登録情報 | データベース: PDB / ID: 6i4m |
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タイトル | Crystal Structure of Plasmodium berghei actin II in the Mg-ADP state |
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要素 | - Actin-2
アクチン - Gelsolin
![](img/lk-wikipe.gif) |
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キーワード | CONTRACTILE PROTEIN / hydrolase (加水分解酵素) / filamentous / cytoskeleton (細胞骨格) |
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機能・相同性 | 機能・相同性情報
positive regulation of development of symbiont in host / exit from host cell / glial filament / apical ectoplasmic specialization / basal ectoplasmic specialization / male gamete generation / Caspase-mediated cleavage of cytoskeletal proteins / striated muscle atrophy / regulation of establishment of T cell polarity / regulation of plasma membrane raft polarization ...positive regulation of development of symbiont in host / exit from host cell / glial filament / apical ectoplasmic specialization / basal ectoplasmic specialization / male gamete generation / Caspase-mediated cleavage of cytoskeletal proteins / striated muscle atrophy / regulation of establishment of T cell polarity / regulation of plasma membrane raft polarization / regulation of receptor clustering / renal protein absorption / positive regulation of keratinocyte apoptotic process / positive regulation of protein processing in phagocytic vesicle / positive regulation of actin nucleation / phosphatidylinositol 3-kinase catalytic subunit binding / cilium organization / actin cap / regulation of podosome assembly / sequestering of actin monomers / myosin II binding / negative regulation of viral entry into host cell / actin filament severing / actin filament capping / barbed-end actin filament capping / actin polymerization or depolymerization / actin filament depolymerization / cell projection assembly / cardiac muscle cell contraction / podosome / relaxation of cardiac muscle / positive regulation of p38MAPK cascade / phagocytosis, engulfment / positive regulation of cardiac muscle hypertrophy / hepatocyte apoptotic process / cilium assembly / 筋形質 / vesicle-mediated transport / phagocytic vesicle / ruffle / phosphatidylinositol-4,5-bisphosphate binding / cellular response to cadmium ion / response to muscle stretch / actin filament polymerization / Neutrophil degranulation / central nervous system development / 加水分解酵素; 酸無水物に作用; 酸無水物に作用・細胞または細胞小器官の運動に関与 / protein destabilization / cellular response to type II interferon / actin filament binding / マイクロフィラメント / lamellipodium / 髄鞘 / actin binding / actin cytoskeleton organization / amyloid fibril formation / 細胞骨格 / calcium ion binding / perinuclear region of cytoplasm / ATP hydrolysis activity / protein-containing complex / extracellular space / extracellular region / ATP binding / 細胞核 / 細胞膜 / 細胞質基質 / 細胞質類似検索 - 分子機能 Villin/Gelsolin / Gelsolin homology domain / Severin / Severin / Gelsolin-like domain / Gelsolin repeat / ADF-H/Gelsolin-like domain superfamily / ATPase, substrate binding domain, subdomain 4 / Actin; Chain A, domain 4 / ATPase, nucleotide binding domain ...Villin/Gelsolin / Gelsolin homology domain / Severin / Severin / Gelsolin-like domain / Gelsolin repeat / ADF-H/Gelsolin-like domain superfamily / ATPase, substrate binding domain, subdomain 4 / Actin; Chain A, domain 4 / ATPase, nucleotide binding domain / Actins signature 1. / Actin, conserved site / Actins signature 2. / Actin/actin-like conserved site / Actins and actin-related proteins signature. / アクチン / Actin family / アクチン / ATPase, nucleotide binding domain / Nucleotidyltransferase; domain 5 / Alpha-Beta Complex / 2-Layer Sandwich / 3-Layer(aba) Sandwich / Alpha Beta類似検索 - ドメイン・相同性 ADENOSINE-5'-DIPHOSPHATE / THIOCYANATE ION / Gelsolin / Actin-2類似検索 - 構成要素 |
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生物種 | ![](img/tx_eukaryote.gif) ![](data/taxo/icon/Plasmodium_falciparum_S.png) Plasmodium berghei (ネズミマラリア原虫)
![](img/tx_mammal.gif) ![](data/taxo/icon/Mus_musculus_S.png) Mus musculus (ハツカネズミ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.873 Å |
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データ登録者 | Kumpula, E.-P. / Lopez, A.J. / Tajedin, L. / Han, H. / Kursula, I. |
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資金援助 | フィンランド, ノルウェー, 3件 組織 | 認可番号 | 国 |
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Academy of Finland | | フィンランド | Sigrid Juselius Foundation | | フィンランド | Research Council of Norway | | ノルウェー |
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引用 | ジャーナル: Plos Biol. / 年: 2019 タイトル: Atomic view into Plasmodium actin polymerization, ATP hydrolysis, and fragmentation. 著者: Kumpula, E.P. / Lopez, A.J. / Tajedin, L. / Han, H. / Kursula, I. |
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履歴 | 登録 | 2018年11月9日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2019年6月26日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年1月24日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_asym_id / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_asym_id / _pdbx_struct_conn_angle.ptnr2_auth_comp_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr2_label_atom_id / _pdbx_struct_conn_angle.ptnr2_label_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id |
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