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Yorodumi- PDB-6b88: E. coli LepB in complex with GNE0775 ((4S,7S,10S)-10-((S)-4-amino... -
+Open data
-Basic information
Entry | Database: PDB / ID: 6b88 | ||||||
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Title | E. coli LepB in complex with GNE0775 ((4S,7S,10S)-10-((S)-4-amino-2-(2-(4-(tert-butyl)phenyl)-4-methylpyrimidine-5-carboxamido)-N-methylbutanamido)-16,26-bis(2-aminoethoxy)-N-(2-iminoethyl)-7-methyl-6,9-dioxo-5,8-diaza-1,2(1,3)-dibenzenacyclodecaphane-4-carboxamide) | ||||||
Components | Signal peptidase I | ||||||
Keywords | HYDROLASE/HYDROLASE inhibitor / Signal peptidase / SBDD / antibiotic / HYDROLASE / HYDROLASE-HYDROLASE inhibitor complex | ||||||
Function / homology | Function and homology information signal peptidase I / signal peptide processing / protein processing / peptidase activity / endopeptidase activity / serine-type endopeptidase activity / proteolysis / plasma membrane Similarity search - Function | ||||||
Biological species | Escherichia coli (E. coli) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 2.407 Å | ||||||
Authors | Murray, J.M. / Rouge, L. | ||||||
Citation | Journal: Nature / Year: 2018 Title: Optimized arylomycins are a new class of Gram-negative antibiotics. Authors: Smith, P.A. / Koehler, M.F.T. / Girgis, H.S. / Yan, D. / Chen, Y. / Chen, Y. / Crawford, J.J. / Durk, M.R. / Higuchi, R.I. / Kang, J. / Murray, J. / Paraselli, P. / Park, S. / Phung, W. / ...Authors: Smith, P.A. / Koehler, M.F.T. / Girgis, H.S. / Yan, D. / Chen, Y. / Chen, Y. / Crawford, J.J. / Durk, M.R. / Higuchi, R.I. / Kang, J. / Murray, J. / Paraselli, P. / Park, S. / Phung, W. / Quinn, J.G. / Roberts, T.C. / Rouge, L. / Schwarz, J.B. / Skippington, E. / Wai, J. / Xu, M. / Yu, Z. / Zhang, H. / Tan, M.W. / Heise, C.E. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 6b88.cif.gz | 209.9 KB | Display | PDBx/mmCIF format |
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PDB format | pdb6b88.ent.gz | 167.3 KB | Display | PDB format |
PDBx/mmJSON format | 6b88.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/b8/6b88 ftp://data.pdbj.org/pub/pdb/validation_reports/b8/6b88 | HTTPS FTP |
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-Related structure data
Related structure data | 1t7dS S: Starting model for refinement |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Ens-ID: 1
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