登録情報 データベース : PDB / ID : 4hix 構造の表示 ダウンロードとリンクタイトル Crystal structure of a humanised 3D6 Fab bound to amyloid beta peptide 要素Beta-amyloid protein 40 アミロイドβ Humanized 3D6 Fab heavy chain Humanized 3D6 Fab light chain 詳細キーワード PROTEIN FIBRIL/Immune System / immunoglobulin (抗体) / immunotherapy candidate / amyloid beta peptide (アミロイドβ) / PROTEIN FIBRIL-Immune System complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
IgD immunoglobulin complex / IgM immunoglobulin complex / IgA immunoglobulin complex / IgE immunoglobulin complex / regulation of epidermal growth factor-activated receptor activity / CD22 mediated BCR regulation / signaling receptor activator activity / cytosolic mRNA polyadenylation / collateral sprouting in absence of injury / 補体依存性細胞傷害 ... IgD immunoglobulin complex / IgM immunoglobulin complex / IgA immunoglobulin complex / IgE immunoglobulin complex / regulation of epidermal growth factor-activated receptor activity / CD22 mediated BCR regulation / signaling receptor activator activity / cytosolic mRNA polyadenylation / collateral sprouting in absence of injury / 補体依存性細胞傷害 / microglia development / regulation of synapse structure or activity / Formyl peptide receptors bind formyl peptides and many other ligands / axo-dendritic transport / synaptic assembly at neuromuscular junction / smooth endoplasmic reticulum calcium ion homeostasis / axon midline choice point recognition / astrocyte activation involved in immune response / regulation of spontaneous synaptic transmission / regulation of Wnt signaling pathway / mating behavior / positive regulation of amyloid fibril formation / 抗体依存性細胞傷害 / Fc epsilon receptor (FCERI) signaling / Fc-gamma receptor I complex binding / 繊毛 / Lysosome Vesicle Biogenesis / PTB domain binding / Classical antibody-mediated complement activation / neuron remodeling / Golgi-associated vesicle / Insertion of tail-anchored proteins into the endoplasmic reticulum membrane / Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models / presynaptic active zone / Initial triggering of complement / : / nuclear envelope lumen / modulation of excitatory postsynaptic potential / suckling behavior / COPII-coated ER to Golgi transport vesicle / immunoglobulin complex, circulating / dendrite development / IgG immunoglobulin complex / immunoglobulin receptor binding / 小胞体 / regulation of NMDA receptor activity / TRAF6 mediated NF-kB activation / negative regulation of long-term synaptic potentiation / Advanced glycosylation endproduct receptor signaling / neuromuscular process controlling balance / regulation of presynapse assembly / The NLRP3 inflammasome / immunoglobulin mediated immune response / intracellular copper ion homeostasis / transition metal ion binding / FCGR activation / regulation of multicellular organism growth / negative regulation of neuron differentiation / ECM proteoglycans / spindle midzone / positive regulation of T cell migration / Role of phospholipids in phagocytosis / Role of LAT2/NTAL/LAB on calcium mobilization / Scavenging of heme from plasma / Purinergic signaling in leishmaniasis infection / positive regulation of calcium-mediated signaling / complement activation, classical pathway / forebrain development / regulation of peptidyl-tyrosine phosphorylation / positive regulation of chemokine production / クラスリン / Notchシグナリング / cholesterol metabolic process / antigen binding / positive regulation of G2/M transition of mitotic cell cycle / positive regulation of protein metabolic process / ionotropic glutamate receptor signaling pathway / neuron projection maintenance / positive regulation of glycolytic process / extracellular matrix organization / response to interleukin-1 / positive regulation of mitotic cell cycle / 軸索誘導 / adult locomotory behavior / FCERI mediated Ca+2 mobilization / FCGR3A-mediated IL10 synthesis / dendritic shaft / trans-Golgi network membrane / locomotory behavior / platelet alpha granule lumen / positive regulation of peptidyl-threonine phosphorylation / Antigen activates B Cell Receptor (BCR) leading to generation of second messengers / 学習 / positive regulation of interleukin-1 beta production / central nervous system development / positive regulation of long-term synaptic potentiation / Regulation of Complement cascade / astrocyte activation / endosome lumen / Post-translational protein phosphorylation 類似検索 - 分子機能 Amyloidogenic glycoprotein, copper-binding / Amyloidogenic glycoprotein, copper-binding domain conserved site / Amyloidogenic glycoprotein, copper-binding domain superfamily / Copper-binding of amyloid precursor, CuBD / Amyloid precursor protein (APP) copper-binding (CuBD) domain signature. / Amyloidogenic glycoprotein, amyloid-beta peptide superfamily / Beta-amyloid peptide (beta-APP) / Amyloidogenic glycoprotein, amyloid-beta peptide / Beta-amyloid precursor protein C-terminal / Amyloidogenic glycoprotein, intracellular domain, conserved site ... Amyloidogenic glycoprotein, copper-binding / Amyloidogenic glycoprotein, copper-binding domain conserved site / Amyloidogenic glycoprotein, copper-binding domain superfamily / Copper-binding of amyloid precursor, CuBD / Amyloid precursor protein (APP) copper-binding (CuBD) domain signature. / Amyloidogenic glycoprotein, amyloid-beta peptide superfamily / Beta-amyloid peptide (beta-APP) / Amyloidogenic glycoprotein, amyloid-beta peptide / Beta-amyloid precursor protein C-terminal / Amyloidogenic glycoprotein, intracellular domain, conserved site / Beta-amyloid precursor protein C-terminus / Amyloid precursor protein (APP) intracellular domain signature. / Amyloid precursor protein (APP) E1 domain profile. / Amyloid precursor protein (APP) E2 domain profile. / Amyloidogenic glycoprotein, extracellular / Amyloidogenic glycoprotein, heparin-binding / Amyloidogenic glycoprotein, E2 domain / E2 domain superfamily / Amyloidogenic glycoprotein, heparin-binding domain superfamily / Amyloid A4 N-terminal heparin-binding / E2 domain of amyloid precursor protein / amyloid A4 / Amyloidogenic glycoprotein / Proteinase inhibitor I2, Kunitz, conserved site / Pancreatic trypsin inhibitor (Kunitz) family signature. / BPTI/Kunitz family of serine protease inhibitors. / Pancreatic trypsin inhibitor Kunitz domain / Kunitz/Bovine pancreatic trypsin inhibitor domain / Pancreatic trypsin inhibitor (Kunitz) family profile. / Pancreatic trypsin inhibitor Kunitz domain superfamily / PH-like domain superfamily / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / 抗体 / Immunoglobulin-like fold / Immunoglobulin-like / サンドイッチ / Mainly Beta 類似検索 - ドメイン・相同性 Immunoglobulin kappa constant / Immunoglobulin heavy constant gamma 1 / アミロイド前駆体タンパク質 類似検索 - 構成要素生物種 homo Sapiens (ヒト)Mus musculus (ハツカネズミ)Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.204 Å 詳細データ登録者 Miles, L.A. / Crespi, G.A.N. / Parker, M.W. 引用ジャーナル : Sci Rep / 年 : 2013タイトル : Bapineuzumab captures the N-terminus of the Alzheimer's disease amyloid-beta peptide in a helical conformation.著者 : Miles, L.A. / Crespi, G.A. / Doughty, L. / Parker, M.W. 履歴 登録 2012年10月12日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2013年3月13日 Provider : repository / タイプ : Initial release改定 1.1 2013年3月20日 Group : Structure summary改定 1.2 2013年10月2日 Group : Source and taxonomy改定 1.3 2014年3月19日 Group : Source and taxonomy
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