PDB keyword search results

2OUL
THE STRUCTURE OF CHAGASIN IN COMPLEX WITH A CYSTEINE PROTEASE CLARIFIES THE BINDING MODE AND EVOLUTION OF A NEW INHIBITOR FAMILY
Descriptor:Falcipain 2 (E.C.3.4.22)/Chagasin
Authors:Wang, S.X., Chand, K., Huang, R., Whisstock, J., Jacobelli, J, Fletterick, R.J., Rosenthal, P.J., McKerrow, J.H.
Deposit date:2007-02-11
Release date:2008-02-26
Modification date:2011-07-13
Cite:The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family.
Structure, 15, 2007
1AU3
CRYSTAL STRUCTURE OF THE CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH A COVALENT PYRROLIDINONE INHIBITOR
Descriptor:CATHEPSIN K, 1-[N[(PHENYLMETHOXY)CARBONYL]-L-LEUCYL-4-[[N/N-[(PHENYLMETHOXY)CARBONYL]-/NL-LEUCYL]AMINO]-3-PYRROLIDINONE/N
Authors:Zhao, B., Smith, W.W., Janson, C.A., Abdel-Meguid, S.S.
Deposit date:1997-09-10
Release date:1998-10-14
Modification date:2009-02-24
Cite:Conformationally constrained 1,3-diamino ketones: a series of potent inhibitors of the cysteine protease cathepsin K.
J.Med.Chem., 41, 1998
1CPJ
CRYSTAL STRUCTURES OF RECOMBINANT RAT CATHEPSIN B AND A CATHEPSIN B-INHIBITOR COMPLEX: IMPLICATIONS FOR STRUCTURE-BASED INHIBITOR DESIGN
Descriptor:CATHEPSIN B
Authors:Huber, C.P., Jia, Z.
Deposit date:1995-07-17
Release date:1995-12-07
Modification date:2009-02-24
Cite:Crystal structures of recombinant rat cathepsin B and a cathepsin B-inhibitor complex. Implications for structure-based inhibitor design.
J.Biol.Chem., 270, 1995
1CTE
CRYSTAL STRUCTURES OF RECOMBINANT RAT CATHEPSIN B AND A CATHEPSIN B-INHIBITOR COMPLEX: IMPLICATIONS FOR STRUCTURE-BASED INHIBITOR DESIGN
Descriptor:CATHEPSIN B, 2-PYRIDINETHIOL
Authors:Huber, C.P., Jia, Z.
Deposit date:1995-05-03
Release date:1995-07-31
Modification date:2009-02-24
Cite:Crystal structures of recombinant rat cathepsin B and a cathepsin B-inhibitor complex. Implications for structure-based inhibitor design.
J.Biol.Chem., 270, 1995
1MEM
CRYSTAL STRUCTURE OF CATHEPSIN K COMPLEXED WITH A POTENT VINYL SULFONE INHIBITOR
Descriptor:CATHEPSIN K, INHIBITOR APC3328, 4-SULFONYLBENZENE GROUP
Authors:Mcgrath, M.E.
Deposit date:1997-01-08
Release date:1998-01-14
Modification date:2014-01-29
Cite:Crystal structure of human cathepsin K complexed with a potent inhibitor.
Nat.Struct.Biol., 4, 1997
1THE
CRYSTAL STRUCTURES OF RECOMBINANT RAT CATHEPSIN B AND A CATHEPSIN B-INHIBITOR COMPLEX: IMPLICATIONS FOR STRUCTURE-BASED INHIBITOR DESIGN
Descriptor:CATHEPSIN B, CARBOBENZOXY GROUP, ARGININE, 3-AMINO-4-OXYBENZYL-2-BUTANONE
Authors:Huber, C.P., Jia, Z.
Deposit date:1995-09-15
Release date:1996-03-10
Modification date:2011-07-13
Cite:Crystal structures of recombinant rat cathepsin B and a cathepsin B-inhibitor complex. Implications for structure-based inhibitor design.
J.Biol.Chem., 270, 1995
3AI8
CATHEPSIN B IN COMPLEX WITH THE NITROXOLINE
Descriptor:Cathepsin B (E.C.3.4.22.1)
Authors:Renko, M., Mirkovic, B., Gobec, S., Kos, J., Turk, D.
Deposit date:2010-05-11
Release date:2011-05-18
Modification date:2014-01-29
Cite:Novel mechanism of cathepsin B inhibition by antibiotic nitroxoline and related compounds
Chemmedchem, 6, 2011
3H89
A COMBINED CRYSTALLOGRAPHIC AND MOLECULAR DYNAMICS STUDY OF CATHEPSIN-L RETRO-BINDING INHIBITORS(COMPOUND 4)
Descriptor:Cathepsin L1 (E.C.3.4.22.15)
Authors:Tulsidas, S.R., Chowdhury, S.F., Kumar, S., Joseph, L., Purisima, E.O., Sivaraman, J.
Deposit date:2009-04-29
Release date:2009-10-20
Modification date:2014-02-05
Cite:A combined crystallographic and molecular dynamics study of cathepsin L retrobinding inhibitors
J.Med.Chem., 52, 2009
3H8B
A COMBINED CRYSTALLOGRAPHIC AND MOLECULAR DYNAMICS STUDY OF CATHEPSIN-L RETRO-BINDING INHIBITORS(COMPOUND 9)
Descriptor:Cathepsin L1 (E.C.3.4.22.15)
Authors:Tulsidas, S.R., Chowdhury, S.F., Kumar, S., Joseph, L., Purisima, E.O., Sivaraman, J.
Deposit date:2009-04-29
Release date:2009-10-20
Modification date:2014-02-05
Cite:A combined crystallographic and molecular dynamics study of cathepsin L retrobinding inhibitors
J.Med.Chem., 52, 2009
1MIR
RAT PROCATHEPSIN B
Descriptor:PROCATHEPSIN B
Authors:Cygler, M., Sivaraman, J., Grochulski, P., Coulombe, R., Storer, A.C., Mort, J.S.
Deposit date:1996-01-12
Release date:1997-01-11
Modification date:2009-02-24
Cite:Structure of rat procathepsin B: model for inhibition of cysteine protease activity by the proregion.
Structure, 4, 1996
1AEC
CRYSTAL STRUCTURE OF ACTINIDIN-E-64 COMPLEX+
Descriptor:ACTINIDIN (E.C.3.4.22.14) COMPLEX WITH THE INHIBITOR ([N-(L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCYL]-AMIDO(4-GUANIDO)BUTANE) (E-64)
Authors:Varughese, K.I.
Deposit date:1992-02-05
Release date:1993-10-31
Modification date:2009-02-24
Cite:Crystal structure of an actinidin-E-64 complex.
Biochemistry, 31, 1992
1AIM
CRUZAIN INHIBITED BY BENZOYL-TYROSINE-ALANINE-FLUOROMETHYLKETONE
Descriptor:CRUZAIN, BENZOYL-TYROSINE-ALANINE-METHYL KETONE
Authors:Fletterick, R., Gillmor, S.
Deposit date:1997-04-21
Release date:1997-10-22
Modification date:2011-07-13
Cite:Structural determinants of specificity in the cysteine protease cruzain.
Protein Sci., 6, 1997
1BP4
USE OF PAPAIN AS A MODEL FOR THE STRUCTURE-BASED DESIGN OF CATHEPSIN K INHIBITORS. CRYSTAL STRUCTURES OF TWO PAPAIN INHIBITOR COMPLEXES DEMONSTRATE BINDING TO S'-SUBSITES.
Descriptor:PAPAIN, CARBOBENZYLOXYLEUCINYL-LEUCINYL-LEUCINAL
Authors:Lalonde, J.M., Zhao, B., Smith, W.W., Janson, C.A., Desjarlais, R.L., Tomaszek, T.A., Carr, T.J., Thompson, S.K., Yamashita, D.S., Veber, D.F., Abdel-Mequid, S.S.
Deposit date:1998-08-12
Release date:1999-08-12
Modification date:2012-02-08
Cite:Use of papain as a model for the structure-based design of cathepsin K inhibitors: crystal structures of two papain-inhibitor complexes demonstrate binding to S'-subsites.
J.Med.Chem., 41, 1998
1BQI
USE OF PAPAIN AS A MODEL FOR THE STRUCTURE-BASED DESIGN OF CATHEPSIN K INHIBITORS. CRYSTAL STRUCTURES OF TWO PAPAIN INHIBITOR COMPLEXES DEMONSTRATE BINDING TO S'-SUBSITES.
Descriptor:PAPAIN, CARBOBENZYLOXY-(L)-LEUCINYL-(L)LEUCINYL METHOXYMETHYLKETONE
Authors:Lalonde, J.M., Zhao, B., Smith, W.W., Janson, C.A., Desjarlais, R.L., Tomaszek, T.A., Carr, T.J., Thompson, S.K., Yamashita, D.S., Veber, D.F., Abdel-Mequid, S.S.
Deposit date:1998-08-16
Release date:1999-08-16
Modification date:2009-02-24
Cite:Use of papain as a model for the structure-based design of cathepsin K inhibitors: crystal structures of two papain-inhibitor complexes demonstrate binding to S'-subsites.
J.Med.Chem., 41, 1998
1CVZ
CRYSTAL STRUCTURE ANALYSIS OF PAPAIN WITH CLIK148(CATHEPSIN L SPECIFIC INHIBITOR)
Descriptor:PAPAIN (E.C.3.4.22.2)
Authors:Tsuge, H.
Deposit date:1999-08-24
Release date:2000-08-30
Modification date:2009-02-24
Cite:Inhibition mechanism of cathepsin L-specific inhibitors based on the crystal structure of papain-CLIK148 complex.
Biochem.Biophys.Res.Commun., 266, 1999
1EWM
THE CYSTEINE PROTEASE CRUZAIN BOUND TO WRR-112
Descriptor:CRUZAIN (E.C.3.4.22.-)
Authors:Brinen, L.S., Gillmor, S.A., Fletterick, R.J.
Deposit date:2000-04-26
Release date:2003-06-10
Modification date:2011-07-13
Cite:Crystal Structure of Cruzain bound to WRR-112
To be Published
1EWO
THE CYSTEINE PROTEASE CRUZAIN BOUND TO WRR-204
Descriptor:CRUZAIN (E.C.3.4.22.-)
Authors:Brinen, L.S., Gillmor, S.A., Fletterick, R.J.
Deposit date:2000-04-26
Release date:2003-06-10
Modification date:2011-07-13
Cite:Crystal Structure of Cruzain bound to WRR-204
To be Published
1EWP
CRUZAIN BOUND TO MOR-LEU-HPQ
Descriptor:CRUZAIN (E.C.3.4.22.-)
Authors:Gillmor, S.A.
Deposit date:2000-04-26
Release date:2000-05-17
Modification date:2011-07-13
Cite:Chapter 3: X-ray Structures of Complexes of Cruzain with Designed Covalent Inhibitors
Enzyme-ligand Interactions, Inhibition and Specificity, 1998
1F2A
CRYSTAL STRUCTURE ANALYSIS OF CRUZAIN BOUND TO A VINYL SULFONE DERIVED INHIBITOR (II)
Descriptor:CRUZAIN (E.C.3.4.22.-)
Authors:Brinen, L.S., Hansell, E., Roush, W.R., McKerrow, J.H., Fletterick, R.J.
Deposit date:2000-05-23
Release date:2000-07-26
Modification date:2009-02-24
Cite:A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease.
Structure Fold.Des., 8, 2000
1F2B
CRYSTAL STRUCTURE ANALYSIS OF CRUZAIN BOUND TO VINYL SULFONE DERIVED INHIBITOR (III)
Descriptor:CRUZAIN (E.C.3.4.22.-)
Authors:Brinen, L.S., Hansell, E., Roush, W.R., McKerrow, J.H., Fletterick, R.J.
Deposit date:2000-05-23
Release date:2000-07-26
Modification date:2009-02-24
Cite:A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease.
Structure Fold.Des., 8, 2000
1F2C
CRYSTAL STRUCTURE ANALYSIS OF CRYZAIN BOUND TO VINYL SULFONE DERIVED INHIBITOR (IV)
Descriptor:CRUZAIN (E.C.3.4.22.-)
Authors:Brinen, L.S., Hansell, E., Roush, W.R., McKerrow, J.H., Fletterick, R.J.
Deposit date:2000-05-23
Release date:2000-07-26
Modification date:2009-02-24
Cite:A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease.
Structure Fold.Des., 8, 2000
1GLO
CRYSTAL STRUCTURE OF CYS25SER MUTANT OF HUMAN CATHEPSIN S
Descriptor:CATHEPSIN S (E.C.3.4.22.27)
Authors:Turkenburg, J.P., Lamers, M.B.A.C., Brzozowski, A.M., Wright, L.M., Hubbard, R.E., Sturt, S.L., Williams, D.H.
Deposit date:2001-08-31
Release date:2002-08-29
Modification date:2009-02-24
Cite:Structure of a Cys25->Ser Mutant of Human Cathepsin Cathepsin S
Acta Crystallogr.,Sect.D, 58, 2002
1IWD
PROPOSED AMINO ACID SEQUENCE AND THE 1.63 ANGSTROM X-RAY CRYSTAL STRUCTURE OF A PLANT CYSTEINE PROTEASE ERVATAMIN B: INSIGHT INTO THE STRUCTURAL BASIS OF ITS STABILITY AND SUBSTRATE SPECIFICITY.
Descriptor:ERVATAMIN B (E.C.3.4.22.-)
Authors:Chakrabarti, C., Biswas, S., Dattagupta, J.K.
Deposit date:2002-05-02
Release date:2003-05-06
Modification date:2011-07-13
Cite:Proposed amino acid sequence and the 1.63 A X-ray crystal structure of a plant cysteine protease, ervatamin B: Some insights into the structural basis of its stability and substrate specificity
Proteins, 51, 2003
1KHP
MONOCLINIC FORM OF PAPAIN/ZLFG-DAM COVALENT COMPLEX
Descriptor:Papain (E.C.3.4.22.2)
Authors:Janowski, R., Kozak, M., Jankowska, E., Grzonka, Z., Jaskolski, M.
Deposit date:2001-11-30
Release date:2003-09-09
Modification date:2011-07-13
Cite:Two polymorphs of a covalent complex between papain and a diazomethylketone inhibitor
J.Pept.Res., 64, 2004
1KHQ
ORTHORHOMBIC FORM OF PAPAIN/ZLFG-DAM COVALENT COMPLEX
Descriptor:Papain (E.C.3.4.22.2)
Authors:Janowski, R., Kozak, M., Jankowska, E., Grzonka, Z., Jaskolski, M.
Deposit date:2001-11-30
Release date:2003-09-09
Modification date:2011-07-13
Cite:Two polymorphs of a covalent complex between papain and a diazomethylketone inhibitor
J.Pept.Res., 64, 2004
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