2009
3FE7
CRYSTAL STRUCTURE OF HDMX BOUND TO THE P53-PEPTIDOMIMETIC AC-PHE-MET-AIB-PMP-TRP-GLU-AC3C-LEU-NH2 AT 1.35A
Descriptor:Mdm4 protein, p53-peptidomimetic Ac-Phe-Met-Aib-Pmp-Trp-Glu-Ac3c-Leu-NH2
Authors:Kallen, J.
Deposit date:2008-11-28
Release date:2009-01-27
Modification date:2009-04-07
Cite:Crystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes
J.Biol.Chem., 284, 2009
3FEA
CRYSTAL STRUCTURE OF HDMX BOUND TO THE P53-PEPTIDOMIMETIC AC-PHE-MET-AIB-PMP-6-CL-TRP-GLU-AC3C-LEU-NH2 AT 1.33A
Descriptor:Mdm4 protein, p53-peptidomimetic Ac-Phe-Met-Aib-Pmp-6-Cl-Trp-Glu-Ac3c-Leu-NH2
Authors:Kallen, J.
Deposit date:2008-11-28
Release date:2009-01-27
Modification date:2009-04-07
Cite:Crystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes
J.Biol.Chem., 284, 2009
3G03
STRUCTURE OF HUMAN MDM2 IN COMPLEX WITH HIGH AFFINITY PEPTIDE
Descriptor:E3 ubiquitin-protein ligase Mdm2, High affinity synthetic peptide
Authors:Czarna, A.L., Popowicz, G.M., Holak, T.A.
Deposit date:2009-01-27
Release date:2009-04-14
Modification date:2009-04-28
Cite:High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx
Cell Cycle, 8, 2009
3IUX
CRYSTAL STRUCTURE OF HUMAN MDM2 IN COMPLEX WITH A POTENT MINIATURE PROTEIN INHIBITOR (18-RESIDUES)
Descriptor:E3 ubiquitin-protein ligase Mdm2 (E.C.6.3.2.-), p53 binding domain
Authors:Pazgier, M., Lu, W.
Deposit date:2009-08-31
Release date:2009-10-27
Modification date:2011-07-13
Cite:Apamin as a template for structure-based rational design of potent peptide activators of p53.
Angew.Chem.Int.Ed.Engl., 48, 2009
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