Entry Database : PDB / ID : 6p5l Structure visualization Downloads & linksTitle Crystal Structure of Ubl123 with an EZH2 peptide ComponentsPRO-ARG-LYS-LYS-LYS-ARG-LYS-HIS Ubiquitin carboxyl-terminal hydrolase 7 DetailsKeywords HYDROLASE / Complex Deubiquitinase / NUCLEAR PROTEINFunction / homology Function and homology informationFunction Domain/homology Component
regulation of kidney development / hepatocyte homeostasis / cellular response to trichostatin A / regulation of gliogenesis / [histone H3]-lysine27 N-trimethyltransferase / negative regulation of striated muscle cell differentiation / regulation of telomere capping / negative regulation of keratinocyte differentiation / histone H3K27 trimethyltransferase activity / negative regulation of retinoic acid receptor signaling pathway ... regulation of kidney development / hepatocyte homeostasis / cellular response to trichostatin A / regulation of gliogenesis / [histone H3]-lysine27 N-trimethyltransferase / negative regulation of striated muscle cell differentiation / regulation of telomere capping / negative regulation of keratinocyte differentiation / histone H3K27 trimethyltransferase activity / negative regulation of retinoic acid receptor signaling pathway / primary miRNA binding / skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration / response to tetrachloromethane / cerebellar cortex development / facultative heterochromatin formation / histone H3K27 methyltransferase activity / monoubiquitinated protein deubiquitination / positive regulation of cell cycle G1/S phase transition / regulation of retrograde transport, endosome to Golgi / deubiquitinase activity / : / chromatin silencing complex / ESC/E(Z) complex / protein-lysine N-methyltransferase activity / negative regulation of stem cell differentiation / DNA alkylation repair / pronucleus / cardiac muscle hypertrophy in response to stress / synaptic transmission, GABAergic / regulation of DNA-binding transcription factor activity / lncRNA binding / negative regulation of gene expression via chromosomal CpG island methylation / positive regulation of dendrite development / histone H3 methyltransferase activity / K48-linked deubiquitinase activity / symbiont-mediated disruption of host cell PML body / G1 to G0 transition / negative regulation of G1/S transition of mitotic cell cycle / negative regulation of gene expression, epigenetic / histone methyltransferase activity / negative regulation of NF-kappaB transcription factor activity / protein deubiquitination / Transcriptional Regulation by E2F6 / negative regulation of transcription elongation by RNA polymerase II / negative regulation of proteasomal ubiquitin-dependent protein catabolic process / subtelomeric heterochromatin formation / negative regulation of cytokine production involved in inflammatory response / RNA polymerase II core promoter sequence-specific DNA binding / transcription-coupled nucleotide-excision repair / pericentric heterochromatin / negative regulation of gluconeogenesis / heterochromatin formation / positive regulation of epithelial to mesenchymal transition / ribonucleoprotein complex binding / keratinocyte differentiation / protein localization to chromatin / negative regulation of TORC1 signaling / Regulation of PTEN localization / Synthesis of active ubiquitin: roles of E1 and E2 enzymes / B cell differentiation / transcription corepressor binding / regulation of signal transduction by p53 class mediator / PRC2 methylates histones and DNA / Regulation of PTEN gene transcription / Defective pyroptosis / liver regeneration / stem cell differentiation / promoter-specific chromatin binding / hippocampus development / positive regulation of MAP kinase activity / protein modification process / regulation of protein stability / positive regulation of protein serine/threonine kinase activity / regulation of circadian rhythm / G1/S transition of mitotic cell cycle / Transcription-Coupled Nucleotide Excision Repair (TC-NER) / Formation of TC-NER Pre-Incision Complex / chromatin DNA binding / PKMTs methylate histone lysines / PML body / positive regulation of GTPase activity / cellular response to hydrogen peroxide / Activation of anterior HOX genes in hindbrain development during early embryogenesis / HCMV Early Events / Dual incision in TC-NER / Gap-filling DNA repair synthesis and ligation in TC-NER / transcription corepressor activity / Regulation of TP53 Degradation / rhythmic process / p53 binding / response to estradiol / chromosome / chromatin organization / Oxidative Stress Induced Senescence / ubiquitinyl hydrolase 1 / cysteine-type deubiquitinase activity / chromosome, telomeric region / nuclear body / protein stabilization / Ub-specific processing proteases Similarity search - Function EZH2, SET domain / : / Ezh2, MCSS domain / Histone-lysine N-methyltransferase EZH1/EZH2 / Polycomb repressive complex 2 subunit EZH1/EZH2, tri-helical domain / Pre-SET CXC domain / WD repeat binding protein EZH2 / Polycomb repressive complex 2 tri-helical domain / CXC domain / Tesmin/TSO1-like CXC domain ... EZH2, SET domain / : / Ezh2, MCSS domain / Histone-lysine N-methyltransferase EZH1/EZH2 / Polycomb repressive complex 2 subunit EZH1/EZH2, tri-helical domain / Pre-SET CXC domain / WD repeat binding protein EZH2 / Polycomb repressive complex 2 tri-helical domain / CXC domain / Tesmin/TSO1-like CXC domain / Tesmin/TSO1-like CXC domain / Histone-lysine N-methyltransferase EZH1/2-like / CXC domain / CXC domain profile. / Ubiquitin carboxyl-terminal hydrolase 7, ICP0-binding domain / ICP0-binding domain of Ubiquitin-specific protease 7 / Ubiquitin carboxyl-terminal hydrolase, C-terminal / Ubiquitin-specific protease C-terminal / MATH domain / MATH/TRAF domain / MATH/TRAF domain profile. / meprin and TRAF homology / TRAF-like / Ubiquitin specific protease (USP) domain signature 2. / Ubiquitin specific protease (USP) domain signature 1. / Ubiquitin specific protease, conserved site / Peptidase C19, ubiquitin carboxyl-terminal hydrolase / Ubiquitin carboxyl-terminal hydrolase / Ubiquitin specific protease domain / Ubiquitin specific protease (USP) domain profile. / SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain / SET domain superfamily / SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains / SET domain / SET domain profile. / SET domain / SANT/Myb domain / Papain-like cysteine peptidase superfamily Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 3.296 Å DetailsAuthors Saridakis, V. Funding support Canada, 1items Details Hide detailsOrganization Grant number Country Canadian Institutes of Health Research (CIHR) 106583 Canada
CitationJournal : J.Mol.Biol. / Year : 2020Title : Structural Basis of the Interaction Between Ubiquitin Specific Protease 7 and Enhancer of Zeste Homolog 2.Authors : Gagarina, V. / Bojagora, A. / Lacdao, I.K. / Luthra, N. / Pfoh, R. / Mohseni, S. / Chaharlangi, D. / Tan, N. / Saridakis, V. History Deposition May 30, 2019 Deposition site : RCSB / Processing site : RCSBRevision 1.0 May 6, 2020 Provider : repository / Type : Initial releaseRevision 1.1 Oct 11, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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