Entry Database : PDB / ID : 5n9g Structure visualization Downloads & linksTitle TFIIIB -TBP/Brf2/DNA and SANT domain of Bdp1- Components(Transcription factor ... ) x 2 DNA/RNA (25-MER) DNA/RNA (27-MER) TATA-box-binding protein DetailsKeywords TRANSCRIPTIONFunction / homology Function and homology informationFunction Domain/homology Component
transcription preinitiation complex assembly / transcription factor TFIIIB complex / RNA polymerase III preinitiation complex assembly / TFIIIC-class transcription factor complex binding / RNA polymerase III type 3 promoter sequence-specific DNA binding / RNA polymerase III general transcription initiation factor activity / RNA polymerase transcription factor SL1 complex / regulation of transcription by RNA polymerase III / RNA polymerase I core promoter sequence-specific DNA binding / RNA Polymerase III Transcription Initiation From Type 1 Promoter ... transcription preinitiation complex assembly / transcription factor TFIIIB complex / RNA polymerase III preinitiation complex assembly / TFIIIC-class transcription factor complex binding / RNA polymerase III type 3 promoter sequence-specific DNA binding / RNA polymerase III general transcription initiation factor activity / RNA polymerase transcription factor SL1 complex / regulation of transcription by RNA polymerase III / RNA polymerase I core promoter sequence-specific DNA binding / RNA Polymerase III Transcription Initiation From Type 1 Promoter / RNA Polymerase III Transcription Initiation From Type 2 Promoter / RNA Polymerase III Transcription Initiation From Type 3 Promoter / RNA Polymerase III Abortive And Retractive Initiation / transcription factor TFIIA complex / female germ cell nucleus / male pronucleus / female pronucleus / RNA polymerase II general transcription initiation factor binding / transcription preinitiation complex / RNA Polymerase I Transcription Termination / HIV Transcription Initiation / RNA Polymerase II HIV Promoter Escape / Transcription of the HIV genome / RNA Polymerase II Promoter Escape / RNA Polymerase II Transcription Pre-Initiation And Promoter Opening / RNA Polymerase II Transcription Initiation / RNA Polymerase II Transcription Initiation And Promoter Clearance / RNA Polymerase I Transcription Initiation / aryl hydrocarbon receptor binding / RNA polymerase II transcribes snRNA genes / transcription factor TFIID complex / TFIIB-class transcription factor binding / RNA polymerase II general transcription initiation factor activity / transcription by RNA polymerase III / positive regulation of transcription initiation by RNA polymerase II / RNA polymerase II core promoter sequence-specific DNA binding / core promoter sequence-specific DNA binding / RNA polymerase II preinitiation complex assembly / RNA Polymerase II Pre-transcription Events / TBP-class protein binding / SIRT1 negatively regulates rRNA expression / male germ cell nucleus / DNA-templated transcription initiation / transcription initiation at RNA polymerase II promoter / RNA Polymerase I Promoter Escape / euchromatin / mRNA transcription by RNA polymerase II / NoRC negatively regulates rRNA expression / B-WICH complex positively regulates rRNA expression / cellular response to oxidative stress / spermatogenesis / DNA-binding transcription factor binding / Estrogen-dependent gene expression / Regulation of TP53 Activity through Phosphorylation / transcription by RNA polymerase II / transcription cis-regulatory region binding / RNA polymerase II cis-regulatory region sequence-specific DNA binding / chromatin / enzyme binding / protein-containing complex / nucleoplasm / metal ion binding / nucleus / cytoplasm Similarity search - Function Transcription factor TFIIIB component B'', Myb domain / Myb DNA-binding like / TATA-Binding Protein / Transcription factor TFIIB / Zinc finger TFIIB-type profile. / Cyclin-like / Zinc finger, TFIIB-type / TFIIB zinc-binding / TATA-box binding protein, eukaryotic / TATA-Binding Protein ... Transcription factor TFIIIB component B'', Myb domain / Myb DNA-binding like / TATA-Binding Protein / Transcription factor TFIIB / Zinc finger TFIIB-type profile. / Cyclin-like / Zinc finger, TFIIB-type / TFIIB zinc-binding / TATA-box binding protein, eukaryotic / TATA-Binding Protein / TATA-box binding protein / TATA-box binding protein, conserved site / Transcription factor TFIID (or TATA-binding protein, TBP) / Transcription factor TFIID repeat signature. / Cyclin A; domain 1 / TBP domain superfamily / SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains / SANT/Myb domain / Cyclin-like superfamily / Homeobox-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta Similarity search - Domain/homology DNA/RNA hybrid / DNA/RNA hybrid (> 10) / Transcription factor TFIIIB component B'' homolog / TATA-box-binding protein / Transcription factor IIIB 50 kDa subunit Similarity search - ComponentBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.7 Å DetailsAuthors Gouge, J. / Vannini, A. / Guthertz, N. Funding support United Kingdom, 3items Details Hide detailsOrganization Grant number Country Biotechnology and Biological Sciences Research Council BB/K014390/1 United Kingdom Cancer Research UK C47547/A21536 United Kingdom Wellcome Trust 200818/Z/16/Z United Kingdom
CitationJournal : Nat Commun / Year : 2017Title : Molecular mechanisms of Bdp1 in TFIIIB assembly and RNA polymerase III transcription initiation.Authors : Gouge, J. / Guthertz, N. / Kramm, K. / Dergai, O. / Abascal-Palacios, G. / Satia, K. / Cousin, P. / Hernandez, N. / Grohmann, D. / Vannini, A. History Deposition Feb 24, 2017 Deposition site : PDBE / Processing site : PDBERevision 1.0 Jun 14, 2017 Provider : repository / Type : Initial releaseRevision 1.1 Aug 2, 2017 Group : Database references / Category : citation / citation_authorItem : _citation.journal_abbrev / _citation.journal_id_CSD ... _citation.journal_abbrev / _citation.journal_id_CSD / _citation.pdbx_database_id_DOI / _citation.title / _citation.year Revision 1.2 Aug 9, 2017 Group : Database references / Category : citationItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title Revision 1.3 Aug 30, 2017 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.4 Jan 17, 2024 Group : Advisory / Data collection ... Advisory / Data collection / Database references / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_unobs_or_zero_occ_atoms / pdbx_unobs_or_zero_occ_residues Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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