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- PDB-3pvm: Structure of Complement C5 in Complex with CVF -

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Basic information

Entry
Database: PDB / ID: 3pvm
TitleStructure of Complement C5 in Complex with CVF
Components
  • Cobra venom factor
  • Complement C5Complement component 5
KeywordsIMMUNE SYSTEM / complement
Function / homology
Function and homology information


Terminal pathway of complement / membrane attack complex / Activation of C3 and C5 / negative regulation of macrophage chemotaxis / complement activation, alternative pathway / complement activation / chemokine activity / endopeptidase inhibitor activity / positive regulation of vascular endothelial growth factor production / complement activation, classical pathway ...Terminal pathway of complement / membrane attack complex / Activation of C3 and C5 / negative regulation of macrophage chemotaxis / complement activation, alternative pathway / complement activation / chemokine activity / endopeptidase inhibitor activity / positive regulation of vascular endothelial growth factor production / complement activation, classical pathway / positive regulation of chemokine production / Peptide ligand-binding receptors / Regulation of Complement cascade / chemotaxis / G alpha (i) signalling events / toxin activity / killing of cells of another organism / cell surface receptor signaling pathway / inflammatory response / G protein-coupled receptor signaling pathway / signaling receptor binding / extracellular space / extracellular exosome / extracellular region / metal ion binding
Similarity search - Function
: / Complement component 5, CUB domain / : / : / Complement component 3, CUB domain 2 / Complement component 3, CUB domain 1 / Complement C3-like, NTR domain / Alpha-2-macroglobulin, conserved site / Alpha-2-macroglobulin family thiolester region signature. / Complement C3/4/5, macroglobulin domain MG1 ...: / Complement component 5, CUB domain / : / : / Complement component 3, CUB domain 2 / Complement component 3, CUB domain 1 / Complement C3-like, NTR domain / Alpha-2-macroglobulin, conserved site / Alpha-2-macroglobulin family thiolester region signature. / Complement C3/4/5, macroglobulin domain MG1 / Macroglobulin domain MG1 / : / Alpha-macro-globulin thiol-ester bond-forming region / Anaphylatoxin, complement system domain / Anaphylatoxin domain signature. / Anaphylatoxin/fibulin / Anaphylatoxin, complement system / Anaphylotoxin-like domain / Anaphylatoxin domain profile. / Anaphylatoxin homologous domain / Netrin C-terminal Domain / Netrin module, non-TIMP type / UNC-6/NTR/C345C module / Netrin domain / NTR domain profile. / Alpha-macroglobulin, receptor-binding / Alpha-macroglobulin, receptor-binding domain superfamily / Macroglobulin domain MG4 / Macroglobulin domain MG3 / A-macroglobulin receptor binding domain / Macroglobulin domain MG4 / Macroglobulin domain MG3 / A-macroglobulin receptor / Tissue inhibitor of metalloproteinases-like, OB-fold / Alpha-2-macroglobulin / Macroglobulin domain / Alpha-2-macroglobulin, bait region domain / Alpha-macroglobulin-like, TED domain / Alpha-2-macroglobulin family / MG2 domain / A-macroglobulin TED domain / Alpha-2-macroglobulin bait region domain / Alpha-2-Macroglobulin / Alpha-2-macroglobulin family / Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid / Immunoglobulin-like fold
Similarity search - Domain/homology
Complement C5 / Cobra venom factor
Similarity search - Component
Biological speciesHomo sapiens (human)
Naja kaouthia (monocled cobra)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 4.3 Å
AuthorsLaursen, N.S. / Andersen, K.R. / Braren, I. / Sottrup-Jensen, L. / Spillner, E. / Andersen, G.R.
CitationJournal: Embo J. / Year: 2011
Title: Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex.
Authors: Laursen, N.S. / Andersen, K.R. / Braren, I. / Spillner, E. / Sottrup-Jensen, L. / Andersen, G.R.
History
DepositionDec 7, 2010Deposition site: RCSB / Processing site: RCSB
Revision 1.0Jan 19, 2011Provider: repository / Type: Initial release
Revision 1.1Jul 13, 2011Group: Version format compliance
Revision 1.2Jan 22, 2014Group: Refinement description
Revision 1.3Jul 29, 2020Group: Data collection / Derived calculations / Structure summary
Category: chem_comp / entity ...chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / struct_conn / struct_site / struct_site_gen
Item: _chem_comp.name / _chem_comp.type ..._chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id
Description: Carbohydrate remediation / Provider: repository / Type: Remediation
Revision 1.4Sep 6, 2023Group: Data collection / Database references ...Data collection / Database references / Refinement description / Structure summary
Category: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model
Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: Complement C5
B: Cobra venom factor
C: Complement C5
D: Cobra venom factor
hetero molecules


Theoretical massNumber of molelcules
Total (without water)747,80510
Polymers746,4784
Non-polymers1,3276
Water0
1
A: Complement C5
B: Cobra venom factor
hetero molecules


Theoretical massNumber of molelcules
Total (without water)373,9025
Polymers373,2392
Non-polymers6643
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Buried area5420 Å2
ΔGint-2 kcal/mol
Surface area128470 Å2
MethodPISA
2
C: Complement C5
D: Cobra venom factor
hetero molecules


Theoretical massNumber of molelcules
Total (without water)373,9025
Polymers373,2392
Non-polymers6643
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Buried area5620 Å2
ΔGint-3 kcal/mol
Surface area128240 Å2
MethodPISA
Unit cell
Length a, b, c (Å)176.520, 179.200, 389.690
Angle α, β, γ (deg.)90.00, 90.00, 90.00
Int Tables number17
Space group name H-MP2221
Noncrystallographic symmetry (NCS)NCS domain:
IDEns-ID
11
21
12
22

NCS domain segments:
Dom-IDComponent-IDEns-IDSelection details
111chain A and (resid 20:398 or resid 400:2010)
211chain C
112chain B
212chain D

NCS ensembles :
ID
1
2

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Components

#1: Protein Complement C5 / Complement component 5 / C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 / Complement C5 beta chain / ...C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 / Complement C5 beta chain / Complement C5 alpha chain / C5a anaphylatoxin / Complement C5 alpha' chain


Mass: 188512.094 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P01031
#2: Protein Cobra venom factor / CVF / Complement C3 homolog / Cobra venom factor alpha chain / Cobra venom factor gamma chain / ...CVF / Complement C3 homolog / Cobra venom factor alpha chain / Cobra venom factor gamma chain / Cobra venom factor beta chain


Mass: 184726.734 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Naja kaouthia (monocled cobra) / References: UniProt: Q91132
#3: Sugar
ChemComp-NAG / 2-acetamido-2-deoxy-beta-D-glucopyranose / N-acetyl-beta-D-glucosamine / 2-acetamido-2-deoxy-beta-D-glucose / 2-acetamido-2-deoxy-D-glucose / 2-acetamido-2-deoxy-glucose / N-ACETYL-D-GLUCOSAMINE / N-Acetylglucosamine


Type: D-saccharide, beta linking / Mass: 221.208 Da / Num. of mol.: 6
Source method: isolated from a genetically manipulated source
Formula: C8H15NO6
IdentifierTypeProgram
DGlcpNAcbCONDENSED IUPAC CARBOHYDRATE SYMBOLGMML 1.0
N-acetyl-b-D-glucopyranosamineCOMMON NAMEGMML 1.0
b-D-GlcpNAcIUPAC CARBOHYDRATE SYMBOLPDB-CARE 1.0
GlcNAcSNFG CARBOHYDRATE SYMBOLGMML 1.0

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION

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Sample preparation

CrystalDensity Matthews: 4.13 Å3/Da / Density % sol: 70.21 %

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Data collection

DiffractionMean temperature: 100 K
Diffraction sourceSource: SYNCHROTRON / Site: ESRF / Beamline: ID14-4 / Wavelength: 0.9765
DetectorType: ADSC QUANTUM 315r / Detector: CCD / Date: Mar 12, 2010
RadiationMonochromator: channel cut ESRF / Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 0.9765 Å / Relative weight: 1
ReflectionResolution: 4.3→49.469 Å / Num. obs: 79835 / % possible obs: 94.2 % / Redundancy: 5.6 % / Rsym value: 0.143 / Net I/σ(I): 10.9
Reflection shellHighest resolution: 4.3 Å / Redundancy: 5.6 % / Mean I/σ(I) obs: 3.1 / Rsym value: 0.625 / % possible all: 96

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Processing

Software
NameVersionClassification
PHENIX(phenix.refine: 1.6.4_486)refinement
XDSdata reduction
XSCALEdata scaling
PHASERphasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT
Starting model: PDB ENTRIES 3CU7 and 3HRZ

3cu7

3hrz


Resolution: 4.3→49.469 Å / SU ML: 0.55 / σ(F): 1.35 / Phase error: 25.02 / Stereochemistry target values: MLHL
RfactorNum. reflection% reflection
Rfree0.2623 1734 2.17 %
Rwork0.233 --
obs0.2336 79835 94.25 %
Solvent computationShrinkage radii: 0.27 Å / VDW probe radii: 0.6 Å / Solvent model: FLAT BULK SOLVENT MODEL / Bsol: 190.172 Å2 / ksol: 0.353 e/Å3
Displacement parameters
Baniso -1Baniso -2Baniso -3
1-21.0257 Å20 Å2-0 Å2
2--26.1164 Å2-0 Å2
3----47.1421 Å2
Refinement stepCycle: LAST / Resolution: 4.3→49.469 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms45184 0 84 0 45268
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.01248343
X-RAY DIFFRACTIONf_angle_d1.53562750
X-RAY DIFFRACTIONf_dihedral_angle_d26.22928480
X-RAY DIFFRACTIONf_chiral_restr0.1017188
X-RAY DIFFRACTIONf_plane_restr0.0078004
Refine LS restraints NCS
Ens-IDDom-IDAuth asym-IDNumberRefine-IDTypeRms dev position (Å)
11A12886X-RAY DIFFRACTIONPOSITIONAL
12C12886X-RAY DIFFRACTIONPOSITIONAL0.053
21B9739X-RAY DIFFRACTIONPOSITIONAL
22D9739X-RAY DIFFRACTIONPOSITIONAL0.048
LS refinement shell
Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkRefine-ID% reflection obs (%)
4.3-4.42650.36671530.32646524X-RAY DIFFRACTION96
4.4265-4.56920.35341460.29336559X-RAY DIFFRACTION96
4.5692-4.73240.3041430.27816534X-RAY DIFFRACTION96
4.7324-4.92170.26021430.25756535X-RAY DIFFRACTION96
4.9217-5.14550.29351470.23596550X-RAY DIFFRACTION96
5.1455-5.41650.25461460.23066524X-RAY DIFFRACTION95
5.4165-5.75540.29091470.23866484X-RAY DIFFRACTION95
5.7554-6.1990.33861470.26516526X-RAY DIFFRACTION95
6.199-6.82130.25381350.23716516X-RAY DIFFRACTION94
6.8213-7.80510.19821460.19466447X-RAY DIFFRACTION93
7.8051-9.82090.18851390.15556484X-RAY DIFFRACTION92
9.8209-49.47210.24811420.2346419X-RAY DIFFRACTION88
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
10.8113-0.12230.28090.2051-0.48620.8090.0412-0.0794-0.9172-0.1223-0.12820.12710.65080.03180.11481.89260.46120.16731.4226-0.00961.6931135.656-79.2803-80.6318
21.787-1.27830.13230.90310.09550.63910.15160.17220.48590.0842-0.419-0.00410.09580.26150.16940.98980.13660.26441.15590.3621.3391137.3908-76.4332-43.1147
32.06232.0548-1.23471.4854-1.24514.80650.10870.03640.21970.57410.13850.4651-0.59130.122-0.17691.30790.1383-0.09491.03760.13731.3963129.1341-43.9745-32.9189
41.4459-0.17230.72210.88380.21751.6868-0.1082-0.19740.34280.02750.0821-0.5419-0.00680.39320.18981.2078-0.02510.0221.35870.29281.5304123.3546-43.033-67.3736
52.6886-0.73231.39743.263-1.35060.98760.19220.24030.0136-0.37650.06430.11290.24270.5087-0.16781.26250.02060.00731.6850.12581.2412118.7749-62.51-79.9309
60.6091-0.87740.29111.35770.08181.6499-0.1453-0.1178-0.1667-0.2464-0.25150.4001-0.0909-0.1370.18041.2324-0.15160.10891.25910.21571.3559114.5233-75.8239-34.4072
71.91370.5119-0.18620.3585-0.58030.73070.04490.0418-0.12580.7890.11180.0904-0.1104-0.0319-0.12581.62270.09680.07490.91260.02761.3629122.9907-67.2487-7.2003
82.51870.0059-0.09360.00331.27782.9315-0.0256-0.1318-0.66280.00330.00960.09580.49120.12960.01221.39510.3663-0.07640.99730.20671.7313157.549-83.4473-34.0865
93.5248-0.9132-0.15210.1321-0.77432.278-0.52590.0759-0.39961.16890.27760.0142-0.70250.02630.19341.72950.1944-0.120.9428-0.02981.1083130.9006-46.5345-4.2065
104.7425-0.0846-3.07153.4628-0.61512.69860.11410.00550.1310.7371-0.35910.72120.10280.11360.25341.2125-0.1521-0.20640.77140.03071.0052138.2345-82.499717.8336
11-0.1684-0.63460.93340.6889-1.03618.577-0.3031-0.016-0.5163-0.0846-0.0418-0.0656-0.48560.96670.3040.87160.02910.13721.03360.17761.113132.9102-63.2251-66.4342
123.2687-0.79760.53411.0582-0.34990.9939-0.38630.3009-0.3626-0.08430.01990.69380.1355-0.87570.31111.21370.5573-0.11351.9578-0.35851.5015.478349.3129-16.5936
131.657-0.92060.79121.0845-0.07791.9892-0.7765-0.08450.12620.30460.4986-0.48560.0602-0.40360.15291.3370.1828-0.31561.2335-0.25291.356110.637452.4472-53.7716
140.41141.15481.27242.63690.9725.25850.41670.2535-0.1240.1068-0.1814-0.52980.08560.2346-0.14781.36170.1219-0.01741.87660.05491.534343.540444.0554-62.3056
150.34071.1226-0.93571.8428-0.1583.7887-0.09310.16910.1768-0.0841-0.2801-0.72240.12340.26190.23091.08420.1124-0.28871.48-0.09951.405342.299536.9363-28.1062
160.8493-0.14991.27423.4691-0.60241.90070.168-0.2699-0.08330.0234-0.21660.0459-0.28910.0999-0.02091.46930.1478-0.13691.6132-0.08161.248122.027132.198-16.9497
173.1288-0.29110.19781.9665-0.49021.5233-0.2417-0.152-0.177-0.3313-0.478-0.07440.2751-0.05840.35221.368-0.0915-0.22781.1919-0.12571.224411.456329.9266-63.3252
181.6399-1.3394-0.39732.1595-1.18392.85680.10080.3630.3091-0.00920.1283-0.0834-0.04480.1705-0.18991.0829-0.0237-0.04911.27990.00421.36621.79539.2875-89.6092
190.23790.93150.1732.6450.40040.2279-0.158-0.2735-0.5728-0.2822-0.13870.9524-0.3343-0.18440.14731.17060.3403-0.06441.36030.21351.57214.46373.043-62.4163
201.0323-0.61931.77164.1462-1.74182.50690.0761.00090.1054-0.0703-0.6178-0.24730.05151.07030.38811.14560.08310.07811.74150.06431.227142.764246.9636-91.0295
215.00151.37910.28623.52952.78131.5841-0.0010.4166-0.1937-0.5641-0.0461-0.1455-0.5942-0.21020.06191.2972-0.0823-0.04251.20910.15161.08558.297955.6842-114.8843
220.6567-0.5096-0.0951-0.0504-0.00252.13-0.2537-0.14920.428-0.1617-0.5949-0.1081-0.2582-0.19270.36581.49950.2134-0.21631.3188-0.19781.450922.334846.8569-29.8928
230.71580.2546-0.29072.61891.51953.56480.60540.00890.12410.2946-0.4108-0.5678-0.3602-1.0103-0.18941.21680.30570.18021.23540.73561.100986.4285-25.6056-78.5041
244.8421-0.36871.47012.0831-2.14742.21380.11040.13730.22110.3622-0.0765-0.214-0.3123-0.2373-0.07641.31620.15870.06931.2646-0.04791.269175.4373-43.4507-46.3068
250.69221.30160.05372.41461.40792.1978-0.39010.0257-0.09690.4035-0.62960.62020.5155-0.04320.73211.6510.11950.2881.40240.17091.743676.2786-80.7042-47.1529
261.3606-1.0973-0.13791.7158-0.531.79980.00570.8807-0.28510.3814-0.18570.2889-0.39290.38530.23331.4219-0.35290.14191.7947-0.00551.384795.1407-67.0075-77.6972
274.2768-1.1511-0.76050.9511-0.67722.9908-0.1419-0.29930.5779-0.01480.1635-0.497-0.0330.0258-0.07230.86850.10860.06881.35390.15531.1299102.494-42.7792-78.2601
280.1823-0.5151-0.12251.5426-0.49511.4013-0.65440.5460.6551-0.00390.548-0.25660.15050.43380.0921.0118-0.0146-0.15322.03360.26971.594793.5582-49.411-37.7276
291.42070.40740.16291.71370.28550.53490.13720.04560.02920.57770.4072-0.1186-0.25710.1686-0.31821.81490.17680.34631.51470.27771.549788.4942-67.7253-9.335
300.759-0.6239-1.3932.62620.09642.0305-0.3813-0.59530.06570.50950.2382-0.01220.06870.37510.09841.7502-0.09470.20321.6054-0.08761.253859.9763-36.3378-0.6051
314.36421.0253-2.1387-0.53271.6912.8866-0.10530.263-0.17040.24430.0556-0.11960.2294-0.1020.0580.96360.14850.14040.68410.02860.938145.6227-41.008-25.4148
324.3687-0.50561.74040.2943-1.06042.7262-0.0318-0.1113-1.0384-0.11070.1755-0.03820.5985-0.2487-0.08561.38630.03980.42281.06560.03771.436254.3302-68.8721-15.2588
332.4542-0.9156-0.26882.44770.0291-0.1215-0.464-0.4885-0.01242.9329-0.4685-0.0747-1.06510.13870.71523.4637-0.2558-0.09932.22320.31321.401965.2944-64.924324.3758
342.14910.36150.02442.6385-0.044-0.08510.13650.2469-0.78390.6808-0.4035-0.16710.11990.06010.21512.20540.03660.29592.0666-0.25342.254652.0769-81.3458-40.2977
352.69480.5153-3.51222.6373-4.2912.0688-0.8991.128-0.34990.04020.195-0.5967-0.0764-2.62370.47331.5506-0.33750.3021.833101.491486.1712-48.6032-70.0735
361.9787-1.1868-2.27462.2810.52123.2443-0.5783-0.39410.3407-0.18250.2787-0.29470.60510.29440.23071.12350.2525-0.33431.4346-0.0991.011358.0992-0.702-17.9299
372.5067-0.6862.3013.9369-2.41033.5015-0.46810.08850.35290.394-0.06320.39720.37630.18620.44361.38780.1371-0.0141.1475-0.07741.173442.2234-9.7808-51.7179
381.54691.4093-1.19361.3143-0.44952.7285-0.4173-0.3439-0.41930.035-0.5208-0.3118-0.3031-0.38430.67321.4753-0.0183-0.19281.6953-0.36271.67565.0024-8.4781-53.1903
390.2259-0.7372-0.55452.37011.0211.1682-0.22040.6318-0.16630.2372-0.72180.63340.1005-0.71630.74651.3805-0.2803-0.0351.9399-0.49021.548616.92428.6053-20.8982
401.659-1.03770.5083.6988-1.31250.5931-0.2438-0.08260.1347-0.0748-0.0921-0.31210.116-0.22110.20591.19950.1953-0.09341.2958-0.2221.228341.141115.5579-18.4206
411.58890.04320.2073-0.10670.12521.7830.45730.1350.2290.6432-0.4848-0.7054-0.9671-0.0950.05421.6504-0.064-0.20080.96470.03861.410337.01078.8312-59.7028
421.0667-0.5381-0.15823.0094-0.76080.9460.69160.33140.20650.2122-0.6955-0.3718-0.1896-0.0330.02181.45330.1439-0.10211.5535-0.20121.519820.48675.478-89.4232
432.4976-0.49182.04870.82680.42021.55910.59360.4230.1134-0.234-0.6544-0.04770.06490.31870.10751.4051-0.0626-0.01161.7479-0.03331.173752.0829-22.9553-97.6323
441.0150.6456-1.03272.80190.82172.5646-0.08240.3522-0.06630.379-0.08540.28910.0740.01070.12920.90890.04680.01821.0325-0.14071.099645.7051-38.5022-73.9369
451.5667-0.70590.96463.1632-1.09961.907-0.1957-0.2699-0.3951-0.11340.35070.65960.148-0.3589-0.04850.950.10430.04731.2855-0.38881.273418.6261-28.9205-85.358
460.92260.7656-0.03462.60441.71261.16340.75212.1346-0.223-1.1762-1.5186-0.13-1.3555-0.74710.56192.06360.8396-0.043.2637-0.01851.413225.1934-15.9903-124.0467
472.3797-0.5667-0.29471.8186-0.12590.1851-0.698-0.1380.3033-0.02810.58970.27940.4859-0.14410.21222.09060.27280.3022.16250.02741.92954.5649-32.2894-61.305
481.00170.77753.24371.00173.10458.96560.28950.11680.33050.474-0.46480.13511.7956-0.23430.15241.6242-0.0608-0.09951.5971-0.2751.402635.6815-0.2137-27.8023
Refinement TLS group
IDRefine-IDRefine TLS-IDSelection detailsAuth asym-IDAuth seq-ID
1X-RAY DIFFRACTION1chain B and resid 23:125B23 - 125
2X-RAY DIFFRACTION2chain B and ( resid 126:220 or resid 2001 )B126 - 220
3X-RAY DIFFRACTION2chain B and ( resid 126:220 or resid 2001 )B2001
4X-RAY DIFFRACTION3chain B and resid 221:340B221 - 340
5X-RAY DIFFRACTION4chain B and resid 341:437B341 - 437
6X-RAY DIFFRACTION5chain B and resid 438:542B438 - 542
7X-RAY DIFFRACTION6chain B and ( resid 543:582 or resid 735:812 )B543 - 582
8X-RAY DIFFRACTION6chain B and ( resid 543:582 or resid 735:812 )B735 - 812
9X-RAY DIFFRACTION7chain B and resid 813:917B813 - 917
10X-RAY DIFFRACTION8chain B and ( resid 918:969 or resid 1270:1333 )B918 - 969
11X-RAY DIFFRACTION8chain B and ( resid 918:969 or resid 1270:1333 )B1270 - 1333
12X-RAY DIFFRACTION9chain B and ( resid 1339:1473 or resid 2002 )B1339 - 1473
13X-RAY DIFFRACTION9chain B and ( resid 1339:1473 or resid 2002 )B2002
14X-RAY DIFFRACTION10chain B and resid 1474:1642B1474 - 1642
15X-RAY DIFFRACTION11chain B and resid 583:648B583 - 648
16X-RAY DIFFRACTION12chain D and resid 23:125D23 - 125
17X-RAY DIFFRACTION13chain D and ( resid 126:220 or resid 2001 )D126 - 220
18X-RAY DIFFRACTION13chain D and ( resid 126:220 or resid 2001 )D2001
19X-RAY DIFFRACTION14chain D and resid 221:340D221 - 340
20X-RAY DIFFRACTION15chain D and resid 341:437D341 - 437
21X-RAY DIFFRACTION16chain D and resid 438:542D438 - 542
22X-RAY DIFFRACTION17chain D and ( resid 543:582 or resid 735:812 )D543 - 582
23X-RAY DIFFRACTION17chain D and ( resid 543:582 or resid 735:812 )D735 - 812
24X-RAY DIFFRACTION18chain D and resid 813:917D813 - 917
25X-RAY DIFFRACTION19chain D and ( resid 918:969 or resid 1270:1333 )D918 - 969
26X-RAY DIFFRACTION19chain D and ( resid 918:969 or resid 1270:1333 )D1270 - 1333
27X-RAY DIFFRACTION20chain D and ( resid 1339:1473 or resid 2002 )D1339 - 1473
28X-RAY DIFFRACTION20chain D and ( resid 1339:1473 or resid 2002 )D2002
29X-RAY DIFFRACTION21chain D and resid 1474:1642D1474 - 1642
30X-RAY DIFFRACTION22chain D and resid 583:648D583 - 648
31X-RAY DIFFRACTION23chain A and resid 20:120A20 - 120
32X-RAY DIFFRACTION24chain A and resid 121:224A121 - 224
33X-RAY DIFFRACTION25chain A and resid 225:349A225 - 349
34X-RAY DIFFRACTION26chain A and resid 350:460A350 - 460
35X-RAY DIFFRACTION27chain A and resid 461:566A461 - 566
36X-RAY DIFFRACTION28chain A and ( resid 567:606 or resid 760:821 )A567 - 606
37X-RAY DIFFRACTION28chain A and ( resid 567:606 or resid 760:821 )A760 - 821
38X-RAY DIFFRACTION29chain A and ( resid 822:930 or resid 2003 )A822 - 930
39X-RAY DIFFRACTION29chain A and ( resid 822:930 or resid 2003 )A2003
40X-RAY DIFFRACTION30chain A and ( resid 931:983 or resid 1305:1367 )A931 - 983
41X-RAY DIFFRACTION30chain A and ( resid 931:983 or resid 1305:1367 )A1305 - 1367
42X-RAY DIFFRACTION31chain A and resid 984:1304A984 - 1304
43X-RAY DIFFRACTION32chain A and resid 1368:1514A1368 - 1514
44X-RAY DIFFRACTION33chain A and resid 1525:1676A1525 - 1676
45X-RAY DIFFRACTION34chain A and resid 678:759A678 - 759
46X-RAY DIFFRACTION35chain A and resid 607:673A607 - 673
47X-RAY DIFFRACTION36chain C and resid 20:120C20 - 120
48X-RAY DIFFRACTION37chain C and resid 121:224C121 - 224
49X-RAY DIFFRACTION38chain C and resid 225:349C225 - 349
50X-RAY DIFFRACTION39chain C and resid 350:460C350 - 460
51X-RAY DIFFRACTION40chain C and resid 461:566C461 - 566
52X-RAY DIFFRACTION41chain C and ( resid 567:606 or resid 760:821 )C567 - 606
53X-RAY DIFFRACTION41chain C and ( resid 567:606 or resid 760:821 )C760 - 821
54X-RAY DIFFRACTION42chain C and ( resid 822:930 or resid 2003 )C822 - 930
55X-RAY DIFFRACTION42chain C and ( resid 822:930 or resid 2003 )C2003
56X-RAY DIFFRACTION43chain C and ( resid 931:983 or resid 1305:1367 )C931 - 983
57X-RAY DIFFRACTION43chain C and ( resid 931:983 or resid 1305:1367 )C1305 - 1367
58X-RAY DIFFRACTION44chain C and resid 984:1304C984 - 1304
59X-RAY DIFFRACTION45chain C and resid 1368:1514C1368 - 1514
60X-RAY DIFFRACTION46chain C and resid 1525:1676C1525 - 1676
61X-RAY DIFFRACTION47chain C and resid 678:759C678 - 759
62X-RAY DIFFRACTION48chain C and resid 607:673C607 - 673

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