- PDB-5yuf: Crystal Structure of PML RING tetramer -
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Basic information
Entry
Database: PDB / ID: 5yuf
Title
Crystal Structure of PML RING tetramer
Components
Protein PML
Keywords
ONCOPROTEIN / PML nuclear body biogenesis / sumoylation / RING tetramerization / PML-RARA / targeted therapy
Function / homology
Function and homology information
regulation of calcium ion transport into cytosol / negative regulation of translation in response to oxidative stress / ubiquitin-like protein ligase activity / SUMO-modified protein reader activity / positive regulation of protein localization to chromosome, telomeric region / positive regulation of peptidyl-lysine acetylation / suppression of viral release by host / PML body organization / SUMO binding / fibroblast migration ...regulation of calcium ion transport into cytosol / negative regulation of translation in response to oxidative stress / ubiquitin-like protein ligase activity / SUMO-modified protein reader activity / positive regulation of protein localization to chromosome, telomeric region / positive regulation of peptidyl-lysine acetylation / suppression of viral release by host / PML body organization / SUMO binding / fibroblast migration / positive regulation of apoptotic process involved in mammary gland involution / negative regulation of telomerase activity / regulation of double-strand break repair / myeloid cell differentiation / positive regulation of telomere maintenance / SMAD protein signal transduction / maintenance of protein location in nucleus / protein-containing complex localization / Transferases; Acyltransferases; Aminoacyltransferases / endoplasmic reticulum calcium ion homeostasis / positive regulation of extrinsic apoptotic signaling pathway / oncogene-induced cell senescence / Regulation of RUNX1 Expression and Activity / branching involved in mammary gland duct morphogenesis / SUMO transferase activity / negative regulation of interleukin-1 beta production / intrinsic apoptotic signaling pathway in response to oxidative stress / cobalt ion binding / SUMOylation of ubiquitinylation proteins / entrainment of circadian clock by photoperiod / SMAD binding / protein monoubiquitination / positive regulation of signal transduction by p53 class mediator / protein sumoylation / negative regulation of telomere maintenance via telomerase / negative regulation of mitotic cell cycle / intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress / intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / retinoic acid receptor signaling pathway / cell fate commitment / protein targeting / cellular response to interleukin-4 / regulation of cell adhesion / SUMOylation of DNA damage response and repair proteins / response to UV / extrinsic apoptotic signaling pathway / positive regulation of defense response to virus by host / Regulation of TP53 Activity through Acetylation / DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest / negative regulation of ubiquitin-dependent protein catabolic process / Regulation of PTEN localization / negative regulation of angiogenesis / transforming growth factor beta receptor signaling pathway / cellular response to leukemia inhibitory factor / response to cytokine / response to gamma radiation / circadian regulation of gene expression / regulation of circadian rhythm / negative regulation of cell growth / PML body / nuclear matrix / HCMV Early Events / Transcriptional regulation of granulopoiesis / protein import into nucleus / intrinsic apoptotic signaling pathway in response to DNA damage / Interferon gamma signaling / ubiquitin protein ligase activity / cellular senescence / positive regulation of fibroblast proliferation / early endosome membrane / nuclear membrane / proteasome-mediated ubiquitin-dependent protein catabolic process / protein-containing complex assembly / chromosome, telomeric region / transcription coactivator activity / molecular adaptor activity / protein stabilization / response to hypoxia / regulation of cell cycle / chromatin remodeling / protein heterodimerization activity / negative regulation of cell population proliferation / innate immune response / negative regulation of DNA-templated transcription / apoptotic process / ubiquitin protein ligase binding / endoplasmic reticulum membrane / regulation of DNA-templated transcription / nucleolus / protein homodimerization activity / DNA binding / zinc ion binding / nucleoplasm / identical protein binding / nucleus / cytosol / cytoplasm Similarity search - Function
Protein of unknown function DUF3583 / PML-like, coiled-coil / : / B-box zinc finger / B-Box-type zinc finger / B-box-type zinc finger / Zinc finger B-box type profile. / Zinc finger, C3HC4 RING-type / Zinc finger, C3HC4 type (RING finger) / Zinc finger, RING-type, conserved site ...Protein of unknown function DUF3583 / PML-like, coiled-coil / : / B-box zinc finger / B-Box-type zinc finger / B-box-type zinc finger / Zinc finger B-box type profile. / Zinc finger, C3HC4 RING-type / Zinc finger, C3HC4 type (RING finger) / Zinc finger, RING-type, conserved site / Zinc finger RING-type signature. / Ring finger / Zinc finger RING-type profile. / Zinc finger, RING-type / Zinc finger, RING/FYVE/PHD-type Similarity search - Domain/homology