登録情報 | データベース: PDB / ID: 7b56 |
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タイトル | Crystal structure of CaMKII-actinin complex bound to AMPPNP |
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要素 | - Alpha-actinin-2
![](img/lk-wikipe.gif) - Calcium/calmodulin-dependent protein kinase type II subunit alpha
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キーワード | STRUCTURAL PROTEIN (タンパク質) / CaMKII (Ca2+/カルモジュリン依存性プロテインキナーゼII) / actinin / dendritic spine (樹状突起スパイン) |
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機能・相同性 | 機能・相同性情報
regulation of synaptic vesicle docking / glutamatergic postsynaptic density / actin filament uncapping / FATZ binding / titin Z domain binding / HSF1-dependent transactivation / Interferon gamma signaling / Ion transport by P-type ATPases / phospholipase C-activating angiotensin-activated signaling pathway / positive regulation of endocytic recycling ...regulation of synaptic vesicle docking / glutamatergic postsynaptic density / actin filament uncapping / FATZ binding / titin Z domain binding / HSF1-dependent transactivation / Interferon gamma signaling / Ion transport by P-type ATPases / phospholipase C-activating angiotensin-activated signaling pathway / positive regulation of endocytic recycling / Unblocking of NMDA receptors, glutamate binding and activation / peptidyl-threonine autophosphorylation / positive regulation of potassium ion transmembrane transporter activity / neurotransmitter receptor transport to plasma membrane / negative regulation of potassium ion transmembrane transporter activity / Trafficking of AMPA receptors / regulation of endocannabinoid signaling pathway / RAF activation / calcium- and calmodulin-dependent protein kinase complex / calmodulin dependent kinase signaling pathway / Ca2+ pathway / RAF/MAP kinase cascade / regulation of neuron migration / Ca2+/calmodulin-dependent protein kinase / positive regulation of cation channel activity / LIM domain binding / negative regulation of protein localization to cell surface / regulation of neurotransmitter secretion / calcium-dependent protein serine/threonine kinase activity / microspike assembly / postsynaptic actin cytoskeleton / dendritic spine development / positive regulation of potassium ion transport / muscle cell development / Ion homeostasis / positive regulation of calcium ion transport / presynaptic cytosol / focal adhesion assembly / negative regulation of hydrolase activity / postsynaptic neurotransmitter receptor diffusion trapping / Striated Muscle Contraction / Assembly and cell surface presentation of NMDA receptors / postsynaptic specialization membrane / GTPase activating protein binding / cardiac muscle cell development / Nephrin family interactions / dendrite morphogenesis / NMDA selective glutamate receptor signaling pathway / regulation of mitochondrial membrane permeability involved in apoptotic process / calmodulin-dependent protein kinase activity / regulation of neurotransmitter receptor localization to postsynaptic specialization membrane / postsynaptic cytosol / structural constituent of muscle / cortical actin cytoskeleton / sarcomere organization / positive regulation of cardiac muscle cell apoptotic process / Negative regulation of NMDA receptor-mediated neuronal transmission / Unblocking of NMDA receptors, glutamate binding and activation / regulation of neuronal synaptic plasticity / 仮足 / negative regulation of potassium ion transport / 長期増強 / cellular response to interferon-beta / glutamate receptor binding / postsynaptic density, intracellular component / regulation of protein localization to plasma membrane / titin binding / phosphatidylinositol-4,5-bisphosphate binding / cytoskeletal protein binding / ionotropic glutamate receptor signaling pathway / Ras activation upon Ca2+ influx through NMDA receptor / dendrite cytoplasm / nuclear receptor coactivator activity / platelet alpha granule lumen / filopodium / regulation of membrane potential / cell projection / protein localization to plasma membrane / response to ischemia / マイクロフィラメント / postsynaptic density membrane / positive regulation of receptor signaling pathway via JAK-STAT / Schaffer collateral - CA1 synapse / G1/S transition of mitotic cell cycle / Z disc / calcium ion transport / actin filament binding / integrin binding / Platelet degranulation / 細胞結合 / actin cytoskeleton organization / RAF/MAP kinase cascade / peptidyl-serine phosphorylation / regulation of apoptotic process / transmembrane transporter binding / 樹状突起スパイン / postsynaptic density / 細胞骨格 / calmodulin binding / 細胞接着類似検索 - 分子機能 Calcium/calmodulin-dependent protein kinase II, association-domain / Calcium/calmodulin dependent protein kinase II association domain / EF-hand, Ca insensitive / Ca2+ insensitive EF hand / Ca2+ insensitive EF hand / Spectrin repeat / Spectrin repeat / Spectrin/alpha-actinin / Actinin-type actin-binding domain signature 1. / Actinin-type actin-binding domain signature 2. ...Calcium/calmodulin-dependent protein kinase II, association-domain / Calcium/calmodulin dependent protein kinase II association domain / EF-hand, Ca insensitive / Ca2+ insensitive EF hand / Ca2+ insensitive EF hand / Spectrin repeat / Spectrin repeat / Spectrin/alpha-actinin / Actinin-type actin-binding domain signature 1. / Actinin-type actin-binding domain signature 2. / Spectrin repeats / Actinin-type actin-binding domain, conserved site / Calponin homology domain / Calponin homology (CH) domain / Calponin homology domain / CH domain superfamily / Calponin homology (CH) domain profile. / NTF2-like domain superfamily / EF-hand domain pair / EF-hand, calcium binding motif / EF-hand calcium-binding domain profile. / EF-hand domain / EF-hand domain pair / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily類似検索 - ドメイン・相同性 PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / Calcium/calmodulin-dependent protein kinase type II subunit alpha / Alpha-actinin-2類似検索 - 構成要素 |
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生物種 | ![](img/tx_mammal.gif) ![](data/taxo/icon/Mus_musculus_S.png) Mus musculus (ハツカネズミ)
![](img/tx_human.gif) Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.45 Å |
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データ登録者 | Zhu, J. / Gold, M. |
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引用 | ジャーナル: To Be Published タイトル: Crystal structure of CaMKII-actinin complex bound to MES 著者: Zhu, J. / Gold, M. |
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履歴 | 登録 | 2020年12月3日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2022年6月22日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年1月31日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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