PDB keyword search results

1A5Y
PROTEIN TYROSINE PHOSPHATASE 1B CYSTEINYL-PHOSPHATE INTERMEDIATE
Descriptor:PROTEIN TYROSINE PHOSPHATASE 1B
Authors:Pannifer, A.D.P., Flint, A.J., Tonks, N.K., Barford, D.
Deposit date:1998-02-19
Release date:1998-06-17
Modification date:2009-02-24
Cite:Visualization of the cysteinyl-phosphate intermediate of a protein-tyrosine phosphatase by x-ray crystallography.
J.Biol.Chem., 273, 1998
1AAX
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH TWO BIS(PARA-PHOSPHOPHENYL)METHANE (BPPM) MOLECULES
Descriptor:PROTEIN TYROSINE PHOSPHATASE 1B, 4-PHOSPHONOOXY-PHENYL-METHYL-[4-PHOSPHONOOXY]BENZEN
Authors:Puius, Y.A., Zhao, Y., Sullivan, M., Lawrence, D., Almo, S.C., Zhang, Z.-Y.
Deposit date:1997-01-16
Release date:1998-03-04
Modification date:2012-07-18
Cite:Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design.
Proc.Natl.Acad.Sci.USA, 94, 1997
1BZC
HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH TPI
Descriptor:PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE) (3.1.3.48)
Authors:Groves, M.R., Yao, Z.J., Jr Burke, T.R., Barford, D.
Deposit date:1998-10-27
Release date:1999-02-16
Modification date:2009-02-24
Cite:Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.
Biochemistry, 37, 1998
1BZH
CYCLIC PEPTIDE INHIBITOR OF HUMAN PTP1B
Descriptor:PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE) (3.1.3.48)
Authors:Groves, M.R., Yao, Z.J., Burke Jr., T.R., Barford, D.
Deposit date:1998-10-28
Release date:1999-02-16
Modification date:2011-07-13
Cite:Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.
Biochemistry, 37, 1998
1BZJ
HUMAN PTP1B COMPLEXED WITH TPICOOH
Descriptor:PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE) (3.1.3.48)
Authors:Groves, M.R., Yao, Z.-J., Barford Jr., D.T.B.
Deposit date:1998-10-29
Release date:1999-02-16
Modification date:2010-03-02
Cite:Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.
Biochemistry, 37, 1998
1C83
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 6-(OXALYL-AMINO)-1H-INDOLE-5-CARBOXYLIC ACID
Descriptor:PROTEIN-TYROSINE PHOSPHATASE 1B (E.C.3.1.3.48)
Authors:Andersen, H.S., Iversen, L.F., Branner, S., Rasmussen, H.B., Moller, N.P.
Deposit date:2000-04-14
Release date:2000-05-03
Modification date:2009-02-24
Cite:2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases.
J.Biol.Chem., 275, 2000
1C84
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 3-(OXALYL-AMINO)-NAPHTHALENE-2-CARBOXLIC ACID
Descriptor:PROTEIN-TYROSINE PHOSPHATASE 1B (E.C.3.1.3.48)
Authors:Andersen, H.S., Iversen, L.F., Branner, S., Rasmussen, H.B., Moller, N.P.
Deposit date:2000-04-14
Release date:2000-05-03
Modification date:2009-02-24
Cite:2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases.
J.Biol.Chem., 275, 2000
1C85
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO)-BENZOIC ACID
Descriptor:PROTEIN-TYROSINE PHOSPHATASE 1B (E.C.3.1.3.48)
Authors:Andersen, H.S., Iversen, L.F., Branner, S., Rasmussen, H.B., Moller, N.P.
Deposit date:2000-04-16
Release date:2000-05-03
Modification date:2009-02-24
Cite:2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases.
J.Biol.Chem., 275, 2000
1C86
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B (R47V,D48N) COMPLEXED WITH 2-(OXALYL-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID
Descriptor:PROTEIN-TYROSINE PHOSPHATASE 1B (E.C.3.1.3.48)
Authors:Iversen, L.F., Andersen, H.S., Mortensen, S.B., Moller, N.P.
Deposit date:2000-04-16
Release date:2000-05-03
Modification date:2009-02-24
Cite:Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B.
J.Biol.Chem., 275, 2000
1C87
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID
Descriptor:PROTEIN-TYROSINE PHOSPHATASE 1B (E.C.3.1.3.48)
Authors:Iversen, L.F., Andersen, H.S., Mortensen, S.B., Moller, N.P.
Deposit date:2000-04-16
Release date:2000-05-03
Modification date:2009-02-24
Cite:Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B.
J.Biol.Chem., 275, 2000
1C88
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID
Descriptor:PROTEIN-TYROSINE PHOSPHATASE 1B (E.C.3.1.3.48)
Authors:Iversen, L.F., Andersen, H.S., Mortensen, S.B., Moller, N.P.
Deposit date:2000-04-16
Release date:2000-05-03
Modification date:2009-02-24
Cite:Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B.
J.Biol.Chem., 275, 2000
1D5R
CRYSTAL STRUCTURE OF THE PTEN TUMOR SUPPRESSOR
Descriptor:PROTEIN-TYROSINE PHOSPHATASE PTEN (E.C.3.1.3.48)
Authors:Lee, J.O., Yang, H., Georgescu, M.-M., Di Cristofano, A., Pavletich, N.P.
Deposit date:1999-10-11
Release date:1999-11-04
Modification date:2009-02-24
Cite:Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association.
Cell(Cambridge,Mass.), 99, 1999
1ECV
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 5-IODO-2-(OXALYL-AMINO)-BENZOIC ACID
Descriptor:PROTEIN-TYROSINE PHOSPHATASE 1B (E.C.3.1.3.48)
Authors:Andersen, H.S., Iversen, L.F., Branner, S., Rasmussen, H.B., Moller, N.P.H.
Deposit date:2000-01-26
Release date:2000-03-15
Modification date:2009-02-24
Cite:2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases.
J.Biol.Chem., 275, 2000
1EEN
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH ACETYL-D-A-D-BPA-PTYR-L-I-P-Q-Q-G
Descriptor:PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH ACETYL-D-A- D-BPA-PTYR-L-I-P-Q-Q-G
Authors:Puius, Y.A., Zhao, Y., Almo, S.C., Zhang, Z.Y.
Deposit date:2000-02-01
Release date:2001-02-01
Modification date:2009-02-24
Cite:Structural basis of plasticity in protein tyrosine phosphatase 1B substrate recognition.
Biochemistry, 39, 2000
1EEO
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH ACETYL-E-L-E-F-PTYR-M-D-Y-E-NH2
Descriptor:PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH ACETYL-E-L- E-F-PTYR-M-D-Y-E-NH2
Authors:Sarmiento, M., Puius, Y.A., Vetter, S.W., Lawrence, D.S., Almo, S.C., Zhang, Z.Y.
Deposit date:2000-02-01
Release date:2001-02-01
Modification date:2012-07-18
Cite:Structural basis of plasticity in protein tyrosine phosphatase 1B substrate recognition.
Biochemistry, 39, 2000
1FPR
CRYSTAL STRUCTURE OF THE COMPLEX FORMED BETWEEN THE CATALYTIC DOMAIN OF SHP-1 AND AN IN VITRO PEPTIDE SUBSTRATE PY469 DERIVED FROM SHPS-1.
Descriptor:PROTEIN-TYROSINE PHOSPHATASE 1C (E.C.3.1.3.48)
Authors:Yang, J., Cheng, Z., Niu, Z., Zhao, Z.J., Zhou, G.W.
Deposit date:2000-08-31
Release date:2001-03-07
Modification date:2009-02-24
Cite:Structural basis for substrate specificity of protein-tyrosine phosphatase SHP-1.
J.Biol.Chem., 275, 2000
1G1F
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH A TRI-PHOSPHORYLATED PEPTIDE (RDI(PTR)ETD(PTR)(PTR)RK) FROM THE INSULIN RECEPTOR KINASE
Descriptor:PROTEIN TYROSINE PHOSPHATASE 1B (E.C.3.1.3.48), INSULIN RECEPTOR KINASE FRAGMENT
Authors:Salmeen, A., Andersen, J.N., Myers, M.P., Tonks, N.K., Barford, D.
Deposit date:2000-10-11
Release date:2001-01-17
Modification date:2009-02-24
Cite:Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B.
Mol.Cell, 6, 2000
1G1G
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH A MONO-PHOSPHORYLATED PEPTIDE (ETDY(PTR)RKGGKGLL) FROM THE INSULIN RECEPTOR KINASE
Descriptor:PROTEIN TYROSINE PHOSPHATASE 1B (E.C.3.1.3.48), INSULIN RECEPTOR KINASE FRAGMENT
Authors:Salmeen, A., Andersen, J.N., Myers, M.P., Tonks, N.K., Barford, D.
Deposit date:2000-10-11
Release date:2001-01-17
Modification date:2009-02-24
Cite:Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B.
Mol.Cell, 6, 2000
1G1H
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH A BIS-PHOSPHORYLATED PEPTIDE (ETD(PTR)(PTR)RKGGKGLL) FROM THE INSULIN RECEPTOR KINASE
Descriptor:PROTEIN TYROSINE PHOSPHATASE 1B (E.C.3.1.3.48), INSULIN RECEPTOR KINASE FRAGMENT
Authors:Salmeen, A., Andersen, J.N., Myers, M.P., Tonks, N.K., Barford, D.
Deposit date:2000-10-11
Release date:2001-01-17
Modification date:2009-02-24
Cite:Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B.
Mol.Cell, 6, 2000
1G7F
HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH PNU177496
Descriptor:PROTEIN-TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1 (E.C.3.1.3.48)
Authors:Bleasdale, J.E., Ogg, D., Larsen, S.D.
Deposit date:2000-11-10
Release date:2001-06-06
Modification date:2009-02-24
Cite:Small molecule peptidomimetics containing a novel phosphotyrosine bioisostere inhibit protein tyrosine phosphatase 1B and augment insulin action.
Biochemistry, 40, 2001
1G7G
HUMAN PTP1B CATALYTIC DOMAIN COMPLEXES WITH PNU179326
Descriptor:PROTEIN-TYROSINE PHOSPHOTASE, NON RECEPTOR TYPE 1 (E.C.3.1.3.48)
Authors:Bleasdale, J.E., Ogg, D., Larsen, S.D.
Deposit date:2000-11-10
Release date:2001-06-06
Modification date:2009-02-24
Cite:Small molecule peptidomimetics containing a novel phosphotyrosine bioisostere inhibit protein tyrosine phosphatase 1B and augment insulin action.
Biochemistry, 40, 2001
1GFY
RESIDUE 259 IS A KEY DETERMINANT OF SUBSTRATE SPECIFICITY OF PROTEIN-TYROSINE PHOSPHATASE 1B AND ALPHA
Descriptor:PROTEIN-TYROSINE PHOSPHATASE 1B (E.C.3.1.3.48)
Authors:Iversen, L.F.
Deposit date:2000-06-26
Release date:2000-07-04
Modification date:2009-02-24
Cite:Residue 259 is a key determinant of substrate specificity of protein-tyrosine phosphatases 1B and alpha.
J.Biol.Chem., 275, 2000
1GWZ
CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTEIN TYROSINE PHOSPHATASE SHP-1
Descriptor:SHP-1
Authors:Yang, J., Liang, X., Niu, T., Meng, W., Zhao, Z., Zhou, G.W.
Deposit date:1998-08-22
Release date:1999-08-22
Modification date:2009-02-24
Cite:Crystal structure of the catalytic domain of protein-tyrosine phosphatase SHP-1.
J.Biol.Chem., 273, 1998
1I57
CRYSTAL STRUCTURE OF APO HUMAN PTP1B (C215S) MUTANT
Descriptor:PHOSPHO-TYROSINE PHOSPHATASE 1B (E.C.3.1.3.48)
Authors:Scapin, G., Patel, S., Patel, V., Kennedy, B., Asante-Appiah, E.
Deposit date:2001-02-26
Release date:2001-08-08
Modification date:2009-02-24
Cite:The structure of apo protein-tyrosine phosphatase 1B C215S mutant: more than just an S --> O change.
Protein Sci., 10, 2001
1JF7
HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH PNU177836
Descriptor:PROTEIN-TYROSINE PHOSPHATASE 1B (E.C.3.1.3.48)
Authors:Larsen, S.D., Barf, T., Liljebris, C., May, P.D., Ogg, D., O'Sullivan, T.J., Palazuk, B.J., Schostarez, H.J., Stevens, F.C., Bleasdale, J.E.
Deposit date:2001-06-20
Release date:2002-02-13
Modification date:2009-02-24
Cite:Synthesis and biological activity of a novel class of small molecular weight peptidomimetic competitive inhibitors of protein tyrosine phosphatase 1B.
J.Med.Chem., 45, 2002
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