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Yorodumi- PDB-6v7o: Structural Elucidation of Peptide Binding to KLHL-12, a Substrate... -
+Open data
-Basic information
Entry | Database: PDB / ID: 6v7o | ||||||
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Title | Structural Elucidation of Peptide Binding to KLHL-12, a Substrate Specific Adapter Protein in a Cul3-Ring E3 Ligase Complex | ||||||
Components |
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Keywords | LIGASE / E3 ligase / KLHL-12 / Ubiquitination | ||||||
Function / homology | Function and homology information Negative regulation of TCF-dependent signaling by DVL-interacting proteins / planar cell polarity pathway involved in neural tube closure / neural crest formation / non-canonical Wnt signaling pathway / positive regulation of neuron projection arborization / neural crest cell development / COPII vesicle coat / COPII vesicle coating / WNT5:FZD7-mediated leishmania damping / frizzled binding ...Negative regulation of TCF-dependent signaling by DVL-interacting proteins / planar cell polarity pathway involved in neural tube closure / neural crest formation / non-canonical Wnt signaling pathway / positive regulation of neuron projection arborization / neural crest cell development / COPII vesicle coat / COPII vesicle coating / WNT5:FZD7-mediated leishmania damping / frizzled binding / PCP/CE pathway / WNT mediated activation of DVL / Disassembly of the destruction complex and recruitment of AXIN to the membrane / Wnt signaling pathway, planar cell polarity pathway / Cul3-RING ubiquitin ligase complex / COPII-coated ER to Golgi transport vesicle / protein monoubiquitination / centriolar satellite / canonical Wnt signaling pathway / endoplasmic reticulum to Golgi vesicle-mediated transport / TCF dependent signaling in response to WNT / RHO GTPases Activate Formins / Degradation of DVL / regulation of actin cytoskeleton organization / positive regulation of JNK cascade / small GTPase binding / beta-catenin binding / Wnt signaling pathway / positive regulation of GTPase activity / regulation of protein localization / protease binding / protein stabilization / intracellular signal transduction / response to xenobiotic stimulus / positive regulation of protein phosphorylation / signaling receptor binding / intracellular membrane-bounded organelle / chromatin / positive regulation of DNA-templated transcription / positive regulation of transcription by RNA polymerase II / identical protein binding / cytosol Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.9 Å | ||||||
Authors | Zhao, B. | ||||||
Funding support | United States, 1items
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Citation | Journal: Biochemistry / Year: 2020 Title: Structural Elucidation of Peptide Binding to KLHL-12, a Substrate Specific Adapter Protein in a Cul3-Ring E3 Ligase Complex. Authors: Zhao, B. / Payne, W.G. / Sai, J. / Lu, Z. / Olejniczak, E.T. / Fesik, S.W. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 6v7o.cif.gz | 224.8 KB | Display | PDBx/mmCIF format |
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PDB format | pdb6v7o.ent.gz | 180.2 KB | Display | PDB format |
PDBx/mmJSON format | 6v7o.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/v7/6v7o ftp://data.pdbj.org/pub/pdb/validation_reports/v7/6v7o | HTTPS FTP |
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-Related structure data
Related structure data | 2vpjS S: Starting model for refinement |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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