National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health & Human Development (NIH/NICHD)
R01 GM61576
米国
引用
ジャーナル: Microbiology (Reading) / 年: 2021 タイトル: Ribosome hibernation: a new molecular framework for targeting nonreplicating persisters of mycobacteria. 著者: Yunlong Li / Manjuli R Sharma / Ravi K Koripella / Nilesh K Banavali / Rajendra K Agrawal / Anil K Ojha / 要旨: Treatment of tuberculosis requires a multi-drug regimen administered for at least 6 months. The long-term chemotherapy is attributed in part to a minor subpopulation of nonreplicating cells that ...Treatment of tuberculosis requires a multi-drug regimen administered for at least 6 months. The long-term chemotherapy is attributed in part to a minor subpopulation of nonreplicating cells that exhibit phenotypic tolerance to antibiotics. The origins of these cells in infected hosts remain unclear. Here we discuss some recent evidence supporting the hypothesis that hibernation of ribosomes in induced by zinc starvation, could be one of the primary mechanisms driving the development of nonreplicating persisters in hosts. We further analyse inconsistencies in previously reported studies to clarify the molecular principles underlying mycobacterial ribosome hibernation.