+Open data
-Basic information
Entry | Database: PDB / ID: 6z5n | ||||||
---|---|---|---|---|---|---|---|
Title | DnaJB1 JD-GF | ||||||
Components | DnaJ homolog subfamily B member 1 | ||||||
Keywords | CHAPERONE / Molecular Chaperone / J-domain protein / Hsp40 / DnaJ | ||||||
Function / homology | Function and homology information sperm head / negative regulation of inclusion body assembly / positive regulation of ATP-dependent activity / transcription regulator inhibitor activity / ATPase activator activity / chaperone cofactor-dependent protein refolding / HSF1-dependent transactivation / response to unfolded protein / Regulation of HSF1-mediated heat shock response / Attenuation phase ...sperm head / negative regulation of inclusion body assembly / positive regulation of ATP-dependent activity / transcription regulator inhibitor activity / ATPase activator activity / chaperone cofactor-dependent protein refolding / HSF1-dependent transactivation / response to unfolded protein / Regulation of HSF1-mediated heat shock response / Attenuation phase / regulation of cellular response to heat / protein folding chaperone / forebrain development / Hsp70 protein binding / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / MAPK6/MAPK4 signaling / transcription corepressor activity / unfolded protein binding / cellular response to heat / ATPase binding / protein-folding chaperone binding / dendritic spine / postsynaptic density / cadherin binding / neuronal cell body / glutamatergic synapse / nucleolus / negative regulation of transcription by RNA polymerase II / extracellular exosome / nucleoplasm / nucleus / cytosol / cytoplasm Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | SOLUTION NMR / na | ||||||
Authors | Avraham-Abayev, M. / London, N. / Rosenzweig, R. | ||||||
Funding support | European Union, 1items
| ||||||
Citation | Journal: Nature / Year: 2020 Title: HSP40 proteins use class-specific regulation to drive HSP70 functional diversity. Authors: Faust, O. / Abayev-Avraham, M. / Wentink, A.S. / Maurer, M. / Nillegoda, N.B. / London, N. / Bukau, B. / Rosenzweig, R. | ||||||
History |
|
-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
---|
-Downloads & links
-Download
PDBx/mmCIF format | 6z5n.cif.gz | 328.3 KB | Display | PDBx/mmCIF format |
---|---|---|---|---|
PDB format | pdb6z5n.ent.gz | 274.7 KB | Display | PDB format |
PDBx/mmJSON format | 6z5n.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/z5/6z5n ftp://data.pdbj.org/pub/pdb/validation_reports/z5/6z5n | HTTPS FTP |
---|
-Related structure data
Similar structure data | |
---|---|
Other databases |
-Links
-Assembly
Deposited unit |
| |||||||||
---|---|---|---|---|---|---|---|---|---|---|
1 |
| |||||||||
NMR ensembles |
|
-Components
#1: Protein | Mass: 12223.381 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: DNAJB1, DNAJ1, HDJ1, HSPF1 / Production host: Escherichia coli (E. coli) / References: UniProt: P25685 |
---|
-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
NMR experiment |
|
-Sample preparation
Details |
| ||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sample |
| ||||||||||||||||||||||||||||||
Sample conditions |
|
-NMR measurement
NMR spectrometer |
|
---|
-Processing
NMR software |
| |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Refinement | Method: na / Software ordinal: 1 | |||||||||||||||
NMR representative | Selection criteria: lowest energy | |||||||||||||||
NMR ensemble | Conformer selection criteria: structures with the lowest energy Conformers calculated total number: 25000 / Conformers submitted total number: 10 |