Entry | Database: PDB / ID: 6g4y |
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Title | Crystal structure of murine NF-kappaB inducing kinase (NIK) in complex with compound 1a |
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Components | Mitogen-activated protein kinase kinase kinase 14 |
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Keywords | TRANSFERASE / PROTEIN SERINE/THREONINE KINASE / NF-KAPPAB / MAP3K14 |
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Function / homology | Function and homology information |
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Biological species | ![](img/tx_mammal.gif) ![](data/taxo/icon/Mus_musculus_S.png) Mus musculus (house mouse) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.65 Å |
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Authors | Hole, A.J. / Hymowitz, S.G. / McEwan, P.A. |
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Citation | Journal: J. Med. Chem. / Year: 2018 Title: Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-kappa B Inducing Kinase. Authors: Blaquiere, N. / Castanedo, G.M. / Burch, J.D. / Berezhkovskiy, L.M. / Brightbill, H. / Brown, S. / Chan, C. / Chiang, P.C. / Crawford, J.J. / Dong, T. / Fan, P. / Feng, J. / Ghilardi, N. / ...Authors: Blaquiere, N. / Castanedo, G.M. / Burch, J.D. / Berezhkovskiy, L.M. / Brightbill, H. / Brown, S. / Chan, C. / Chiang, P.C. / Crawford, J.J. / Dong, T. / Fan, P. / Feng, J. / Ghilardi, N. / Godemann, R. / Gogol, E. / Grabbe, A. / Hole, A.J. / Hu, B. / Hymowitz, S.G. / Alaoui Ismaili, M.H. / Le, H. / Lee, P. / Lee, W. / Lin, X. / Liu, N. / McEwan, P.A. / McKenzie, B. / Silvestre, H.L. / Suto, E. / Sujatha-Bhaskar, S. / Wu, G. / Wu, L.C. / Zhang, Y. / Zhong, Z. / Staben, S.T. |
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History | Deposition | Mar 28, 2018 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Jul 4, 2018 | Provider: repository / Type: Initial release |
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Revision 1.1 | Aug 1, 2018 | Group: Data collection / Database references / Category: citation / citation_author / Item: _citation.title |
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Revision 1.2 | Aug 22, 2018 | Group: Data collection / Database references / Structure summary Category: citation / struct Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _struct.title |
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Revision 1.3 | May 8, 2024 | Group: Data collection / Database references / Category: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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