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Open data
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Basic information
Entry | Database: PDB / ID: 6y0f | ||||||
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Title | Structure of human FAPalpha in complex with linagliptin | ||||||
![]() | Prolyl endopeptidase FAP | ||||||
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Function / homology | ![]() negative regulation of extracellular matrix organization / melanocyte proliferation / ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() Similarity search - Function | ||||||
Biological species | ![]() ![]() | ||||||
Method | ![]() ![]() ![]() | ||||||
![]() | Nar, H. / Schnapp, G. / Schreiner, P. | ||||||
![]() | ![]() Title: Structure of human FAPalpha in complex with linagliptin Authors: Nar, H. / Schnapp, G. / Schreiner, P. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 1.1 MB | Display | ![]() |
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PDB format | ![]() | 990.8 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Arichive directory | ![]() ![]() | HTTPS FTP |
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-Related structure data
Related structure data | ![]() 1z68S S: Starting model for refinement |
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Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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2 | ![]()
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Unit cell |
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Components
-Protein / Non-polymers , 2 types, 8 molecules ABCD![](data/chem/img/356.gif)
![](data/chem/img/356.gif)
#1: Protein | Mass: 83629.148 Da / Num. of mol.: 4 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() Production host: ![]() References: UniProt: Q12884, ![]() ![]() ![]() #6: Chemical | ChemComp-356 / ![]() |
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-Sugars , 4 types, 15 molecules ![](data/chem/img/NAG.gif)
#2: Polysaccharide | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose ![]() Source method: isolated from a genetically manipulated source #3: Polysaccharide | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta- ...beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | ![]() Source method: isolated from a genetically manipulated source #4: Polysaccharide | ![]() Source method: isolated from a genetically manipulated source #5: Sugar | ChemComp-NAG / ![]() |
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-Details
Has ligand of interest | Y |
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-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 2.95 Å3/Da / Density % sol: 58.34 % |
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Crystal grow![]() | Temperature: 293 K / Method: vapor diffusion / pH: 9 / Details: 35% (v/v) PEG2000MME, 0.40 M lithium salt |
-Data collection
Diffraction | Mean temperature: 100 K / Serial crystal experiment: N |
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Diffraction source | Source: ![]() ![]() ![]() |
Detector | Type: DECTRIS PILATUS3 6M / Detector: PIXEL / Date: Oct 1, 2008 |
Radiation | Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength![]() |
Reflection | Resolution: 2.92→48 Å / Num. obs: 81742 / % possible obs: 98 % / Redundancy: 2.9 % / Rsym value: 0.098 / Net I/σ(I): 11.8 |
Reflection shell | Resolution: 2.92→3.15 Å / Num. unique obs: 16579 / Rsym value: 0.447 |
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Processing
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Refinement | Method to determine structure![]() ![]() Starting model: 1z68 Resolution: 2.924→47.93 Å / Cor.coef. Fo:Fc: 0.868 / Cor.coef. Fo:Fc free: 0.824 / Cross valid method: THROUGHOUT / σ(F): 0 / SU Rfree Blow DPI: 0.368
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Displacement parameters | Biso max: 107.12 Å2 / Biso mean: 52.73 Å2 / Biso min: 25.03 Å2
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Refine analyze | Luzzati coordinate error obs: 0.42 Å | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refinement step | Cycle: final / Resolution: 2.924→47.93 Å
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Refine LS restraints |
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LS refinement shell | Resolution: 2.924→2.96 Å / Rfactor Rfree error: 0
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Refinement TLS params. | Method: refined / Refine-ID: X-RAY DIFFRACTION
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Refinement TLS group |
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