PDB keyword search results

1A30
HIV-1 PROTEASE COMPLEXED WITH A TRIPEPTIDE INHIBITOR
Descriptor:HIV-1 PROTEASE, TRIPEPTIDE GLU-ASP-LEU
Authors:Louis, J.M., Dyda, F., Nashed, N.T., Kimmel, A.R., Davies, D.R.
Deposit date:1998-01-27
Release date:1998-04-29
Modification date:2011-07-13
Cite:Hydrophilic peptides derived from the transframe region of Gag-Pol inhibit the HIV-1 protease.
Biochemistry, 37, 1998
1A8G
HIV-1 PROTEASE IN COMPLEX WITH SDZ283-910
Descriptor:HIV-1 PROTEASE, INHIBITOR SDZ283-910
Authors:Kallen, J., Billich, A., Scholz, D., Auer, M., Kungl, A.
Deposit date:1998-03-24
Release date:1998-07-15
Modification date:2011-07-13
Cite:X-ray structure and conformational dynamics of the HIV-1 protease in complex with the inhibitor SDZ283-910: agreement of time-resolved spectroscopy and molecular dynamics simulations.
J.Mol.Biol., 286, 1999
1A8K
CRYSTALLOGRAPHIC ANALYSIS OF HUMAN IMMUNODEFICIENCY VIRUS 1 PROTEASE WITH AN ANALOG OF THE CONSERVED CA-P2 SUBSTRATE: INTERACTIONS WITH FREQUENTLY OCCURRING GLUTAMIC ACID RESIDUE AT P2' POSITION OF SUBSTRATES
Descriptor:HIV PROTEASE, PEPTIDE
Authors:Weber, I.T., Wu, J., Adomat, J., Harrison, R.W., Kimmel, A.R., Wondrak, E.M., Louis, J.M.
Deposit date:1998-03-27
Release date:1999-01-13
Modification date:2011-07-13
Cite:Crystallographic analysis of human immunodeficiency virus 1 protease with an analog of the conserved CA-p2 substrate -- interactions with frequently occurring glutamic acid residue at P2' position of substrates.
Eur.J.Biochem., 249, 1997
1A94
STRUCTURAL BASIS FOR SPECIFICITY OF RETROVIRAL PROTEASES
Descriptor:HIV PROTEASE, PEPTIDE
Authors:Wu, J., Adomat, J.M., Ridky, T.W., Louis, J.M., Leis, J., Harrison, R.W., Weber, I.T.
Deposit date:1998-04-16
Release date:1999-01-13
Modification date:2011-07-13
Cite:Structural basis for specificity of retroviral proteases.
Biochemistry, 37, 1998
1A9M
G48H MUTANT OF HIV-1 PROTEASE IN COMPLEX WITH A PEPTIDIC INHIBITOR U-89360E
Descriptor:HIV-1 PROTEASE, N-[[1-[N-ACETAMIDYL]-[1-CYCLOHEXYLMETHYL-2-HYDROXY-4-ISOPROPYL]-BUT-4-YL]-CARBONYL]-GLUTAMINYL-ARGINYL-AMIDE
Authors:Hong, L., Zhang, X.-J., Foundling, S., Hartsuck, J.A., Tang, J.
Deposit date:1998-04-08
Release date:1998-06-17
Modification date:2009-02-24
Cite:Structure of a G48H mutant of HIV-1 protease explains how glycine-48 replacements produce mutants resistant to inhibitor drugs.
FEBS Lett., 420, 1997
1AAQ
HYDROXYETHYLENE ISOSTERE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS-1 PROTEASE: STRUCTURE-ACTIVITY ANALYSIS USING ENZYME KINETICS, X-RAY CRYSTALLOGRAPHY, AND INFECTED T-CELL ASSAYS
Descriptor:HIV-1 PROTEASE COMPLEXED WITH HYDROXYETHYLENE ISOSTERE
Authors:Lewis, M.
Deposit date:1992-04-13
Release date:1994-06-22
Modification date:2011-07-13
Cite:Hydroxyethylene isostere inhibitors of human immunodeficiency virus-1 protease: structure-activity analysis using enzyme kinetics, X-ray crystallography, and infected T-cell assays.
Biochemistry, 31, 1992
1AID
STRUCTURE OF A NON-PEPTIDE INHIBITOR COMPLEXED WITH HIV-1 PROTEASE: DEVELOPING A CYCLE OF STRUCTURE-BASED DRUG DESIGN
Descriptor:HUMAN IMMUNODEFICIENCY VIRUS PROTEASE, 4-(4-CHLORO-PHENYL)-1-{3-[2-(4-FLUORO-PHENYL)-[1,3]DITHIOLAN-2-YL]-PROPYL}-PIPERIDIN-4-OL
Authors:Rutenber, E.E., Fauman, E.B., Keenan, R.J., Stroud, R.M.
Deposit date:1997-04-16
Release date:1997-10-15
Modification date:2012-02-29
Cite:Structure of a non-peptide inhibitor complexed with HIV-1 protease. Developing a cycle of structure-based drug design.
J.Biol.Chem., 268, 1993
1AJV
HIV-1 PROTEASE IN COMPLEX WITH THE CYCLIC SULFAMIDE INHIBITOR AHA006
Descriptor:HIV-1 PROTEASE, 2,7-DIBENZYL-1,1-DIOXO-3,6-BIS-PHENOXYMETHYL-[1,2,7]THIADIAZEPANE-4,5-DIOL
Authors:Backbro, K., Unge, T.
Deposit date:1997-05-11
Release date:1997-08-20
Modification date:2009-02-24
Cite:Unexpected binding mode of a cyclic sulfamide HIV-1 protease inhibitor.
J.Med.Chem., 40, 1997
1AJX
HIV-1 PROTEASE IN COMPLEX WITH THE CYCLIC UREA INHIBITOR AHA001
Descriptor:HIV-1 PROTEASE, AHA001
Authors:Backbro, K., Unge, T.
Deposit date:1997-05-11
Release date:1997-09-17
Modification date:2009-02-24
Cite:Unexpected binding mode of a cyclic sulfamide HIV-1 protease inhibitor.
J.Med.Chem., 40, 1997
1AXA
ACTIVE-SITE MOBILITY IN HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE AS DEMONSTRATED BY CRYSTAL STRUCTURE OF A28S MUTANT
Descriptor:HIV-1 PROTEASE, N-[[1-[N-ACETAMIDYL]-[1-CYCLOHEXYLMETHYL-2-HYDROXY-4-ISOPROPYL]-BUT-4-YL]-CARBONYL]-GLUTAMINYL-ARGINYL-AMIDE
Authors:Hong, L., Hartsuck, J.A., Foundling, S., Ermolieff, J., Tang, J.
Deposit date:1997-10-13
Release date:1998-04-15
Modification date:2009-02-24
Cite:Active-site mobility in human immunodeficiency virus, type 1, protease as demonstrated by crystal structure of A28S mutant.
Protein Sci., 7, 1998
1AZ5
UNLIGANDED SIV PROTEASE STRUCTURE IN AN "OPEN" CONFORMATION
Descriptor:SIV PROTEASE
Authors:Rose, R.B., Craik, C.S., Stroud, R.M.
Deposit date:1997-11-25
Release date:1998-05-27
Modification date:2011-11-16
Cite:Domain flexibility in retroviral proteases: structural implications for drug resistant mutations.
Biochemistry, 37, 1998
1B6J
HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 1
Descriptor:RETROPEPSIN (E.C.3.4.23.16)
Authors:Martin, J.L., Begun, J., Schindeler, A., Wickramasinghe, W.A., Alewood, D., Alewood, P.F., Bergman, D.A., Brinkworth, R.I., Abbenante, G., March, D.R., Reid, R.C., Fairlie, D.P.
Deposit date:1999-01-17
Release date:2000-01-07
Modification date:2013-03-13
Cite:Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease.
Biochemistry, 38, 1999
1B6K
HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 5
Descriptor:RETROPEPSIN (E.C.3.4.23.16)
Authors:Martin, J.L., Begun, J., Schindeler, A., Wickramasinghe, W.A., Alewood, D., Alewood, P.F., Bergman, D.A., Brinkworth, R.I., Abbenante, G., March, D.R., Reid, R.C., Fairlie, D.P.
Deposit date:1999-01-17
Release date:2000-01-07
Modification date:2009-02-24
Cite:Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease.
Biochemistry, 38, 1999
1B6L
HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 4
Descriptor:RETROPEPSIN (E.C.3.4.23.16)
Authors:Martin, J.L., Begun, J., Schindeler, A., Wickramasinghe, W.A., Alewood, D., Alewood, P.F., Bergman, D.A., Brinkworth, R.I., Abbenante, G., March, D.R., Reid, R.C., Fairlie, D.P.
Deposit date:1999-01-17
Release date:2000-01-07
Modification date:2009-09-22
Cite:Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease.
Biochemistry, 38, 1999
1B6M
HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 6
Descriptor:RETROPEPSIN (E.C.3.4.23.16)
Authors:Martin, J.L., Begun, J., Schindeler, A., Wickramasinghe, W.A., Alewood, D., Alewood, P.F., Bergman, D.A., Brinkworth, R.I., Abbenante, G., March, D.R., Reid, R.C., Fairlie, D.P.
Deposit date:1999-01-17
Release date:2000-01-07
Modification date:2012-07-25
Cite:Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease.
Biochemistry, 38, 1999
1B6P
HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 7
Descriptor:RETROPEPSIN (E.C.3.4.23.16)
Authors:Martin, J.L., Begun, J., Schindeler, A., Wickramasinghe, W.A., Alewood, D., Alewood, P.F., Bergman, D.A., Brinkworth, R.I., Abbenante, G., March, D.R., Reid, R.C., Fairlie, D.P.
Deposit date:1999-01-17
Release date:2000-01-07
Modification date:2009-02-24
Cite:Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease.
Biochemistry, 38, 1999
1BAI
CRYSTAL STRUCTURE OF ROUS SARCOMA VIRUS PROTEASE IN COMPLEX WITH INHIBITOR
Descriptor:ROUS SARCOMA VIRUS PROTEASE, INHIBITOR
Authors:Wu, J., Adomat, J.M., Ridky, T.W., Louis, J.M., Leis, J., Harrison, R.W., Weber, I.T.
Deposit date:1998-04-17
Release date:1999-01-13
Modification date:2011-07-13
Cite:Structural basis for specificity of retroviral proteases.
Biochemistry, 37, 1998
1BDL
HIV-1 (2:31-37) PROTEASE COMPLEXED WITH INHIBITOR SB203386
Descriptor:HIV-1 PROTEASE, (2R,4S,5S,1'S)-2-PHENYLMETHYL-4-HYDROXY-5-(TERT-BUTOXYCARBONYL)AMINO-6-PHENYL HEXANOYL-N-(1'-IMIDAZO-2-YL)-2'-METHYLPROPANAMIDE
Authors:Swairjo, M.A., Abdel-Meguid, S.S.
Deposit date:1998-05-10
Release date:1998-08-12
Modification date:2009-02-24
Cite:Structural role of the 30's loop in determining the ligand specificity of the human immunodeficiency virus protease.
Biochemistry, 37, 1998
1BDQ
HIV-1 (2:31-37, 47, 82) PROTEASE COMPLEXED WITH INHIBITOR SB203386
Descriptor:HIV-1 PROTEASE, (2R,4S,5S,1'S)-2-PHENYLMETHYL-4-HYDROXY-5-(TERT-BUTOXYCARBONYL)AMINO-6-PHENYL HEXANOYL-N-(1'-IMIDAZO-2-YL)-2'-METHYLPROPANAMIDE
Authors:Swairjo, M.A., Abdel-Meguid, S.S.
Deposit date:1998-05-10
Release date:1998-08-12
Modification date:2009-02-24
Cite:Structural role of the 30's loop in determining the ligand specificity of the human immunodeficiency virus protease.
Biochemistry, 37, 1998
1BDR
HIV-1 (2: 31, 33-37) PROTEASE COMPLEXED WITH INHIBITOR SB203386
Descriptor:HIV-1 PROTEASE, (2R,4S,5S,1'S)-2-PHENYLMETHYL-4-HYDROXY-5-(TERT-BUTOXYCARBONYL)AMINO-6-PHENYL HEXANOYL-N-(1'-IMIDAZO-2-YL)-2'-METHYLPROPANAMIDE
Authors:Swairjo, M.A., Abdel-Meguid, S.S.
Deposit date:1998-05-10
Release date:1998-10-14
Modification date:2009-02-24
Cite:Structural role of the 30's loop in determining the ligand specificity of the human immunodeficiency virus protease.
Biochemistry, 37, 1998
1BV7
COUNTERACTING HIV-1 PROTEASE DRUG RESISTANCE: STRUCTURAL ANALYSIS OF MUTANT PROTEASES COMPLEXED WITH XV638 AND SD146, CYCLIC UREA AMIDES WITH BROAD SPECIFICITIES
Descriptor:PROTEIN (HIV-1 PROTEASE COMPLEX WITH XV638 OF DUPONT MERCK) MUTANT (V82F)
Authors:Ala, P., Chang, C.H.
Deposit date:1998-09-22
Release date:1998-09-30
Modification date:2009-02-24
Cite:Counteracting HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with XV638 and SD146, cyclic urea amides with broad specificities.
Biochemistry, 37, 1998
1BV9
HIV-1 PROTEASE (I84V) COMPLEXED WITH XV638 OF DUPONT PHARMACEUTICALS
Descriptor:PROTEIN (HIV PROTEASE) MUTANT (I84V)
Authors:Ala, P., Chang, C.H.
Deposit date:1998-09-22
Release date:1998-09-30
Modification date:2009-02-24
Cite:Counteracting HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with XV638 and SD146, cyclic urea amides with broad specificities.
Biochemistry, 37, 1998
1BVE
HIV-1 PROTEASE-DMP323 COMPLEX IN SOLUTION, NMR, 28 STRUCTURES
Descriptor:HIV-1 PROTEASE, [4-R-(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-[1,3-BIS([4-HYDROXYMETHYL-PHENYL]METHYL)-4,7-BIS(PHENYLMETHYL)]-2H-1,3-DIAZEPINONE
Authors:Yamazaki, T., Hinck, A.P., Wang, Y.-X., Nicholson, L.K., Torchia, D.A., Wingfield, P., Stahl, S.J., Kaufman, J.D., Chang, C., Domaille, P.J., Lam, P.Y.S.
Deposit date:1996-01-16
Release date:1996-08-17
Modification date:2009-02-24
Cite:Three-dimensional solution structure of the HIV-1 protease complexed with DMP323, a novel cyclic urea-type inhibitor, determined by nuclear magnetic resonance spectroscopy.
Protein Sci., 5, 1996
1BVG
HIV-1 PROTEASE-DMP323 COMPLEX IN SOLUTION, NMR MINIMIZED AVERAGE STRUCTURE
Descriptor:HIV-1 PROTEASE, [4-R-(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-[1,3-BIS([4-HYDROXYMETHYL-PHENYL]METHYL)-4,7-BIS(PHENYLMETHYL)]-2H-1,3-DIAZEPINONE
Authors:Yamazaki, T., Hinck, A.P., Wang, Y.-X., Nicholson, L.K., Torchia, D.A., Wingfield, P., Stahl, S.J., Kaufman, J.D., Chang, C., Domaille, P.J., Lam, P.Y.S.
Deposit date:1996-01-16
Release date:1996-08-17
Modification date:2009-02-24
Cite:Three-dimensional solution structure of the HIV-1 protease complexed with DMP323, a novel cyclic urea-type inhibitor, determined by nuclear magnetic resonance spectroscopy.
Protein Sci., 5, 1996
1BWA
HIV-1 PROTEASE (V82F/I84V) DOUBLE MUTANT COMPLEXED WITH XV638 OF DUPONT PHARMACEUTICALS
Descriptor:PROTEIN (HIV-1 PROTEINASE) MUTANT (V82F, I84V)
Authors:Ala, P., Chang, C.H.
Deposit date:1998-09-22
Release date:1998-10-30
Modification date:2009-02-24
Cite:Counteracting HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with XV638 and SD146, cyclic urea amides with broad specificities.
Biochemistry, 37, 1998
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