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Yorodumi- PDB-6fwu: Crystal structure of human wild type beta-1,4-galactosyltransfera... -
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-Basic information
Entry | Database: PDB / ID: 6fwu | ||||||
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Title | Crystal structure of human wild type beta-1,4-galactosyltransferase-1 (B4GalT1) in apo-closed dimeric form | ||||||
Components | Beta-1,4-galactosyltransferase 1 | ||||||
Keywords | TRANSFERASE / Galactosyltransferase / beta-1 / 4-galactosyltransferase I / B4GalT1 / GalT1 / glycosyltransferase / N-linked glycosylation / apo / monomer / monomeric / open conformation | ||||||
Function / homology | Function and homology information Defective B4GALT1 causes CDG-2d / galactosyltransferase activity / Interaction With Cumulus Cells And The Zona Pellucida / Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) / regulation of acrosome reaction / penetration of zona pellucida / Lactose synthesis / Keratan sulfate biosynthesis / lactose synthase / neolactotriaosylceramide beta-1,4-galactosyltransferase ...Defective B4GALT1 causes CDG-2d / galactosyltransferase activity / Interaction With Cumulus Cells And The Zona Pellucida / Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) / regulation of acrosome reaction / penetration of zona pellucida / Lactose synthesis / Keratan sulfate biosynthesis / lactose synthase / neolactotriaosylceramide beta-1,4-galactosyltransferase / beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase / N-acetyllactosamine synthase / N-acetyllactosamine synthase activity / positive regulation of circulating fibrinogen levels / beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity / N-Glycan antennae elongation / UDP-galactosyltransferase activity / Golgi trans cisterna / macrophage migration / lactose synthase activity / development of secondary sexual characteristics / lactose biosynthetic process / oligosaccharide biosynthetic process / desmosome / galactose metabolic process / acute inflammatory response / positive regulation of epithelial cell proliferation involved in wound healing / Pre-NOTCH Processing in Golgi / binding of sperm to zona pellucida / angiogenesis involved in wound healing / protein N-linked glycosylation / Transferases; Glycosyltransferases; Hexosyltransferases / azurophil granule membrane / Golgi cisterna membrane / beta-tubulin binding / epithelial cell development / alpha-tubulin binding / cytoskeletal protein binding / extracellular matrix organization / secretory granule membrane / epithelial cell proliferation / filopodium / brush border membrane / lipid metabolic process / negative regulation of epithelial cell proliferation / manganese ion binding / basolateral plasma membrane / cell adhesion / positive regulation of apoptotic process / external side of plasma membrane / Golgi membrane / Neutrophil degranulation / Golgi apparatus / protein-containing complex / extracellular space / extracellular exosome / membrane / identical protein binding / plasma membrane Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.35 Å | ||||||
Authors | Harrus, D. / Kellokumpu, S. / Glumoff, T. | ||||||
Funding support | Finland, 1items
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Citation | Journal: PLoS ONE / Year: 2018 Title: The dimeric structure of wild-type human glycosyltransferase B4GalT1. Authors: Harrus, D. / Khoder-Agha, F. / Peltoniemi, M. / Hassinen, A. / Ruddock, L. / Kellokumpu, S. / Glumoff, T. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 6fwu.cif.gz | 194.2 KB | Display | PDBx/mmCIF format |
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PDB format | pdb6fwu.ent.gz | 156.4 KB | Display | PDB format |
PDBx/mmJSON format | 6fwu.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/fw/6fwu ftp://data.pdbj.org/pub/pdb/validation_reports/fw/6fwu | HTTPS FTP |
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-Related structure data
Related structure data | 6fwtC 4ee3S S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Ens-ID: 1
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