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Yorodumi- PDB-6j6l: Crystal structure of mouse Ryanodine Receptor 2 SPRY1 Domain (650... -
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-Basic information
Entry | Database: PDB / ID: 6j6l | ||||||
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Title | Crystal structure of mouse Ryanodine Receptor 2 SPRY1 Domain (650-844) disease mutant I784F | ||||||
Components | Ryanodine receptor 2 | ||||||
Keywords | METAL TRANSPORT / Ryanodine Receptor 2 / SPRY1 / disease mutation | ||||||
Function / homology | Function and homology information manganese ion transmembrane transport / suramin binding / establishment of protein localization to endoplasmic reticulum / type B pancreatic cell apoptotic process / Purkinje myocyte to ventricular cardiac muscle cell signaling / regulation of SA node cell action potential / regulation of atrial cardiac muscle cell action potential / left ventricular cardiac muscle tissue morphogenesis / organic cyclic compound binding / regulation of AV node cell action potential ...manganese ion transmembrane transport / suramin binding / establishment of protein localization to endoplasmic reticulum / type B pancreatic cell apoptotic process / Purkinje myocyte to ventricular cardiac muscle cell signaling / regulation of SA node cell action potential / regulation of atrial cardiac muscle cell action potential / left ventricular cardiac muscle tissue morphogenesis / organic cyclic compound binding / regulation of AV node cell action potential / calcium-induced calcium release activity / sarcoplasmic reticulum calcium ion transport / Stimuli-sensing channels / Ion homeostasis / ventricular cardiac muscle cell action potential / regulation of ventricular cardiac muscle cell action potential / positive regulation of sequestering of calcium ion / embryonic heart tube morphogenesis / cardiac muscle hypertrophy / ryanodine-sensitive calcium-release channel activity / response to muscle activity / release of sequestered calcium ion into cytosol by sarcoplasmic reticulum / calcium ion transport into cytosol / regulation of cardiac muscle contraction by calcium ion signaling / calcium ion transmembrane import into cytosol / response to caffeine / A band / response to redox state / positive regulation of heart rate / negative regulation of cytosolic calcium ion concentration / cellular response to caffeine / protein kinase A regulatory subunit binding / intracellularly gated calcium channel activity / protein kinase A catalytic subunit binding / positive regulation of the force of heart contraction / response to magnesium ion / : / detection of calcium ion / smooth endoplasmic reticulum / regulation of cardiac muscle contraction / regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion / striated muscle contraction / release of sequestered calcium ion into cytosol / cardiac muscle contraction / extrinsic component of cytoplasmic side of plasma membrane / monoatomic ion transmembrane transport / sarcoplasmic reticulum membrane / cellular response to epinephrine stimulus / calcium channel complex / regulation of cytosolic calcium ion concentration / response to muscle stretch / regulation of heart rate / sarcomere / sarcoplasmic reticulum / establishment of localization in cell / calcium-mediated signaling / calcium ion transmembrane transport / calcium channel activity / sarcolemma / Z disc / response to calcium ion / intracellular calcium ion homeostasis / calcium ion transport / : / nuclear envelope / scaffold protein binding / calmodulin binding / response to hypoxia / calcium ion binding / protein kinase binding / enzyme binding / protein-containing complex / membrane / identical protein binding Similarity search - Function | ||||||
Biological species | Mus musculus (house mouse) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.452 Å | ||||||
Authors | Ma, R. / Lin, L. / Yuchi, Z. | ||||||
Citation | Journal: Sci Rep / Year: 2021 Title: A SPRY1 domain cardiac ryanodine receptor variant associated with short-coupled torsade de pointes. Authors: Touat-Hamici, Z. / Blancard, M. / Ma, R. / Lin, L. / Iddir, Y. / Denjoy, I. / Leenhardt, A. / Yuchi, Z. / Guicheney, P. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 6j6l.cif.gz | 162.8 KB | Display | PDBx/mmCIF format |
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PDB format | pdb6j6l.ent.gz | 127.6 KB | Display | PDB format |
PDBx/mmJSON format | 6j6l.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/j6/6j6l ftp://data.pdbj.org/pub/pdb/validation_reports/j6/6j6l | HTTPS FTP |
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-Related structure data
Related structure data | 5c33S S: Starting model for refinement |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Ens-ID: 1
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