Entry Database : PDB / ID : 6k3a Structure visualization Downloads & linksTitle Crystal structure of human PCNA in complex with DNMT1 PIP box motif. ComponentsPeptide from DNA (cytosine-5)-methyltransferase 1 Proliferating cell nuclear antigen DetailsKeywords REPLICATION / DNMT1 / PCNA / DNA methylation / PIP boxFunction / homology Function and homology informationFunction Domain/homology Component
negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching / : / epigenetic programming of gene expression / positive regulation of deoxyribonuclease activity / dinucleotide insertion or deletion binding / PCNA-p21 complex / cellular response to bisphenol A / negative regulation of vascular associated smooth muscle cell apoptotic process / DNA-methyltransferase activity / mitotic telomere maintenance via semi-conservative replication ... negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching / : / epigenetic programming of gene expression / positive regulation of deoxyribonuclease activity / dinucleotide insertion or deletion binding / PCNA-p21 complex / cellular response to bisphenol A / negative regulation of vascular associated smooth muscle cell apoptotic process / DNA-methyltransferase activity / mitotic telomere maintenance via semi-conservative replication / purine-specific mismatch base pair DNA N-glycosylase activity / positive regulation of DNA-directed DNA polymerase activity / nuclear lamina / MutLalpha complex binding / Polymerase switching / DNA (cytosine-5-)-methyltransferase / Telomere C-strand (Lagging Strand) Synthesis / Processive synthesis on the lagging strand / DNA (cytosine-5-)-methyltransferase activity / PCNA complex / DNA methylation-dependent heterochromatin formation / SUMOylation of DNA methylation proteins / Removal of the Flap Intermediate / Processive synthesis on the C-strand of the telomere / Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) / Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) / Transcription of E2F targets under negative control by DREAM complex / negative regulation of gene expression via chromosomal CpG island methylation / Polymerase switching on the C-strand of the telomere / Removal of the Flap Intermediate from the C-strand / female germ cell nucleus / replisome / methyl-CpG binding / response to L-glutamate / histone acetyltransferase binding / leading strand elongation / DNA polymerase processivity factor activity / G1/S-Specific Transcription / replication fork processing / response to dexamethasone / nuclear replication fork / SUMOylation of DNA replication proteins / estrous cycle / PCNA-Dependent Long Patch Base Excision Repair / cyclin-dependent protein kinase holoenzyme complex / mismatch repair / translesion synthesis / pericentric heterochromatin / response to cadmium ion / DNA polymerase binding / base-excision repair, gap-filling / positive regulation of vascular associated smooth muscle cell proliferation / epithelial cell differentiation / positive regulation of DNA repair / Translesion synthesis by REV1 / Translesion synthesis by POLK / Gap-filling DNA repair synthesis and ligation in GG-NER / Translesion synthesis by POLI / DNA methylation / TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest / replication fork / positive regulation of DNA replication / PRC2 methylates histones and DNA / male germ cell nucleus / Defective pyroptosis / liver regeneration / promoter-specific chromatin binding / nuclear estrogen receptor binding / Recognition of DNA damage by PCNA-containing replication complex / cellular response to amino acid stimulus / Termination of translesion DNA synthesis / Translesion Synthesis by POLH / NoRC negatively regulates rRNA expression / HDR through Homologous Recombination (HRR) / Dual Incision in GG-NER / receptor tyrosine kinase binding / cellular response to hydrogen peroxide / Dual incision in TC-NER / Gap-filling DNA repair synthesis and ligation in TC-NER / cellular response to UV / cellular response to xenobiotic stimulus / response to estradiol / E3 ubiquitin ligases ubiquitinate target proteins / heart development / chromosome, telomeric region / damaged DNA binding / nuclear body / negative regulation of gene expression / centrosome / DNA-templated transcription / chromatin binding / chromatin / protein-containing complex binding / positive regulation of gene expression / negative regulation of transcription by RNA polymerase II / enzyme binding / DNA binding / RNA binding / extracellular exosome / zinc ion binding Similarity search - Function DNA (cytosine-5)-methyltransferase 1-like / DNA (cytosine-5)-methyltransferase 1, replication foci domain / Cytosine specific DNA methyltransferase replication foci domain / DMAP1-binding Domain / DMAP1-binding Domain / DMAP1-binding domain / DMAP1-binding domain profile. / DNA methylase, C-5 cytosine-specific, conserved site / C-5 cytosine-specific DNA methylases C-terminal signature. / Box ... DNA (cytosine-5)-methyltransferase 1-like / DNA (cytosine-5)-methyltransferase 1, replication foci domain / Cytosine specific DNA methyltransferase replication foci domain / DMAP1-binding Domain / DMAP1-binding Domain / DMAP1-binding domain / DMAP1-binding domain profile. / DNA methylase, C-5 cytosine-specific, conserved site / C-5 cytosine-specific DNA methylases C-terminal signature. / Box / Proliferating Cell Nuclear Antigen / Proliferating Cell Nuclear Antigen - #10 / DNA methylase, C-5 cytosine-specific, active site / C-5 cytosine-specific DNA methylases active site. / C-5 cytosine-specific DNA methylase (Dnmt) domain profile. / CXXC zinc finger domain / Zinc finger, CXXC-type / Zinc finger CXXC-type profile. / C-5 cytosine methyltransferase / C-5 cytosine-specific DNA methylase / Proliferating cell nuclear antigen signature 2. / Bromo adjacent homology (BAH) domain superfamily / Bromo adjacent homology domain / Bromo adjacent homology (BAH) domain / BAH domain / BAH domain profile. / Proliferating cell nuclear antigen, PCNA, conserved site / Proliferating cell nuclear antigen signature 1. / Proliferating cell nuclear antigen, PCNA / Proliferating cell nuclear antigen, PCNA, N-terminal / Proliferating cell nuclear antigen, PCNA, C-terminal / Proliferating cell nuclear antigen, N-terminal domain / Proliferating cell nuclear antigen, C-terminal domain / : / S-adenosyl-L-methionine-dependent methyltransferase superfamily / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.3 Å DetailsAuthors Jimenji, T. / Kori, S. / Arita, K. Funding support Japan, 2items Details Hide detailsOrganization Grant number Country Ministry of Education, Culture, Sports, Science and Technology (Japan) 18H02392 Japan Japan Science and Technology 14530337 Japan
CitationJournal : Biochem.Biophys.Res.Commun. / Year : 2019Title : Structure of PCNA in complex with DNMT1 PIP box reveals the basis for the molecular mechanism of the interaction.Authors : Jimenji, T. / Matsumura, R. / Kori, S. / Arita, K. History Deposition May 17, 2019 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Jun 26, 2019 Provider : repository / Type : Initial releaseRevision 1.1 Jul 10, 2019 Group : Data collection / Database references / Category : citationItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year Revision 1.2 Jul 24, 2019 Group : Data collection / Database references / Category : citationItem : _citation.journal_volume / _citation.page_first / _citation.page_lastRevision 1.3 Nov 22, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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