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- PDB-8bdj: VCB in complex with compound 30 -

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Open data

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Basic information

Entry

Database: PDB / ID: 8bdj

Title

VCB in complex with compound 30

Components

(Elongin-B) x 2
Elongin-C
von Hippel-Lindau disease tumor suppressor

Keywords

LIGASE /

PROTAC / degrader /

complex /

E3 ligase / VHL / VCB / VH032

Function / homology

Function and homology information

regulation of cellular response to hypoxia / RHOBTB3 ATPase cycle / negative regulation of receptor signaling pathway via JAK-STAT / transcription elongation factor activity / target-directed miRNA degradation / elongin complex / VCB complex / Replication of the SARS-CoV-1 genome / Cul5-RING ubiquitin ligase complex / Cul2-RING ubiquitin ligase complex ...regulation of cellular response to hypoxia / RHOBTB3 ATPase cycle / negative regulation of receptor signaling pathway via JAK-STAT / transcription elongation factor activity / target-directed miRNA degradation / elongin complex / VCB complex / Replication of the SARS-CoV-1 genome / Cul5-RING ubiquitin ligase complex / Cul2-RING ubiquitin ligase complex / intracellular non-membrane-bounded organelle / SUMOylation of ubiquitinylation proteins / negative regulation of transcription elongation by RNA polymerase II / Pausing and recovery of Tat-mediated HIV elongation / Tat-mediated HIV elongation arrest and recovery / HIV elongation arrest and recovery / Pausing and recovery of HIV elongation / ubiquitin-like ligase-substrate adaptor activity / Tat-mediated elongation of the HIV-1 transcript / Formation of HIV-1 elongation complex containing HIV-1 Tat / Formation of HIV elongation complex in the absence of HIV Tat / negative regulation of signal transduction / RNA Polymerase II Transcription Elongation / Formation of RNA Pol II elongation complex / negative regulation of TORC1 signaling / RNA Polymerase II Pre-transcription Events / negative regulation of autophagy / transcription corepressor binding / Evasion by RSV of host interferon responses / transcription elongation by RNA polymerase II /

transcription initiation at RNA polymerase II promoter / positive regulation of cell differentiation / TP53 Regulates Transcription of DNA Repair Genes / Vif-mediated degradation of APOBEC3G / Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha / cell morphogenesis / Inactivation of CSF3 (G-CSF) signaling / Regulation of expression of SLITs and ROBOs / ubiquitin-protein transferase activity / transcription corepressor activity / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / Antigen processing: Ubiquitination & Proteasome degradation / protein-macromolecule adaptor activity /

Neddylation / Replication of the SARS-CoV-2 genome / cellular response to hypoxia / ubiquitin-dependent protein catabolic process /

regulation of gene expression / proteasome-mediated ubiquitin-dependent protein catabolic process / protein-containing complex assembly / DNA-binding transcription factor binding / amyloid fibril formation / molecular adaptor activity / protein stabilization / protein ubiquitination / negative regulation of cell population proliferation / negative regulation of gene expression /

ubiquitin protein ligase binding / regulation of DNA-templated transcription / regulation of transcription by RNA polymerase II / negative regulation of apoptotic process / positive regulation of DNA-templated transcription /

enzyme binding / negative regulation of transcription by RNA polymerase II /

endoplasmic reticulum /

mitochondrion /

proteolysis /

nucleoplasm /

nucleus /

plasma membrane /

cytosol
Similarity search - Function

Biological species

Homo sapiens (human)

Method

X-RAY DIFFRACTION /

SYNCHROTRON /

MOLECULAR REPLACEMENT /

molecular replacement / Resolution: 2.02 Å

Authors

Sorrell, F.J. / Mueller, J.E. / Lehmann, M. / Wegener, A.

Funding support

Germany, 1items

Citation

Journal: Chemmedchem / Year: 2023
Title: Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design.
Authors: Krieger, J. / Sorrell, F.J. / Wegener, A.A. / Leuthner, B. / Machrouhi-Porcher, F. / Hecht, M. / Leibrock, E.M. / Muller, J.E. / Eisert, J. / Hartung, I.V. / Schlesiger, S.

History

Deposition	Oct 19, 2022	Deposition site: PDBE / Processing site: PDBE
Revision 1.0	Feb 15, 2023	Provider: repository / Type: Initial release
Revision 1.1	Mar 22, 2023	Group: Database references / Category: citation / citation_author Item: _citation.page_first / _citation.page_last ..._citation.page_first / _citation.page_last / _citation.title / _citation_author.identifier_ORCID / _citation_author.name
Revision 1.2	Apr 26, 2023	Group: Database references / Category: citation / Item: _citation.journal_volume
Revision 1.3	Feb 7, 2024	Group: Data collection / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model / struct_ncs_dom_lim Item: _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id ..._struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id

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Structure visualization

Structure viewer	Molecule: MolmilJmol/JSmol

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Downloads & links

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Download

PDBx/mmCIF format	8bdj.cif.gz	574.7 KB	Display	PDBx/mmCIF format
PDB format	pdb8bdj.ent.gz	478.3 KB	Display	PDB format
PDBx/mmJSON format	8bdj.json.gz		Tree view	PDBx/mmJSON format
Others	Other downloads

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Validation report

Arichive directory	https://data.pdbj.org/pub/pdb/validation_reports/bd/8bdj ftp://data.pdbj.org/pub/pdb/validation_reports/bd/8bdj	HTTPS FTP

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Related structure data

Related structure data	8bdiC 8bdlC 8bdmC 8bdnC 8bdoC 8bdsC 8bdtC 8bdxC 8bebC 5nw1S S: Starting model for refinement C: citing same article (ref.)
Similar structure data	Similarity search - Function & homologyF&H Search Similarity search - FunctionF&H Search Similarity search - HomologyF&H Search

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Links

PDB pages	PDBj / wwPDB / NCBI
Related items in Molecule of the Month	#240 - Dec 2019 Hypoxia-Inducible Factors similarity (32) #110 - Feb 2009 Auxin and TIR1 Ubiquitin Ligase similarity (5) #60 - Dec 2004 Ubiquitin similarity (5) #218 - Feb 2018 EPSP Synthase and Weedkillers similarity (5) #234 - Jun 2019 MDM2 and Cancer similarity (2) #242 - Feb 2020 Coronavirus Proteases similarity (1) #205 - Jan 2017 Nuclear Pore Complex similarity (1) #67 - Jul 2005 TATA-Binding Protein similarity (1) #31 - Jul 2002 p53 Tumor Suppressor similarity (1) #249 - Sep 2020 SARS-CoV-2 RNA-dependent RNA Polymerase similarity (1) #47 - Nov 2003 Simian Virus 40 similarity (1) #122 - Feb 2010 Enhanceosome similarity (1) #213 - Sep 2017 Sirtuins similarity (1) #221 - May 2018 Human Papillomavirus and Vaccines similarity (1)

PDB pages

PDBj /

wwPDB /

NCBI

Related items in Molecule of the Month

#240 - Dec 2019
Hypoxia-Inducible Factors
similarity (32)
#110 - Feb 2009
Auxin and TIR1 Ubiquitin Ligase
similarity (5)
#60 - Dec 2004
Ubiquitin
similarity (5)
#218 - Feb 2018
EPSP Synthase and Weedkillers
similarity (5)
#234 - Jun 2019
MDM2 and Cancer
similarity (2)
#242 - Feb 2020
Coronavirus Proteases
similarity (1)
#205 - Jan 2017
Nuclear Pore Complex
similarity (1)
#67 - Jul 2005
TATA-Binding Protein
similarity (1)
#31 - Jul 2002
p53 Tumor Suppressor
similarity (1)
#249 - Sep 2020
SARS-CoV-2 RNA-dependent RNA Polymerase
similarity (1)
#47 - Nov 2003
Simian Virus 40
similarity (1)
#122 - Feb 2010
Enhanceosome
similarity (1)
#213 - Sep 2017
Sirtuins
similarity (1)
#221 - May 2018
Human Papillomavirus and Vaccines
similarity (1)

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Assembly

Deposited unit

A: Elongin-B

B: Elongin-C

C: von Hippel-Lindau disease tumor suppressor

D: Elongin-B

E: Elongin-C

F: von Hippel-Lindau disease tumor suppressor

G: Elongin-B

H: Elongin-C

I: von Hippel-Lindau disease tumor suppressor

J: Elongin-B

K: Elongin-C

L: von Hippel-Lindau disease tumor suppressor

hetero molecules

168 kDa, 12 polymers
Search similar-shape structures of this assembly by Omokage search (details)

A: Elongin-B

B: Elongin-C

C: von Hippel-Lindau disease tumor suppressor

hetero molecules

defined by author&software
Evidence: gel filtration
42 kDa, 3 polymers
Search similar-shape structures of this assembly by Omokage search (details)

D: Elongin-B

E: Elongin-C

F: von Hippel-Lindau disease tumor suppressor

hetero molecules

defined by author&software
42 kDa, 3 polymers
Search similar-shape structures of this assembly by Omokage search (details)

G: Elongin-B

H: Elongin-C

I: von Hippel-Lindau disease tumor suppressor

hetero molecules

defined by author&software
42 kDa, 3 polymers
Search similar-shape structures of this assembly by Omokage search (details)

J: Elongin-B

K: Elongin-C

L: von Hippel-Lindau disease tumor suppressor

hetero molecules

defined by author&software
42.1 kDa, 3 polymers
Search similar-shape structures of this assembly by Omokage search (details)

Unit cell

Length a, b, c (Å)	93.334, 93.334, 365.296
Angle α, β, γ (deg.)	90.000, 90.000, 90.000
Int Tables number	91
Space group name H-M	P4₁22

Noncrystallographic symmetry (NCS)

NCS domain:
NCS domain segments:

Component-ID: 0 / Refine code: 0

Dom-ID	Ens-ID	Beg auth comp-ID	Beg label comp-ID	End auth comp-ID	End label comp-ID	Auth asym-ID	Label asym-ID	Auth seq-ID	Label seq-ID
1	1	MET	MET	MET	MET	A	A	1 - 103	1 - 103
2	1	MET	MET	MET	MET	D	D	1 - 103	1 - 103
1	2	MET	MET	LYS	LYS	A	A	1 - 104	1 - 104
2	2	MET	MET	LYS	LYS	G	G	1 - 104	1 - 104
1	3	MET	MET	LYS	LYS	A	A	1 - 104	1 - 104
2	3	MET	MET	LYS	LYS	J	J	1 - 104	1 - 104
1	4	MET	MET	CYS	CYS	B	B	16 - 112	1 - 97
2	4	MET	MET	CYS	CYS	E	E	16 - 112	1 - 97
1	5	MET	MET	CYS	CYS	B	B	16 - 112	1 - 97
2	5	MET	MET	CYS	CYS	H	H	16 - 112	1 - 97
1	6	MET	MET	CYS	CYS	B	B	16 - 112	1 - 97
2	6	MET	MET	CYS	CYS	K	K	16 - 112	1 - 97
1	7	VAL	VAL	GLN	GLN	C	C	62 - 203	11 - 152
2	7	VAL	VAL	GLN	GLN	F	F	62 - 203	11 - 152
1	8	VAL	VAL	ARG	ARG	C	C	62 - 205	11 - 154
2	8	VAL	VAL	ARG	ARG	I	I	62 - 205	11 - 154
1	9	VAL	VAL	ARG	ARG	C	C	62 - 205	11 - 154
2	9	VAL	VAL	ARG	ARG	L	L	62 - 205	11 - 154
1	10	MET	MET	MET	MET	D	D	1 - 103	1 - 103
2	10	MET	MET	MET	MET	G	G	1 - 103	1 - 103
1	11	MET	MET	MET	MET	D	D	1 - 103	1 - 103
2	11	MET	MET	MET	MET	J	J	1 - 103	1 - 103
1	12	MET	MET	CYS	CYS	E	E	16 - 112	1 - 97
2	12	MET	MET	CYS	CYS	H	H	16 - 112	1 - 97
1	13	MET	MET	CYS	CYS	E	E	16 - 112	1 - 97
2	13	MET	MET	CYS	CYS	K	K	16 - 112	1 - 97
1	14	VAL	VAL	GLN	GLN	F	F	62 - 203	11 - 152
2	14	VAL	VAL	GLN	GLN	I	I	62 - 203	11 - 152
1	15	VAL	VAL	GLN	GLN	F	F	62 - 203	11 - 152
2	15	VAL	VAL	GLN	GLN	L	L	62 - 203	11 - 152
1	16	MET	MET	LYS	LYS	G	G	1 - 104	1 - 104
2	16	MET	MET	LYS	LYS	J	J	1 - 104	1 - 104
1	17	MET	MET	CYS	CYS	H	H	16 - 112	1 - 97
2	17	MET	MET	CYS	CYS	K	K	16 - 112	1 - 97
1	18	VAL	VAL	ILE	ILE	I	I	62 - 206	11 - 155
2	18	VAL	VAL	ILE	ILE	L	L	62 - 206	11 - 155

NCS ensembles :

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Components

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Protein , 4 types, 12 molecules ADGBEHKCFILJ

#1: Protein	Elongin-B / EloB / Elongin 18 kDa subunit / RNA polymerase II transcription factor SIII subunit B / SIII p18 / ...EloB / Elongin 18 kDa subunit / RNA polymerase II transcription factor SIII subunit B / SIII p18 / Transcription elongation factor B polypeptide 2 Mass: 11748.406 Da / Num. of mol.: 3 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: ELOB, TCEB2 / Production host: Escherichia coli (E. coli) / References: UniProt: Q15370
#2: Protein	Elongin-C / EloC / Elongin 15 kDa subunit / RNA polymerase II transcription factor SIII subunit C / SIII p15 / ...EloC / Elongin 15 kDa subunit / RNA polymerase II transcription factor SIII subunit C / SIII p15 / Transcription elongation factor B polypeptide 1 Mass: 10974.616 Da / Num. of mol.: 4 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: ELOC, TCEB1 / Production host: Escherichia coli (E. coli) / References: UniProt: Q15369
#3: Protein	von Hippel-Lindau disease tumor suppressor / Protein G7 / pVHL Mass: 18806.273 Da / Num. of mol.: 4 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: VHL / Production host: Escherichia coli (E. coli) / References: UniProt: P40337
#4: Protein	Elongin-B / EloB / Elongin 18 kDa subunit / RNA polymerase II transcription factor SIII subunit B / SIII p18 / ...EloB / Elongin 18 kDa subunit / RNA polymerase II transcription factor SIII subunit B / SIII p18 / Transcription elongation factor B polypeptide 2 Mass: 11852.389 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: ELOB, TCEB2 / Production host: Escherichia coli (E. coli) / References: UniProt: Q15370

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Non-polymers , 2 types, 429 molecules

#5: Chemical	ChemComp-QE0 / (2~{S},4~{R})-~{N}-[(1~{S})-1-[4-chloranyl-2-(2-methoxyethoxy)phenyl]ethyl]-1-[(2~{R})-3-methyl-2-(3-methyl-1,2-oxazol-5-yl)butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide Mass: 508.007 Da / Num. of mol.: 4 / Source method: obtained synthetically / Formula: C₂₅H₃₄ClN₃O₆ / Feature type: SUBJECT OF INVESTIGATION
#6: Water	ChemComp-HOH / water / Water Mass: 18.015 Da / Num. of mol.: 425 / Source method: isolated from a natural source / Formula: H₂O

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Details

Has ligand of interest	Y

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Experimental details

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Experiment

Experiment	Method: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

Crystal	Density Matthews: 2.4 Å³/Da / Density % sol: 48.76 %
Crystal grow	Temperature: 293 K / Method: vapor diffusion, hanging drop Details: 10-20% PEG 8000, 0.2 M magnesium acetate and 0.1 M sodium cacodylate pH 6.5, 1 mM Compound soak

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Data collection

Diffraction	Mean temperature: 100 K / Serial crystal experiment: N
Diffraction source	Source: SYNCHROTRON / Site: SLS / Beamline: X10SA / Wavelength: 0.97625 Å
Detector	Type: DECTRIS PILATUS 6M / Detector: PIXEL / Date: Nov 8, 2021
Radiation	Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelength	Wavelength: 0.97625 Å / Relative weight: 1
Reflection	Resolution: 2.016→91.33 Å / Num. obs: 88515 / % possible obs: 100 % / Redundancy: 26.6 % / CC_1/2: 0.998 / R_merge(I) obs: 0.135 / R_pim(I) all: 0.027 / R_rim(I) all: 0.138 / Net I/σ(I): 14.8
Reflection shell	Resolution: 2.016→2.168 Å / Redundancy: 24.4 % / R_merge(I) obs: 2.69 / Mean I/σ(I) all: 1.4 / Num. measured obs: 108028 / Num. unique obs: 4426 / CC_1/2: 0.63 / R_pim(I) all: 0.772 / R_rim(I) all: 2.799

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Phasing

Phasing	Method: molecular replacement

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Processing

Software

Name	Version	Classification
XDS		data reduction
Aimless		data scaling
PHASER		phasing
REFMAC	5.8.0267	refinement
PDB_EXTRACT	3.27	data extraction

Refinement

Method to determine structure:

MOLECULAR REPLACEMENT
Starting model: 5nw1

5nw1

Resolution: 2.02→91.33 Å / Cor.coef. F_o:F_c: 0.967 / Cor.coef. F_o:F_c free: 0.954 / SU B: 11.74 / SU ML: 0.152 / SU R Cruickshank DPI: 0.2306 / Cross valid method: THROUGHOUT / σ(F): 0 / ESU R: 0.231 / ESU R Free: 0.193 / Stereochemistry target values: MAXIMUM LIKELIHOOD
Details: U VALUES : WITH TLS ADDED HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

	R_factor	Num. reflection	% reflection	Selection details
R_free	0.2394	4449	5 %	RANDOM
R_work	0.1941	-	-	-
obs	0.1964	84066	82.2 %	-

Solvent computation

Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.2 Å / Solvent model: MASK

Displacement parameters

B_iso max: 148.92 Å² / B_iso mean: 57.375 Å² / B_iso min: 29.68 Å²

	B_aniso -1	B_aniso -2	B_aniso -3
1-	-0.01 Å²	0 Å²	0 Å²
2-	-	-0.01 Å²	0 Å²
3-	-	-	0.02 Å²

Refinement step

Cycle: final / Resolution: 2.02→91.33 Å

	Protein	Nucleic acid	Ligand	Solvent	Total
Num. atoms	10791	0	140	425	11356
B_iso mean	-	-	59.04	51.68	-
Num. residues	-	-	-	-	1351

Refine LS restraints

Refine-ID	Type	Dev ideal	Dev ideal target	Number
X-RAY DIFFRACTION	r_bond_refined_d	0.013	0.013	11192
X-RAY DIFFRACTION	r_bond_other_d	0.001	0.017	10659
X-RAY DIFFRACTION	r_angle_refined_deg	1.821	1.66	15209
X-RAY DIFFRACTION	r_angle_other_deg	1.327	1.599	24560
X-RAY DIFFRACTION	r_dihedral_angle_1_deg	7.462	5	1336
X-RAY DIFFRACTION	r_dihedral_angle_2_deg	32.791	21.279	602
X-RAY DIFFRACTION	r_dihedral_angle_3_deg	16.051	15	1872
X-RAY DIFFRACTION	r_dihedral_angle_4_deg	20.642	15	94
X-RAY DIFFRACTION	r_chiral_restr	0.082	0.2	1471
X-RAY DIFFRACTION	r_gen_planes_refined	0.009	0.02	12418
X-RAY DIFFRACTION	r_gen_planes_other	0.001	0.02	2518

Refine LS restraints NCS

Refine-ID: X-RAY DIFFRACTION / Type: interatomic distance / Weight position: 0.05

Ens-ID	Dom-ID	Auth asym-ID	Number	Rms dev position (Å)
1	1	A	3048	0.08
1	2	D	3048	0.08
2	1	A	3101	0.07
2	2	G	3101	0.07
3	1	A	3122	0.07
3	2	J	3122	0.07
4	1	B	2684	0.06
4	2	E	2684	0.06
5	1	B	2629	0.06
5	2	H	2629	0.06
6	1	B	2646	0.06
6	2	K	2646	0.06
7	1	C	4520	0.07
7	2	F	4520	0.07
8	1	C	4545	0.07
8	2	I	4545	0.07
9	1	C	4563	0.07
9	2	L	4563	0.07
10	1	D	3036	0.06
10	2	G	3036	0.06
11	1	D	3036	0.07
11	2	J	3036	0.07
12	1	E	2628	0.06
12	2	H	2628	0.06
13	1	E	2647	0.06
13	2	K	2647	0.06
14	1	F	4493	0.07
14	2	I	4493	0.07
15	1	F	4488	0.08
15	2	L	4488	0.08
16	1	G	3113	0.06
16	2	J	3113	0.06
17	1	H	2665	0.05
17	2	K	2665	0.05
18	1	I	4641	0.07
18	2	L	4641	0.07

LS refinement shell

Resolution: 2.02→2.068 Å / R_factor R_free error: 0

	R_factor	Num. reflection	% reflection
R_free	0.36	15	-
R_work	0.339	267	-
obs	-	-	3.59 %

Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

ID	L11 (°²)	L12 (°²)	L13 (°²)	L22 (°²)	L23 (°²)	L33 (°²)	S11 (Å °)	S12 (Å °)	S13 (Å °)	S21 (Å °)	S22 (Å °)	S23 (Å °)	S31 (Å °)	S32 (Å °)	S33 (Å °)	T11 (Å²)	T12 (Å²)	T13 (Å²)	T22 (Å²)	T23 (Å²)	T33 (Å²)	Origin x (Å)	Origin y (Å)	Origin z (Å)
1	15.64	-8.4696	1.8925	11.112	-3.9243	13.6822	0.2172	0.2336	-0.8655	-0.1991	-0.0303	0.0501	1.0848	0.3025	-0.187	0.2694	-0.0155	-0.0522	0.2885	-0.0319	0.3213	21.1605	-10.8637	36.0567
2	4.9259	-2.945	-0.7824	7.0822	0.3027	6.0276	-0.0174	-0.2394	0.4105	0.2404	0.0712	-0.1668	-0.3282	-0.1185	-0.0538	0.2214	-0.012	-0.035	0.1919	-0.0292	0.2534	16.7171	2.7252	40.023
3	4.1459	-1.2758	0.4418	5.8181	-2.2096	5.2307	-0.2454	-0.1619	0.3412	0.1709	0.0177	-0.2778	-0.4011	0.4422	0.2278	0.1097	-0.0467	-0.1057	0.2162	0.0048	0.2196	27.6153	-1.6987	44.6103
4	19.5497	7.6194	1.0573	14.1555	-0.2457	6.9623	-0.0327	-0.6371	-0.0237	0.4594	0.0998	0.1211	-0.2311	-0.1833	-0.067	0.2898	0.0901	-0.0151	0.2874	-0.0086	0.2151	18.4968	-1.4447	51.7759
5	5.8293	-1.2078	1.2777	6.2317	-0.4058	5.8709	0.0355	-0.5235	-0.3274	0.4301	0.2944	0.1868	0.143	-0.1704	-0.3299	0.1621	-0.0097	-0.0356	0.2614	0.0823	0.2106	22.2165	-10.5453	50.5325
6	10.7465	0.661	3.6343	14.2308	-8.0821	17.8304	0.2766	-0.0038	-0.8439	-0.6672	-0.1463	-0.0663	1.4841	-0.6329	-0.1302	0.2377	-0.0066	0.0005	0.2305	0.0081	0.3272	15.5478	-13.9242	38.5333
7	2.5064	1.5187	3.1836	6.8301	6.9165	12.0899	-0.2104	-0.2274	0.2223	-0.0857	-0.0039	0.3472	-0.2269	-0.0634	0.2143	0.2384	-0.0037	-0.0326	0.2085	0.0031	0.2488	16.002	-2.7215	41.1407
8	14.0426	0.4709	6.9398	6.5362	3.3512	10.5481	-0.4176	-0.775	0.9312	0.7496	0.2325	-0.3047	-0.9658	0.1523	0.1851	0.4536	0.0273	0.0083	0.305	-0.1189	0.3323	17.2668	7.6378	53.5237
9	25.9412	-1.2475	16.0366	8.2699	1.3846	18.4888	0.0675	-0.203	0.0072	-0.2102	-0.2719	0.6668	0.165	-1.2983	0.2044	0.2528	0.0162	0.0671	0.2777	-0.0211	0.3091	0.0126	4.5039	34.8374
10	8.0205	3.6178	9.8286	1.7145	5.2016	25.8478	0.1821	-0.5106	-0.3237	-0.0044	-0.2341	0.0721	0.1752	-1.3013	0.052	0.4417	-0.0371	-0.1783	0.5867	0.0109	1.2453	-10.5353	-0.794	24.3207
11	30.7425	-6.2756	-0.7634	16.931	-4.9793	25.1169	-0.321	0.3059	-0.0679	-0.2447	-0.0919	-1.4074	0.8466	1.6546	0.4129	0.334	-0.1107	0.0716	0.3396	-0.1374	0.6942	25.7526	5.4916	31.988
12	9.6109	-4.7258	0.2464	3.9277	-0.3682	1.1466	-0.2002	-0.1076	0.4884	0.1884	0.0337	-0.1402	-0.3139	0.0486	0.1665	0.2683	0.0149	-0.0217	0.1738	-0.0191	0.2886	13.8349	9.0779	33.8597
13	16.2309	1.8673	3.722	19.721	-2.0598	25.5245	0.0903	0.1153	0.2484	-0.3837	-0.1172	-1.0882	0.4141	1.0813	0.0269	0.2278	0.0189	0.0277	0.2543	-0.0031	0.308	24.2033	1.9057	25.8719
14	8.0383	-0.3681	2.4911	9.1371	-3.5617	13.0166	-0.0995	0.0026	0.5564	-0.1773	-0.2111	-0.4723	-0.3874	0.7839	0.3106	0.2731	0.01	-0.0123	0.2526	0.0514	0.293	20.7733	9.1992	19.9599
15	4.9152	-1.3857	-3.8134	4.5666	-2.3103	5.9469	-0.0046	0.2854	0.639	0.0503	0.0608	-0.529	-0.3315	-0.1242	-0.0562	0.5586	-0.144	-0.1167	0.308	0.0879	0.4626	15.8811	13.8764	26.3808
16	2.6363	-1.7608	0.6719	5.0816	0.092	4.5627	0.0275	-0.1285	0.0737	0.1799	0.0218	0.2655	-0.0699	-0.2079	-0.0493	0.2419	0.0016	-0.0161	0.1556	-0.0172	0.2914	9.6867	1.671	29.154
17	5.5634	-2.6155	0.6165	12.4635	2.8504	4.6386	0.1573	0.2631	-0.0724	-0.4367	0.0796	-0.5231	0.3725	0.4243	-0.2369	0.2685	0.0267	-0.0269	0.2084	-0.0093	0.24	18.4684	-7.8385	24.6303
18	19.9652	-2.6547	1.6825	0.4843	-0.0962	0.2819	-0.4823	-0.8969	-1.453	0.0639	0.504	0.1604	0.0044	0.304	-0.0217	0.9449	0.0367	0.1824	1.1573	0.04	1.2077	19.1055	-17.1649	21.7696
19	3.0942	-3.6747	0.1646	12.4536	-1.4919	3.239	-0.0973	-0.3122	-0.1323	0.2135	0.1473	0.5637	0.2265	-0.4672	-0.0499	0.2657	-0.0504	-0.0444	0.2508	-0.0088	0.2666	4.5339	-7.5885	26.4649
20	11.0507	4.907	-2.3984	9.5145	-5.425	8.6589	0.0688	-0.2171	0.0907	-0.153	-0.2453	0.1535	-0.2975	-0.2097	0.1764	0.2588	0.0407	-0.0417	0.1416	-0.026	0.2584	6.5093	3.8785	20.7045
21	5.0182	-6.099	-0.6113	26.7345	-0.5006	2.0631	0.098	0.4063	0.5904	-1.2727	0.0566	-0.787	-0.3871	-0.1326	-0.1546	0.283	-0.0322	0.0106	0.2447	0.0143	0.321	13.8494	-25.7117	-6.189
22	1.3493	-1.2651	-8.2861	10.6203	16.4065	58.8538	-0.1844	0.1207	-0.0527	-0.0599	0.1307	-0.1493	1.024	-0.5569	0.0536	0.2879	0.0038	-0.0532	0.2831	0.0099	0.4343	15.0544	-36.0178	2.8332
23	1.5904	-0.3971	-0.6296	3.6821	2.3263	6.3915	0.0186	0.0435	-0.0013	0.2059	0.0338	-0.1458	0.1095	0.0184	-0.0524	0.2318	-0.0205	-0.0842	0.0283	0.0358	0.1807	6.058	-24.5289	7.0503
24	10.6731	-13.1784	-10.0823	20.8804	17.6465	15.4478	0.0559	0.112	-0.3825	0.4304	-0.3326	0.31	0.4041	-0.3472	0.2766	0.4138	-0.0018	-0.0376	0.1791	0.0489	0.3234	6.574	-30.784	15.6836
25	2.9834	-2.7524	-2.7399	7.2334	5.3674	5.3505	0.1244	0.1068	-0.0117	-0.0841	-0.0452	-0.1782	-0.1381	-0.0269	-0.0792	0.2495	-0.0151	-0.104	0.0992	0.049	0.2086	9.1411	-23.4156	6.7026
26	25.6237	2.1375	4.3586	23.4332	-5.0437	41.3504	-0.4229	-0.4732	1.0395	0.1602	-0.0575	-0.6231	-1.2985	0.1425	0.4804	0.2727	-0.0102	-0.0257	0.1941	-0.078	0.3368	17.2873	-19.2263	10.8425
27	0.9466	0.876	-0.2283	2.318	1.9381	3.13	0.04	0.0196	-0.1371	0.2178	0.1793	-0.3262	0.2347	0.1901	-0.2193	0.3727	-0.0045	-0.1704	0.1501	-0.0105	0.3074	10.8629	-17.5915	13.8679
28	10.8229	4.5811	-2.5972	6.6466	0.9855	11.582	0.1749	0.192	0.8951	-0.403	0.0291	0.9076	-0.9088	-1.2472	-0.204	0.3356	0.1916	-0.1767	0.2786	0.0897	0.3957	-4.9381	1.6482	11.987
29	15.9467	-11.8188	-16.9115	12.1743	14.4086	24.3955	0.509	0.7376	0.7257	-0.5024	-0.0752	-0.1822	-0.5996	-0.8607	-0.4338	0.408	0.0257	-0.0571	0.2287	0.0917	0.3611	4.9481	-11.2833	2.4584
30	13.23	-0.3621	7.0473	0.384	-0.8937	5.1429	-0.1902	-0.1428	-0.0918	0.5814	0.2544	-0.1351	-1.2795	-0.5158	-0.0643	1.0972	0.0841	0.1209	1.0646	-0.1179	1.0402	14.8777	-10.8971	-1.3424
31	20.0113	-4.0825	-0.9058	14.5089	-7.5007	21.7332	-0.0606	0.088	-1.0491	-0.3616	0.0437	-0.271	0.9226	1.03	0.0169	0.229	-0.0743	-0.007	0.3314	0.0076	0.2476	66.8454	-6.9322	36.1114
32	4.4822	-1.3798	0.7315	3.988	-2.8553	5.9472	-0.0063	-0.4266	0.166	0.4405	-0.0107	-0.4651	-1.1479	0.5186	0.017	0.3903	-0.1894	-0.0003	0.2764	-0.0521	0.1038	68.0733	1.8843	42.2292
33	8.341	-1.2467	0.1709	2.3476	1.7807	6.0017	-0.18	-0.6103	0.4376	0.6198	-0.0463	-0.799	-0.8393	0.5382	0.2263	0.8183	-0.2354	-0.2599	0.5389	0.0053	0.6132	71.3693	7.9345	48.1135
34	22.6364	11.3164	4.2523	18.2556	6.0132	11.8033	0.2071	-0.3324	-0.5114	0.3226	-0.082	0.3478	0.0976	-0.5422	-0.125	0.4656	-0.0255	0.0378	0.3816	0.0582	0.2703	60.3438	-2.0462	51.9457
35	12.0781	9.6795	3.8482	17.6372	7.033	12.7922	0.2671	-1.0287	-0.6451	0.9068	-0.2937	-0.3511	-0.1538	-0.0823	0.0266	0.2891	-0.0525	-0.0689	0.476	0.056	0.2092	70.0751	-6.8519	50.3639
36	8.3155	-1.7405	2.382	9.2005	-0.8068	17.0509	0.2293	-0.1277	-0.4179	-0.3771	-0.0244	-0.2178	0.5501	-0.0055	-0.2049	0.2023	-0.0508	0.0086	0.2609	0.0439	0.3044	62.9827	-10.3628	42.7039
37	2.2503	-3.4023	-0.5408	6.3876	1.1053	23.3069	0.1644	-0.0005	0.0138	-0.0554	-0.3372	0.514	0.2395	-0.4349	0.1728	0.3086	-0.0512	0.0412	0.3014	-0.0304	0.3038	59.7735	-4.0193	36.1218
38	3.3066	5.0583	6.455	7.827	9.8407	12.6171	-0.2079	-0.0003	0.1418	0.0002	-0.0784	0.0873	-0.5373	0.0361	0.2864	1.4412	-0.1831	-0.143	0.8287	-0.1725	0.5829	66.966	10.4447	53.6971
39	7.5162	4.5247	13.0921	4.7263	4.1892	29.7222	-0.1794	-0.3435	0.6084	0.157	-0.4327	0.5349	-0.6119	-0.2226	0.6121	0.6454	0.0343	-0.0034	0.4752	-0.1063	0.5199	57.0006	10.0206	48.1661
40	10.8235	-1.1756	5.8253	0.2352	-0.6884	6.1219	0.0199	-0.2233	0.0025	0.2162	0.062	0.3371	0.1838	-0.834	-0.0819	0.8297	0.085	0.4805	0.8104	0.0781	1.1898	40.2706	6.3158	28.6801
41	24.5171	-3.3586	-0.6683	21.9619	-3.2728	21.7025	-0.1007	0.5328	-0.494	0.2642	-0.4288	-1.9082	0.4463	1.5439	0.5295	0.4191	-0.1843	-0.0244	0.3747	-0.0011	0.3738	71.9588	9.4244	31.7549
42	11.8016	-5.1815	-2.8712	5.979	-1.673	3.1986	-0.1804	-0.0518	-0.1818	0.6051	0.0809	0.313	-0.3888	0.0303	0.0995	0.498	-0.0227	0.037	0.2872	-0.0331	0.4008	57.4335	15.163	33.4899
43	13.452	-4.6235	-8.3046	3.2644	2.1596	15.6928	-0.2448	0.2502	-0.0759	0.309	0.116	-0.4993	-0.2912	0.6478	0.1288	0.45	-0.1018	-0.029	0.2837	-0.0087	0.2186	67.4067	8.5268	30.9998
44	2.1673	-3.0809	4.7465	6.5696	-8.8367	12.4207	-0.0435	0.1708	0.1983	0.16	-0.4997	-0.412	-0.3086	0.6966	0.5432	0.4987	-0.129	0.0388	0.3568	-0.05	0.3289	67.1915	11.1333	21.281
45	66.5878	-11.3311	37.1299	27.4341	6.9057	27.5665	-0.5467	1.409	0.095	1.1607	0.5142	-0.0601	0.3196	1.1622	0.0326	1.0089	-0.0679	0.4097	0.5231	0.1179	0.8502	68.9598	18.7775	29.4675
46	11.9489	-0.1389	1.8714	1.9855	3.6444	10.5288	-0.3013	0.0666	0.3358	-0.312	-0.0306	0.0839	-0.5452	-0.1053	0.3318	0.5242	0.0706	0.0843	0.0898	-0.0553	0.2494	54.8139	14.3543	28.29
47	5.8093	-3.2417	-0.0843	8.4413	-0.7539	8.699	0.1419	0.0427	-0.187	0.2092	0.0433	-0.0111	-0.1226	0.4152	-0.1852	0.292	-0.0611	0.0019	0.2016	-0.025	0.1347	61.6026	-0.8325	26.3057
48	10.0689	-0.0715	2.5376	2.888	3.0967	4.0014	0.2693	-0.7397	-1.1551	0.4383	0.4466	-0.3985	0.5523	0.3226	-0.7159	0.5966	0.1178	0.0012	0.6801	0.1815	0.7001	65.8223	-12.142	21.4228
49	3.9067	-2.7848	0.7289	10.1824	-1.2634	4.3583	0.0902	-0.3387	0.217	0.5071	0.2969	0.4718	-0.1688	-0.5777	-0.3871	0.3056	-0.0311	0.107	0.2759	0.007	0.2557	50.0846	-0.8663	25.5633
50	8.7976	6.647	-0.1577	14.3158	-3.141	6.6736	0.1269	0.1208	0.2749	0.1679	-0.0922	0.1016	-0.4476	0.1561	-0.0347	0.3414	0.0172	0.0612	0.1277	-0.0212	0.2609	55.0798	9.0046	19.0092
51	6.3406	-7.8144	1.4495	24.6301	0.5669	0.7198	0.2198	0.4467	0.3846	-1.6726	-0.1986	-0.6589	-0.147	0.1622	-0.0212	0.442	-0.0779	0.0011	0.401	0.0292	0.3795	60.9726	-21.0859	-5.8459
52	5.3307	-2.5884	-2.7227	8.8424	3.3386	3.2332	0.0269	0.1516	-0.4251	-0.0967	-0.0434	-0.0681	0.1414	-0.0763	0.0165	0.2618	-0.0268	-0.08	0.1428	0.0399	0.3846	60.8086	-29.5089	6.1915
53	2.0681	-0.2336	-0.5711	3.4009	0.8892	6.1714	0.0784	0.016	-0.1142	0.0915	0.0096	0.1266	0.2193	-0.1457	-0.0879	0.1916	-0.0223	-0.0631	0.1132	0.0415	0.244	51.8562	-20.081	8.1703
54	0.9121	1.1114	-3.6302	6.4054	-0.8586	17.6141	-0.1344	0.0324	-0.1718	0.2004	-0.1804	0.0573	0.6392	-0.2887	0.3148	0.3214	0.0173	0.0077	0.2491	0.0563	0.6003	58.3484	-29.8007	6.2284
55	3.9649	-2.4212	-1.9528	4.4026	3.3296	4.7357	0.1408	0.1536	0.1219	-0.1071	-0.0732	0.0702	-0.2072	-0.104	-0.0676	0.2257	-0.0425	-0.0511	0.0599	0.0554	0.2294	54.1011	-15.2334	8.8055
56	7.9056	3.0671	0.8116	18.2056	0.1963	30.6966	-0.2931	-0.1553	0.6231	-0.0854	0.2702	-0.3346	-1.4995	-0.0717	0.023	0.2051	-0.0083	0.0195	0.2215	0.0036	0.3353	63.6645	-14.3486	9.9904
57	1.3476	-0.982	-1.2707	5.0184	1.1503	2.2811	0.0396	-0.1547	-0.0498	0.4354	0.1276	0.2858	0.0526	0.0086	-0.1672	0.1998	-0.0539	-0.0403	0.0931	0.0375	0.2246	54.5325	-11.5119	14.1595
58	4.3664	2.579	1.2398	1.5952	0.1064	6.1079	-0.1659	0.3145	0.6032	-0.0029	0.3005	0.4288	-0.8422	-1.1535	-0.1346	0.3974	0.1273	0.0276	0.4291	-0.0187	0.6994	41.5646	9.3205	12.9654
59	6.1719	-7.0078	-4.8166	23.9653	8.7934	4.4703	0.0999	0.3592	0.0363	-0.6728	-0.1169	0.5981	-0.2016	-0.2378	0.017	0.2885	0.0506	-0.0466	0.2743	0.104	0.3725	47.3133	-1.4849	6.2547
60	12.8806	-5.1711	-1.4629	6.983	-2.6632	13.0052	0.5725	0.3734	1.4437	0.1056	0.1299	-0.0603	-1.451	0.8977	-0.7025	0.6291	-0.0969	0.1002	0.3694	-0.0318	0.432	58.4421	-6.1457	-0.7009
61	12.2972	-5.2209	0.5283	10.7441	2.1087	9.8611	0.1829	-0.1471	-0.4717	0.3972	0.1078	-0.7377	0.5775	0.9647	-0.2907	0.4697	0.0976	-0.0551	0.5241	-0.0362	0.3057	63.0045	-51.0498	37.1404
62	0.9503	-1.9357	-1.9902	5.3674	1.3577	9.6441	-0.0341	-0.0672	0.1994	0.3109	0.1341	-0.4518	-0.6291	0.0088	-0.0999	0.4272	-0.0235	-0.0399	0.2431	-0.0594	0.2695	57.9472	-37.6385	40.5709
63	5.9571	-5.3108	-1.2162	12.9071	-1.5321	9.0025	-0.1832	-0.2797	-0.0842	0.2566	0.34	-0.9796	0.2928	1.2765	-0.1567	0.2225	-0.0871	-0.1044	0.4932	0.0041	0.3386	69.2484	-48.3469	45.1604
64	3.3118	-3.5081	0.8259	4.8976	-4.2835	10.1537	-0.0645	-0.2431	0.4645	0.4638	0.0275	-0.4366	-1.1861	0.7896	0.037	0.4659	-0.2141	-0.1328	0.474	-0.0408	0.4974	68.8007	-35.5698	47.0086
65	10.894	0.3588	0.8642	9.5248	-2.9846	6.9287	-0.1869	-0.613	-0.5524	0.6493	0.2749	-0.1819	-0.0801	0.0387	-0.088	0.4938	0.0387	-0.0336	0.3748	-0.0161	0.1913	59.1939	-45.4487	52.3723
66	9.3113	7.3513	6.7609	12.7055	2.0892	9.5852	-0.0759	-0.415	-0.6465	0.456	0.5221	-0.3141	0.7975	0.1567	-0.4462	0.5844	0.1645	0.0217	0.603	0.0765	0.4728	64.2293	-54.443	49.2574
67	11.1813	3.2118	-1.3795	2.3583	-5.8627	21.0406	-0.0853	-0.3617	-1.3207	-0.3374	0.0142	-0.3841	1.1817	-0.3354	0.0711	0.4059	0.0467	-0.0735	0.2648	-0.0218	0.4593	58.4968	-55.0799	37.852
68	1.7463	0.5485	1.6857	10.5228	9.0741	9.6779	-0.3949	-0.2513	0.2851	0.4332	0.3298	-0.2338	-0.3735	0.606	0.0651	0.5059	-0.0766	-0.0657	0.3459	-0.0161	0.2653	59.5739	-38.9657	47.6407
69	3.6681	1.7895	5.9522	1.7259	2.069	15.5058	-0.2732	-0.1768	0.411	0.407	-0.2535	0.1325	-0.358	0.1325	0.5267	0.4972	0.0096	0.0072	0.295	-0.0288	0.3188	52.2035	-36.2399	46.2644
70	6.8982	8.6302	9.6796	11.0094	11.5892	21.3414	0.2176	-0.3498	-0.0307	0.2746	-0.3851	0.2971	0.6001	-0.9189	0.1676	0.387	0.077	-0.0354	0.5281	-0.0732	0.731	35.257	-41.7198	24.71
71	23.7004	0.5861	-3.6916	8.0931	-3.0998	27.2792	-0.1033	-0.2827	-0.0033	0.2336	-0.1386	-1.9074	0.659	1.7942	0.242	0.4738	-0.1358	-0.0426	0.3495	-0.063	0.4778	68.3584	-35.8913	32.9857
72	12.709	-3.2674	1.1945	8.0732	-2.4239	2.9272	-0.4123	-0.0185	0.6317	0.2727	0.1278	-0.2772	-0.6212	0.2809	0.2845	0.4411	-0.0213	-0.0019	0.1741	-0.0637	0.1931	55.3332	-32.3212	33.6478
73	9.5578	-3.6923	6.5884	7.7025	-5.6694	25.0272	0.3445	0.0745	0.073	-0.1724	-0.2277	-0.2431	-0.0208	1.2711	-0.1168	0.3487	-0.0646	0.0091	0.2945	-0.0188	0.3503	66.4453	-39.5289	25.8774
74	1.512	4.2389	0.1205	12.433	3.7794	21.5899	0.0404	-0.182	-0.3087	0.0034	-0.1337	-0.8346	-0.6274	2.2981	0.0933	0.5077	-0.068	0.0033	0.6257	-0.1189	0.9174	65.6427	-32.1486	20.5677
75	7.307	6.5112	-0.0231	10.9888	-2.6262	4.1376	-0.1675	0.9863	0.3819	-0.0329	0.0873	-0.1802	-0.5882	0.6416	0.0802	0.5528	-0.03	0.0008	0.3551	0.0248	0.2818	57.4357	-28.4151	26.7336
76	1.8999	-1.6817	-1.8683	6.6256	1.7369	1.8983	0.0149	-0.0567	0.0965	-0.1705	0.0463	0.0813	-0.1008	-0.0248	-0.0613	0.4135	0.0127	-0.0186	0.1444	-0.0472	0.1935	54.802	-42.0906	27.9531
77	16.5804	5.9131	-1.3287	14.8685	5.4535	11.7154	-0.2464	0.4391	-0.4828	-0.6276	0.2113	-0.9755	0.2938	0.9986	0.0351	0.3323	0.0281	0.009	0.255	-0.0283	0.2953	65.0137	-52.4877	23.6638
78	6.5661	-0.8381	-4.2746	15.5112	0.5546	7.1972	-0.1735	-0.2836	-0.284	0.1522	-0.0545	-1.0801	0.3804	0.5626	0.228	0.3813	-0.0177	-0.0335	0.2292	0.0035	0.2302	57.3178	-56.4741	24.4461
79	2.1969	-5.5085	2.6479	18.3238	-5.5155	5.3892	0.1475	-0.131	-0.2921	0.086	-0.1057	0.7397	0.1335	-0.3919	-0.0418	0.3384	-0.0097	-0.0048	0.3005	-0.0365	0.3445	43.603	-44.3879	24.9053
80	12.4071	3.4092	2.9149	9.8711	-3.9975	5.4651	0.025	0.2311	0.3118	-0.0222	-0.1349	-0.0485	-0.3713	0.0034	0.1099	0.4154	0.0324	0.0027	0.0984	-0.0633	0.2192	52.4346	-37.6699	19.0703
81	1.5389	-5.5309	-0.0981	20.6283	0.494	0.0342	0.3527	0.2587	0.2176	-1.6655	-0.3331	-0.883	-0.0841	0.1044	-0.0196	0.5979	-0.1425	0.0642	0.5769	0.0154	0.3782	61.2629	-68.1212	-5.572
82	7.8088	-5.4818	-8.8896	8.4635	7.9033	15.6246	-0.1978	0.1461	-0.4468	0.0231	-0.1352	0.047	0.5596	-0.11	0.333	0.2996	-0.0531	-0.0202	0.195	0.023	0.3271	60.2847	-75.4944	7.65
83	2.8505	-0.2714	-1.8667	2.9912	2.1288	6.8632	-0.0702	0.1742	-0.1513	0.0658	-0.07	0.0531	0.1474	-0.4228	0.1402	0.251	0.0119	-0.0228	0.1274	0.0072	0.2044	51.7285	-67.0363	7.8037
84	5.2069	1.9106	-2.0869	4.2787	-2.3634	11.481	-0.1296	0.2223	-0.5885	0.0628	0.0921	-0.0917	0.194	-0.0713	0.0375	0.2761	-0.0014	-0.0114	0.1569	-0.0171	0.2718	58.9204	-75.2679	5.3861
85	2.8454	-0.5349	-2.0345	4.6507	1.6835	2.4971	0.0455	0.0709	0.1076	-0.1459	-0.0146	0.0008	-0.2498	-0.113	-0.031	0.3789	-0.0017	-0.0495	0.0399	-0.0045	0.1427	55.2834	-60.9711	10.4159
86	3.3481	-1.8628	-1.416	8.4302	1.7244	3.2036	-0.2095	-0.0886	-0.2981	0.3423	0.1423	-0.3646	0.4081	0.1683	0.0672	0.2771	-0.0421	-0.0292	0.1835	0.002	0.2586	64.1825	-70.3064	11.4636
87	7.6027	-1.569	1.2851	4.5719	0.3864	3.9075	0.3373	0.4135	0.2076	-0.5246	-0.3619	0.7106	-0.3078	-0.5719	0.0247	0.394	0.0814	-0.0365	0.1477	-0.0438	0.2507	43.2704	-44.1094	14.0916
88	7.1595	-5.769	-5.209	20.4328	10.8623	6.7085	0.0494	0.4174	0.4718	-0.4141	-0.1895	0.6484	-0.2239	-0.4189	0.1401	0.4665	0.1146	-0.0931	0.3675	0.0361	0.3449	45.7569	-46.3752	6.8163
89	33.7877	8.1752	-4.1349	26.1025	3.6826	17.5885	-0.0471	0.3859	0.9567	0.3016	-0.1729	0.3817	-0.9453	0.27	0.22	0.476	0.0421	0.0072	0.1875	0.0765	0.2498	54.7843	-53.8337	0.1793
90	11.1017	3.9794	-19.7586	8.4881	0.5456	43.412	0.3685	-0.3242	0.5826	-0.2308	0.4241	0.4941	-1.0373	1.1611	-0.7926	0.6126	0.0135	0.0381	0.8264	0.2257	0.8232	63.9269	-51.6723	-2.4167
91	22.722	-11.2132	-3.8075	10.8789	2.4104	13.0004	-0.3072	-0.4164	-0.6248	0.2128	0.2367	-0.5214	0.6012	0.9023	0.0706	0.4744	0.083	-0.0636	0.3825	-0.1033	0.3844	56.6573	-17.9404	54.901
92	3.3668	-1.7359	-0.2526	3.5548	0.3644	4.2411	-0.1351	-0.0641	-0.164	-0.1467	0.1293	-0.022	0.267	-0.3881	0.0058	0.1564	-0.0764	0.004	0.2203	-0.0757	0.1838	47.5422	-16.586	49.8762
93	5.4652	-0.3205	0.0551	6.3862	-1.4431	7.3258	0.2389	0.5251	-0.5507	-0.2364	-0.1801	0.4601	0.6392	-0.582	-0.0588	0.2525	-0.075	-0.0132	0.2368	-0.1696	0.2286	42.4095	-22.3949	44.0221
94	18.4475	9.8643	1.5642	25.2782	8.0905	22.0005	0.017	0.1157	0.7367	-0.2713	-0.0128	-0.316	-0.8018	-0.0233	-0.0042	0.3074	0.0264	0.042	0.2988	0.0072	0.2473	50.6801	-9.4753	39.759
95	20.144	-8.0265	4.4198	12.4938	1.7355	5.6515	0.2388	1.2994	0.3139	-0.9843	-0.4623	-0.5012	0.0096	0.3941	0.2235	0.3616	-0.0246	0.0831	0.2894	-0.0313	0.272	54.6607	-19.769	38.9083
96	8.9981	0.689	0.8469	5.1538	4.3569	10.0649	0.2463	0.0751	-0.0059	-0.268	-0.1101	-0.2501	0.0267	0.3628	-0.1361	0.262	-0.0337	0.0749	0.2149	-0.0381	0.3884	59.1435	-15.5417	46.7306
97	0.7617	-2.2596	1.9226	8.9841	-0.071	19.8754	-0.0112	0.0309	0.1216	-0.1901	-0.0106	-0.5036	-0.5447	0.8949	0.0218	0.2599	-0.0476	0.0048	0.3748	-0.0677	0.3726	57.4632	-10.6428	56.7526
98	17.2246	1.7682	11.5476	3.0781	0.7392	11.1956	0.0638	1.0996	-0.6934	-0.7861	0.2007	0.3252	0.1335	0.0919	-0.2645	0.3445	0.0147	-0.0292	0.3385	-0.0584	0.2941	39.7972	-15.0487	39.8809
99	24.238	-2.9342	0.9968	6.9534	0.1364	11.8635	-0.1466	-0.2624	0.8054	-0.046	-0.2586	0.4972	-0.4343	-0.4374	0.4051	0.2525	0.007	-0.0447	0.3191	0.0256	0.1748	39.5098	-9.9963	38.9713
100	1.6252	0.603	2.894	6.3923	7.3777	12.2884	-0.3413	-0.1291	0.5244	-0.4557	0.2712	-0.3927	-1.3391	0.0775	0.0701	0.3734	0.0226	-0.0208	0.3377	-0.0422	0.4684	44.026	5.9103	61.41
101	17.2322	-9.6848	3.0503	24.7663	-4.8687	20.2074	0.5064	0.6397	-1.8207	-0.1644	-0.472	0.266	1.7476	0.459	-0.0344	0.2422	-0.0943	-0.0514	0.3149	-0.0603	0.2991	40.2979	-22.6369	58.9687
102	5.6437	-4.6534	-0.569	12.5396	-0.7471	3.2679	-0.1134	0.109	-0.2529	0.0835	-0.1061	0.615	0.2612	-0.4283	0.2195	0.1037	-0.0213	-0.0333	0.36	-0.0449	0.1984	37.0028	-10.4033	58.2973
103	7.66	0.5465	-4.1681	10.3692	4.6594	24.5581	-0.3152	-0.098	-0.4846	0.078	0.1542	0.1068	0.9312	0.2549	0.161	0.2371	-0.0204	-0.0221	0.2796	0.0078	0.2809	44.1577	-20.6593	66.6172
104	6.3001	2.4609	-1.7401	0.9628	-0.4938	27.8892	-0.2672	0.13	-0.4865	-0.0872	0.0324	-0.1873	2.4422	-1.0678	0.2349	0.5528	-0.0789	-0.1789	0.5316	-0.1033	1.0956	36.6689	-19.6922	71.426
105	11.542	11.1117	-1.1227	33.1193	-0.5712	4.2767	-0.1391	0.3447	-0.6455	-0.5449	0.2419	-0.596	0.0891	-0.4881	-0.1028	0.3412	0.0192	0.0541	0.5345	-0.0177	0.2579	32.7675	-16.0888	63.7213
106	8.0823	-2.6726	1.5923	2.5454	-0.8483	4.2019	0.1038	-0.1457	0.0925	0.1609	-0.1086	0.1485	-0.2001	-0.4045	0.0048	0.141	0.0014	-0.0146	0.2834	-0.0532	0.1731	42.5921	-7.6248	64.0393
107	18.4344	2.4583	-0.2026	11.8884	4.5127	12.6351	0.0073	-0.9681	-1.0526	0.5006	-0.0346	-0.1122	0.8866	0.4431	0.0274	0.1924	0.0334	-0.0175	0.2697	-0.0061	0.2608	56.175	-17.477	67.5432
108	12.5236	3.0782	0.0317	5.9256	0.1016	5.404	-0.0769	-0.388	-1.1078	0.0042	-0.0577	-0.564	0.6003	0.6726	0.1346	0.1969	-0.0002	0.0143	0.3464	-0.0215	0.2391	60.9789	-11.8014	67.2316
109	19.7085	-0.4391	-3.8552	3.1046	-1.7945	7.3856	0.1855	0.4985	0.7262	-0.3614	0.0312	-0.0236	-0.5347	-0.1627	-0.2167	0.2951	0.0264	-0.0181	0.2315	-0.029	0.3229	47.5287	2.2404	66.6654
110	12.6061	7.4812	-4.6761	12.7464	0.7493	7.253	-0.1623	-0.2643	-0.0495	0.3594	0.1216	0.1241	0.1857	-0.0821	0.0408	0.1145	0.0373	-0.0246	0.344	-0.0308	0.214	42.113	-7.1783	73.1539
111	20.4536	-6.7722	0.4225	2.8448	0.2369	0.276	-0.2391	-1.4328	-1.0538	0.3523	0.2495	0.3316	0.0748	-0.1852	-0.0104	0.4406	-0.0061	0.054	0.4385	0.0214	0.391	72.6253	-14.389	97.2174
112	5.8089	-2.1328	3.2363	5.5467	-2.6817	6.6177	0.1629	0.1398	-0.2133	-0.1426	-0.1056	-0.5091	0.2903	0.6011	-0.0573	0.0516	-0.0093	0.0528	0.2559	-0.0505	0.3208	79.1212	-13.6428	82.1664
113	3.0098	-0.3338	0.6989	3.1568	-0.2774	3.3359	-0.0044	-0.0644	0.0593	0.1098	-0.068	-0.1395	-0.1105	0.034	0.0724	0.0101	-0.0007	0.0111	0.2144	-0.0684	0.1504	71.9787	-6.9542	83.8297
114	17.8118	0.9248	-5.6561	13.7062	4.5317	37.2385	0.0775	0.2904	-0.1639	-0.351	-0.3595	0.8096	-0.548	-1.7484	0.282	0.1628	-0.0071	0.0082	0.2149	0.0198	0.2878	65.5426	-16.7478	81.5106
115	19.449	-9.312	-2.2776	12.1652	-1.5642	5.3135	0.316	-0.0356	-0.7113	-0.6459	-0.2174	-0.718	0.6521	0.7239	-0.0986	0.2749	0.0103	-0.0312	0.3162	-0.0308	0.3846	79.693	-20.7333	84.5006
116	18.6392	-5.3295	3.0395	3.2837	-1.5295	2.8283	0.2085	0.2582	-0.462	-0.3081	-0.1445	-0.1024	0.2068	0.19	-0.064	0.2058	-0.0114	0.0188	0.2403	-0.0294	0.2482	71.6024	-15.3405	75.952
117	4.7962	-1.3911	1.2595	5.0535	0.2695	3.638	-0.3609	-0.5031	0.6424	0.0748	0.1914	0.0084	-0.4672	-0.2968	0.1695	0.0729	0.0674	-0.068	0.3181	-0.1488	0.2314	50.1664	3.1973	76.6389
118	4.6121	-1.9638	6.414	9.0261	-1.4286	17.6651	-0.3731	-0.3452	0.9282	0.3769	0.3047	0.5907	-0.9879	-0.9394	0.0684	0.4468	0.0924	0.158	0.438	-0.0507	0.6313	40.6064	2.7028	81.1216
119	12.7903	-3.5245	6.8424	6.2759	-4.222	5.8152	0.144	-0.3759	0.5985	0.1946	-0.1694	0.4079	-0.2138	-0.1502	0.0254	0.1678	0.0845	0.0481	0.3575	-0.1453	0.2497	51.2741	0.4398	84.7413
120	4.5793	6.2997	-2.531	25.3105	-9.3104	16.1754	-0.1181	0.0137	0.0907	0.7423	0.184	0.8363	0.846	-0.5055	-0.0659	0.1849	0.0238	0.069	0.4381	-0.0427	0.2522	58.8452	-10.9445	92.3135

Refinement TLS group

ID	Refine-ID	Refine TLS-ID	Auth asym-ID	Auth seq-ID
1	X-RAY DIFFRACTION	1	A	1 - 5
2	X-RAY DIFFRACTION	2	A	6 - 17
3	X-RAY DIFFRACTION	3	A	18 - 39
4	X-RAY DIFFRACTION	4	A	40 - 49
5	X-RAY DIFFRACTION	5	A	50 - 61
6	X-RAY DIFFRACTION	6	A	62 - 68
7	X-RAY DIFFRACTION	7	A	69 - 79
8	X-RAY DIFFRACTION	8	A	80 - 91
9	X-RAY DIFFRACTION	9	A	92 - 98
10	X-RAY DIFFRACTION	10	A	99 - 104
11	X-RAY DIFFRACTION	11	B	16 - 20
12	X-RAY DIFFRACTION	12	B	21 - 31
13	X-RAY DIFFRACTION	13	B	32 - 37
14	X-RAY DIFFRACTION	14	B	38 - 48
15	X-RAY DIFFRACTION	15	B	49 - 65
16	X-RAY DIFFRACTION	16	B	66 - 76
17	X-RAY DIFFRACTION	17	B	77 - 84
18	X-RAY DIFFRACTION	18	B	85 - 90
19	X-RAY DIFFRACTION	19	B	91 - 98
20	X-RAY DIFFRACTION	20	B	99 - 112
21	X-RAY DIFFRACTION	21	C	62 - 68
22	X-RAY DIFFRACTION	22	C	69 - 75
23	X-RAY DIFFRACTION	23	C	76 - 100
24	X-RAY DIFFRACTION	24	C	101 - 109
25	X-RAY DIFFRACTION	25	C	110 - 129
26	X-RAY DIFFRACTION	26	C	130 - 134
27	X-RAY DIFFRACTION	27	C	135 - 170
28	X-RAY DIFFRACTION	28	C	171 - 190
29	X-RAY DIFFRACTION	29	C	191 - 199
30	X-RAY DIFFRACTION	30	C	200 - 205
31	X-RAY DIFFRACTION	31	D	1 - 5
32	X-RAY DIFFRACTION	32	D	6 - 30
33	X-RAY DIFFRACTION	33	D	31 - 45
34	X-RAY DIFFRACTION	34	D	46 - 51
35	X-RAY DIFFRACTION	35	D	52 - 58
36	X-RAY DIFFRACTION	36	D	59 - 66
37	X-RAY DIFFRACTION	37	D	67 - 75
38	X-RAY DIFFRACTION	38	D	76 - 85
39	X-RAY DIFFRACTION	39	D	86 - 92
40	X-RAY DIFFRACTION	40	D	93 - 103
41	X-RAY DIFFRACTION	41	E	16 - 20
42	X-RAY DIFFRACTION	42	E	21 - 27
43	X-RAY DIFFRACTION	43	E	28 - 34
44	X-RAY DIFFRACTION	44	E	35 - 47
45	X-RAY DIFFRACTION	45	E	56 - 60
46	X-RAY DIFFRACTION	46	E	61 - 70
47	X-RAY DIFFRACTION	47	E	71 - 83
48	X-RAY DIFFRACTION	48	E	84 - 89
49	X-RAY DIFFRACTION	49	E	90 - 102
50	X-RAY DIFFRACTION	50	E	103 - 112
51	X-RAY DIFFRACTION	51	F	62 - 68
52	X-RAY DIFFRACTION	52	F	69 - 77
53	X-RAY DIFFRACTION	53	F	78 - 105
54	X-RAY DIFFRACTION	54	F	106 - 114
55	X-RAY DIFFRACTION	55	F	115 - 130
56	X-RAY DIFFRACTION	56	F	131 - 135
57	X-RAY DIFFRACTION	57	F	136 - 174
58	X-RAY DIFFRACTION	58	F	175 - 185
59	X-RAY DIFFRACTION	59	F	186 - 195
60	X-RAY DIFFRACTION	60	F	196 - 204
61	X-RAY DIFFRACTION	61	G	1 - 6
62	X-RAY DIFFRACTION	62	G	7 - 16
63	X-RAY DIFFRACTION	63	G	17 - 29
64	X-RAY DIFFRACTION	64	G	30 - 41
65	X-RAY DIFFRACTION	65	G	42 - 53
66	X-RAY DIFFRACTION	66	G	54 - 61
67	X-RAY DIFFRACTION	67	G	62 - 69
68	X-RAY DIFFRACTION	68	G	70 - 84
69	X-RAY DIFFRACTION	69	G	85 - 94
70	X-RAY DIFFRACTION	70	G	95 - 104
71	X-RAY DIFFRACTION	71	H	16 - 20
72	X-RAY DIFFRACTION	72	H	21 - 30
73	X-RAY DIFFRACTION	73	H	31 - 40
74	X-RAY DIFFRACTION	74	H	41 - 47
75	X-RAY DIFFRACTION	75	H	48 - 65
76	X-RAY DIFFRACTION	76	H	66 - 79
77	X-RAY DIFFRACTION	77	H	80 - 86
78	X-RAY DIFFRACTION	78	H	87 - 94
79	X-RAY DIFFRACTION	79	H	95 - 101
80	X-RAY DIFFRACTION	80	H	102 - 112
81	X-RAY DIFFRACTION	81	I	62 - 68
82	X-RAY DIFFRACTION	82	I	69 - 78
83	X-RAY DIFFRACTION	83	I	79 - 105
84	X-RAY DIFFRACTION	84	I	106 - 116
85	X-RAY DIFFRACTION	85	I	117 - 134
86	X-RAY DIFFRACTION	86	I	135 - 155
87	X-RAY DIFFRACTION	87	I	156 - 184
88	X-RAY DIFFRACTION	88	I	185 - 194
89	X-RAY DIFFRACTION	89	I	195 - 200
90	X-RAY DIFFRACTION	90	I	201 - 206
91	X-RAY DIFFRACTION	91	J	1 - 5
92	X-RAY DIFFRACTION	92	J	6 - 25
93	X-RAY DIFFRACTION	93	J	26 - 44
94	X-RAY DIFFRACTION	94	J	45 - 50
95	X-RAY DIFFRACTION	95	J	51 - 56
96	X-RAY DIFFRACTION	96	J	57 - 64
97	X-RAY DIFFRACTION	97	J	65 - 72
98	X-RAY DIFFRACTION	98	J	73 - 84
99	X-RAY DIFFRACTION	99	J	85 - 89
100	X-RAY DIFFRACTION	100	J	90 - 104
101	X-RAY DIFFRACTION	101	K	16 - 20
102	X-RAY DIFFRACTION	102	K	21 - 31
103	X-RAY DIFFRACTION	103	K	32 - 40
104	X-RAY DIFFRACTION	104	K	41 - 47
105	X-RAY DIFFRACTION	105	K	57 - 62
106	X-RAY DIFFRACTION	106	K	63 - 78
107	X-RAY DIFFRACTION	107	K	79 - 85
108	X-RAY DIFFRACTION	108	K	86 - 94
109	X-RAY DIFFRACTION	109	K	95 - 102
110	X-RAY DIFFRACTION	110	K	103 - 112
111	X-RAY DIFFRACTION	111	L	62 - 68
112	X-RAY DIFFRACTION	112	L	69 - 79
113	X-RAY DIFFRACTION	113	L	80 - 130
114	X-RAY DIFFRACTION	114	L	131 - 135
115	X-RAY DIFFRACTION	115	L	136 - 144
116	X-RAY DIFFRACTION	116	L	145 - 155
117	X-RAY DIFFRACTION	117	L	156 - 179
118	X-RAY DIFFRACTION	118	L	180 - 185
119	X-RAY DIFFRACTION	119	L	186 - 193
120	X-RAY DIFFRACTION	120	L	194 - 205

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