登録情報 データベース : PDB / ID : 4kju 構造の表示 ダウンロードとリンクタイトル Crystal structure of XIAP-Bir2 with a bound benzodiazepinone inhibitor. 要素E3 ubiquitin-protein ligase XIAP 詳細 キーワード APOPTOSIS/APOPTOSIS INHIBITOR / XIAP inhibitors / BIR2 / benzodiazepinone / oncology / caspase / APOPTOSIS-APOPTOSIS INHIBITOR complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
endopeptidase regulator activity / regulation of apoptosis involved in tissue homeostasis / inhibition of cysteine-type endopeptidase activity / positive regulation of protein linear polyubiquitination / regulation of BMP signaling pathway / copper ion homeostasis / nucleotide-binding oligomerization domain containing 1 signaling pathway / regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway / nucleotide-binding oligomerization domain containing 2 signaling pathway / SMAC, XIAP-regulated apoptotic response ... endopeptidase regulator activity / regulation of apoptosis involved in tissue homeostasis / inhibition of cysteine-type endopeptidase activity / positive regulation of protein linear polyubiquitination / regulation of BMP signaling pathway / copper ion homeostasis / nucleotide-binding oligomerization domain containing 1 signaling pathway / regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway / nucleotide-binding oligomerization domain containing 2 signaling pathway / SMAC, XIAP-regulated apoptotic response / Activation of caspases through apoptosome-mediated cleavage / Regulation of the apoptosome activity / SMAC (DIABLO) binds to IAPs / SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes / TNFR1-induced proapoptotic signaling / RIPK1-mediated regulated necrosis / cysteine-type endopeptidase inhibitor activity / regulation of innate immune response / cysteine-type endopeptidase inhibitor activity involved in apoptotic process / protein K63-linked ubiquitination / negative regulation of tumor necrosis factor-mediated signaling pathway / positive regulation of type I interferon production / protein serine/threonine kinase binding / Regulation of PTEN localization / negative regulation of cysteine-type endopeptidase activity involved in apoptotic process / TNFR1-induced NF-kappa-B signaling pathway / positive regulation of protein ubiquitination / Deactivation of the beta-catenin transactivating complex / Regulation of TNFR1 signaling / positive regulation of JNK cascade / RING-type E3 ubiquitin transferase / Regulation of necroptotic cell death / Wnt signaling pathway / Regulation of PTEN stability and activity / positive regulation of canonical Wnt signaling pathway / ubiquitin-protein transferase activity / ubiquitin protein ligase activity / regulation of inflammatory response / regulation of cell population proliferation / positive regulation of canonical NF-kappaB signal transduction / neuron apoptotic process / regulation of apoptotic process / regulation of cell cycle / defense response to bacterium / DNA damage response / negative regulation of apoptotic process / nucleoplasm / identical protein binding / nucleus / metal ion binding / cytoplasm / cytosol 類似検索 - 分子機能 XIAP/BIRC8, UBA domain / : / BIRC2/3-like, UBA domain / Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A / Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A / : / BIR repeat. / BIR repeat / Inhibitor of Apoptosis domain / BIR repeat profile. ... XIAP/BIRC8, UBA domain / : / BIRC2/3-like, UBA domain / Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A / Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A / : / BIR repeat. / BIR repeat / Inhibitor of Apoptosis domain / BIR repeat profile. / Baculoviral inhibition of apoptosis protein repeat / Zinc finger, C3HC4 type (RING finger) / Death-like domain superfamily / Ring finger / Zinc finger RING-type profile. / Zinc finger, RING-type / Orthogonal Bundle / Mainly Alpha 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / フーリエ合成 / 解像度 : 1.6 Å 詳細データ登録者 Lukacs, C.M. / Janson, C.A. 引用ジャーナル : J.Med.Chem. / 年 : 2013タイトル : Optimization of Benzodiazepinones as Selective Inhibitors of the X-Linked Inhibitor of Apoptosis Protein (XIAP) Second Baculovirus IAP Repeat (BIR2) Domain.著者: Kester, R.F. / Donnell, A.F. / Lou, Y. / Remiszewski, S.W. / Lombardo, L.J. / Chen, S. / Le, N.T. / Lo, J. / Moliterni, J.A. / Han, X. / Hogg, J.H. / Liang, W. / Michoud, C. / Rupert, K.C. / ... 著者 : Kester, R.F. / Donnell, A.F. / Lou, Y. / Remiszewski, S.W. / Lombardo, L.J. / Chen, S. / Le, N.T. / Lo, J. / Moliterni, J.A. / Han, X. / Hogg, J.H. / Liang, W. / Michoud, C. / Rupert, K.C. / Mischke, S. / Le, K. / Weisel, M. / Janson, C.A. / Lukacs, C.M. / Fretland, A.J. / Hong, K. / Polonskaia, A. / Gao, L. / Li, S. / Solis, D.S. / Aguilar, D. / Tardell, C. / Dvorozniak, M. / Tannu, S. / Lee, E.C. / Schutt, A.D. / Goggin, B. 履歴 登録 2013年5月3日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2013年11月27日 Provider : repository / タイプ : Initial release改定 1.1 2014年2月5日 Group : Database references改定 1.2 2017年11月15日 Group : Refinement description / カテゴリ : software / Item : _software.name改定 1.3 2023年9月20日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_label_asym_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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