+Open data
-Basic information
Entry | Database: PDB / ID: 6pxb | ||||||
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Title | N-Terminal SH2 domain of the p120RasGAP | ||||||
Components | Ras GTPase-activating protein 1 | ||||||
Keywords | SIGNALING PROTEIN / SH2 GTPase Activating Proteins Ras pathway SIGNALING PROTEIN | ||||||
Function / homology | Function and homology information regulation of RNA metabolic process / regulation of actin filament polymerization / potassium channel inhibitor activity / negative regulation of cell adhesion / blood vessel morphogenesis / negative regulation of cell-matrix adhesion / mitotic cytokinesis / ephrin receptor signaling pathway / vasculogenesis / PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases ...regulation of RNA metabolic process / regulation of actin filament polymerization / potassium channel inhibitor activity / negative regulation of cell adhesion / blood vessel morphogenesis / negative regulation of cell-matrix adhesion / mitotic cytokinesis / ephrin receptor signaling pathway / vasculogenesis / PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases / ruffle / EPHB-mediated forward signaling / phosphotyrosine residue binding / Downstream signal transduction / GTPase activator activity / VEGFR2 mediated cell proliferation / Regulation of RAS by GAPs / GTPase binding / regulation of cell shape / negative regulation of neuron apoptotic process / intracellular signal transduction / signaling receptor binding / GTPase activity / negative regulation of apoptotic process / signal transduction / plasma membrane / cytosol / cytoplasm Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.747 Å | ||||||
Authors | Jaber Chehayeb, R. / Stiegler, A.L. / Boggon, T.J. | ||||||
Funding support | United States, 1items
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Citation | Journal: Plos One / Year: 2019 Title: Crystal structures of p120RasGAP N-terminal SH2 domain in its apo form and in complex with a p190RhoGAP phosphotyrosine peptide. Authors: Jaber Chehayeb, R. / Stiegler, A.L. / Boggon, T.J. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 6pxb.cif.gz | 271.2 KB | Display | PDBx/mmCIF format |
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PDB format | pdb6pxb.ent.gz | 223 KB | Display | PDB format |
PDBx/mmJSON format | 6pxb.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/px/6pxb ftp://data.pdbj.org/pub/pdb/validation_reports/px/6pxb | HTTPS FTP |
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-Related structure data
Related structure data | 6pxcC 4k44S S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data | |
Experimental dataset #1 | Data reference: 10.15785/SBGRID/698 / Data set type: diffraction image data |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Ens-ID: 1
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