PDB keyword search results

1Y6Z
MIDDLE DOMAIN OF PLASMODIUM FALCIPARUM PUTATIVE HEAT SHOCK PROTEIN PF14_0417
Descriptor:heat shock protein, putative
Authors:Lunin, V.V., Botchkareva, E., Loppnau, P., Amani, M., Bray, J., Vedadi, M., Edwards, A., Arrowsmith, C., Sundstrom, M., Bochkarev, A., Hui, R., Plotnikova, O., Structural Genomics Consortium (SGC)
Deposit date:2004-12-07
Release date:2005-02-08
Modification date:2011-07-13
Cite:Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.
Mol.Biochem.Parasitol., 151, 2007
1AH6
STRUCTURE OF THE TETRAGONAL FORM OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE
Descriptor:HEAT SHOCK PROTEIN 90
Authors:Prodromou, C., Roe, S.M., Pearl, L.H.
Deposit date:1997-04-14
Release date:1997-10-22
Modification date:2009-02-24
Cite:A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone.
Nat.Struct.Biol., 4, 1997
1HK7
MIDDLE DOMAIN OF HSP90
Descriptor:HEAT SHOCK PROTEIN HSP82
Authors:Meyer, P., Prodromou, C., Roe, S.M., Pearl, L.H.
Deposit date:2003-03-06
Release date:2004-01-29
Modification date:2009-02-24
Cite:Structural and Functional Analysis of the Middle Segment of Hsp90. Implications for ATP Hydrolysis and Client Protein and Cochaperone Interactions
Mol.Cell, 11, 2003
1SF8
CRYSTAL STRUCTURE OF THE CARBOXY-TERMINAL DOMAIN OF HTPG, THE E. COLI HSP90
Descriptor:Chaperone protein htpG
Authors:Harris, S.F., Shiau, A.K., Agard, D.A.
Deposit date:2004-02-19
Release date:2004-06-15
Modification date:2009-02-24
Cite:The crystal structure of the carboxy-terminal dimerization domain of htpG, the Escherichia coli Hsp90, reveals a potential substrate binding site.
Structure, 12, 2004
1U0Y
N-DOMAIN OF GRP94, WITH THE CHARGED DOMAIN, IN COMPLEX WITH THE NOVEL LIGAND N-PROPYL CARBOXYAMIDO ADENOSINE
Descriptor:Endoplasmin
Authors:Gewirth, D.T., Immormino, R.M.
Deposit date:2004-07-14
Release date:2005-07-05
Modification date:2009-02-24
Cite:N-Domain Of Grp94, with the Charged Domain, In Complex With the Novel Ligand N-Propyl Carboxyamido Adenosine
TO BE PUBLISHED
1USU
THE STRUCTURE OF THE COMPLEX BETWEEN AHA1 AND HSP90
Descriptor:HEAT SHOCK PROTEIN HSP82, AHA1
Authors:Meyer, P., Roe, S.M., Pearl, L.H.
Deposit date:2003-12-01
Release date:2004-01-29
Modification date:2009-02-24
Cite:Structural Basis for Recruitment of the ATPase Activator Aha1 to the Hsp90 Chaperone Machinery.
Embo J., 23, 2004
1USV
THE STRUCTURE OF THE COMPLEX BETWEEN AHA1 AND HSP90
Descriptor:HEAT SHOCK PROTEIN HSP82, AHA1
Authors:Meyer, P., Roe, S.M., Pearl, L.H.
Deposit date:2003-12-01
Release date:2004-01-29
Modification date:2009-02-24
Cite:Structural Basis for Recruitment of the ATPase Activator Aha1 to the Hsp90 Chaperone Machinery.
Embo J., 23, 2004
1YSZ
CRYSTAL STRUCTURE OF THE UNLIGANDED FORM OF GRP94, THE ER HSP90: BASIS FOR NUCLEOTIDE-INDUCED CONFORMATIONAL CHANGE, GRP94N(DELTA)41 APO CRYSTAL SOAKED WITH NECA
Descriptor:Endoplasmin
Authors:Dollins, D.E., Immormino, R.M., Gewirth, D.T.
Deposit date:2005-02-09
Release date:2005-06-14
Modification date:2009-02-24
Cite:Structure of Unliganded GRP94, the Endoplasmic Reticulum Hsp90: BASIS FOR NUCLEOTIDE-INDUCED CONFORMATIONAL CHANGE
J.Biol.Chem., 280, 2005
1YT0
CRYSTAL STRUCTURE OF THE UNLIGANDED FORM OF GRP94, THE ER HSP90: BASIS FOR NUCLEOTIDE-INDUCED CONFORMATIONAL CHANGE, GRP94N(DELTA)41 APO CRYSTAL SOAKED WITH ADP
Descriptor:Endoplasmin
Authors:Dollins, D.E., Immormino, R.M., Gewirth, D.T.
Deposit date:2005-02-09
Release date:2005-06-14
Modification date:2009-02-24
Cite:Structure of Unliganded GRP94, the Endoplasmic Reticulum Hsp90: BASIS FOR NUCLEOTIDE-INDUCED CONFORMATIONAL CHANGE
J.Biol.Chem., 280, 2005
1ZW9
YEAST HSP82 IN COMPLEX WITH THE NOVEL HSP90 INHIBITOR 8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE
Descriptor:HSP82
Authors:Immormino, R.M., Gewirth, D.T., Chiosis, G.
Deposit date:2005-06-03
Release date:2006-06-13
Modification date:2011-11-16
Cite:Inhibitory Ligands Adopt Different Conformations When Bound to Hsp90 or GRP94: Implications for Paralog-specific Drug Design
To be Published
1ZWH
YEAST HSP82 IN COMPLEX WITH THE NOVEL HSP90 INHIBITOR RADESTER AMINE
Descriptor:ATP-dependent molecular chaperone HSP82
Authors:Immormino, R.M., Blagg, B.S., Gewirth, D.T.
Deposit date:2005-06-03
Release date:2006-06-13
Modification date:2011-11-16
Cite:Inhibitory Ligands Adopt Different Conformations When Bound to Hsp90 or GRP94: Implications for Paralog-specific Drug Design
To be Published
2BRC
STRUCTURE OF A HSP90 INHIBITOR BOUND TO THE N-TERMINUS OF YEAST HSP90.
Descriptor:ATP-DEPENDENT MOLECULAR CHAPERONE HSP82
Authors:Roe, S.M., Pearl, L.H., Prodromou, C.
Deposit date:2005-05-04
Release date:2005-09-29
Modification date:2009-02-24
Cite:The Identification, Synthesis, Protein Crystal Structure and in Vitro Biochemical Evaluation of a New 3,4-Diarylpyrazole Class of Hsp90 Inhibitors.
Bioorg.Med.Chem.Lett., 15, 2005
2CGE
CRYSTAL STRUCTURE OF AN HSP90-SBA1 CLOSED CHAPERONE COMPLEX
Descriptor:ATP-DEPENDENT MOLECULAR CHAPERONE HSP82
Authors:Ali, M.M.U., Roe, S.M., Prodromou, C., Pearl, L.H.
Deposit date:2006-03-01
Release date:2006-04-12
Modification date:2009-02-24
Cite:Crystal Structure of an Hsp90-Nucleotide-P23/Sba1 Closed Chaperone Complex
Nature, 440, 2006
2CGF
A RADICICOL ANALOGUE BOUND TO THE ATP BINDING SITE OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE
Descriptor:ATP-DEPENDENT MOLECULAR CHAPERONE HSP82
Authors:Roe, S.M., Prodromou, C., Pearl, L.H., Moody, C.J.
Deposit date:2006-03-02
Release date:2006-11-29
Modification date:2009-02-24
Cite:Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol.
Chem.Biol., 13, 2006
2GQ0
CRYSTAL STRUCTURE OF THE MIDDLE DOMAIN OF HTPG, THE E. COLI HSP90
Descriptor:Chaperone protein htpG (E.C.3.6.4.10)
Authors:Harris, S.F., Shiau, A.K., Agard, D.A.
Deposit date:2006-04-19
Release date:2006-10-31
Modification date:2009-02-24
Cite:Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements.
Cell(Cambridge,Mass.), 127, 2006
2IWS
RADICICOL ANALOGUES BOUND TO THE ATP SITE OF HSP90
Descriptor:ATP-DEPENDENT MOLECULAR CHAPERONE HSP82
Authors:Roe, S.M., Prodromou, C., Pearl, L.H.
Deposit date:2006-07-04
Release date:2006-11-30
Modification date:2009-02-24
Cite:Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol.
Chem.Biol., 13, 2006
2IWU
ANALOGUES OF RADICICOL BOUND TO THE ATP-BINDING SITE OF HSP90
Descriptor:ATP-DEPENDENT MOLECULAR CHAPERONE HSP82
Authors:Roe, S.M., Prodromou, C., Pearl, L.H.
Deposit date:2006-07-04
Release date:2006-11-30
Modification date:2009-02-24
Cite:Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol.
Chem.Biol., 13, 2006
2IWX
ANALOGUES OF RADICICOL BOUND TO THE ATP-BINDING SITE OF HSP90.
Descriptor:ATP-DEPENDENT MOLECULAR CHAPERONE HSP82
Authors:Roe, S.M., Prodromou, C., Pearl, L.H.
Deposit date:2006-07-05
Release date:2006-11-30
Modification date:2011-07-13
Cite:Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol.
Chem.Biol., 13, 2006
2O1T
STRUCTURE OF MIDDLE PLUS C-TERMINAL DOMAINS (M+C) OF GRP94
Descriptor:Endoplasmin
Authors:Dollins, D.E., Warren, J.J., Immormino, R.M., Gewirth, D.T.
Deposit date:2006-11-29
Release date:2007-10-23
Modification date:2011-07-13
Cite:Structures of GRP94-Nucleotide Complexes Reveal Mechanistic Differences between the hsp90 Chaperones.
Mol.Cell, 28, 2007
2WEP
YEAST HSP90 N-TERMINAL DOMAIN LI-IV MUTANT WITH ADP
Descriptor:ATP-DEPENDENT MOLECULAR CHAPERONE HSP82
Authors:Roe, S.M., Prodromou, C., Pearl, L.H.
Deposit date:2009-04-01
Release date:2009-04-14
Modification date:2011-11-02
Cite:Structural Basis of the Radicicol Resistance Displayed by a Fungal Hsp90.
Acs Chem.Biol., 4, 2009
2WEQ
YEAST HSP90 N-TERMINAL DOMAIN LI-IV MUTANT WITH GELDANAMYCIN
Descriptor:ATP-DEPENDENT MOLECULAR CHAPERONE HSP82
Authors:Roe, S.M., Prodromou, C., Pearl, L.H.
Deposit date:2009-04-01
Release date:2009-04-14
Modification date:2012-03-21
Cite:Structural Basis of the Radicicol Resistance Displayed by a Fungal Hsp90
Acs Chem.Biol., 4, 2009
2XD6
HSP90 COMPLEXED WITH A RESORCYLIC ACID MACROLACTONE.
Descriptor:ATP-DEPENDENT MOLECULAR CHAPERONE HSP82
Authors:Roe, S.M., Prodromou, C., Pearl, L.H., Moody, C.J.
Deposit date:2010-04-29
Release date:2010-08-11
Modification date:2013-05-01
Cite:Inhibition of Hsp90 with Resorcylic Acid Macrolactones. Synthesis and Binding Studies.
Chemistry, 16, 2010
2XX4
MACROLACTONE INHIBITOR BOUND TO HSP90 N-TERM
Descriptor:ATP-DEPENDENT MOLECULAR CHAPERONE HSP82
Authors:Moody, C.J., Prodromou, C., Pearl, L.H., Roe, S.M.
Deposit date:2010-11-08
Release date:2011-11-16
Modification date:2011-12-28
Cite:Targeting the Hsp90 Molecular Chaperone with Novel Macrolactams. Synthesis, Structural, Binding, and Cellular Studies.
Acs Chem.Biol., 6, 2011
2XX5
MACROLACTONE INHIBITOR BOUND TO HSP90 N-TERM
Descriptor:ATP-DEPENDENT MOLECULAR CHAPERONE HSP82
Authors:Moody, C.J., Prodromou, C., Pearl, L.H., Roe, S.M.
Deposit date:2010-11-08
Release date:2011-11-16
Modification date:2011-12-28
Cite:Targeting the Hsp90 Molecular Chaperone with Novel Macrolactams. Synthesis, Structural, Binding, and Cellular Studies.
Acs Chem.Biol., 6, 2011
3C0E
YEAST HSP82 N-TERMINAL DOMAIN: EFFECTS OF MUTANTS 98-99 KS-AA
Descriptor:ATP-dependent molecular chaperone HSP82
Authors:Immormino, R.M., Gewirth, D.T.
Deposit date:2008-01-19
Release date:2008-07-29
Modification date:2009-02-24
Cite:Crystal Structure of GRP94 with the Specific Mutation KS168-169AA with Bound Geldanamycin
To be Published
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