登録情報 | データベース: PDB / ID: 5mpg |
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タイトル | Solution NMR structure of hnRNP A1 RRM1 in complex with 5'-UUAGGUC-3' RNA |
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要素 | - Heterogeneous nuclear ribonucleoprotein A1
- RNA UUAGGUC
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キーワード | SPLICING / RRM / RNA (リボ核酸) |
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機能・相同性 | 機能・相同性情報
cellular response to sodium arsenite / SARS-CoV-1-host interactions / import into nucleus / telomeric repeat-containing RNA binding / G-rich strand telomeric DNA binding / pre-mRNA binding / 核外搬出シグナル / RNA export from nucleus / miRNA binding / FGFR2 alternative splicing ...cellular response to sodium arsenite / SARS-CoV-1-host interactions / import into nucleus / telomeric repeat-containing RNA binding / G-rich strand telomeric DNA binding / pre-mRNA binding / 核外搬出シグナル / RNA export from nucleus / miRNA binding / FGFR2 alternative splicing / regulation of alternative mRNA splicing, via spliceosome / intracellular non-membrane-bounded organelle / SARS-CoV-1 modulates host translation machinery / regulation of RNA splicing / negative regulation of telomere maintenance via telomerase / Processing of Capped Intron-Containing Pre-mRNA / mRNA transport / cellular response to glucose starvation / localization / positive regulation of telomere maintenance via telomerase / catalytic step 2 spliceosome / molecular condensate scaffold activity / mRNA Splicing - Major Pathway / mRNA 3'-UTR binding / spliceosomal complex / mRNA splicing, via spliceosome / single-stranded DNA binding / amyloid fibril formation / single-stranded RNA binding / ribonucleoprotein complex / protein domain specific binding / DNA binding / RNA binding / extracellular exosome / 核質 / 生体膜 / identical protein binding / 細胞核 / 細胞質基質 / 細胞質類似検索 - 分子機能 hnRNP A3, RNA recognition motif 2 / hnRNP A1, RNA recognition motif 1 / Heterogeneous nuclear ribonucleoprotein A1/A2, C-terminal / Heterogeneous nuclear ribonucleoprotein A1, LC domain / RRM (RNA recognition motif) domain / RNA認識モチーフ / RNA認識モチーフ / Eukaryotic RNA Recognition Motif (RRM) profile. / RNA recognition motif domain / RNA-binding domain superfamily ...hnRNP A3, RNA recognition motif 2 / hnRNP A1, RNA recognition motif 1 / Heterogeneous nuclear ribonucleoprotein A1/A2, C-terminal / Heterogeneous nuclear ribonucleoprotein A1, LC domain / RRM (RNA recognition motif) domain / RNA認識モチーフ / RNA認識モチーフ / Eukaryotic RNA Recognition Motif (RRM) profile. / RNA recognition motif domain / RNA-binding domain superfamily / Nucleotide-binding alpha-beta plait domain superfamily / Alpha-Beta Plaits / 2-Layer Sandwich / Alpha Beta類似検索 - ドメイン・相同性 リボ核酸 / Heterogeneous nuclear ribonucleoprotein A1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 溶液NMR / simulated annealing |
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データ登録者 | Barraud, P. / Allain, F.H.-T. |
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資金援助 | スイス, フランス, 6件 組織 | 認可番号 | 国 |
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Swiss National Science Foundation | NCCR structural biology | スイス | Swiss National Science Foundation | NCCR RNA and disease | スイス | CNRS | | フランス | ETH | Postdoctoral ETH Fellowship Program | スイス | Novartis Foundation | | スイス | SMA Europe | | スイス |
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引用 | ジャーナル: Elife / 年: 2017 タイトル: Tandem hnRNP A1 RNA recognition motifs act in concert to repress the splicing of survival motor neuron exon 7. 著者: Beusch, I. / Barraud, P. / Moursy, A. / Clery, A. / Allain, F.H. |
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履歴 | 登録 | 2016年12月16日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2017年7月5日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2017年7月12日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_volume ..._citation.country / _citation.journal_volume / _citation.pdbx_database_id_PubMed / _citation.title |
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改定 1.2 | 2019年5月8日 | Group: Data collection / カテゴリ: pdbx_nmr_software / Item: _pdbx_nmr_software.name |
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改定 1.3 | 2024年5月15日 | Group: Data collection / Database references カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_nmr_spectrometer Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_spectrometer.model |
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