登録情報 | データベース: PDB / ID: 6c0b |
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タイトル | Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B |
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要素 | - Frizzled-2
- Toxin B
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キーワード | TOXIN (毒素) / complex |
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機能・相同性 | 機能・相同性情報
muscular septum morphogenesis / planar cell polarity pathway involved in neural tube closure / cochlea morphogenesis / WNT5A-dependent internalization of FZD2, FZD5 and ROR2 / hard palate development / Wnt receptor activity / membranous septum morphogenesis / non-canonical Wnt signaling pathway / inner ear receptor cell development / glucosyltransferase activity ...muscular septum morphogenesis / planar cell polarity pathway involved in neural tube closure / cochlea morphogenesis / WNT5A-dependent internalization of FZD2, FZD5 and ROR2 / hard palate development / Wnt receptor activity / membranous septum morphogenesis / non-canonical Wnt signaling pathway / inner ear receptor cell development / glucosyltransferase activity / Wnt-protein binding / endothelial cell differentiation / Class B/2 (Secretin family receptors) / Disassembly of the destruction complex and recruitment of AXIN to the membrane / Wnt signaling pathway, planar cell polarity pathway / host cell cytosol / 転移酵素; グリコシル基を移すもの; 六炭糖残基を移すもの / glycosyltransferase activity / outflow tract morphogenesis / canonical Wnt signaling pathway / cysteine-type peptidase activity / host cell endosome membrane / Asymmetric localization of PCP proteins / TCF dependent signaling in response to WNT / G protein-coupled receptor activity / PDZ domain binding / clathrin-coated endocytic vesicle membrane / neuron differentiation / Wntシグナル経路 / positive regulation of DNA-binding transcription factor activity / sensory perception of smell / Ca2+ pathway / peptidase activity / toxin activity / 加水分解酵素; プロテアーゼ; ペプチド結合加水分解酵素; システインプロテアーゼ / focal adhesion / lipid binding / host cell plasma membrane / positive regulation of DNA-templated transcription / タンパク質分解 / extracellular region / 生体膜 / metal ion binding / 細胞膜 / 細胞質類似検索 - 分子機能 Frizzled 2, cysteine-rich domain / Frizzled cysteine-rich domain / Frizzled cysteine-rich domain / TcdA/TcdB toxin, N-terminal helical domain / TcdB toxin N-terminal helical domain / Dermonecrotic/RTX toxin, membrane localization domain / TcdA/TcdB toxin, catalytic glycosyltransferase domain / Membrane Localization Domain / TcdA/TcdB catalytic glycosyltransferase domain / Frizzled/Smoothened, transmembrane domain ...Frizzled 2, cysteine-rich domain / Frizzled cysteine-rich domain / Frizzled cysteine-rich domain / TcdA/TcdB toxin, N-terminal helical domain / TcdB toxin N-terminal helical domain / Dermonecrotic/RTX toxin, membrane localization domain / TcdA/TcdB toxin, catalytic glycosyltransferase domain / Membrane Localization Domain / TcdA/TcdB catalytic glycosyltransferase domain / Frizzled/Smoothened, transmembrane domain / TcdA/TcdB toxin, pore forming domain / Frizzled/Smoothened family membrane region / TcdA/TcdB pore forming domain / Frizzled/Smoothened family membrane region / Frizzled/secreted frizzled-related protein / Frizzled / CGT/MARTX, cysteine protease (CPD) domain / CGT/MARTX, cysteine protease (CPD) domain superfamily / Peptidase C80 family / CGT/MARTX cysteine protease (CPD) domain profile. / Frizzled domain / Frizzled cysteine-rich domain superfamily / Fz domain / Frizzled (fz) domain profile. / Choline-binding repeat / Putative cell wall binding repeat / Cell wall/choline-binding repeat / Cell wall-binding repeat profile. / GPCR, family 2-like / G-protein coupled receptors family 2 profile 2. / Nucleotide-diphospho-sugar transferases / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 マロン酸 / パルミトレイン酸 / Glycosylating toxin TcdB / Toxin B / Frizzled-2類似検索 - 構成要素 |
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生物種 | Clostridioides difficile (クロストリディオイデス・ディフィシル) Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 単波長異常分散 / 解像度: 2.5 Å |
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データ登録者 | Chen, P. / Lam, K. / Jin, R. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | R01AI091823, R01 AI125704, and R21AI123920 | 米国 |
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引用 | ジャーナル: Science / 年: 2018 タイトル: Structural basis for recognition of frizzled proteins byClostridium difficiletoxin B. 著者: Chen, P. / Tao, L. / Wang, T. / Zhang, J. / He, A. / Lam, K.H. / Liu, Z. / He, X. / Perry, K. / Dong, M. / Jin, R. |
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履歴 | 登録 | 2017年12月28日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2018年5月16日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2018年5月23日 | Group: Data collection / Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.name |
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改定 1.2 | 2019年2月20日 | Group: Author supporting evidence / Data collection / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.3 | 2019年12月18日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.4 | 2020年7月29日 | Group: Data collection / Derived calculations / Structure summary カテゴリ: chem_comp / entity ...chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / struct_conn / struct_site / struct_site_gen Item: _chem_comp.name / _chem_comp.type ..._chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_conn.pdbx_role 解説: Carbohydrate remediation / Provider: repository / タイプ: Remediation |
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