- PDB-3qzt: Crystal Structure of BPTF bromo in complex with histone H4K16ac -... -
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基本情報
登録情報
データベース: PDB / ID: 3qzt
タイトル
Crystal Structure of BPTF bromo in complex with histone H4K16ac - Form II
要素
Histone H4ヒストンH4
Nucleosome-remodeling factor subunit BPTF
キーワード
TRANSCRIPTION/NUCLEAR PROTEIN / protein-peptide complex / all alpha helix / transcription (転写 (生物学)) / histone h4 (ヒストンH4) / nuclear / TRANSCRIPTION-NUCLEAR PROTEIN complex
機能・相同性
機能・相同性情報
NURF complex / endoderm development / anterior/posterior pattern specification / ATPase complex / embryonic placenta development / negative regulation of megakaryocyte differentiation / protein localization to CENP-A containing chromatin / Replacement of protamines by nucleosomes in the male pronucleus / CENP-A containing nucleosome / Packaging Of Telomere Ends ...NURF complex / endoderm development / anterior/posterior pattern specification / ATPase complex / embryonic placenta development / negative regulation of megakaryocyte differentiation / protein localization to CENP-A containing chromatin / Replacement of protamines by nucleosomes in the male pronucleus / CENP-A containing nucleosome / Packaging Of Telomere Ends / Recognition and association of DNA glycosylase with site containing an affected purine / Cleavage of the damaged purine / Deposition of new CENPA-containing nucleosomes at the centromere / Recognition and association of DNA glycosylase with site containing an affected pyrimidine / Cleavage of the damaged pyrimidine / methylated histone binding / Inhibition of DNA recombination at telomere / Meiotic synapsis / telomere organization / RNA Polymerase I Promoter Opening / Assembly of the ORC complex at the origin of replication / SUMOylation of chromatin organization proteins / DNAメチル化 / cellular response to nerve growth factor stimulus / Condensation of Prophase Chromosomes / ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression / SIRT1 negatively regulates rRNA expression / Chromatin modifications during the maternal to zygotic transition (MZT) / HCMV Late Events / PRC2 methylates histones and DNA / Defective pyroptosis / HDACs deacetylate histones / RNA Polymerase I Promoter Escape / Nonhomologous End-Joining (NHEJ) / Transcriptional regulation by small RNAs / brain development / Formation of the beta-catenin:TCF transactivating complex / RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function / Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 / NoRC negatively regulates rRNA expression / HDMs demethylate histones / G2/M DNA damage checkpoint / B-WICH complex positively regulates rRNA expression / DNA Damage/Telomere Stress Induced Senescence / PKMTs methylate histone lysines / RMTs methylate histone arginines / 遺伝的組換え / Pre-NOTCH Transcription and Translation / Activation of anterior HOX genes in hindbrain development during early embryogenesis / HCMV Early Events / Transcriptional regulation of granulopoiesis / structural constituent of chromatin / ヌクレオソーム / nucleosome assembly / Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks / cell body / RUNX1 regulates transcription of genes involved in differentiation of HSCs / chromatin organization / HATs acetylate histones / Processing of DNA double-strand break ends / Senescence-Associated Secretory Phenotype (SASP) / Oxidative Stress Induced Senescence / Estrogen-dependent gene expression / sequence-specific DNA binding / chromosome, telomeric region / クロマチンリモデリング / RNA polymerase II cis-regulatory region sequence-specific DNA binding / protein heterodimerization activity / Amyloid fiber formation / 樹状突起 / クロマチン / regulation of DNA-templated transcription / regulation of transcription by RNA polymerase II / perinuclear region of cytoplasm / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / protein-containing complex / DNA binding / RNA binding / extracellular exosome / extracellular region / 核質 / 生体膜 / metal ion binding / 細胞核 / 細胞質 類似検索 - 分子機能
解像度: 1.5→19.86 Å / Cor.coef. Fo:Fc: 0.967 / Cor.coef. Fo:Fc free: 0.953 / WRfactor Rfree: 0.1984 / WRfactor Rwork: 0.1638 / Occupancy max: 1 / Occupancy min: 0.5 / FOM work R set: 0.8994 / SU B: 2.415 / SU ML: 0.041 / SU R Cruickshank DPI: 0.0746 / SU Rfree: 0.0779 / 交差検証法: THROUGHOUT / σ(F): 0 / ESU R: 0.075 / ESU R Free: 0.078 / 立体化学のターゲット値: MAXIMUM LIKELIHOOD 詳細: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS U VALUES : RESIDUAL ONLY
Rfactor
反射数
%反射
Selection details
Rfree
0.1984
1529
7.9 %
RANDOM
Rwork
0.1638
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obs
0.1664
19406
97.68 %
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溶媒の処理
イオンプローブ半径: 0.8 Å / 減衰半径: 0.8 Å / VDWプローブ半径: 1.4 Å / 溶媒モデル: MASK