登録情報 データベース : PDB / ID : 4ehf 構造の表示 ダウンロードとリンクタイトル Allosteric Modulation of Caspase-3 through Mutagenesis 要素ACE-ASP-GLU-VAL-ASP-CHLOROMETHYLKETONE INHIBITOR Caspase-3 カスパーゼ-3 詳細キーワード HYDROLASE/HYDROLASE INHIBITOR / caspase (カスパーゼ) / apoptosis (アポトーシス) / allosteric inhibition (アロステリック効果) / protein ensembles / HYDROLASE-HYDROLASE INHIBITOR complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
カスパーゼ-3 / Stimulation of the cell death response by PAK-2p34 / phospholipase A2 activator activity / anterior neural tube closure / intrinsic apoptotic signaling pathway in response to osmotic stress / leukocyte apoptotic process / positive regulation of pyroptotic inflammatory response / glial cell apoptotic process / NADE modulates death signalling / luteolysis ... カスパーゼ-3 / Stimulation of the cell death response by PAK-2p34 / phospholipase A2 activator activity / anterior neural tube closure / intrinsic apoptotic signaling pathway in response to osmotic stress / leukocyte apoptotic process / positive regulation of pyroptotic inflammatory response / glial cell apoptotic process / NADE modulates death signalling / luteolysis / response to cobalt ion / cysteine-type endopeptidase activity involved in apoptotic signaling pathway / death-inducing signaling complex / cyclin-dependent protein serine/threonine kinase inhibitor activity / cellular response to staurosporine / Apoptosis induced DNA fragmentation / cysteine-type endopeptidase activity involved in execution phase of apoptosis / Caspase activation via Dependence Receptors in the absence of ligand / Apoptotic cleavage of cell adhesion proteins / death receptor binding / SMAC, XIAP-regulated apoptotic response / axonal fasciculation / Activation of caspases through apoptosome-mediated cleavage / Signaling by Hippo / SMAC (DIABLO) binds to IAPs / SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes / cysteine-type endopeptidase activity involved in apoptotic process / fibroblast apoptotic process / execution phase of apoptosis / negative regulation of cytokine production / epithelial cell apoptotic process / platelet formation / Other interleukin signaling / positive regulation of amyloid-beta formation / Apoptotic cleavage of cellular proteins / negative regulation of B cell proliferation / pyroptotic inflammatory response / T cell homeostasis / negative regulation of activated T cell proliferation / neurotrophin TRK receptor signaling pathway / B cell homeostasis / protein maturation / negative regulation of cell cycle / response to X-ray / regulation of macroautophagy / Caspase-mediated cleavage of cytoskeletal proteins / 細胞分化 / response to amino acid / Pyroptosis / response to tumor necrosis factor / enzyme activator activity / response to glucose / response to UV / response to glucocorticoid / keratinocyte differentiation / striated muscle cell differentiation / Degradation of the extracellular matrix / intrinsic apoptotic signaling pathway / 赤血球形成 / hippocampus development / apoptotic signaling pathway / sensory perception of sound / response to nicotine / protein catabolic process / regulation of protein stability / neuron differentiation / response to hydrogen peroxide / protein processing / response to wounding / positive regulation of neuron apoptotic process / response to estradiol / heart development / peptidase activity / neuron apoptotic process / protease binding / response to lipopolysaccharide / aspartic-type endopeptidase activity / learning or memory / response to hypoxia / response to xenobiotic stimulus / cysteine-type endopeptidase activity / neuronal cell body / apoptotic process / DNA damage response / protein-containing complex binding / タンパク質分解 / 核質 / 細胞核 / 細胞質基質 / 細胞質 類似検索 - 分子機能 Rossmann fold - #1460 / Peptidase family C14A, His active site / Caspase family histidine active site. / Peptidase C14, caspase non-catalytic subunit p10 / Peptidase family C14A, cysteine active site / Caspase family cysteine active site. / Caspase family p10 domain profile. / Peptidase C14A, caspase catalytic domain / Caspase, interleukin-1 beta converting enzyme (ICE) homologues / Peptidase C14, p20 domain ... Rossmann fold - #1460 / Peptidase family C14A, His active site / Caspase family histidine active site. / Peptidase C14, caspase non-catalytic subunit p10 / Peptidase family C14A, cysteine active site / Caspase family cysteine active site. / Caspase family p10 domain profile. / Peptidase C14A, caspase catalytic domain / Caspase, interleukin-1 beta converting enzyme (ICE) homologues / Peptidase C14, p20 domain / Caspase family p20 domain profile. / : / Caspase domain / Caspase-like domain superfamily / ロスマンフォールド / 3-Layer(aba) Sandwich / Alpha Beta 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)synthetic construct (人工物) 手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.655 Å 詳細データ登録者 Walters, J. / Schipper, J.L. / Swartz, P.D. / Mattos, C. / Clark, A.C. 引用ジャーナル : Biosci.Rep. / 年 : 2012タイトル : Allosteric modulation of caspase 3 through mutagenesis.著者 : Walters, J. / Schipper, J.L. / Swartz, P. / Mattos, C. / Clark, A.C. 履歴 登録 2012年4月2日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2012年6月6日 Provider : repository / タイプ : Initial release改定 1.1 2012年7月18日 Group : Database references改定 1.2 2012年12月12日 Group : Other改定 1.3 2017年11月15日 Group : Advisory / Refinement description / Source and taxonomyカテゴリ : pdbx_entity_src_syn / pdbx_unobs_or_zero_occ_atoms / software
すべて表示 表示を減らす