+データを開く
-基本情報
登録情報 | データベース: PDB / ID: 3zrt | ||||||
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タイトル | Crystal structure of human PSD-95 PDZ1-2 | ||||||
要素 | DISKS LARGE HOMOLOG 4 | ||||||
キーワード | SIGNALING PROTEIN | ||||||
機能・相同性 | 機能・相同性情報 LGI-ADAM interactions / P2Y1 nucleotide receptor binding / beta-1 adrenergic receptor binding / neuroligin family protein binding / NrCAM interactions / positive regulation of neuron projection arborization / regulation of grooming behavior / synaptic vesicle maturation / receptor localization to synapse / cerebellar mossy fiber ...LGI-ADAM interactions / P2Y1 nucleotide receptor binding / beta-1 adrenergic receptor binding / neuroligin family protein binding / NrCAM interactions / positive regulation of neuron projection arborization / regulation of grooming behavior / synaptic vesicle maturation / receptor localization to synapse / cerebellar mossy fiber / cellular response to potassium ion / protein localization to synapse / vocalization behavior / Synaptic adhesion-like molecules / neuron spine / AMPA glutamate receptor clustering / juxtaparanode region of axon / Trafficking of AMPA receptors / dendritic spine morphogenesis / negative regulation of receptor internalization / neuron projection terminus / RHO GTPases activate CIT / postsynaptic neurotransmitter receptor diffusion trapping / Assembly and cell surface presentation of NMDA receptors / acetylcholine receptor binding / establishment or maintenance of epithelial cell apical/basal polarity / Neurexins and neuroligins / neurotransmitter receptor localization to postsynaptic specialization membrane / regulation of NMDA receptor activity / Activation of Ca-permeable Kainate Receptor / cortical cytoskeleton / Signaling by ERBB4 / Negative regulation of NMDA receptor-mediated neuronal transmission / Unblocking of NMDA receptors, glutamate binding and activation / locomotory exploration behavior / social behavior / positive regulation of excitatory postsynaptic potential / AMPA glutamate receptor complex / 長期増強 / neuromuscular process controlling balance / excitatory synapse / positive regulation of protein tyrosine kinase activity / D1 dopamine receptor binding / positive regulation of synaptic transmission / extrinsic component of cytoplasmic side of plasma membrane / ionotropic glutamate receptor binding / Ras activation upon Ca2+ influx through NMDA receptor / dendrite cytoplasm / synaptic membrane / 学習 / PDZ domain binding / postsynaptic density membrane / 接着結合 / regulation of long-term neuronal synaptic plasticity / neuromuscular junction / establishment of protein localization / kinase binding / 細胞接着 / endocytic vesicle membrane / シナプス小胞 / 細胞結合 / nervous system development / positive regulation of cytosolic calcium ion concentration / RAF/MAP kinase cascade / scaffold protein binding / chemical synaptic transmission / basolateral plasma membrane / postsynaptic membrane / protein phosphatase binding / protein-containing complex assembly / 樹状突起スパイン / postsynaptic density / neuron projection / glutamatergic synapse / シナプス / protein-containing complex binding / 小胞体 / シグナル伝達 / 細胞膜 / 細胞質基質 / 細胞質 類似検索 - 分子機能 | ||||||
生物種 | HOMO SAPIENS (ヒト) | ||||||
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.398 Å | ||||||
データ登録者 | Sorensen, P.L. / Kastrup, J.S. / Gajhede, M. | ||||||
引用 | ジャーナル: Proc.Natl.Acad.Sci.USA / 年: 2012 タイトル: A High-Affinity, Dimeric Inhibitor of Psd-95 Bivalently Interacts with Pdz1-2 and Protects Against Ischemic Brain Damage. 著者: Bach, A. / Clausen, B.H. / Moller, M. / Vestergaard, B. / Chi, C.N. / Round, A. / Sorensen, P.L. / Nissen, K.B. / Kastrup, J.S. / Gajhede, M. / Jemth, P. / Kristensen, A.S. / Lundstrom, P. / ...著者: Bach, A. / Clausen, B.H. / Moller, M. / Vestergaard, B. / Chi, C.N. / Round, A. / Sorensen, P.L. / Nissen, K.B. / Kastrup, J.S. / Gajhede, M. / Jemth, P. / Kristensen, A.S. / Lundstrom, P. / Lambertsen, K.L. / Stromgaard, K. | ||||||
履歴 |
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-構造の表示
構造ビューア | 分子: MolmilJmol/JSmol |
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-ダウンロードとリンク
-ダウンロード
PDBx/mmCIF形式 | 3zrt.cif.gz | 273.9 KB | 表示 | PDBx/mmCIF形式 |
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PDB形式 | pdb3zrt.ent.gz | 225.7 KB | 表示 | PDB形式 |
PDBx/mmJSON形式 | 3zrt.json.gz | ツリー表示 | PDBx/mmJSON形式 | |
その他 | その他のダウンロード |
-検証レポート
アーカイブディレクトリ | https://data.pdbj.org/pub/pdb/validation_reports/zr/3zrt ftp://data.pdbj.org/pub/pdb/validation_reports/zr/3zrt | HTTPS FTP |
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-関連構造データ
関連構造データ | 2i1nS S: 精密化の開始モデル |
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