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- PDB-3thy: Human MutSbeta complexed with an IDL of 2 bases (Loop2) and ADP -

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Basic information

Entry
Database: PDB / ID: 3thy
TitleHuman MutSbeta complexed with an IDL of 2 bases (Loop2) and ADP
Components
  • (DNA mismatch repair protein ...) x 2
  • DNA Loop2 minus strand
  • DNA Loop2 plus strand
KeywordsDNA BINDING PROTEIN/DNA / ABC family ATPase / mismatch recognition / mismatched unpaired IDL DNA / DNA BINDING PROTEIN-DNA complex
Function / homology
Function and homology information


somatic recombination of immunoglobulin genes involved in immune response / MutSbeta complex / Defective Mismatch Repair Associated With MSH3 / MutSalpha complex / Defective Mismatch Repair Associated With MSH2 / Defective Mismatch Repair Associated With MSH6 / guanine/thymine mispair binding / somatic recombination of immunoglobulin gene segments / maintenance of DNA repeat elements / B cell mediated immunity ...somatic recombination of immunoglobulin genes involved in immune response / MutSbeta complex / Defective Mismatch Repair Associated With MSH3 / MutSalpha complex / Defective Mismatch Repair Associated With MSH2 / Defective Mismatch Repair Associated With MSH6 / guanine/thymine mispair binding / somatic recombination of immunoglobulin gene segments / maintenance of DNA repeat elements / B cell mediated immunity / positive regulation of helicase activity / positive regulation of isotype switching to IgA isotypes / centromeric DNA binding / positive regulation of isotype switching to IgG isotypes / mismatched DNA binding / negative regulation of DNA recombination / mitotic recombination / isotype switching / Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) / Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) / oxidative phosphorylation / postreplication repair / response to UV-B / mitotic intra-S DNA damage checkpoint signaling / ATP-dependent DNA damage sensor activity / germ cell development / response to X-ray / intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / somatic hypermutation of immunoglobulin genes / ATP-dependent activity, acting on DNA / mismatch repair / protein localization to chromatin / B cell differentiation / determination of adult lifespan / TP53 Regulates Transcription of DNA Repair Genes / male gonad development / double-strand break repair / double-stranded DNA binding / in utero embryonic development / negative regulation of neuron apoptotic process / damaged DNA binding / chromosome, telomeric region / DNA repair / chromatin binding / enzyme binding / protein homodimerization activity / ATP hydrolysis activity / DNA binding / nucleoplasm / ATP binding / membrane / nucleus
Similarity search - Function
DNA mismatch repair Msh2-type / DNA mismatch repair protein Msh2 / MutS, connector domain / DNA repair protein MutS, domain I / MutS, DNA mismatch repair protein; Chain A, domain 3 / MutS, DNA mismatch repair protein; Chain A, domain 3 - #10 / DNA mismatch repair protein MutS-like, N-terminal / DNA mismatch repair protein MutS, connector domain / DNA mismatch repair protein MutS, clamp / DNA mismatch repair protein MutS, N-terminal ...DNA mismatch repair Msh2-type / DNA mismatch repair protein Msh2 / MutS, connector domain / DNA repair protein MutS, domain I / MutS, DNA mismatch repair protein; Chain A, domain 3 / MutS, DNA mismatch repair protein; Chain A, domain 3 - #10 / DNA mismatch repair protein MutS-like, N-terminal / DNA mismatch repair protein MutS, connector domain / DNA mismatch repair protein MutS, clamp / DNA mismatch repair protein MutS, N-terminal / MutS, connector domain superfamily / MutS domain I / MutS domain II / MutS family domain IV / MutS domain III / DNA mismatch repair MutS family / DNA mismatch repair protein MutS, C-terminal / DNA mismatch repair protein MutS, core / DNA mismatch repair protein MutS, core domain superfamily / MutS domain V / DNA mismatch repair proteins mutS family signature. / DNA-binding domain of DNA mismatch repair MUTS family / ATPase domain of DNA mismatch repair MUTS family / MutS, DNA mismatch repair protein, domain I / Nucleotidyltransferase; domain 5 / P-loop containing nucleotide triphosphate hydrolases / P-loop containing nucleoside triphosphate hydrolase / Rossmann fold / 2-Layer Sandwich / Orthogonal Bundle / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha Beta
Similarity search - Domain/homology
ADENOSINE-5'-DIPHOSPHATE / : / DNA / DNA (> 10) / DNA mismatch repair protein Msh3 / DNA mismatch repair protein Msh2
Similarity search - Component
Biological speciesHomo sapiens (human)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.894 Å
AuthorsYang, W.
CitationJournal: Nat.Struct.Mol.Biol. / Year: 2012
Title: Mechanism of mismatch repair revealed by human MutSbeta bound to unpaired DNA loops
Authors: Gupta, S. / Gellert, M. / Yang, W.
History
DepositionAug 19, 2011Deposition site: RCSB / Processing site: RCSB
Revision 1.0Dec 21, 2011Provider: repository / Type: Initial release
Revision 1.1Jun 26, 2013Group: Database references
Revision 1.2Jul 17, 2019Group: Data collection / Database references / Refinement description
Category: software / struct_ref_seq
Item: _software.classification / _software.name ..._software.classification / _software.name / _software.version / _struct_ref_seq.db_align_beg / _struct_ref_seq.db_align_end
Revision 1.3Feb 28, 2024Group: Data collection / Database references / Derived calculations
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / struct_ref_seq_dif / struct_site
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: DNA mismatch repair protein Msh2
B: DNA mismatch repair protein Msh3
D: DNA Loop2 minus strand
E: DNA Loop2 plus strand
hetero molecules


Theoretical massNumber of molelcules
Total (without water)224,2945
Polymers223,8674
Non-polymers4271
Water27015
1


  • Idetical with deposited unit
  • defined by author&software
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Buried area14550 Å2
ΔGint-112 kcal/mol
Surface area78230 Å2
MethodPISA
Unit cell
Length a, b, c (Å)66.270, 91.106, 95.628
Angle α, β, γ (deg.)67.82, 86.98, 73.35
Int Tables number1
Space group name H-MP1

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Components

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DNA mismatch repair protein ... , 2 types, 2 molecules AB

#1: Protein DNA mismatch repair protein Msh2 / / hMSH2 / MutS protein homolog 2


Mass: 104861.875 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: MSH2 / Cell line (production host): Hi5 / Production host: Spodoptera frugiperda (fall armyworm) / References: UniProt: P43246
#2: Protein DNA mismatch repair protein Msh3 / / hMSH3 / Divergent upstream protein / DUP / Mismatch repair protein 1 / MRP1


Mass: 104289.664 Da / Num. of mol.: 1 / Fragment: UNP residues 219- 1134
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: DUC1, DUG, MSH3 / Cell line (production host): Hi5 / Production host: Spodoptera frugiperda (fall armyworm) / References: GenBank: 119616268, UniProt: P20585*PLUS

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DNA chain , 2 types, 2 molecules DE

#3: DNA chain DNA Loop2 minus strand


Mass: 7345.741 Da / Num. of mol.: 1 / Source method: obtained synthetically / Details: chemically synthesized DNA
#4: DNA chain DNA Loop2 plus strand


Mass: 7369.766 Da / Num. of mol.: 1 / Source method: obtained synthetically / Details: chemically synthesized DNA

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Non-polymers , 2 types, 16 molecules

#5: Chemical ChemComp-ADP / ADENOSINE-5'-DIPHOSPHATE / Adenosine diphosphate


Mass: 427.201 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C10H15N5O10P2 / Comment: ADP, energy-carrying molecule*YM
#6: Water ChemComp-HOH / water / Water


Mass: 18.015 Da / Num. of mol.: 15 / Source method: isolated from a natural source / Formula: H2O

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 2.28 Å3/Da / Density % sol: 46.14 %
Crystal growTemperature: 277 K / Method: vapor diffusion, hanging drop
Details: 0.2M Ammonium Acetate, 20-25% PEG3350 (w/v) and 0.1M MES pH 6.5-7.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
PH range: 6.5-7.5

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Data collection

DiffractionMean temperature: 100 K
Diffraction sourceSource: SYNCHROTRON / Site: APS / Beamline: 23-ID-B / Wavelength: 1 Å
DetectorType: MAR scanner 300 mm plate / Detector: IMAGE PLATE / Date: Nov 30, 2010 / Details: mirror
RadiationMonochromator: Si 111 CHANNEL / Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 1 Å / Relative weight: 1
ReflectionResolution: 2.894→50 Å / Num. all: 41551 / Num. obs: 39892 / % possible obs: 94.4 % / Observed criterion σ(F): 1 / Observed criterion σ(I): 1 / Redundancy: 1.9 % / Rmerge(I) obs: 0.046 / Net I/σ(I): 15.1
Reflection shellResolution: 2.9→2.95 Å / Redundancy: 1.5 % / Rmerge(I) obs: 0.248 / Mean I/σ(I) obs: 2.3 / Num. unique all: 1388 / % possible all: 64.5

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Processing

Software
NameVersionClassification
PHENIX(phenix.refine: 1.6.4_486)refinement
CNSrefinement
Blu-Icedata collection
DENZOdata reduction
SCALEPACKdata scaling
CNSphasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT / Resolution: 2.894→44.189 Å / SU ML: 0.42 / σ(F): 1 / Phase error: 30.05 / Stereochemistry target values: ML
RfactorNum. reflection% reflection
Rfree0.2739 1125 2.82 %
Rwork0.1943 --
obs0.1965 39845 90.28 %
Solvent computationShrinkage radii: 0.83 Å / VDW probe radii: 1.1 Å / Solvent model: FLAT BULK SOLVENT MODEL / Bsol: 53.716 Å2 / ksol: 0.31 e/Å3
Displacement parameters
Baniso -1Baniso -2Baniso -3
1-12.9594 Å2-2.576 Å213.7621 Å2
2--3.3457 Å23.3388 Å2
3----16.3051 Å2
Refinement stepCycle: LAST / Resolution: 2.894→44.189 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms13670 916 27 15 14628
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.00315026
X-RAY DIFFRACTIONf_angle_d0.68220505
X-RAY DIFFRACTIONf_dihedral_angle_d17.4135666
X-RAY DIFFRACTIONf_chiral_restr0.0452358
X-RAY DIFFRACTIONf_plane_restr0.0022468
LS refinement shell
Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkRefine-ID% reflection obs (%)
2.8941-3.02580.3904850.31243249X-RAY DIFFRACTION61
3.0258-3.18530.34471300.27444430X-RAY DIFFRACTION83
3.1853-3.38480.34531550.25544904X-RAY DIFFRACTION92
3.3848-3.6460.29181680.21955098X-RAY DIFFRACTION95
3.646-4.01270.2921540.19435197X-RAY DIFFRACTION97
4.0127-4.59280.22541350.16415269X-RAY DIFFRACTION98
4.5928-5.78440.26841400.17765282X-RAY DIFFRACTION99
5.7844-44.19430.23191580.16275291X-RAY DIFFRACTION98
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
12.3115-0.9281.53122.9973-0.33281.2617-0.0783-0.35260.07230.2019-0.0083-0.40310.1335-0.3189-0.00010.340.011-0.1460.3026-0.09510.34391.0523-1.469628.7427
20.2492-1.03620.83841.394-1.74771.10830.09170.45880.24550.0138-0.1391-0.16420.5203-0.2151-0.01660.24090.034-0.06240.29990.02260.3545.5775-19.29499.1275
31.0522-0.5214-0.26091.2511-1.17621.7619-0.15450.03440.0811-0.3158-0.2779-0.4376-0.39270.6006-0.00050.3906-0.0939-0.06680.440.13820.41215.9948-14.80962.2256
40.3548-0.016-0.07860.17070.17020.2648-0.2908-0.42330.0188-1.0729-0.389-0.25291.36560.849-0.00121.020.15940.07970.38550.14670.59439.7804-36.374213.9073
51.4964-0.50.71370.5852-1.0281.36010.1642-0.3845-0.24340.455-0.4729-0.06171.027-0.3866-0.01030.7543-0.0133-0.00180.2850.0180.47288.1342-27.564111.8127
61.84990.8104-0.85710.7959-2.01311.0019-0.25880.2440.4535-0.17390.5886-0.07880.2117-0.71730.11130.413-0.2199-0.07260.69580.11320.2179-8.6831-19.6327-8.7369
7-0.26410.18540.29940.69340.65560.7846-0.24450.85030.54840.34870.60770.13660.23680.26550.01240.5346-0.447-0.12631.11090.11560.6518-20.3581-29.72034.5175
80.28970.06250.26820.25340.20130.1762-0.15110.01420.5370.23690.4551-0.36591.3583-1.14190.00040.8656-0.44070.03221.06020.19420.7386-26.9802-31.894717.6261
90.002-0.00850.0603-0.0086-0.05760.0772-0.49840.3725-0.25091.04070.151-0.00430.8095-0.62910.00031.3381-0.15350.5261.1221-0.37751.3139-32.4139-35.579733.266
102.8048-0.53282.92820.2101-0.15452.8678-0.8093-0.39290.15130.30710.1610.1820.0747-0.0124-3.26111.9532-0.19760.43730.9511-0.20380.9476-39.947-13.338350.8897
110.07740.01740.194-0.0434-0.01920.21770.5332-0.9489-0.17590.234-0.4365-0.4693-0.75750.53960.00011.4943-0.00780.02641.0151-0.20820.7761-28.2326-28.247941.6447
12-0.01810.5734-1.89162.26970.01331.30020.0150.3651-0.1165-0.18920.1730.21050.5254-0.3367-0.00160.2552-0.4229-0.17740.86070.12750.4063-11.2198-22.0869-9.3429
130.07940.0273-0.06740.003-0.02750.0597-0.54280.1128-0.5462-0.1002-0.7352-0.5949-0.1516-0.21790.00071.1737-0.267-0.54950.99470.39020.983-14.8414-0.03-19.9174
142.00120.4957-0.33681.2107-0.43353.0202-0.13670.3170.1536-0.43890.1183-0.1290.4479-0.5111-0.00030.3818-0.1251-0.02490.39120.01480.17174.3921-10.7931-21.6832
150.1404-0.12770.15330.3426-0.02690.17750.35751.07540.9301-0.34810.73010.6373-0.27990.35670.00150.50890.12470.06560.40170.07740.437719.26383.7462-23.9827
160.99410.2164-0.34751.0525-0.32751.2651-0.03130.2988-0.1535-0.48620.4004-0.07340.222-0.32930.04670.4056-0.0817-0.04650.56820.10630.17996.8873-1.5268-31.347
170.15130.2666-0.07010.087-0.07820.6851-0.20270.54170.2634-0.72770.57180.3113-0.4289-0.88050.00041.06180.0169-0.08190.87710.18070.615510.936716.9383-37.0071
180.0550.1226-0.36730.139-0.58242.7109-0.07990.29810.5935-0.30050.2854-0.58942.8950.85820.02031.01320.28910.22910.72940.12510.818733.947419.8576-52.4959
190.02660.04380.00130.07730.07110.0194-1.17210.22450.9284-0.42880.0752-1.07850.22890.61530.00151.0824-0.254-0.00071.37240.05540.995736.676531.415-58.6805
200.0131-0.06850.04270.45780.00030.2514-0.15810.64440.5127-0.39670.62270.006-0.3593-1.26370.00070.7298-0.3262-0.09570.6520.05960.202920.552320.0923-55.091
210.74780.5904-0.49290.64320.45270.8408-0.10530.17140.03350.2401-0.0835-0.04470.2634-0.8401-0.00010.17-0.0167-0.08260.4776-0.06460.378-26.08227.588321.0808
220.7297-0.3180.48511.25940.32560.36870.39340.14420.08130.0697-0.1371-0.035-0.4596-0.39380.00030.36140.1923-0.02810.45330.00880.4162-26.47219.098226.6675
231.55890.34930.00270.2458-0.22530.113-0.41240.31411.00320.4488-0.33730.01641.3739-0.31920.041.13530.01440.1980.3726-0.1980.4518-1.821218.747620.1303
240.9632-0.2639-0.28320.6024-0.09060.20670.27430.43290.24250.163-0.05380.0992-0.8443-0.7890.01770.50150.3550.05310.76030.15390.5201-10.101530.04810.2611
251.11520.275-0.84651.46950.66640.69230.24190.4551-0.0759-0.0966-0.1981-0.20420.122-0.4541-0.00010.37530.2005-0.00690.54460.0570.3239-8.959319.0625-2.9214
261.51240.228-0.00581.81530.41691.8210.69850.4141-0.00490.1663-0.22170.2676-0.3974-0.89130.21390.28370.42760.10540.53810.14170.5007-20.279833.93364.3542
270.7033-0.4559-0.94151.53660.82230.86060.22810.1696-0.0134-0.16050.2261-0.0531-0.1047-0.01030.00030.35730.07530.03650.30090.07670.41485.296524.98325.8943
281.3935-1.00651.89890.9801-1.02092.92341.0453-0.10150.24380.14470.5819-0.0431-1.0386-1.06380.30990.57460.05870.26220.3385-0.06350.624910.035835.14783.7966
290.15330.128-0.64490.44330.17670.80290.5908-0.5580.2881-0.39110.58960.0519-0.84430.51460.02040.6181-0.20580.22060.5163-0.22430.486319.229434.564719.7087
300.2094-0.061-0.11670.4804-0.81780.78790.37110.2186-0.3916-0.2790.22030.32960.58660.03370.00020.39410.0646-0.05210.210.02140.336-8.131128.473526.2482
313.040.43910.42120.58140.08030.1729-0.3261-0.94580.2344-0.29340.2126-0.0504-0.21280.2132-0.020.6704-0.11690.00910.2951-0.26430.4847.072739.847428.6311
320.140.2249-0.31830.5519-0.06450.3661-0.1092-0.7241-0.17490.13880.12470.1513-0.66630.6708-0.00040.8818-0.09020.20020.7843-0.09660.6407-15.731533.25843.4913
331.9372-0.62350.27870.5020.73011.70160.1116-0.9603-0.3390.1274-0.066-0.39080.0990.1371-0.00010.29940.10980.02260.56310.15970.5741-29.874114.495961.7947
340.87820.1077-1.06870.27190.41011.4732-0.0970.1545-0.28140.3006-0.0021-0.0145-0.0889-0.44510.00010.48430.12050.11030.44750.05930.5688-27.286622.115346.1156
350.67450.37091.08320.07260.42311.62080.2872-0.49780.4428-0.08490.3046-0.1948-0.59230.51620.00050.4518-0.1130.06780.3019-0.10750.471310.044532.805416.9972
36-0.38140.0676-1.6617-0.24741.02923.15770.44630.08120.1457-0.34750.1244-0.2509-0.40270.31830.00020.41670.04450.08780.3668-0.06180.571921.362623.3538-5.3257
370.4616-0.21-0.33140.4973-0.05130.81760.22250.3499-0.38930.07370.0085-0.0704-0.353-0.5640.00060.57910.36640.11060.50680.14990.52248.529123.5971-16.4581
381.4407-0.2028-0.40880.44790.10650.84180.35470.36080.1337-0.40940.2847-0.4408-0.9098-0.1921-00.69760.16860.24250.3780.1310.484517.582522.3868-24.6426
390.9528-0.0748-0.02450.64650.75660.6781-0.1152-0.1523-0.2954-0.21240.5675-1.0288-0.17050.0672-0.00050.5291-0.01460.19460.5865-0.19520.865229.898912.8239-13.9883
40-0.38210.8695-1.40660.9083-1.20480.0563-0.1692-0.006-0.06470.30810.135-0.442-0.43480.0559-0.00010.798-0.141-0.07470.4908-0.00440.449128.386113.5665-36.1559
41-0.0023-0.0072-0.00680.0315-0.03420.00390.6261-0.2985-0.1348-0.19390.5121-0.324-0.06030.33780.00082.90840.8150.14512.28140.75452.8805-12.7848-4.271264.1627
420.0691-0.0832-0.05890.1372-0.0140.1056-0.65290.0851-0.1406-0.0476-0.1835-1.5410.1346-0.0421-0.00051.63380.5698-0.3251.40640.28841.051-12.2892-4.770747.3067
430.0582-0.08210.10280.08330.02540.14130.5248-0.5505-0.28330.7381-0.8645-0.56650.0698-1.2046-0.00020.3718-0.1142-0.19710.66810.17830.6549-24.30473.887241.4489
440.2086-0.1730.06040.2244-0.17060.3988-1.2194-0.4079-0.1313-0.04140.00011.5894-0.3639-0.3406-0.00440.2636-0.19940.14231.08580.08940.9975-36.40996.561133.7929
450.1224-0.1720.18040.1516-0.23120.2086-0.6069-0.2581-0.68531.0498-0.07410.1565-0.301-0.4961-0.00020.7868-0.18510.33571.50110.08021.0476-49.18332.60342.1947
460.09360.0673-0.04340.04870.08140.2093-1.13480.4741.2106-0.0134-1.13951.11620.2808-0.7514-0.00351.0744-0.0094-0.03931.7281-0.20561.438-48.29219.839239.2938
470.0853-0.21580.00480.137-0.0469-0.01990.0849-0.1951-0.49610.7944-0.0327-0.21741.023-0.656300.9489-0.06260.26740.89540.07461.1643-31.1909-0.398537.1947
480.13320.0035-0.17880.1522-0.12180.1706-0.1425-0.74870.3980.3312-0.1940.85360.21350.1205-0.00070.6804-0.0583-0.16540.8696-0.04460.5065-15.99173.758935.3763
490.3276-0.14860.02270.06570.08030.2153-0.0455-0.7836-0.83342.17580.51391.45080.78211.5549-01.65170.79490.16641.10330.59171.1283-17.8054-1.387251.7166
500.0651-0.0625-0.03390.02130.0220.0080.1575-0.5106-1.03010.004-0.18980.5492-0.4263-0.1747-0.00033.38010.7335-0.60752.37470.09161.3034-8.2858-8.800362.2217
510.01370.0319-0.02320.037-0.04060.04780.1432-0.580.69760.33650.27980.35260.5289-0.72870.00220.97040.22380.10171.25210.34950.8729-4.14891.8711-21.9724
Refinement TLS group
IDRefine-IDRefine TLS-IDSelection details
1X-RAY DIFFRACTION1(chain A and resid 12:117)
2X-RAY DIFFRACTION2(chain A and resid 118:175)
3X-RAY DIFFRACTION3(chain A and resid 176:231)
4X-RAY DIFFRACTION4(chain A and resid 232:260)
5X-RAY DIFFRACTION5(chain A and resid 261:295)
6X-RAY DIFFRACTION6(chain A and resid 296:380)
7X-RAY DIFFRACTION7(chain A and resid 381:441)
8X-RAY DIFFRACTION8(chain A and resid 442:470)
9X-RAY DIFFRACTION9(chain A and resid 471:482)
10X-RAY DIFFRACTION10(chain A and resid 483:554)
11X-RAY DIFFRACTION11(chain A and resid 555:580)
12X-RAY DIFFRACTION12(chain A and resid 581:645)
13X-RAY DIFFRACTION13(chain A and resid 646:650)
14X-RAY DIFFRACTION14(chain A and resid 651:749)
15X-RAY DIFFRACTION15(chain A and resid 750:763)
16X-RAY DIFFRACTION16(chain A and resid 764:825)
17X-RAY DIFFRACTION17(chain A and resid 826:882)
18X-RAY DIFFRACTION18(chain A and resid 883:897)
19X-RAY DIFFRACTION19(chain A and resid 898:907)
20X-RAY DIFFRACTION20(chain A and resid 908:930)
21X-RAY DIFFRACTION21(chain B and resid 226:301)
22X-RAY DIFFRACTION22(chain B and resid 302:346)
23X-RAY DIFFRACTION23(chain B and resid 347:367)
24X-RAY DIFFRACTION24(chain B and resid 368:405)
25X-RAY DIFFRACTION25(chain B and resid 406:455)
26X-RAY DIFFRACTION26(chain B and resid 456:519)
27X-RAY DIFFRACTION27(chain B and resid 520:577)
28X-RAY DIFFRACTION28(chain B and resid 578:588)
29X-RAY DIFFRACTION29(chain B and resid 589:616)
30X-RAY DIFFRACTION30(chain B and resid 617:638)
31X-RAY DIFFRACTION31(chain B and resid 639:686)
32X-RAY DIFFRACTION32(chain B and resid 687:715)
33X-RAY DIFFRACTION33(chain B and resid 716:770)
34X-RAY DIFFRACTION34(chain B and resid 771:814)
35X-RAY DIFFRACTION35(chain B and resid 815:849)
36X-RAY DIFFRACTION36(chain B and resid 850:953)
37X-RAY DIFFRACTION37(chain B and resid 954:979)
38X-RAY DIFFRACTION38(chain B and resid 980:1022)
39X-RAY DIFFRACTION39(chain B and resid 1023:1070)
40X-RAY DIFFRACTION40(chain B and resid 1071:1129)
41X-RAY DIFFRACTION41(chain D and resid 3:7)
42X-RAY DIFFRACTION42(chain D and resid 8:11)
43X-RAY DIFFRACTION43(chain D and resid 12:15)
44X-RAY DIFFRACTION44(chain D and resid 16:19)
45X-RAY DIFFRACTION45(chain D and resid 20:23)
46X-RAY DIFFRACTION46(chain E and resid 26:31)
47X-RAY DIFFRACTION47(chain E and resid 32:36)
48X-RAY DIFFRACTION48(chain E and resid 37:40)
49X-RAY DIFFRACTION49(chain E and resid 41:45)
50X-RAY DIFFRACTION50(chain E and resid 46:50)
51X-RAY DIFFRACTION51(chain G and resid 1)

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