PDB keyword search results

2J9J
ATOMIC-RESOLUTION CRYSTAL STRUCTURE OF CHEMICALLY-SYNTHESIZED HIV-1 PROTEASE COMPLEXED WITH INHIBITOR JG-365
Descriptor:PROTEASE, INHIBITOR MOLECULE JG365
Authors:Malito, E., Shen, Y., Johnson, E.C.B., Tang, W.J.
Deposit date:2006-11-11
Release date:2007-08-28
Modification date:2011-07-20
Cite:Insights from Atomic-Resolution X-Ray Structures of Chemically Synthesized HIV-1 Protease in Complex with Inhibitors.
J.Mol.Biol., 373, 2007
2P3B
CRYSTAL STRUCTURE OF THE SUBTYPE B WILD TYPE HIV PROTEASE COMPLEXED WITH TL-3 INHIBITOR
Descriptor:Gag-Pol polyprotein
Authors:Sanches, M., Krauchenco, S., Martins, N.H., Gustchina, A., Wlodawer, A., Polikarpov, I.
Deposit date:2007-03-08
Release date:2007-04-24
Modification date:2011-07-13
Cite:Structural Characterization of B and non-B Subtypes of HIV-Protease: Insights into the Natural Susceptibility to Drug Resistance Development.
J.Mol.Biol., 369, 2007
3K4V
NEW CRYSTAL FORM OF HIV-1 PROTEASE/SAQUINAVIR STRUCTURE REVEALS CARBAMYLATION OF N-TERMINAL PROLINE
Descriptor:HIV-1 Protease (E.C.3.4.23.16)
Authors:Olajuyigbe, F.M., Demitri, N., Ajele, J.O., Maurizio, E., Randaccio, L., Geremia, S.
Deposit date:2009-10-06
Release date:2010-06-09
Modification date:2011-12-07
Cite:Carbamylation of N-Terminal Proline
ACS Med.Chem.Lett., 1, 2010
3MIM
X-RAY SNAPSHOT OF HIV-1 PROTEASE IN ACTION: OBSERVATION OF TETRAHEDRAL INTERMEDIATE AND ITS SIHB WITH CATALYTIC ASPARTATE
Descriptor:Protease (E.C.3.4.23.16), peptide ET(PHD)YVD
Authors:Das, A.
Deposit date:2010-04-11
Release date:2011-04-13
Cite:X-ray snapshot of HIV-1 protease in action: observation of tetrahedral intermediate and short ionic hydrogen bond SIHB with catalytic aspartate.
J.Am.Chem.Soc., 132, 2010
3OU1
MDR769 HIV-1 PROTEASE COMPLEXED WITH RH/IN HEPTA-PEPTIDE
Descriptor:MDR HIV-1 protease, RH/IN substrate peptide
Authors:Liu, Z., Wang, Y., Brunzelle, J., Kovari, I.A., Kovari, L.C.
Deposit date:2010-09-14
Release date:2011-03-30
Modification date:2011-04-20
Cite:Nine Crystal Structures Determine the Substrate Envelope of the MDR HIV-1 Protease.
Protein J., 30, 2011
3OU4
MDR769 HIV-1 PROTEASE COMPLEXED WITH TF/PR HEPTA-PEPTIDE
Descriptor:HIV-1 protease, TF/PR substrate peptide
Authors:Liu, Z., Wang, Y., Brunzelle, J., Kovari, I.A., Kovari, L.C.
Deposit date:2010-09-14
Release date:2011-03-30
Modification date:2011-04-20
Cite:Nine Crystal Structures Determine the Substrate Envelope of the MDR HIV-1 Protease.
Protein J., 30, 2011
3OUD
MDR769 HIV-1 PROTEASE COMPLEXED WITH CA/P2 HEPTA-PEPTIDE
Descriptor:MDR HIV-1 protease, CA/p2 substrate peptide
Authors:Liu, Z., Wang, Y., Brunzelle, J., Kovari, I.A., Kovari, L.C.
Deposit date:2010-09-14
Release date:2011-03-30
Modification date:2011-04-20
Cite:Nine Crystal Structures Determine the Substrate Envelope of the MDR HIV-1 Protease.
Protein J., 30, 2011
3S43
HIV-1 PROTEASE TRIPLE MUTANTS V32I, I47V, V82I WITH ANTIVIRAL DRUG AMPRENAVIR
Descriptor:Protease (E.C.3.4.23.16 )
Authors:Wang, Y.-F., Tie, Y.-F., Weber, I.T.
Deposit date:2011-05-18
Release date:2012-03-21
Cite:Critical differences in HIV-1 and HIV-2 protease specificity for clinical inhibitors.
Protein Sci., 21, 2012
1A30
HIV-1 PROTEASE COMPLEXED WITH A TRIPEPTIDE INHIBITOR
Descriptor:HIV-1 PROTEASE, TRIPEPTIDE GLU-ASP-LEU
Authors:Louis, J.M., Dyda, F., Nashed, N.T., Kimmel, A.R., Davies, D.R.
Deposit date:1998-01-27
Release date:1998-04-29
Modification date:2011-07-13
Cite:Hydrophilic peptides derived from the transframe region of Gag-Pol inhibit the HIV-1 protease.
Biochemistry, 37, 1998
1A8G
HIV-1 PROTEASE IN COMPLEX WITH SDZ283-910
Descriptor:HIV-1 PROTEASE, INHIBITOR SDZ283-910
Authors:Kallen, J., Billich, A., Scholz, D., Auer, M., Kungl, A.
Deposit date:1998-03-24
Release date:1998-07-15
Modification date:2011-07-13
Cite:X-ray structure and conformational dynamics of the HIV-1 protease in complex with the inhibitor SDZ283-910: agreement of time-resolved spectroscopy and molecular dynamics simulations.
J.Mol.Biol., 286, 1999
1A8K
CRYSTALLOGRAPHIC ANALYSIS OF HUMAN IMMUNODEFICIENCY VIRUS 1 PROTEASE WITH AN ANALOG OF THE CONSERVED CA-P2 SUBSTRATE: INTERACTIONS WITH FREQUENTLY OCCURRING GLUTAMIC ACID RESIDUE AT P2' POSITION OF SUBSTRATES
Descriptor:HIV PROTEASE, PEPTIDE
Authors:Weber, I.T., Wu, J., Adomat, J., Harrison, R.W., Kimmel, A.R., Wondrak, E.M., Louis, J.M.
Deposit date:1998-03-27
Release date:1999-01-13
Modification date:2011-07-13
Cite:Crystallographic analysis of human immunodeficiency virus 1 protease with an analog of the conserved CA-p2 substrate -- interactions with frequently occurring glutamic acid residue at P2' position of substrates.
Eur.J.Biochem., 249, 1997
1A94
STRUCTURAL BASIS FOR SPECIFICITY OF RETROVIRAL PROTEASES
Descriptor:HIV PROTEASE, PEPTIDE
Authors:Wu, J., Adomat, J.M., Ridky, T.W., Louis, J.M., Leis, J., Harrison, R.W., Weber, I.T.
Deposit date:1998-04-16
Release date:1999-01-13
Modification date:2011-07-13
Cite:Structural basis for specificity of retroviral proteases.
Biochemistry, 37, 1998
1A9M
G48H MUTANT OF HIV-1 PROTEASE IN COMPLEX WITH A PEPTIDIC INHIBITOR U-89360E
Descriptor:HIV-1 PROTEASE, N-[[1-[N-ACETAMIDYL]-[1-CYCLOHEXYLMETHYL-2-HYDROXY-4-ISOPROPYL]-BUT-4-YL]-CARBONYL]-GLUTAMINYL-ARGINYL-AMIDE
Authors:Hong, L., Zhang, X.-J., Foundling, S., Hartsuck, J.A., Tang, J.
Deposit date:1998-04-08
Release date:1998-06-17
Modification date:2009-02-24
Cite:Structure of a G48H mutant of HIV-1 protease explains how glycine-48 replacements produce mutants resistant to inhibitor drugs.
FEBS Lett., 420, 1997
1AAQ
HYDROXYETHYLENE ISOSTERE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS-1 PROTEASE: STRUCTURE-ACTIVITY ANALYSIS USING ENZYME KINETICS, X-RAY CRYSTALLOGRAPHY, AND INFECTED T-CELL ASSAYS
Descriptor:HIV-1 PROTEASE COMPLEXED WITH HYDROXYETHYLENE ISOSTERE
Authors:Lewis, M.
Deposit date:1992-04-13
Release date:1994-06-22
Modification date:2011-07-13
Cite:Hydroxyethylene isostere inhibitors of human immunodeficiency virus-1 protease: structure-activity analysis using enzyme kinetics, X-ray crystallography, and infected T-cell assays.
Biochemistry, 31, 1992
1AID
STRUCTURE OF A NON-PEPTIDE INHIBITOR COMPLEXED WITH HIV-1 PROTEASE: DEVELOPING A CYCLE OF STRUCTURE-BASED DRUG DESIGN
Descriptor:HUMAN IMMUNODEFICIENCY VIRUS PROTEASE, 4-(4-CHLORO-PHENYL)-1-{3-[2-(4-FLUORO-PHENYL)-[1,3]DITHIOLAN-2-YL]-PROPYL}-PIPERIDIN-4-OL
Authors:Rutenber, E.E., Fauman, E.B., Keenan, R.J., Stroud, R.M.
Deposit date:1997-04-16
Release date:1997-10-15
Modification date:2012-02-29
Cite:Structure of a non-peptide inhibitor complexed with HIV-1 protease. Developing a cycle of structure-based drug design.
J.Biol.Chem., 268, 1993
1AJV
HIV-1 PROTEASE IN COMPLEX WITH THE CYCLIC SULFAMIDE INHIBITOR AHA006
Descriptor:HIV-1 PROTEASE, 2,7-DIBENZYL-1,1-DIOXO-3,6-BIS-PHENOXYMETHYL-[1,2,7]THIADIAZEPANE-4,5-DIOL
Authors:Backbro, K., Unge, T.
Deposit date:1997-05-11
Release date:1997-08-20
Modification date:2009-02-24
Cite:Unexpected binding mode of a cyclic sulfamide HIV-1 protease inhibitor.
J.Med.Chem., 40, 1997
1AJX
HIV-1 PROTEASE IN COMPLEX WITH THE CYCLIC UREA INHIBITOR AHA001
Descriptor:HIV-1 PROTEASE, AHA001
Authors:Backbro, K., Unge, T.
Deposit date:1997-05-11
Release date:1997-09-17
Modification date:2009-02-24
Cite:Unexpected binding mode of a cyclic sulfamide HIV-1 protease inhibitor.
J.Med.Chem., 40, 1997
1AXA
ACTIVE-SITE MOBILITY IN HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE AS DEMONSTRATED BY CRYSTAL STRUCTURE OF A28S MUTANT
Descriptor:HIV-1 PROTEASE, N-[[1-[N-ACETAMIDYL]-[1-CYCLOHEXYLMETHYL-2-HYDROXY-4-ISOPROPYL]-BUT-4-YL]-CARBONYL]-GLUTAMINYL-ARGINYL-AMIDE
Authors:Hong, L., Hartsuck, J.A., Foundling, S., Ermolieff, J., Tang, J.
Deposit date:1997-10-13
Release date:1998-04-15
Modification date:2009-02-24
Cite:Active-site mobility in human immunodeficiency virus, type 1, protease as demonstrated by crystal structure of A28S mutant.
Protein Sci., 7, 1998
1AZ5
UNLIGANDED SIV PROTEASE STRUCTURE IN AN "OPEN" CONFORMATION
Descriptor:SIV PROTEASE
Authors:Rose, R.B., Craik, C.S., Stroud, R.M.
Deposit date:1997-11-25
Release date:1998-05-27
Modification date:2011-11-16
Cite:Domain flexibility in retroviral proteases: structural implications for drug resistant mutations.
Biochemistry, 37, 1998
1B11
STRUCTURE OF FELINE IMMUNODEFICIENCY VIRUS PROTEASE COMPLEXED WITH TL-3-093
Descriptor:FIV PROTEASE (E.C.3.4.23.16) + INHIBITOR TL-3-093
Authors:Gustchina, A., Li, M., Wlodawer, A.
Deposit date:1998-11-25
Release date:1998-12-02
Modification date:2011-07-13
Cite:Structural studies of FIV and HIV-1 proteases complexed with an efficient inhibitor of FIV protease
Proteins, 38, 2000
1B6J
HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 1
Descriptor:RETROPEPSIN (E.C.3.4.23.16)
Authors:Martin, J.L., Begun, J., Schindeler, A., Wickramasinghe, W.A., Alewood, D., Alewood, P.F., Bergman, D.A., Brinkworth, R.I., Abbenante, G., March, D.R., Reid, R.C., Fairlie, D.P.
Deposit date:1999-01-17
Release date:2000-01-07
Modification date:2013-03-13
Cite:Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease.
Biochemistry, 38, 1999
1B6K
HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 5
Descriptor:RETROPEPSIN (E.C.3.4.23.16)
Authors:Martin, J.L., Begun, J., Schindeler, A., Wickramasinghe, W.A., Alewood, D., Alewood, P.F., Bergman, D.A., Brinkworth, R.I., Abbenante, G., March, D.R., Reid, R.C., Fairlie, D.P.
Deposit date:1999-01-17
Release date:2000-01-07
Modification date:2009-02-24
Cite:Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease.
Biochemistry, 38, 1999
1B6L
HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 4
Descriptor:RETROPEPSIN (E.C.3.4.23.16)
Authors:Martin, J.L., Begun, J., Schindeler, A., Wickramasinghe, W.A., Alewood, D., Alewood, P.F., Bergman, D.A., Brinkworth, R.I., Abbenante, G., March, D.R., Reid, R.C., Fairlie, D.P.
Deposit date:1999-01-17
Release date:2000-01-07
Modification date:2009-09-22
Cite:Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease.
Biochemistry, 38, 1999
1B6M
HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 6
Descriptor:RETROPEPSIN (E.C.3.4.23.16)
Authors:Martin, J.L., Begun, J., Schindeler, A., Wickramasinghe, W.A., Alewood, D., Alewood, P.F., Bergman, D.A., Brinkworth, R.I., Abbenante, G., March, D.R., Reid, R.C., Fairlie, D.P.
Deposit date:1999-01-17
Release date:2000-01-07
Modification date:2012-07-25
Cite:Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease.
Biochemistry, 38, 1999
1B6P
HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 7
Descriptor:RETROPEPSIN (E.C.3.4.23.16)
Authors:Martin, J.L., Begun, J., Schindeler, A., Wickramasinghe, W.A., Alewood, D., Alewood, P.F., Bergman, D.A., Brinkworth, R.I., Abbenante, G., March, D.R., Reid, R.C., Fairlie, D.P.
Deposit date:1999-01-17
Release date:2000-01-07
Modification date:2009-02-24
Cite:Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease.
Biochemistry, 38, 1999
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