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Open data
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Basic information
Entry | Database: PDB / ID: 8ory | ||||||
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Title | Solution NMR structure of Notch1 L1740-1743 TMD | ||||||
![]() | Notch 1 extracellular truncation | ||||||
![]() | ![]() ![]() ![]() | ||||||
Function / homology | ![]() Defective LFNG causes SCDO3 / coronary sinus valve morphogenesis / cardiac right atrium morphogenesis / cardiac right ventricle formation / growth involved in heart morphogenesis / Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation / ![]() ![]() ![]() ![]() ![]() ![]() Similarity search - Function | ||||||
Biological species | ![]() ![]() | ||||||
Method | ![]() ![]() | ||||||
![]() | Guschtschin-Schmidt, N. / Muhle-Goll, C. | ||||||
Funding support | ![]()
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![]() | ![]() Title: Permissive Conformations of a Transmembrane Helix Allow Intramembrane Proteolysis by gamma-Secretase. Authors: Ortner, M. / Guschtschin-Schmidt, N. / Stelzer, W. / Muhle-Goll, C. / Langosch, D. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 460.2 KB | Display | ![]() |
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PDB format | ![]() | 394.4 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Arichive directory | ![]() ![]() | HTTPS FTP |
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-Related structure data
Related structure data | ![]() 8or5C ![]() 8orzC ![]() 8os0C C: citing same article ( |
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Similar structure data | Similarity search - Function & homology ![]() |
Other databases |
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Links
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Assembly
Deposited unit | ![]()
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NMR ensembles |
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Components
#1: Protein/peptide | Mass: 3533.573 Da / Num. of mol.: 1 / Mutation: A1740L, A1741L, A1742L, A1743L / Source method: obtained synthetically / Source: (synth.) ![]() ![]() |
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-Experimental details
-Experiment
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NMR experiment |
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Sample preparation
Details | Type: solution Contents: 500 uM Notch1 L1740-1743 TMD, trifluoroethanol/water 80/20 Label: Notch1 L1740-1743 / Solvent system: trifluoroethanol/water 80/20 |
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Sample | Conc.: 500 uM / Component: Notch1 L1740-1743 TMD / Isotopic labeling: natural abundance |
Sample conditions | Ionic strength units: mM / Label: 1 / pH: 6.5 / Pressure: 1 bar / Temperature: 300 K |
-NMR measurement
NMR spectrometer | Type: Bruker AVANCE III / Manufacturer: Bruker / Model![]() |
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Processing
NMR software |
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Refinement | Method: ![]() | ||||||||||||||||||||
NMR representative | Selection criteria: closest to the average | ||||||||||||||||||||
NMR ensemble | Conformer selection criteria: structures with the lowest energy Conformers calculated total number: 400 / Conformers submitted total number: 40 |