登録情報 | データベース: PDB / ID: 4inr |
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タイトル | Yeast 20S proteasome in complex with the vinyl sulfone LU102 |
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要素 | (Proteasome component ... プロテアソーム) x 14 |
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キーワード | HYDROLASE/HYDROLASE INHIBITOR / UPS / drug discovery (創薬) / irreversible inhibition (酵素阻害剤) / Ntn hydrolase / non-lysosomal protein breakdown / HYDROLASE-HYDROLASE INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
proteasome core complex assembly / nuclear outer membrane-endoplasmic reticulum membrane network / Cross-presentation of soluble exogenous antigens (endosomes) / TNFR2 non-canonical NF-kB pathway / proteasomal ubiquitin-independent protein catabolic process / proteasome storage granule / endopeptidase activator activity / proteasome assembly / proteasome endopeptidase complex / Ub-specific processing proteases ...proteasome core complex assembly / nuclear outer membrane-endoplasmic reticulum membrane network / Cross-presentation of soluble exogenous antigens (endosomes) / TNFR2 non-canonical NF-kB pathway / proteasomal ubiquitin-independent protein catabolic process / proteasome storage granule / endopeptidase activator activity / proteasome assembly / proteasome endopeptidase complex / Ub-specific processing proteases / proteasome core complex, beta-subunit complex / proteasome core complex, alpha-subunit complex / threonine-type endopeptidase activity / Neutrophil degranulation / proteasome complex / proteasomal protein catabolic process / proteasome-mediated ubiquitin-dependent protein catabolic process / endopeptidase activity / mRNA binding / endoplasmic reticulum membrane / ミトコンドリア / 細胞核 / 細胞質基質 / 細胞質類似検索 - 分子機能 Aminohydrolase, N-terminal nucleophile (Ntn) domain / Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1 / Proteasome beta subunit, C-terminal / Proteasome beta subunits C terminal / Proteasome subunit beta 4 / Proteasome subunit beta 2 / Proteasome beta 3 subunit / Proteasome subunit alpha6 / Proteasome subunit alpha5 / Proteasome beta-type subunits signature. ... Aminohydrolase, N-terminal nucleophile (Ntn) domain / Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1 / Proteasome beta subunit, C-terminal / Proteasome beta subunits C terminal / Proteasome subunit beta 4 / Proteasome subunit beta 2 / Proteasome beta 3 subunit / Proteasome subunit alpha6 / Proteasome subunit alpha5 / Proteasome beta-type subunits signature. / Peptidase T1A, proteasome beta-subunit / Proteasome beta-type subunit, conserved site / Proteasome subunit A N-terminal signature / Proteasome alpha-type subunits signature. / Proteasome alpha-subunit, N-terminal domain / Proteasome subunit A N-terminal signature Add an annotation / Proteasome alpha-type subunit / Proteasome alpha-type subunit profile. / Proteasome B-type subunit / Proteasome beta-type subunit profile. / Proteasome subunit / Proteasome, subunit alpha/beta / Nucleophile aminohydrolases, N-terminal / 4-Layer Sandwich / Alpha Beta類似検索 - ドメイン・相同性N3PHE-LEU-LEU-PHE(4-NH2CH2)-METHYL VINYL SULFONE, BOUND FORM / Chem-1G1 / Probable proteasome subunit alpha type-7 / Proteasome subunit alpha type-1 / Proteasome subunit beta type-4 / Proteasome subunit alpha type-3 / Proteasome subunit alpha type-2 / Proteasome subunit beta type-6 / Proteasome subunit beta type-2 / Proteasome subunit beta type-3 ...N3PHE-LEU-LEU-PHE(4-NH2CH2)-METHYL VINYL SULFONE, BOUND FORM / Chem-1G1 / Probable proteasome subunit alpha type-7 / Proteasome subunit alpha type-1 / Proteasome subunit beta type-4 / Proteasome subunit alpha type-3 / Proteasome subunit alpha type-2 / Proteasome subunit beta type-6 / Proteasome subunit beta type-2 / Proteasome subunit beta type-3 / Proteasome subunit beta type-5 / Proteasome subunit beta type-7 / Proteasome subunit alpha type-5 / Proteasome subunit beta type-1 / Proteasome subunit alpha type-6 / Proteasome subunit alpha type-4類似検索 - 構成要素 |
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生物種 | ![](img/tx_yeast.gif) ![](data/taxo/icon/Saccharomyces_cerevisiae_S.png) Saccharomyces cerevisiae (パン酵母) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.7 Å |
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データ登録者 | Geurink, P.P. / van der Linden, W.A. / Mirabella, A.C. / Gallastegui, N. / de Bruin, G. / Blom, A.E.M. / Voges, M.J. / Mock, E.D. / Florea, B.I. / van der Marel, G.A. ...Geurink, P.P. / van der Linden, W.A. / Mirabella, A.C. / Gallastegui, N. / de Bruin, G. / Blom, A.E.M. / Voges, M.J. / Mock, E.D. / Florea, B.I. / van der Marel, G.A. / Driessen, C. / van der Stelt, M. / Groll, M. / Overkleeft, H.S. / Kisselev, A.F. |
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引用 | ジャーナル: J.Med.Chem. / 年: 2013 タイトル: Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites. 著者: Geurink, P.P. / van der Linden, W.A. / Mirabella, A.C. / Gallastegui, N. / de Bruin, G. / Blom, A.E. / Voges, M.J. / Mock, E.D. / Florea, B.I. / van der Marel, G.A. / Driessen, C. / van der ...著者: Geurink, P.P. / van der Linden, W.A. / Mirabella, A.C. / Gallastegui, N. / de Bruin, G. / Blom, A.E. / Voges, M.J. / Mock, E.D. / Florea, B.I. / van der Marel, G.A. / Driessen, C. / van der Stelt, M. / Groll, M. / Overkleeft, H.S. / Kisselev, A.F. |
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履歴 | 登録 | 2013年1月6日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2013年1月30日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2013年2月27日 | Group: Database references |
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改定 1.2 | 2023年9月20日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn / struct_ncs_dom_lim / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_label_asym_id / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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