Entry Database : PDB / ID : 6jv9 Structure visualization Downloads & linksTitle Crystal Structure of Human CRMP2 1-532, unmodified ComponentsDihydropyrimidinase-related protein 2 Details Keywords STRUCTURAL PROTEIN / Microtubule associated protein / GAP activity / Neuronal proteinFunction / homology Function and homology informationFunction Domain/homology Component
dihydropyrimidinase activity / hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides / CRMPs in Sema3A signaling / nucleobase-containing compound metabolic process / Recycling pathway of L1 / cytoskeleton organization / endocytosis / nervous system development / cell differentiation / cytoskeleton ... dihydropyrimidinase activity / hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides / CRMPs in Sema3A signaling / nucleobase-containing compound metabolic process / Recycling pathway of L1 / cytoskeleton organization / endocytosis / nervous system development / cell differentiation / cytoskeleton / signal transduction / extracellular exosome / identical protein binding / plasma membrane / cytosol Similarity search - Function Hydantoinase/dihydropyrimidinase / Urease, subunit C; domain 1 / Urease, subunit C, domain 1 / Amidohydrolase family / Metal-dependent hydrolase, composite domain superfamily / Amidohydrolase-related / Metal-dependent hydrolases / Metal-dependent hydrolase / Roll / TIM Barrel ... Hydantoinase/dihydropyrimidinase / Urease, subunit C; domain 1 / Urease, subunit C, domain 1 / Amidohydrolase family / Metal-dependent hydrolase, composite domain superfamily / Amidohydrolase-related / Metal-dependent hydrolases / Metal-dependent hydrolase / Roll / TIM Barrel / Alpha-Beta Barrel / Mainly Beta / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.26 Å DetailsAuthors Jiang, X. / Ogawa, T. / Hirokawa, N. Funding support Japan, 3items Details Hide detailsOrganization Grant number Country Japan Agency for Medical Research and Development (AMED) JP18dm0908001 Japan Japan Agency for Medical Research and Development (AMED) JP18dm0107083 Japan Japan Agency for Medical Research and Development (AMED) JP18am0101070 Japan
CitationJournal : Life Sci Alliance / Year : 2019Title : Enhanced carbonyl stress induces irreversible multimerization of CRMP2 in schizophrenia pathogenesis.Authors : Toyoshima, M. / Jiang, X. / Ogawa, T. / Ohnishi, T. / Yoshihara, S. / Balan, S. / Yoshikawa, T. / Hirokawa, N. History Deposition Apr 16, 2019 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Oct 9, 2019 Provider : repository / Type : Initial releaseRevision 1.1 Oct 23, 2019 Group : Data collection / Database references / Category : citation / citation_authorItem : _citation.journal_volume / _citation.pdbx_database_id_PubMed / _citation_author.identifier_ORCIDRevision 1.2 Nov 22, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ncs_dom_lim Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id
Show all Show less