Entry Database : PDB / ID : 8bdy Structure visualization Downloads & linksTitle Crystal structure of TRIM33 alpha PHD-Bromo domain in complex with 9 ComponentsE3 ubiquitin-protein ligase TRIM33 Details Keywords TRANSCRIPTION / TRIM33 alpha / PHD-Bromo domain / complexFunction / homology Function and homology informationFunction Domain/homology Component
co-SMAD binding / regulation of transforming growth factor beta receptor signaling pathway / Germ layer formation at gastrulation / R-SMAD binding / negative regulation of BMP signaling pathway / Downregulation of SMAD2/3:SMAD4 transcriptional activity / RING-type E3 ubiquitin transferase / ubiquitin-protein transferase activity / protein ubiquitination / negative regulation of DNA-templated transcription ... co-SMAD binding / regulation of transforming growth factor beta receptor signaling pathway / Germ layer formation at gastrulation / R-SMAD binding / negative regulation of BMP signaling pathway / Downregulation of SMAD2/3:SMAD4 transcriptional activity / RING-type E3 ubiquitin transferase / ubiquitin-protein transferase activity / protein ubiquitination / negative regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / DNA binding / zinc ion binding / nucleoplasm / nucleus Similarity search - Function B-box, C-terminal / B-Box C-terminal domain / B-box zinc finger / B-Box-type zinc finger / B-box-type zinc finger / Zinc finger B-box type profile. / Zinc finger, RING-type, conserved site / Zinc finger RING-type signature. / Zinc finger, PHD-type, conserved site / PHD-finger ... B-box, C-terminal / B-Box C-terminal domain / B-box zinc finger / B-Box-type zinc finger / B-box-type zinc finger / Zinc finger B-box type profile. / Zinc finger, RING-type, conserved site / Zinc finger RING-type signature. / Zinc finger, PHD-type, conserved site / PHD-finger / Ring finger / Zinc finger PHD-type signature. / Zinc finger PHD-type profile. / Zinc finger, PHD-finger / Zinc finger, PHD-type / PHD zinc finger / Zinc finger RING-type profile. / Zinc finger, RING-type / Zinc finger, FYVE/PHD-type / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily / Zinc finger, RING/FYVE/PHD-type Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 3.05 Å DetailsAuthors Tassone, G. / Pozzi, C. / Palomba, T. Funding support 1items Details Hide detailsOrganization Grant number Country Not funded
CitationJournal : Int J Mol Sci / Year : 2022Title : Exploiting ELIOT for Scaffold-Repurposing Opportunities: TRIM33 a Possible Novel E3 Ligase to Expand the Toolbox for PROTAC Design.Authors : Palomba, T. / Tassone, G. / Vacca, C. / Bartalucci, M. / Valeri, A. / Pozzi, C. / Cross, S. / Siragusa, L. / Desantis, J. History Deposition Oct 20, 2022 Deposition site : PDBE / Processing site : PDBERevision 1.0 Dec 7, 2022 Provider : repository / Type : Initial releaseRevision 1.1 Jan 31, 2024 Group : Data collection / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
Show all Show less