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- PDB-8fas: Crystal structure of Ky230 Fab in complex with circumsporozoite p... -
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Open data
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Basic information
Entry | Database: PDB / ID: 8fas | ||||||
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Title | Crystal structure of Ky230 Fab in complex with circumsporozoite protein NANP5 peptide | ||||||
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Function / homology | ![]() entry into host cell by a symbiont-containing vacuole / side of membrane / ![]() ![]() ![]() Similarity search - Function | ||||||
Biological species | ![]() ![]() ![]() ![]() ![]() ![]() | ||||||
Method | ![]() ![]() ![]() | ||||||
![]() | Kassardjian, A. / Thai, E. / Julien, J.P. | ||||||
Funding support | ![]()
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![]() | ![]() Title: Molecular determinants of cross-reactivity and potency by VH3-33 antibodies against the Plasmodium falciparum circumsporozoite protein. Authors: Thai, E. / Murugan, R. / Binter, S. / Burn Aschner, C. / Prieto, K. / Kassardjian, A. / Obraztsova, A.S. / Kang, R.W. / Flores-Garcia, Y. / Mathis-Torres, S. / Li, K. / Horn, G.Q. / ...Authors: Thai, E. / Murugan, R. / Binter, S. / Burn Aschner, C. / Prieto, K. / Kassardjian, A. / Obraztsova, A.S. / Kang, R.W. / Flores-Garcia, Y. / Mathis-Torres, S. / Li, K. / Horn, G.Q. / Huntwork, R.H.C. / Bolscher, J.M. / de Bruijni, M.H.C. / Sauerwein, R. / Dennison, S.M. / Tomaras, G.D. / Zavala, F. / Kellam, P. / Wardemann, H. / Julien, J.P. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 200.8 KB | Display | ![]() |
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PDB format | ![]() | 157.6 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Arichive directory | ![]() ![]() | HTTPS FTP |
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-Related structure data
Related structure data | ![]() 8f95C ![]() 8f9eC ![]() 8f9fC ![]() 8f9sC ![]() 8f9tC ![]() 8f9uC ![]() 8f9vC ![]() 8f9wC ![]() 8fa6C ![]() 8fa7C ![]() 8fa8C ![]() 8fa9C ![]() 8fanC ![]() 8fatC ![]() 8fb5C ![]() 8fb6C ![]() 8fb7C ![]() 8fb8C ![]() 8fbaC ![]() 8fdcC ![]() 8fddC C: citing same article ( |
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Similar structure data | Similarity search - Function & homology ![]() |
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Links
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Assembly
Deposited unit | ![]()
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Unit cell |
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Components
#1: Antibody | Mass: 23754.600 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() ![]() ![]() | ||||
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#2: Antibody | Mass: 24210.912 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() ![]() ![]() | ||||
#3: Protein/peptide | Mass: 2000.006 Da / Num. of mol.: 1 / Source method: obtained synthetically Source: (synth.) ![]() ![]() ![]() References: UniProt: P02893 | ||||
#4: Chemical | ChemComp-EDO / ![]() #5: Water | ChemComp-HOH / | ![]() Has ligand of interest | N | |
-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 2.26 Å3/Da / Density % sol: 45.49 % |
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Crystal grow![]() | Temperature: 293.15 K / Method: vapor diffusion, sitting drop / Details: 0.2 M di-ammonium tartrate, 20% PEG3350 |
-Data collection
Diffraction | Mean temperature: 100 K / Serial crystal experiment: N |
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Diffraction source | Source: ![]() ![]() ![]() |
Detector | Type: DECTRIS PILATUS 6M / Detector: PIXEL / Date: Oct 17, 2020 |
Radiation | Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength![]() |
Reflection | Resolution: 1.55→40 Å / Num. obs: 66528 / % possible obs: 100 % / Redundancy: 13.1 % / CC1/2: 0.998 / Net I/σ(I): 16 |
Reflection shell | Resolution: 1.55→1.57 Å / Num. unique obs: 2442 / CC1/2: 0.793 |
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Processing
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Refinement | Method to determine structure![]() ![]()
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Solvent computation | Shrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refinement step | Cycle: LAST / Resolution: 1.55→38.92 Å
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Refine LS restraints |
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LS refinement shell |
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Refinement TLS params. | Method: refined / Refine-ID: X-RAY DIFFRACTION
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Refinement TLS group |
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