登録情報 | データベース: PDB / ID: 8fax |
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タイトル | Fab 1249A8-MERS Stem Helix Complex |
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要素 | - 1249A8-HC
- 1249A8-LC
- Spike glycoproteinスパイクタンパク質
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キーワード | IMMUNE SYSTEM/VIRAL PROTEIN (免疫系) / Broadly Neutralizing antibody (中和抗体) / MERS S protein / IMMUNE SYSTEM-VIRAL PROTEIN complex (免疫系) |
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機能・相同性 | 機能・相同性情報
endocytosis involved in viral entry into host cell / host cell endoplasmic reticulum-Golgi intermediate compartment membrane / receptor-mediated virion attachment to host cell / fusion of virus membrane with host plasma membrane / fusion of virus membrane with host endosome membrane / エンベロープ (ウイルス) / host cell plasma membrane / virion membrane / 生体膜類似検索 - 分子機能 Spike (S) protein S1 subunit, receptor-binding domain, MERS-CoV / Spike (S) protein S1 subunit, N-terminal domain, MERS-CoV-like / Spike glycoprotein S2, coronavirus, C-terminal / Coronavirus spike glycoprotein S2, intravirion / Betacoronavirus spike (S) glycoprotein S1 subunit N-terminal (NTD) domain profile. / Spike glycoprotein, N-terminal domain superfamily / Betacoronavirus spike (S) glycoprotein S1 subunit C-terminal (CTD) domain profile. / Spike glycoprotein, betacoronavirus / Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus / Spike S1 subunit, receptor binding domain superfamily, betacoronavirus ...Spike (S) protein S1 subunit, receptor-binding domain, MERS-CoV / Spike (S) protein S1 subunit, N-terminal domain, MERS-CoV-like / Spike glycoprotein S2, coronavirus, C-terminal / Coronavirus spike glycoprotein S2, intravirion / Betacoronavirus spike (S) glycoprotein S1 subunit N-terminal (NTD) domain profile. / Spike glycoprotein, N-terminal domain superfamily / Betacoronavirus spike (S) glycoprotein S1 subunit C-terminal (CTD) domain profile. / Spike glycoprotein, betacoronavirus / Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus / Spike S1 subunit, receptor binding domain superfamily, betacoronavirus / Betacoronavirus spike glycoprotein S1, receptor binding / Spike glycoprotein S1, N-terminal domain, betacoronavirus-like / Betacoronavirus-like spike glycoprotein S1, N-terminal / Spike glycoprotein S2, coronavirus, heptad repeat 1 / Spike glycoprotein S2, coronavirus, heptad repeat 2 / Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 2 (HR2) region profile. / Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 1 (HR1) region profile. / Spike glycoprotein S2 superfamily, coronavirus / Spike glycoprotein S2, coronavirus / Coronavirus spike glycoprotein S2 / Coronavirus spike glycoprotein S1, C-terminal / Coronavirus spike glycoprotein S1, C-terminal類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) Middle East respiratory syndrome-related coronavirus (MERSコロナウイルス) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.1 Å |
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データ登録者 | Deshpande, A. / Schormann, N. / Piepenbrink, M.S. / Martinez-Sobrido, L. / Kobie, J.J. / Walter, M.R. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | AI161175 | 米国 |
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引用 | ジャーナル: Febs J. / 年: 2023 タイトル: Structure and epitope of a neutralizing monoclonal antibody that targets the stem helix of beta coronaviruses. 著者: Deshpande, A. / Schormann, N. / Piepenbrink, M.S. / Martinez Sobrido, L. / Kobie, J.J. / Walter, M.R. |
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履歴 | 登録 | 2022年11月28日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2023年5月3日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年7月19日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID |
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