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- PDB-7w6u: Structure of SARS-CoV-2 spike receptor-binding domain complexed w... -
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Open data
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Basic information
Entry | Database: PDB / ID: 7w6u | ||||||
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Title | Structure of SARS-CoV-2 spike receptor-binding domain complexed with its receptor equine ACE2 | ||||||
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Function / homology | ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() Similarity search - Function | ||||||
Biological species | ![]() ![]() ![]() ![]() ![]() ![]() | ||||||
Method | ![]() ![]() ![]() | ||||||
![]() | Xu, Z.P. / Liu, K.F. / Han, P. / Qi, J.X. | ||||||
Funding support | ![]()
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![]() | ![]() Title: Binding and structural basis of equine ACE2 to RBDs from SARS-CoV, SARS-CoV-2 and related coronaviruses Authors: Xu, Z. / Kang, X. / Han, P. / Du, P. / Li, L. / Zheng, A. / Deng, C. / Qi, J. / Zhao, X. / Wang, Q. / Liu, K. / Gao, G.F. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 369.5 KB | Display | ![]() |
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PDB format | ![]() | 266.2 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Arichive directory | ![]() ![]() | HTTPS FTP |
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-Related structure data
Related structure data | ![]() 7w6rC ![]() 6lzgS C: citing same article ( S: Starting model for refinement |
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Similar structure data | Similarity search - Function & homology ![]() |
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Links
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Assembly
Deposited unit | ![]()
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Unit cell |
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Components
#1: Protein | ![]() Mass: 69777.414 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() ![]() ![]() ![]() References: UniProt: F6V9L3, ![]() |
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#2: Protein | Mass: 25951.219 Da / Num. of mol.: 1 / Fragment: UNP residues 319-541 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() Gene: S, 2 / Cell line (production host): HEK293 / Production host: ![]() ![]() |
#3: Chemical | ChemComp-ZN / |
#4: Sugar | ChemComp-NAG / ![]() |
#5: Water | ChemComp-HOH / ![]() |
Has ligand of interest | Y |
-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 3.74 Å3/Da / Density % sol: 67.11 % |
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Crystal grow![]() | Temperature: 277 K / Method: vapor diffusion, sitting drop / Details: 10% (w/v) PEG 1000, 10% (w/v) PEG 8000 |
-Data collection
Diffraction | Mean temperature: 100 K / Serial crystal experiment: N |
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Diffraction source | Source: ![]() ![]() ![]() |
Detector | Type: DECTRIS EIGER X 9M / Detector: PIXEL / Date: Jan 30, 2021 |
Radiation | Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength![]() |
Reflection | Resolution: 2.56→31.39 Å / Num. obs: 46770 / % possible obs: 99.9 % / Redundancy: 26.8 % / Biso Wilson estimate: 58.33 Å2 / CC1/2: 0.999 / Rmerge(I) obs: 0.172 / Rpim(I) all: 0.034 / Rrim(I) all: 0.175 / Net I/σ(I): 17.8 |
Reflection shell | Resolution: 2.56→2.63 Å / Redundancy: 26.6 % / Num. unique obs: 3434 / CC1/2: 0.728 / Rpim(I) all: 0.45 / % possible all: 100 |
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Processing
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Refinement | Method to determine structure![]() ![]() Starting model: 6LZG Resolution: 2.56→19.21 Å / SU ML: 0.3213 / Cross valid method: FREE R-VALUE / σ(F): 1.35 / Phase error: 24.543 Stereochemistry target values: GeoStd + Monomer Library + CDL v1.2
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Solvent computation | Shrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Displacement parameters | Biso mean: 67.7 Å2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refinement step | Cycle: LAST / Resolution: 2.56→19.21 Å
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Refine LS restraints |
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LS refinement shell |
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