- PDB-6lph: the Sufu-Fu complex crystal structure -
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Basic information
Entry
Database: PDB / ID: 6lph
Title
the Sufu-Fu complex crystal structure
Components
Serine/threonine-protein kinase fused
Suppressor of fused homolog
Keywords
PROTEIN BINDING / kinases / phosphorylation
Function / homology
Function and homology information
Hedgehog signaling complex / Assembly of the CI containing complexes / negative regulation of nucleocytoplasmic transport / Activation of CI / Activation of SMO / : / Hedgehog 'off' state / Phosphorylation of CI / germarium-derived egg chamber formation / Phosphorylation of SMO ...Hedgehog signaling complex / Assembly of the CI containing complexes / negative regulation of nucleocytoplasmic transport / Activation of CI / Activation of SMO / : / Hedgehog 'off' state / Phosphorylation of CI / germarium-derived egg chamber formation / Phosphorylation of SMO / Assembly of the 'signalling complexes' / Ubiquitination and proteolysis of phosphorylated CI / Degradation of GLI1 by the proteasome / GLI3 is processed to GLI3R by the proteasome / Hedgehog 'on' state / wing disc pattern formation / positive regulation of nucleocytoplasmic transport / smoothened binding / segment polarity determination / protein serine/threonine kinase activity => GO:0004674 / intraciliary transport / cytoplasmic sequestering of protein / molecular sequestering activity / nuclear localization sequence binding / smoothened signaling pathway / transcription factor binding / negative regulation of BMP signaling pathway / negative regulation of smoothened signaling pathway / extrinsic component of cytoplasmic side of plasma membrane / positive regulation of protein ubiquitination / cilium / DNA-binding transcription factor binding / RNA polymerase II-specific DNA-binding transcription factor binding / protein autophosphorylation / non-specific serine/threonine protein kinase / protein serine kinase activity / protein serine/threonine kinase activity / protein homodimerization activity / protein-containing complex / ATP binding / nucleus / cytosol / cytoplasm Similarity search - Function
Suppressor of fused / Suppressor of fused, eukaryotic / Suppressor of fused C-terminal / Suppressor of fused, N-terminal / Suppressor of fused, C-terminal domain superfamily / Suppressor of Fused Gli/Ci N terminal binding domain / Suppressor of fused-like domain / Suppressor of fused protein (SUFU) / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. ...Suppressor of fused / Suppressor of fused, eukaryotic / Suppressor of fused C-terminal / Suppressor of fused, N-terminal / Suppressor of fused, C-terminal domain superfamily / Suppressor of Fused Gli/Ci N terminal binding domain / Suppressor of fused-like domain / Suppressor of fused protein (SUFU) / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily Similarity search - Domain/homology
Mass: 29311.008 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Drosophila melanogaster (fruit fly) / Gene: Su(fu) / Production host: Escherichia coli (E. coli) / References: UniProt: Q9VG38
#2: Protein/peptide
Serine/threonine-proteinkinasefused
Mass: 3021.368 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Drosophila melanogaster (fruit fly) / Gene: fu / Production host: Escherichia coli (E. coli) References: UniProt: P23647, non-specific serine/threonine protein kinase
Resolution: 1.91→55.67 Å / Cor.coef. Fo:Fc: 0.963 / Cor.coef. Fo:Fc free: 0.927 / SU B: 7.234 / SU ML: 0.096 / Cross valid method: FREE R-VALUE / σ(F): 0 / ESU R Free: 0.148 Details: HYDROGENS HAVE BEEN USED IF PRESENT IN THE INPUT U VALUES : WITH TLS ADDED
Rfactor
Num. reflection
% reflection
Selection details
Rfree
0.2198
1056
5.2 %
RANDOM
Rwork
0.1476
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-
-
obs
0.1513
19445
97.54 %
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Solvent computation
Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.2 Å
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