Entry Database : PDB / ID : 6jck Structure visualization Downloads & linksTitle Complex structure of Axin-DIX and Dvl2-DIX ComponentsAxin-1 AXIN1 Segment polarity protein dishevelled homolog DVL-2 DetailsKeywords SIGNALING PROTEIN / Wnt signallingFunction / homology Function and homology informationFunction Domain/homology Component
Negative regulation of TCF-dependent signaling by DVL-interacting proteins / convergent extension involved in neural plate elongation / planar cell polarity pathway involved in neural tube closure / armadillo repeat domain binding / cochlea morphogenesis / head development / segment specification / WNT5A-dependent internalization of FZD4 / cell development / dorsal/ventral axis specification ... Negative regulation of TCF-dependent signaling by DVL-interacting proteins / convergent extension involved in neural plate elongation / planar cell polarity pathway involved in neural tube closure / armadillo repeat domain binding / cochlea morphogenesis / head development / segment specification / WNT5A-dependent internalization of FZD4 / cell development / dorsal/ventral axis specification / non-canonical Wnt signaling pathway / positive regulation of neuron projection arborization / axial mesoderm formation / WNT5:FZD7-mediated leishmania damping / clathrin-coated endocytic vesicle / post-anal tail morphogenesis / APC truncation mutants have impaired AXIN binding / AXIN missense mutants destabilize the destruction complex / Truncations of AMER1 destabilize the destruction complex / epigenetic programming in the zygotic pronuclei / beta-catenin destruction complex / positive regulation of ubiquitin-dependent protein catabolic process / frizzled binding / Beta-catenin phosphorylation cascade / Signaling by GSK3beta mutants / CTNNB1 S33 mutants aren't phosphorylated / CTNNB1 S37 mutants aren't phosphorylated / CTNNB1 S45 mutants aren't phosphorylated / CTNNB1 T41 mutants aren't phosphorylated / PCP/CE pathway / I-SMAD binding / Wnt signalosome / Signaling by Hippo / WNT mediated activation of DVL / aggresome / Disassembly of the destruction complex and recruitment of AXIN to the membrane / Wnt signaling pathway, planar cell polarity pathway / nucleocytoplasmic transport / negative regulation of protein metabolic process / negative regulation of fat cell differentiation / RUNX1 regulates transcription of genes involved in WNT signaling / RUNX1 regulates estrogen receptor mediated transcription / heart looping / outflow tract morphogenesis / negative regulation of transcription elongation by RNA polymerase II / positive regulation of transforming growth factor beta receptor signaling pathway / activation of protein kinase activity / SMAD binding / R-SMAD binding / ubiquitin-like ligase-substrate adaptor activity / lateral plasma membrane / canonical Wnt signaling pathway / signaling adaptor activity / cytoplasmic microtubule organization / positive regulation of JUN kinase activity / positive regulation of peptidyl-threonine phosphorylation / positive regulation of protein ubiquitination / Asymmetric localization of PCP proteins / TCF dependent signaling in response to WNT / neural tube closure / RHO GTPases Activate Formins / cell periphery / Degradation of DVL / regulation of actin cytoskeleton organization / Degradation of AXIN / sensory perception of sound / positive regulation of JNK cascade / Degradation of beta-catenin by the destruction complex / negative regulation of canonical Wnt signaling pathway / protein localization / beta-catenin binding / small GTPase binding / protein polyubiquitination / positive regulation of DNA-binding transcription factor activity / positive regulation of protein catabolic process / : / microtubule cytoskeleton / protein-macromolecule adaptor activity / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / p53 binding / Cargo recognition for clathrin-mediated endocytosis / apical part of cell / Clathrin-mediated endocytosis / positive regulation of peptidyl-serine phosphorylation / regulation of cell population proliferation / heart development / cell cortex / cytoplasmic vesicle / proteasome-mediated ubiquitin-dependent protein catabolic process / protein-containing complex assembly / Estrogen-dependent gene expression / in utero embryonic development / molecular adaptor activity / nuclear body / Ub-specific processing proteases / intracellular signal transduction / positive regulation of protein phosphorylation / protein domain specific binding / negative regulation of gene expression / apoptotic process Similarity search - Function Ribosomal Protein L25; Chain P - #130 / Axin beta-catenin binding / Axin-1/2, tankyrase-binding domain / Axin-like / Axin beta-catenin binding motif / Axin-1 tankyrase binding domain / Dishevelled-2 / Dishevelled protein domain / Dishevelled family / Dishevelled C-terminal ... Ribosomal Protein L25; Chain P - #130 / Axin beta-catenin binding / Axin-1/2, tankyrase-binding domain / Axin-like / Axin beta-catenin binding motif / Axin-1 tankyrase binding domain / Dishevelled-2 / Dishevelled protein domain / Dishevelled family / Dishevelled C-terminal / Dishevelled specific domain / Segment polarity protein dishevelled (Dsh) C terminal / Dishevelled-related protein / DIX domain / DIX domain superfamily / DIX domain / DIX domain profile. / Domain present in Dishevelled and axin / RGS, subdomain 1/3 / Ribosomal Protein L25; Chain P / Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) / DEP domain profile. / Domain found in Dishevelled, Egl-10, and Pleckstrin / DEP domain / Regulator of G protein signaling domain / RGS, subdomain 2 / RGS domain / RGS domain profile. / Regulator of G protein signalling domain / RGS domain superfamily / PDZ domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / Ubiquitin-like domain superfamily / Winged helix DNA-binding domain superfamily / Winged helix-like DNA-binding domain superfamily / Beta Barrel / Mainly Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 3.09 Å DetailsAuthors Yamanishi, K. / Shibata, N. Funding support Japan, 2items Details Hide detailsOrganization Grant number Country Ministry of Education, Culture, Sports, Science and Technology (Japan) 23121526 Japan Ministry of Education, Culture, Sports, Science and Technology (Japan) 25121731 Japan
CitationJournal : Sci.Signal. / Year : 2019Title : A direct heterotypic interaction between the DIX domains of Dishevelled and Axin mediates signaling to beta-catenin.Authors : Yamanishi, K. / Fiedler, M. / Terawaki, S.I. / Higuchi, Y. / Bienz, M. / Shibata, N. History Deposition Jan 29, 2019 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Jan 15, 2020 Provider : repository / Type : Initial releaseRevision 1.1 Nov 22, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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