+Open data
-Basic information
Entry | Database: PDB / ID: 6mie | ||||||
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Title | Solution NMR structure of the KCNQ1 voltage-sensing domain | ||||||
Components | Potassium voltage-gated channel subfamily KQT member 1 | ||||||
Keywords | MEMBRANE PROTEIN / ion channel / KCNQ1 / Kv7.1 / voltage sensor / potassium channel | ||||||
Function / homology | Function and homology information gastrin-induced gastric acid secretion / corticosterone secretion / voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization / basolateral part of cell / lumenal side of membrane / negative regulation of voltage-gated potassium channel activity / rhythmic behavior / regulation of gastric acid secretion / stomach development / membrane repolarization during atrial cardiac muscle cell action potential ...gastrin-induced gastric acid secretion / corticosterone secretion / voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization / basolateral part of cell / lumenal side of membrane / negative regulation of voltage-gated potassium channel activity / rhythmic behavior / regulation of gastric acid secretion / stomach development / membrane repolarization during atrial cardiac muscle cell action potential / Phase 3 - rapid repolarisation / voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization / membrane repolarization during action potential / membrane repolarization during ventricular cardiac muscle cell action potential / regulation of atrial cardiac muscle cell membrane repolarization / iodide transport / Phase 2 - plateau phase / potassium ion export across plasma membrane / membrane repolarization during cardiac muscle cell action potential / intracellular chloride ion homeostasis / renal sodium ion absorption / negative regulation of delayed rectifier potassium channel activity / voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization / atrial cardiac muscle cell action potential / auditory receptor cell development / detection of mechanical stimulus involved in sensory perception of sound / regulation of membrane repolarization / delayed rectifier potassium channel activity / protein phosphatase 1 binding / positive regulation of potassium ion transmembrane transport / Voltage gated Potassium channels / outward rectifier potassium channel activity / potassium ion homeostasis / ventricular cardiac muscle cell action potential / non-motile cilium assembly / regulation of ventricular cardiac muscle cell membrane repolarization / intestinal absorption / regulation of heart contraction / monoatomic ion channel complex / ciliary base / inner ear morphogenesis / positive regulation of heart rate / cochlea development / renal absorption / adrenergic receptor signaling pathway / potassium ion import across plasma membrane / protein kinase A regulatory subunit binding / regulation of heart rate by cardiac conduction / voltage-gated potassium channel activity / protein kinase A catalytic subunit binding / inner ear development / social behavior / voltage-gated potassium channel complex / cellular response to cAMP / transport vesicle / positive regulation of cardiac muscle contraction / potassium ion transmembrane transport / cardiac muscle contraction / cellular response to epinephrine stimulus / phosphatidylinositol-4,5-bisphosphate binding / erythrocyte differentiation / sensory perception of sound / response to insulin / cytoplasmic vesicle membrane / regulation of blood pressure / glucose metabolic process / cellular response to xenobiotic stimulus / late endosome / heart development / scaffold protein binding / basolateral plasma membrane / transmembrane transporter binding / lysosome / calmodulin binding / early endosome / neuron projection / membrane raft / apical plasma membrane / neuronal cell body / endoplasmic reticulum / membrane / plasma membrane / cytoplasm Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | SOLUTION NMR / molecular dynamics | ||||||
Authors | Taylor, K.C. / Kuenze, G. / Smith, J.A. / Meiler, J. / McFeeters, R.L. / Sanders, C.R. | ||||||
Funding support | United States, 1items
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Citation | Journal: Elife / Year: 2020 Title: Structure and physiological function of the human KCNQ1 channel voltage sensor intermediate state. Authors: Taylor, K.C. / Kang, P.W. / Hou, P. / Yang, N.D. / Kuenze, G. / Smith, J.A. / Shi, J. / Huang, H. / White, K.M. / Peng, D. / George, A.L. / Meiler, J. / McFeeters, R.L. / Cui, J. / Sanders, C.R. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 6mie.cif.gz | 486.1 KB | Display | PDBx/mmCIF format |
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PDB format | pdb6mie.ent.gz | 411.3 KB | Display | PDB format |
PDBx/mmJSON format | 6mie.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/mi/6mie ftp://data.pdbj.org/pub/pdb/validation_reports/mi/6mie | HTTPS FTP |
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-Related structure data
Similar structure data | |
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Other databases |
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-Links
-Assembly
Deposited unit |
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1 |
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NMR ensembles |
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-Components
#1: Protein | Mass: 18184.631 Da / Num. of mol.: 1 / Fragment: UNP residues 100-249 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: KCNQ1, KCNA8, KCNA9, KVLQT1 / Plasmid: pET16b / Production host: Escherichia coli (E. coli) / Strain (production host): C43(DE3) pRARE / References: UniProt: P51787 |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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NMR experiment |
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-Sample preparation
Details |
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