登録情報 データベース : PDB / ID : 5nbq 構造の表示 ダウンロードとリンクタイトル The structure of the tripartite complex between OspE, the C-terminal domains of factor H and C3dg 要素Complement C3 Complement component 3 Complement factor H Factor H Outer surface protein E Outer surface protein E,Outer surface protein E 詳細キーワード IMMUNE SYSTEM (免疫系) / complement / regulation (規制) / microbe / evasion機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
regulation of complement activation, alternative pathway / symbiont cell surface / oviduct epithelium development / C5L2 anaphylatoxin chemotactic receptor binding / regulation of triglyceride biosynthetic process / positive regulation of activation of membrane attack complex / complement component C3b binding / regulation of complement-dependent cytotoxicity / vertebrate eye-specific patterning / positive regulation of apoptotic cell clearance ... regulation of complement activation, alternative pathway / symbiont cell surface / oviduct epithelium development / C5L2 anaphylatoxin chemotactic receptor binding / regulation of triglyceride biosynthetic process / positive regulation of activation of membrane attack complex / complement component C3b binding / regulation of complement-dependent cytotoxicity / vertebrate eye-specific patterning / positive regulation of apoptotic cell clearance / regulation of complement activation / complement-mediated synapse pruning / Alternative complement activation / positive regulation of lipid storage / positive regulation of G protein-coupled receptor signaling pathway / positive regulation of phagocytosis, engulfment / complement receptor mediated signaling pathway / Activation of C3 and C5 / positive regulation of type IIa hypersensitivity / positive regulation of glucose transmembrane transport / 補体依存性細胞傷害 / heparan sulfate proteoglycan binding / serine-type endopeptidase complex / complement activation, alternative pathway / 補体 / neuron remodeling / endopeptidase inhibitor activity / amyloid-beta clearance / positive regulation of vascular endothelial growth factor production / Purinergic signaling in leishmaniasis infection / Peptide ligand-binding receptors / complement activation, classical pathway / fatty acid metabolic process / Regulation of Complement cascade / Post-translational protein phosphorylation / response to bacterium / positive regulation of receptor-mediated endocytosis / positive regulation of angiogenesis / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / azurophil granule lumen / heparin binding / G alpha (i) signalling events / secretory granule lumen / blood microparticle / 炎症 / 免疫応答 / positive regulation of protein phosphorylation / G protein-coupled receptor signaling pathway / 小胞体 / signaling receptor binding / Neutrophil degranulation / 細胞膜 / シグナル伝達 / protein-containing complex / タンパク質分解 / extracellular space / extracellular exosome / extracellular region / identical protein binding / 細胞膜 類似検索 - 分子機能 Borrelia outer surface protein E/F / OspE-like superfamily / Borrelia outer surface protein E / Borrelia outer surface protein E/F / Transcriptional Co-activator pc4; Chain A / : / : / Complement component 3, CUB domain, second segment / Complement component 3, CUB domain, first segment / Complement C3-like, NTR domain ... Borrelia outer surface protein E/F / OspE-like superfamily / Borrelia outer surface protein E / Borrelia outer surface protein E/F / Transcriptional Co-activator pc4; Chain A / : / : / Complement component 3, CUB domain, second segment / Complement component 3, CUB domain, first segment / Complement C3-like, NTR domain / Alpha-2-macroglobulin, conserved site / Alpha-2-macroglobulin family thiolester region signature. / Complement Module, domain 1 / Complement C3/4/5, macroglobulin domain MG1 / Macroglobulin domain MG1 / : / Alpha-macro-globulin thiol-ester bond-forming region / Anaphylatoxin, complement system domain / Anaphylatoxin domain signature. / Anaphylatoxin/fibulin / Anaphylatoxin, complement system / Anaphylotoxin-like domain / Anaphylatoxin domain profile. / Anaphylatoxin homologous domain / Complement Module; domain 1 / Netrin C-terminal Domain / Netrin module, non-TIMP type / UNC-6/NTR/C345C module / Glycosyltransferase - #20 / Alpha-macroglobulin, receptor-binding / Alpha-macroglobulin, receptor-binding domain superfamily / Macroglobulin domain MG4 / Macroglobulin domain MG3 / A-macroglobulin receptor binding domain / Macroglobulin domain MG4 / Macroglobulin domain MG3 / A-macroglobulin receptor / Netrin domain / NTR domain profile. / Tissue inhibitor of metalloproteinases-like, OB-fold / Α2-マクログロブリン / Macroglobulin domain / Alpha-2-macroglobulin, bait region domain / Alpha-macroglobulin-like, TED domain / Alpha-2-macroglobulin family / MG2 domain / A-macroglobulin TED domain / Alpha-2-macroglobulin bait region domain / Α2-マクログロブリン / Alpha-2-macroglobulin family / Sushi repeat (SCR repeat) / Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR) / Sushi/SCR/CCP domain / Sushi/CCP/SCR domain profile. / Sushi/SCR/CCP superfamily / Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid / グリコシルトランスフェラーゼ / Alpha/alpha barrel / リボン / Roll / Immunoglobulin-like fold / Mainly Beta / Mainly Alpha 類似検索 - ドメイン・相同性 Complement C3 / Complement factor H / Outer surface protein E 類似検索 - 構成要素生物種 Homo sapiens (ヒト)Borreliella burgdorferi (バクテリア)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 3.18 Å 詳細データ登録者 Kolodziejczyk, R. / Mikula, K.M. / Kotila, T.M. / Postis, V.L.G. / Sakari, J.T. / Meri, T. 資金援助 フィンランド, 2件 詳細 詳細を隠す組織 認可番号 国 Academy of Finland 255922 and 259793 フィンランド Sigrid Juselius Foundation フィンランド
引用ジャーナル : PLoS ONE / 年 : 2017タイトル : Crystal structure of a tripartite complex between C3dg, C-terminal domains of factor H and OspE of Borrelia burgdorferi.著者 : Kolodziejczyk, R. / Mikula, K.M. / Kotila, T. / Postis, V.L.G. / Jokiranta, T.S. / Goldman, A. / Meri, T. 履歴 登録 2017年3月2日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2017年12月6日 Provider : repository / タイプ : Initial release改定 1.1 2017年12月13日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year
すべて表示 表示を減らす