PDB keyword search results

1FPP
PROTEIN FARNESYLTRANSFERASE COMPLEX WITH FARNESYL DIPHOSPHATE
Descriptor:PROTEIN FARNESYLTRANSFERASE, FARNESYL DIPHOSPHATE
Authors:Dunten, P., Kammlott, U., Crowther, R., Weber, D., Palermo, R., Birktoft, J.
Deposit date:1998-07-10
Release date:1999-06-08
Modification date:2009-02-24
Cite:Protein farnesyltransferase: structure and implications for substrate binding.
Biochemistry, 37, 1998
1W6J
STRUCTURE OF HUMAN OSC IN COMPLEX WITH RO 48-8071
Descriptor:LANOSTEROL SYNTHASE (E.C.5.4.99.7)
Authors:Thoma, R., Schulz-Gasch, T., Arcy, B.D', Benz, J., Aebi, J., Dehmlow, H., Hennig, M., Ruf, A.
Deposit date:2004-08-18
Release date:2004-10-29
Modification date:2013-11-20
Cite:Insight Into Steroid Scaffold Formation from the Structure of Human Oxidosqualene Cyclase
Nature, 432, 2004
1W6K
STRUCTURE OF HUMAN OSC IN COMPLEX WITH LANOSTEROL
Descriptor:LANOSTEROL SYNTHASE (E.C.5.4.99.7)
Authors:Thoma, R., Schulz-Gasch, T., D'Arcy, B., Benz, J., Aebi, J., Dehmlow, H., Hennig, M., Ruf, A.
Deposit date:2004-08-19
Release date:2004-10-29
Modification date:2009-02-24
Cite:Insight Into Steroid Scaffold Formation from the Structure of Human Oxidosqualene Cyclase
Nature, 432, 2004
1D8D
CO-CRYSTAL STRUCTURE OF RAT PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH A K-RAS4B PEPTIDE SUBSTRATE AND FPP ANALOG AT 2.0A RESOLUTION
Descriptor:farnesyltranserase (alpha subunit)/farnesyltranserase (beta subunit)/K-RAS4B PEPTIDE SUBSTRATE
Authors:Long, S.B., Casey, P.J., Beese, L.S.
Deposit date:1999-10-22
Release date:2000-02-09
Modification date:2009-02-24
Cite:The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures.
Structure Fold.Des., 8, 2000
1D8E
ZINC-DEPLETED FTASE COMPLEXED WITH K-RAS4B PEPTIDE SUBSTRATE AND FPP ANALOG.
Descriptor:FARNESYLTRANSFERASE (ALPHA SUBUNIT) (E.C.2.5.1.-)/ FARNESYLTRANSFERASE (BETA SUBUNIT) (E.C.2.5.1.-)/K-RAS4B PEPTIDE SUBSTRATE
Authors:Long, S.B., Casey, P.J., Beese, L.S.
Deposit date:1999-10-22
Release date:2000-03-20
Modification date:2009-02-24
Cite:The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures.
Structure Fold.Des., 8, 2000
1DCE
CRYSTAL STRUCTURE OF RAB GERANYLGERANYLTRANSFERASE FROM RAT BRAIN
Descriptor:RAB GERANYLGERANYLTRANSFERASE (ALPHA AND BETA SUBUNIT)
Authors:Zhang, H., Seabra, M.C., Deisenhofer, H.
Deposit date:1999-11-04
Release date:2000-03-24
Modification date:2009-02-24
Cite:Crystal structure of Rab geranylgeranyltransferase at 2.0 A resolution.
Structure Fold.Des., 8, 2000
1FT1
CRYSTAL STRUCTURE OF PROTEIN FARNESYLTRANSFERASE AT 2.25 ANGSTROMS RESOLUTION
Descriptor:PROTEIN FARNESYLTRANSFERASE
Authors:Beese, L.S., Park, H.-W.
Deposit date:1997-03-17
Release date:1998-03-18
Modification date:2009-02-24
Cite:Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution.
Science, 275, 1997
1FT2
CO-CRYSTAL STRUCTURE OF PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH A FARNESYL DIPHOSPHATE SUBSTRATE
Descriptor:PROTEIN FARNESYLTRANSFERASE, FARNESYL DIPHOSPHATE
Authors:Beese, L.S., Casey, P.J., Long, S.B.
Deposit date:1998-06-02
Release date:1998-11-04
Modification date:2009-02-24
Cite:Cocrystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate.
Biochemistry, 37, 1998
1GSZ
CRYSTAL STRUCTURE OF A SQUALENE CYCLASE IN COMPLEX WITH THE POTENTIAL ANTICHOLESTEREMIC DRUG RO48-8071
Descriptor:SQUALENE--HOPENE CYCLASE (E.C.5.4.99.17)
Authors:Lenhart, A., Weihofen, W.A., Pleschke, A.E.W., Schulz, G.E.
Deposit date:2002-01-09
Release date:2003-01-16
Modification date:2013-11-20
Cite:Crystal Structure of a Squalene Cyclase in Complex with the Potential Anticholesteremic Drug Ro48-8071
Chem.Biol., 9, 2002
1H35
STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO A HOMOLGOUS ENZYME
Descriptor:SQUALENE--HOPENE CYCLASE (E.C.5.4.99.17)
Authors:Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
Deposit date:2002-08-24
Release date:2003-08-21
Modification date:2013-11-20
Cite:Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1H36
STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO A HOMOLGOUS ENZYME
Descriptor:SQUALENE--HOPENE CYCLASE (E.C.5.4.99.17)
Authors:Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
Deposit date:2002-08-24
Release date:2003-08-21
Modification date:2014-02-05
Cite:Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1H37
STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO A HOMOLGOUS ENZYME
Descriptor:SQUALENE--HOPENE CYCLASE (E.C.5.4.99.17)
Authors:Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
Deposit date:2002-08-24
Release date:2003-08-21
Modification date:2013-11-20
Cite:Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1H39
STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO A HOMOLGOUS ENZYME
Descriptor:SQUALENE--HOPENE CYCLASE (E.C.5.4.99.17)
Authors:Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
Deposit date:2002-08-24
Release date:2003-08-21
Modification date:2013-11-20
Cite:Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1H3A
STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO A HOMOLGOUS ENZYME
Descriptor:SQUALENE--HOPENE CYCLASE (E.C.5.4.99.17)
Authors:Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
Deposit date:2002-08-24
Release date:2003-08-21
Modification date:2013-11-20
Cite:Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1H3B
SQUALENE-HOPENE CYCLASE
Descriptor:SQUALENE--HOPENE CYCLASE (E.C.5.4.99.17)
Authors:Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
Deposit date:2002-08-25
Release date:2003-08-21
Modification date:2013-11-20
Cite:Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1H3C
STRUCTURES OF HUMAN OXIDOSQUALENE CYCLASE INHIBITORS BOUND TO A HOMOLGOUS ENZYME
Descriptor:SQUALENE--HOPENE CYCLASE (E.C.5.4.99.17)
Authors:Lenhart, A., Reinert, D.J., Weihofen, W.A., Aebi, J.D., Dehmlow, H., Morand, O.H., Schulz, G.E.
Deposit date:2002-08-25
Release date:2003-08-21
Modification date:2013-11-20
Cite:Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase
J.Med.Chem., 46, 2003
1JCQ
CRYSTAL STRUCTURE OF HUMAN PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH FARNESYL DIPHOSPHATE AND THE PEPTIDOMIMETIC INHIBITOR L-739,750
Descriptor:Protein Farnesyltransferase, alpha and beta subunits (E.C.2.5.1.-)
Authors:Long, S.B., Casey, P.J., Beese, L.S.
Deposit date:2001-06-11
Release date:2001-11-02
Modification date:2009-02-24
Cite:The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics.
Proc.Natl.Acad.Sci.USA, 98, 2001
1JCR
CRYSTAL STRUCTURE OF RAT PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH THE NON-SUBSTRATE TETRAPEPTIDE INHIBITOR CVFM AND FARNESYL DIPHOSPHATE SUBSTRATE
Descriptor:Protein Farnesyltransferase, alpha and beta subunits (E.C.2.5.1.-)
Authors:Long, S.B., Casey, P.J., Beese, L.S.
Deposit date:2001-06-11
Release date:2001-11-02
Modification date:2011-07-13
Cite:The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics.
Proc.Natl.Acad.Sci.USA, 98, 2001
1JCS
CRYSTAL STRUCTURE OF RAT PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH THE PEPTIDE SUBSTRATE TKCVFM AND AN ANALOG OF FARNESYL DIPHOSPHATE
Descriptor:Protein Farnesyltransferase, alpha and beta subunits (E.C.2.5.1.-)
Authors:Long, S.B., Casey, P.J., Beese, L.S.
Deposit date:2001-06-11
Release date:2001-11-02
Modification date:2011-07-13
Cite:The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics.
Proc.Natl.Acad.Sci.USA, 98, 2001
1KZO
PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH FARNESYLATED K-RAS4B PEPTIDE PRODUCT AND FARNESYL DIPHOSPHATE SUBSTRATE BOUND SIMULTANEOUSLY
Descriptor:Protein Farnesyltransferase alpha subunit(E.C.2.5.1.21)/Protein Farnesyltransferase beta subunit(E.C.2.5.1.21)/Farnesylated K-Ras4B peptide product
Authors:Long, S.B., Casey, P.J., Beese, L.S.
Deposit date:2002-02-07
Release date:2002-10-16
Modification date:2011-07-13
Cite:The Reaction Path of Protein Farnesyltransferase at Atomic Resolution
Nature, 419, 2002
1KZP
PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH A FARNESYLATED K-RAS4B PEPTIDE PRODUCT
Descriptor:Protein Farnesyltransferase alpha subunit (E.C.2.5.1.21)/Protein Farnesyltransferase beta subunit (E.C.2.5.1.21)/Farnesylated K-Ras4B peptide product
Authors:Long, S.B., Casey, P.J., Beese, L.S.
Deposit date:2002-02-07
Release date:2002-10-16
Modification date:2011-07-13
Cite:Reaction path of protein farnesyltransferase at atomic resolution
Nature, 419, 2002
1LD7
CO-CRYSTAL STRUCTURE OF HUMAN FARNESYLTRANSFERASE WITH FARNESYLDIPHOSPHATE AND INHIBITOR COMPOUND 66
Descriptor:protein farnesyltransferase alpha subunit (E.C.2.5.1.-)/protein farnesyltransferase beta subunit (E.C.2.5.1.-)
Authors:Taylor, J.S., Terry, K.L., Beese, L.S.
Deposit date:2002-04-08
Release date:2002-06-19
Modification date:2009-02-24
Cite:3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency.
J.Med.Chem., 45, 2002
1LD8
CO-CRYSTAL STRUCTURE OF HUMAN FARNESYLTRANSFERASE WITH FARNESYLDIPHOSPHATE AND INHIBITOR COMPOUND 49
Descriptor:protein farnesyltransferase alpha subunit (E.C.2.5.1.-), protein farnesyltransferase beta subunit (E.C.2.5.1.-)
Authors:Taylor, J.S., Terry, K.L., Beese, L.S.
Deposit date:2002-04-08
Release date:2002-06-19
Modification date:2009-02-24
Cite:3-Aminopyrrolidinone farnesyltransferase inhibitors: design of macrocyclic compounds with improved pharmacokinetics and excellent cell potency.
J.Med.Chem., 45, 2002
1LTX
STRUCTURE OF RAB ESCORT PROTEIN-1 IN COMPLEX WITH RAB GERANYLGERANYL TRANSFERASE AND ISOPRENOID
Descriptor:RAB GERANYLGERANYLTRANSFERASE ALPHA SUBUNIT(E.C.2.5.1._)/RAB GERANYLGERANYLTRANSFERASE BETA SUBUNIT(E.C.2.5.1._)/Rab Escort Protein 1
Authors:Pylypenko, O., Rak, A., Reents, R., Niculae, A., Thoma, N.H., Waldmann, H., Schlichting, I., Goody, R.S., Alexandrov, K.
Deposit date:2002-05-21
Release date:2003-05-21
Modification date:2009-02-24
Cite:Structure of Rab Escort Protein-1 in Complex with Rab Geranylgeranyltransferase
Mol.Cell, 11, 2003
1MZC
CO-CRYSTAL STRUCTURE OF HUMAN FARNESYLTRANSFERASE WITH FARNESYLDIPHOSPHATE AND INHIBITOR COMPOUND 33A
Descriptor:Protein Farnesyltransferase alpha Subunit (E.C.2.5.1.-)/Protein Farnesyltransferase beta Subunit (E.C.2.5.1.-)
Authors:deSolms, S.J., Ciccarone, T.M., MacTough, S.C., Shaw, A.W., Buser, C.A., Ellis-Hutchings, M., Fernandes, C., Hamilton, K.A., Huber, H.E., Kohl, N.E., Lobell, R.B., Robinson, R.G., Tsou, N.N., Walsh, E.S., Graham, S.L., Beese, L.S., Taylor, J.S.
Deposit date:2002-10-07
Release date:2003-07-08
Modification date:2009-02-24
Cite:Dual Protein Farnesyltransferase-Geranylgeranyltransferase-I Inhibitors as Potential Cancer Chemotherapeutic Agents.
J.Med.Chem., 46, 2003
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