PDB keyword search results

1BQM
HIV-1 RT/HBY 097
Descriptor:REVERSE TRANSCRIPTASE, (S)-4-ISOPROPOXYCARBONYL-6-METHOXY-3-METHYLTHIOMETHYL-3,4-DIHYDROQUINOXALIN-2(1H)-THIONE
Authors:Hsiou, Y., Das, K., Ding, J., Arnold, E.
Deposit date:1998-08-17
Release date:1999-01-06
Modification date:2009-02-24
Cite:Structures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: inhibitor flexibility is a useful design feature for reducing drug resistance.
J.Mol.Biol., 284, 1998
1BQN
TYR 188 LEU HIV-1 RT/HBY 097
Descriptor:REVERSE TRANSCRIPTASE, (S)-4-ISOPROPOXYCARBONYL-6-METHOXY-3-METHYLTHIOMETHYL-3,4-DIHYDROQUINOXALIN-2(1H)-THIONE
Authors:Hsiou, Y., Das, K., Ding, J., Arnold, E.
Deposit date:1998-08-17
Release date:1999-01-06
Modification date:2009-02-24
Cite:Structures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: inhibitor flexibility is a useful design feature for reducing drug resistance.
J.Mol.Biol., 284, 1998
1C0T
CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH BM+21.1326
Descriptor:HIV-1 REVERSE TRANSCRIPTASE (A-CHAIN)/HIV-1 REVERSE TRANSCRIPTASE (B-CHAIN)
Authors:Ren, J., Esnouf, R.M., Hopkins, A.L., Stuart, D.I., Stammers, D.K.
Deposit date:1999-07-19
Release date:2000-07-19
Modification date:2009-02-24
Cite:Crystallographic analysis of the binding modes of thiazoloisoindolinone non-nucleoside inhibitors to HIV-1 reverse transcriptase and comparison with modeling studies.
J.Med.Chem., 42, 1999
1C0U
CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH BM+50.0934
Descriptor:HIV-1 REVERSE TRANSCRIPTASE (A-CHAIN)/HIV-1 REVERSE TRANSCRIPTASE (B-CHAIN)
Authors:Ren, J., Esnouf, R.M., Hopkins, A.L., Stuart, D.I., Stammers, D.K.
Deposit date:1999-07-19
Release date:2000-07-19
Modification date:2009-02-24
Cite:Crystallographic analysis of the binding modes of thiazoloisoindolinone non-nucleoside inhibitors to HIV-1 reverse transcriptase and comparison with modeling studies.
J.Med.Chem., 42, 1999
1C1B
CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GCA-186
Descriptor:HIV-1 REVERSE TRANSCRIPTASE (A-CHAIN)/HIV-1 REVERSE TRANSCRIPTASE (B-CHAIN)
Authors:Hopkins, A.L., Ren, J., Tanaka, H., Baba, B., Okamato, M., Stuart, D.I., Stammers, D.K.
Deposit date:1999-07-21
Release date:2000-07-21
Modification date:2009-02-24
Cite:Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants.
J.Med.Chem., 42, 1999
1C1C
CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH TNK-6123
Descriptor:HIV-1 REVERSE TRANSCRIPTASE A-CHAIN/HIV-1 REVERSE TRANSCRIPTASE B-CHAIN
Authors:Hopkins, A.L., Ren, J., Tanaka, H., Baba, M., Okamato, M., Stuart, D.I., Stammers, D.K.
Deposit date:1999-07-21
Release date:2000-07-21
Modification date:2009-02-24
Cite:Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants.
J.Med.Chem., 42, 1999
1DLO
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
Descriptor:HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE
Authors:Hsiou, Y., Ding, J., Das, K., Hughes, S., Arnold, E.
Deposit date:1996-04-17
Release date:1996-08-01
Modification date:2009-02-24
Cite:Structure of unliganded HIV-1 reverse transcriptase at 2.7 A resolution: implications of conformational changes for polymerization and inhibition mechanisms.
Structure, 4, 1996
1DTQ
CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH PETT-1 (PETT131A94)
Descriptor:CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH PETT-1 (PETT131A94)
Authors:Ren, J., Diprose, J., Warren, J., Esnouf, R.M., Bird, L.E., Ikemizu, S., Slater, M., Milton, J., Balzarini, J., Stuart, D.I., Stammers, D.K.
Deposit date:2000-01-13
Release date:2000-03-20
Modification date:2009-02-24
Cite:Phenylethylthiazolylthiourea (PETT) non-nucleoside inhibitors of HIV-1 and HIV-2 reverse transcriptases. Structural and biochemical analyses.
J.Biol.Chem., 275, 2000
1DTT
CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH PETT-2 (PETT130A94)
Descriptor:HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH PETT-2 (PETT130A94)
Authors:Ren, J., Diprose, J., Warren, J., Esnouf, R.M., Bird, L.E., Ikemizu, S., Slater, M., Milton, J., Balzarini, J., Stuart, D.I., Stammers, D.K.
Deposit date:2000-01-13
Release date:2000-04-02
Modification date:2009-02-24
Cite:Phenylethylthiazolylthiourea (PETT) non-nucleoside inhibitors of HIV-1 and HIV-2 reverse transcriptases. Structural and biochemical analyses.
J.Biol.Chem., 275, 2000
1EET
HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH THE INHIBITOR MSC204
Descriptor:HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH THE INHIBITOR MSC204 (E.C.2.7.7.49)
Authors:Hogberg, M., Sahlberg, C., Engelhardt, P., Noreen, R., Kangasmetsa, J., Johansson, N.G., Oberg, B., Vrang, L., Zhang, H., Sahlberg, B.L., Unge, T., Lovgren, S., Fridborg, K., Backbro, K.
Deposit date:2000-02-03
Release date:2001-02-07
Modification date:2009-02-24
Cite:Urea-PETT compounds as a new class of HIV-1 reverse transcriptase inhibitors. 3. Synthesis and further structure-activity relationship studies of PETT analogues.
J.Med.Chem., 42, 1999
1EP4
CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH S-1153
Descriptor:HIV-1 REVERSE TRANSCRIPTASE
Authors:Ren, J., Nichols, C., Bird, L.E., Fujiwara, T., Suginoto, H., Stuart, D.I., Stammers, D.K.
Deposit date:2000-03-27
Release date:2000-09-27
Modification date:2009-02-24
Cite:Binding of the second generation non-nucleoside inhibitor S-1153 to HIV-1 reverse transcriptase involves extensive main chain hydrogen bonding.
J.Biol.Chem., 275, 2000
1FK9
CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DMP-266(EFAVIRENZ)
Descriptor:HIV-1 REVERSE TRANSCRIPTASE (E.C.2.7.7.49) :DMP-266(EFAVIRENZ) COMPLEX
Authors:Ren, J., Milton, J., Weaver, K.L., Short, S.A, Stuart, D.I., Stammers, D.K.
Deposit date:2000-08-09
Release date:2000-11-03
Modification date:2012-07-18
Cite:Structural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptase.
STRUCTURE FOLD.DES., 8, 2000
1FKO
CRYSTAL STRUCTURE OF NNRTI RESISTANT K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DMP-266(EFAVIRENZ)
Descriptor:HIV-1 RT (MUTANT, K103N) (E.C. 2.7.7.49):DMP-266(EFAVIRENZ) COMPLEX
Authors:Ren, J., Milton, J., Weaver, K.L., Short, S.A., Stuart, D.I., Stammers, D.K.
Deposit date:2000-08-10
Release date:2000-11-03
Modification date:2012-07-18
Cite:Structural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptase.
Structure Fold.Des., 8, 2000
1FKP
CRYSTAL STRUCTURE OF NNRTI RESISTANT K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE
Descriptor:CRYSTAL STRUCTURE OF NNRTI RESISTANT K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE
Authors:Ren, J., Milton, J., Weaver, K.L., Short, S.A., Stuart, D.I., Stammers, D.K.
Deposit date:2000-08-10
Release date:2000-11-03
Modification date:2009-02-24
Cite:Structural basis for the resilience of efavirenz (DMP-266) to drug resistance mutations in HIV-1 reverse transcriptase.
Structure Fold.Des., 8, 2000
1HMV
THE STRUCTURE OF UNLIGANDED REVERSE TRANSCRIPTASE FROM THE HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
Descriptor:HIV-1 REVERSE TRANSCRIPTASE (E.C.2.7.7.49)
Authors:Rodgers, D.W., Gamblin, S.J., Harris, B.A., Ray, S., Culp, J.S., Hellmig, B., Woolf, D.J., Debouck, C., Harrison, S.C.
Deposit date:1994-12-15
Release date:1995-03-31
Modification date:2009-02-24
Cite:The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1.
Proc.Natl.Acad.Sci.USA, 92, 1995
1HNI
STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN A COMPLEX WITH THE NONNUCLEOSIDE INHIBITOR ALPHA-APA R 95845 AT 2.8 ANGSTROMS RESOLUTION
Descriptor:HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE (HIV-1RT) (E.C.2.7.7.49) MUTANT WITH CYS 280 REPLACED BY SER (C280S)
Authors:Ding, J., Das, K., Arnold, E.
Deposit date:1995-02-28
Release date:1995-06-03
Modification date:2012-02-22
Cite:Structure of HIV-1 reverse transcriptase in a complex with the non-nucleoside inhibitor alpha-APA R 95845 at 2.8 A resolution.
Structure, 3, 1995
1HNV
STRUCTURE OF HIV-1 RT(SLASH)TIBO R 86183 COMPLEX REVEALS SIMILARITY IN THE BINDING OF DIVERSE NONNUCLEOSIDE INHIBITORS
Descriptor:HIV-1 REVERSE TRANSCRIPTASE (HIV-1 RT) (E.C.2.7.7.49) MUTANT WITH CYS 280 REPLACED BY SER (C280S)
Authors:Das, K., Ding, J., Arnold, E.
Deposit date:1995-03-30
Release date:1995-07-10
Modification date:2009-02-24
Cite:Structure of HIV-1 RT/TIBO R 86183 complex reveals similarity in the binding of diverse nonnucleoside inhibitors.
Nat.Struct.Biol., 2, 1995
1HPZ
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
Descriptor:REVERSE TRANSCRIPTASE (E.C.2.7.7.49)
Authors:Ding, J., Hsiou, Y., Arnold, E.
Deposit date:2000-12-13
Release date:2001-05-30
Modification date:2009-02-24
Cite:The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance.
J.Mol.Biol., 309, 2001
1HQE
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
Descriptor:REVERSE TRANSCRIPTASE (E.C.2.7.7.49)
Authors:Ding, J., Hsiou, Y., Arnold, E.
Deposit date:2000-12-15
Release date:2001-05-30
Modification date:2009-02-24
Cite:The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance.
J.Mol.Biol., 309, 2001
1HQU
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1
Descriptor:REVERSE TRANSCRIPTASE (E.C.2.7.7.49)
Authors:Hsiou, Y., Ding, J., Arnold, E.
Deposit date:2000-12-19
Release date:2001-05-30
Modification date:2009-02-24
Cite:The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance.
J.Mol.Biol., 309, 2001
1HVU
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE COMPLEXED WITH A 33-BASE NUCLEOTIDE RNA PSEUDOKNOT
Descriptor:HIV-1 REVERSE TRANSCRIPTASE/RNA PSEUDOKNOT COMPLEX
Authors:Jaeger, J., Restle, T., Steitz, T.A.
Deposit date:1998-06-30
Release date:1999-01-13
Modification date:2009-02-24
Cite:The structure of HIV-1 reverse transcriptase complexed with an RNA pseudoknot inhibitor.
EMBO J., 17, 1998
1HYS
CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH A POLYPURINE TRACT RNA:DNA
Descriptor:HIV-1 REVERSE TRANSCRIPTASE/FRAGMENT OF FAB 28//DNA/RNA Complex
Authors:Sarafianos, S.G., Das, K., Tantillo, C., Clark Jr., A.D., Ding, J., Whitcomb, J., Boyer, P.L., Hughes, S.H., Arnold, E.
Deposit date:2001-01-22
Release date:2001-03-26
Modification date:2009-02-24
Cite:Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA.
EMBO J., 20, 2001
1IKV
K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH EFIVARENZ
Descriptor:POL POLYPROTEIN (E.C.2.7.7.49)
Authors:Lindberg, J., Unge, T.
Deposit date:2001-05-07
Release date:2001-06-06
Modification date:2012-07-18
Cite:Structural basis for the inhibitory efficacy of efavirenz (DMP-266), MSC194 and PNU142721 towards the HIV-1 RT K103N mutant.
Eur.J.Biochem., 269, 2002
1IKW
WILD TYPE HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH EFAVIRENZ
Descriptor:POL POLYPROTEIN (E.C.2.7.7.49)
Authors:Lindberg, J., Unge, T.
Deposit date:2001-05-07
Release date:2001-06-06
Modification date:2012-07-18
Cite:Structural basis for the inhibitory efficacy of efavirenz (DMP-266), MSC194 and PNU142721 towards the HIV-1 RT K103N mutant.
Eur.J.Biochem., 269, 2002
1IKX
K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH THE INHIBITOR PNU142721
Descriptor:POL POLYPROTEIN (E.C.2.7.7.49)
Authors:Lindberg, J., Unge, T.
Deposit date:2001-05-07
Release date:2001-06-06
Modification date:2009-02-24
Cite:Structural basis for the inhibitory efficacy of efavirenz (DMP-266), MSC194 and PNU142721 towards the HIV-1 RT K103N mutant.
Eur.J.Biochem., 269, 2002
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