登録情報 データベース : PDB / ID : 4aa1 構造の表示 ダウンロードとリンクタイトル Crystal structure of ANCE in complex with Angiotensin-II 要素ANGIOTENSIN-2 アンジオテンシン ANGIOTENSIN-CONVERTING ENZYME アンジオテンシン変換酵素 詳細キーワード HYDROLASE/HORMONE / HYDROLASE-HORMONE COMPLEX / HYDROLASE (加水分解酵素) / SUBSTRATE BINDING機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
Metabolism of Angiotensinogen to Angiotensins / regulation of blood volume by renin-angiotensin / response to muscle activity involved in regulation of muscle adaptation / 変態 / : / type 2 angiotensin receptor binding / regulation of renal sodium excretion / maintenance of blood vessel diameter homeostasis by renin-angiotensin / response to symbiotic bacterium / negative regulation of neurotrophin TRK receptor signaling pathway ... Metabolism of Angiotensinogen to Angiotensins / regulation of blood volume by renin-angiotensin / response to muscle activity involved in regulation of muscle adaptation / 変態 / : / type 2 angiotensin receptor binding / regulation of renal sodium excretion / maintenance of blood vessel diameter homeostasis by renin-angiotensin / response to symbiotic bacterium / negative regulation of neurotrophin TRK receptor signaling pathway / regulation of extracellular matrix assembly / アンジオテンシン変換酵素 / positive regulation of activation of Janus kinase activity / regulation of renal output by angiotensin / 有性生殖 / G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger / renal system process / renin-angiotensin regulation of aldosterone production / positive regulation of branching involved in ureteric bud morphogenesis / positive regulation of macrophage derived foam cell differentiation / positive regulation of extracellular matrix assembly / 血管収縮 / positive regulation of CoA-transferase activity / type 1 angiotensin receptor binding / low-density lipoprotein particle remodeling / response to angiotensin / positive regulation of extrinsic apoptotic signaling pathway / peptide hormone processing / positive regulation of epidermal growth factor receptor signaling pathway / nitric oxide-cGMP-mediated signaling / positive regulation of cardiac muscle hypertrophy / positive regulation of gap junction assembly / regulation of vasoconstriction / regulation of cardiac conduction / positive regulation of protein tyrosine kinase activity / peptidyl-dipeptidase activity / blood vessel remodeling / Metabolism of Angiotensinogen to Angiotensins / positive regulation of epithelial to mesenchymal transition / carboxypeptidase activity / positive regulation of protein metabolic process / positive regulation of endothelial cell migration / Peptide ligand-binding receptors / negative regulation of MAP kinase activity / kidney development / positive regulation of cytokine production / angiotensin-activated signaling pathway / regulation of cell growth / growth factor activity / serine-type endopeptidase inhibitor activity / hormone activity / PPARA activates gene expression / 血圧 / positive regulation of miRNA transcription / positive regulation of inflammatory response / metallopeptidase activity / positive regulation of reactive oxygen species metabolic process / positive regulation of fibroblast proliferation / cell-cell signaling / phospholipase C-activating G protein-coupled receptor signaling pathway / positive regulation of NF-kappaB transcription factor activity / regulation of cell population proliferation / G alpha (i) signalling events / G alpha (q) signalling events / regulation of apoptotic process / collagen-containing extracellular matrix / blood microparticle / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / G protein-coupled receptor signaling pathway / positive regulation of DNA-templated transcription / タンパク質分解 / extracellular space / extracellular exosome / extracellular region / metal ion binding / 細胞膜 / 細胞質基質 類似検索 - 分子機能 Angiotensinogen, serpin domain / アンジオテンシン / Serpin, conserved site / Serpins signature. / Serpin superfamily, domain 2 / セルピン / Serpin domain / セルピン / Serpin superfamily, domain 1 / Serpin (serine protease inhibitor) ... Angiotensinogen, serpin domain / アンジオテンシン / Serpin, conserved site / Serpins signature. / Serpin superfamily, domain 2 / セルピン / Serpin domain / セルピン / Serpin superfamily, domain 1 / Serpin (serine protease inhibitor) / SERine Proteinase INhibitors / Peptidase family M2 domain profile. / Peptidase M2, peptidyl-dipeptidase A / アンジオテンシン変換酵素 / Neutral zinc metallopeptidases, zinc-binding region signature. 類似検索 - ドメイン・相同性生物種 DROSOPHILA MELANOGASTER (キイロショウジョウバエ)HOMO SAPIENS (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.99 Å 詳細データ登録者 Isaac, R.E. / Akif, M. / Schwager, S.L.U. / Masuyer, G. / Sturrock, E.D. / Acharya, K.R. 引用ジャーナル : FEBS J. / 年 : 2012タイトル : Structural Basis of Peptide Recognition by the Angiotensin-I Converting Enzyme Homologue Ance from Drosophila Melanogaster著者 : Akif, M. / Masuyer, G. / Bingham, R.J. / Sturrock, E.D. / Isaac, R.E. / Acharya, K.R. 履歴 登録 2011年11月30日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2012年10月31日 Provider : repository / タイプ : Initial release改定 1.1 2012年12月5日 Group : Database references改定 1.2 2012年12月19日 Group : Database references改定 2.0 2020年7月29日 Group : Advisory / Atomic model ... Advisory / Atomic model / Data collection / Derived calculations / Other / Structure summary カテゴリ : atom_site / chem_comp ... atom_site / chem_comp / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_database_status / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / pdbx_struct_conn_angle / pdbx_unobs_or_zero_occ_atoms / struct_asym / struct_conn / struct_site / struct_site_gen Item : _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ... _atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_atom_id / _atom_site.auth_comp_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_atom_id / _atom_site.label_comp_id / _atom_site.label_entity_id / _atom_site.type_symbol / _chem_comp.name / _chem_comp.type / _pdbx_database_status.status_code_sf / _pdbx_struct_assembly_gen.asym_id_list / _pdbx_struct_conn_angle.ptnr1_auth_asym_id / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _pdbx_unobs_or_zero_occ_atoms.label_asym_id / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id 解説 : Carbohydrate remediation / Provider : repository / タイプ : Remediation改定 2.1 2023年12月20日 Group : Data collection / Database references ... Data collection / Database references / Refinement description / Structure summary カテゴリ : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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