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Yorodumi- PDB-7u8f: Ternary complex structure of Cereblon-DDB1 bound to IKZF2(ZF2) an... -
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-Basic information
Entry | Database: PDB / ID: 7u8f | ||||||
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Title | Ternary complex structure of Cereblon-DDB1 bound to IKZF2(ZF2) and the molecular glue DKY709 | ||||||
Components |
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Keywords | LIGASE / molecular glue / targeted protein degradation | ||||||
Function / homology | Function and homology information negative regulation of monoatomic ion transmembrane transport / positive regulation by virus of viral protein levels in host cell / epigenetic programming in the zygotic pronuclei / spindle assembly involved in female meiosis / Cul4-RING E3 ubiquitin ligase complex / UV-damage excision repair / biological process involved in interaction with symbiont / regulation of mitotic cell cycle phase transition / WD40-repeat domain binding / Cul4A-RING E3 ubiquitin ligase complex ...negative regulation of monoatomic ion transmembrane transport / positive regulation by virus of viral protein levels in host cell / epigenetic programming in the zygotic pronuclei / spindle assembly involved in female meiosis / Cul4-RING E3 ubiquitin ligase complex / UV-damage excision repair / biological process involved in interaction with symbiont / regulation of mitotic cell cycle phase transition / WD40-repeat domain binding / Cul4A-RING E3 ubiquitin ligase complex / Cul4B-RING E3 ubiquitin ligase complex / ubiquitin ligase complex scaffold activity / negative regulation of reproductive process / negative regulation of developmental process / locomotory exploration behavior / cullin family protein binding / positive regulation of Wnt signaling pathway / viral release from host cell / ectopic germ cell programmed cell death / negative regulation of protein-containing complex assembly / positive regulation of viral genome replication / positive regulation of gluconeogenesis / proteasomal protein catabolic process / nucleotide-excision repair / Recognition of DNA damage by PCNA-containing replication complex / positive regulation of protein-containing complex assembly / DNA Damage Recognition in GG-NER / regulation of circadian rhythm / Dual Incision in GG-NER / Transcription-Coupled Nucleotide Excision Repair (TC-NER) / Formation of TC-NER Pre-Incision Complex / Wnt signaling pathway / Formation of Incision Complex in GG-NER / Dual incision in TC-NER / Gap-filling DNA repair synthesis and ligation in TC-NER / positive regulation of protein catabolic process / cellular response to UV / rhythmic process / protein-macromolecule adaptor activity / site of double-strand break / Neddylation / ubiquitin-dependent protein catabolic process / proteasome-mediated ubiquitin-dependent protein catabolic process / Potential therapeutics for SARS / transmembrane transporter binding / chromosome, telomeric region / damaged DNA binding / protein ubiquitination / DNA repair / apoptotic process / DNA damage response / protein-containing complex binding / nucleolus / negative regulation of apoptotic process / perinuclear region of cytoplasm / protein-containing complex / DNA binding / extracellular space / extracellular exosome / nucleoplasm / membrane / metal ion binding / nucleus / cytosol / cytoplasm Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.15 Å | ||||||
Authors | Ma, X. / Ornelas, E. / Clifton, M.C. | ||||||
Funding support | United States, 1items
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Citation | Journal: Cell Chem Biol / Year: 2023 Title: Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy. Authors: Bonazzi, S. / d'Hennezel, E. / Beckwith, R.E.J. / Xu, L. / Fazal, A. / Magracheva, A. / Ramesh, R. / Cernijenko, A. / Antonakos, B. / Bhang, H.C. / Caro, R.G. / Cobb, J.S. / Ornelas, E. / ...Authors: Bonazzi, S. / d'Hennezel, E. / Beckwith, R.E.J. / Xu, L. / Fazal, A. / Magracheva, A. / Ramesh, R. / Cernijenko, A. / Antonakos, B. / Bhang, H.C. / Caro, R.G. / Cobb, J.S. / Ornelas, E. / Ma, X. / Wartchow, C.A. / Clifton, M.C. / Forseth, R.R. / Fortnam, B.H. / Lu, H. / Csibi, A. / Tullai, J. / Carbonneau, S. / Thomsen, N.M. / Larrow, J. / Chie-Leon, B. / Hainzl, D. / Gu, Y. / Lu, D. / Meyer, M.J. / Alexander, D. / Kinyamu-Akunda, J. / Sabatos-Peyton, C.A. / Dales, N.A. / Zecri, F.J. / Jain, R.K. / Shulok, J. / Wang, Y.K. / Briner, K. / Porter, J.A. / Tallarico, J.A. / Engelman, J.A. / Dranoff, G. / Bradner, J.E. / Visser, M. / Solomon, J.M. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 7u8f.cif.gz | 1006.2 KB | Display | PDBx/mmCIF format |
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PDB format | pdb7u8f.ent.gz | 834.4 KB | Display | PDB format |
PDBx/mmJSON format | 7u8f.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/u8/7u8f ftp://data.pdbj.org/pub/pdb/validation_reports/u8/7u8f | HTTPS FTP |
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-Related structure data
Related structure data | 8deyC 6h0fS S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data | Similarity search - Function & homologyF&H Search |
-Links
-Assembly
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Unit cell |
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Components on special symmetry positions |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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